Mina L. Xu
YOU?
Author Swipe
View article: Cutaneous Extracavitary Primary Effusion Lymphoma: A Case Report and Review of Literature
Cutaneous Extracavitary Primary Effusion Lymphoma: A Case Report and Review of Literature Open
Primary effusion lymphoma (PEL) is a rare B‐cell lymphoma that is most often seen in immunocompromised patients with human herpesvirus‐8 (HHV‐8) and Epstein–Barr virus (EBV) infections. PEL typically affects body cavities with occasional i…
View article: Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT
Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT Open
Chromatin organization within the cell nucleus governs the epigenetic regulation of diverse cellular functions and is tightly controlled within the spatial context of tissues. In human non-Hodgkin B-cell lymphoma (B-NHL), epigenetic regula…
View article: Hi-c FFPE sequencing analysis is highly concordant with FISH and detects additional variants informing diagnosis and treatment in diffuse large B-cell lymphoma
Hi-c FFPE sequencing analysis is highly concordant with FISH and detects additional variants informing diagnosis and treatment in diffuse large B-cell lymphoma Open
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), accounting for approximately 30% of all NHL cases. DLBCL diagnosis relies on histologic examination, immunophenotyping, molecular and …
View article: Transcriptional Analysis of Effusion-Based Lymphoma Supports a Post-Germinal Center Origin and Specific Inflammatory Signal Background
Transcriptional Analysis of Effusion-Based Lymphoma Supports a Post-Germinal Center Origin and Specific Inflammatory Signal Background Open
Background: Effusion-based lymphoma (EBL) is a rare and aggressive large B-cell lymphoma. It presents as a body cavity effusion without a solid mass, lacks HHV-8 association, and typically expresses CD20. Objectives: To better understand t…
View article: Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma
Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma Open
Primary testicular (PT) diffuse large B-cell lymphoma (DLBCL) is a rare and aggressive lymphoma with distinct clinical and molecular characteristics. To identify prognostic biomarkers in PT-DLBCL, in this study we analyzed DNA and RNA samp…
View article: Spatially Resolved Panoramic in vivo CRISPR Screen via Perturb-DBiT
Spatially Resolved Panoramic in vivo CRISPR Screen via Perturb-DBiT Open
Spatially resolved in vivo CRISPR screening integrates gene editing with spatial transcriptomics to examine how genetic perturbations alter gene expression within native tissue environments. However, current methods are limited to small p…
View article: Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement
Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement Open
Excessively restrictive inclusion and exclusion criteria in clinical trials are one of many barriers to clinical trial enrollment for patients with myelodysplastic syndromes/neoplasms (MDSs). Many organizations are developing efforts to in…
View article: Standardization of Bone Marrow Reporting for Myelodysplastic Syndromes/Neoplasms on Behalf of the International Consortium for Myelodysplastic Syndromes/Neoplasms
Standardization of Bone Marrow Reporting for Myelodysplastic Syndromes/Neoplasms on Behalf of the International Consortium for Myelodysplastic Syndromes/Neoplasms Open
Context.— Standardized bone marrow reporting specifically for myelodysplastic syndromes/neoplasms (MDS) is currently lacking in the literature and much needed in practice. Objective.— To propose a standardized approach to MDS evaluation in…
View article: Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma
Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma Open
Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive lymphoma with molecular heterogeneity not well characterize. In this study, we performed next-generation sequencing analysis for a large number of DNA and…
View article: Pax5 as a Diagnostic Tool in Unconventional Acute Leukemia: Establishing Immunohistochemical Evidence of B-Cell Lineage
Pax5 as a Diagnostic Tool in Unconventional Acute Leukemia: Establishing Immunohistochemical Evidence of B-Cell Lineage Open
View article: Dectin-1 participates in β-glucan- or PMA-induced neutrophil extracellular trap formation during antifungal defense
Dectin-1 participates in β-glucan- or PMA-induced neutrophil extracellular trap formation during antifungal defense Open
Dectin-1 promotes NET formation in neutrophils stimulated by β-glucan or PMA through activation of the ERK and p38 signaling pathways, which might contribute to defense against fungal pathogens.
View article: HIF-1α mediates hypertension and vascular remodeling in sleep apnea via hippo–YAP pathway activation
HIF-1α mediates hypertension and vascular remodeling in sleep apnea via hippo–YAP pathway activation Open
Background Sleep apnea syndrome (SAS) is associated with hypertension and vascular remodeling. Hypoxia-inducible factor-1α (HIF-1α) and the Hippo–YAP pathway are implicated in these processes, but their specific roles remain unclear. This …
View article: Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus
Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus Open
View article: Angioimmunoblastic T-cell lymphoma: Current Diagnostic Insights and Advances
Angioimmunoblastic T-cell lymphoma: Current Diagnostic Insights and Advances Open
Angioimmunoblastic T-cell lymphoma (AITL), or nodal T-follicular helper cell lymphoma, angioimmunoblastic type, is a rare and aggressive type of T-cell lymphoma characterized by a spectrum of clinical and histopathological features that ca…
View article: Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus
Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus Open
Spatially mapping the transcriptome and proteome in the same tissue section can significantly advance our understanding of heterogeneous cellular processes and connect cell type to function. Here, we present Deterministic Barcoding in Tiss…
View article: Data-driven, harmonised classification system for myelodysplastic syndromes: a consensus paper from the International Consortium for Myelodysplastic Syndromes
Data-driven, harmonised classification system for myelodysplastic syndromes: a consensus paper from the International Consortium for Myelodysplastic Syndromes Open
View article: Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues
Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues Open
View article: High-grade B-cell lymphoma, not otherwise specified: CNS involvement and outcomes in a multi-institutional series
High-grade B-cell lymphoma, not otherwise specified: CNS involvement and outcomes in a multi-institutional series Open
Little is known about the central nervous system (CNS) risk in high-grade B-cell lymphoma, not otherwise specified (HGBL NOS). Hence, we sought to describe the rates of baseline CNS involvement, risk of CNS recurrence after primary therapy…
View article: Rare Drivers at Low Prevalence with High Cancer Effects in T-Cell and B-Cell Pediatric Acute Lymphoblastic Leukemia
Rare Drivers at Low Prevalence with High Cancer Effects in T-Cell and B-Cell Pediatric Acute Lymphoblastic Leukemia Open
The genomic analyses of pediatric acute lymphoblastic leukemia (ALL) subtypes, particularly T-cell and B-cell lineages, have been pivotal in identifying potential therapeutic targets. Typical genomic analyses have directed attention toward…
View article: Spatially Exploring RNA Biology in Archival Formalin-Fixed Paraffin-Embedded Tissues
Spatially Exploring RNA Biology in Archival Formalin-Fixed Paraffin-Embedded Tissues Open
Spatial transcriptomics has emerged as a powerful tool for dissecting spatial cellular heterogeneity but as of today is largely limited to gene expression analysis. Yet, the life of RNA molecules is multifaceted and dynamic, requiring spat…
View article: Genetics and pathologic landscape of lineage switch of acute leukemia during therapy
Genetics and pathologic landscape of lineage switch of acute leukemia during therapy Open
Table 1.Clinicopathologic features of patients with lineage-switching leukemia.Case # Sex Age at acute #1 Dx of acute #1 Tx of acute #1 Dz status of acute #1 at dx of acute #2 Dx of acute #2 Interval from acute #1 to #2 Tx of acute #2 Pt s…
View article: PD-1H/VISTA mediates immune evasion in acute myeloid leukemia
PD-1H/VISTA mediates immune evasion in acute myeloid leukemia Open
Acute myeloid leukemia (AML) presents a pressing medical need in that it is largely resistant to standard chemotherapy as well as modern therapeutics, such as targeted therapy and immunotherapy, including anti-programmed cell death protein…
Specific Polo-Like Kinase 1 Expression in Nodular Lymphocyte-Predominant Hodgkin Lymphoma Suggests an Intact Immune Surveillance Program Open
View article: Genetics and Pathologic Landscape of Lineage Switch of Acute Leukemia during Therapy: A Multi-institutional Study
Genetics and Pathologic Landscape of Lineage Switch of Acute Leukemia during Therapy: A Multi-institutional Study Open
The dismal outcome of acute leukemia undergoing immunophenotype-switch, compounded by the increased incidence in the era of immunotherapy, highlights the need for in-depth systemic studies. We investigated the clinicopathological, cytogene…
View article: Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS)
Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS) Open
View article: S170: MYELODYSPLASTIC NEOPLASMS (MDS) CLASSIFICATION FROM WHO 2017 TO WHO 2022 AND ICC 2022): AN EXPANDED ANALYSIS OF 7017 PATIENTS ON BEHALF OF THE INTERNATIONAL CONSORTIUM FOR MDS (ICMDS)
S170: MYELODYSPLASTIC NEOPLASMS (MDS) CLASSIFICATION FROM WHO 2017 TO WHO 2022 AND ICC 2022): AN EXPANDED ANALYSIS OF 7017 PATIENTS ON BEHALF OF THE INTERNATIONAL CONSORTIUM FOR MDS (ICMDS) Open
Topic: 10. Myelodysplastic syndromes - Clinical Background: In 2022 two new classifications for myeloid neoplasms were published: the World Health Organization (WHO) and International Consensus Classification (ICC). Aims: To validate and c…
View article: High-grade B-cell lymphoma, not otherwise specified: a multi-institutional retrospective study
High-grade B-cell lymphoma, not otherwise specified: a multi-institutional retrospective study Open
In this multi-institutional retrospective study, we examined the characteristics and outcomes of 160 patients with high-grade B-cell lymphoma, not otherwise specified (HGBL-NOS)—a rare category defined by high-grade morphologic features an…
View article: <scp>IRF8</scp> may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak <scp>CD123</scp> expression
<span>IRF8</span> may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak <span>CD123</span> expression Open
We highlight the utility of interferon regulatory factor 8 (IRF8), a novel marker of monocytic and dendritic cell lineages, in the diagnosis of a case of blastic plasmacytoid dendritic cell neoplasm (BPDCN) presenting initially in the skin…
View article: Data from PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies
Data from PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies Open
Purpose: Programmed cell death ligand 1 (PD-L1) is an immunomodulatory molecule expressed by antigen-presenting cells and select tumors that engages receptors on T cells to inhibit T-cell immunity. Immunotherapies targeting the PD-1…
View article: Data from PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies
Data from PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies Open
Purpose: Programmed cell death ligand 1 (PD-L1) is an immunomodulatory molecule expressed by antigen-presenting cells and select tumors that engages receptors on T cells to inhibit T-cell immunity. Immunotherapies targeting the PD-1…