Ming Zhong
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View article: Coronary Artery Spasm as a Rare Manifestation of Hypereosinophilic Syndrome: A Case Report
Coronary Artery Spasm as a Rare Manifestation of Hypereosinophilic Syndrome: A Case Report Open
Hypereosinophilic syndrome (HES) is a rare hematologic disorder characterized by persistently elevated eosinophil counts, leading to organ involvement. While eosinophilic myocarditis and endocarditis are common manifestations, coronary art…
View article: The combination of inactivated and subunit vaccines enhances protective efficacy against Mycoplasma synoviae
The combination of inactivated and subunit vaccines enhances protective efficacy against Mycoplasma synoviae Open
View article: SinoMAKS—protocol of a randomised controlled trial to evaluate the Chinese version of the non-pharmacological, multimodal MAKS intervention for people with mild to moderate dementia in Chinese nursing homes
SinoMAKS—protocol of a randomised controlled trial to evaluate the Chinese version of the non-pharmacological, multimodal MAKS intervention for people with mild to moderate dementia in Chinese nursing homes Open
Introduction The prevalence of dementia is increasing, both worldwide and in China. This disease is associated with numerous restrictions for those affected but also for caregivers and society. Due to the limited effectiveness of pharmacol…
View article: TRIB3 mediates vascular calcification by facilitating self-ubiquitination and dissociation of Smurf1 in chronic kidney disease
TRIB3 mediates vascular calcification by facilitating self-ubiquitination and dissociation of Smurf1 in chronic kidney disease Open
The osteogenic environment promotes vascular calcium phosphate deposition and aggregation of unfolded and misfolded proteins, resulting in ER stress in chronic kidney disease (CKD). Controlling ER stress through genetic intervention is a p…
View article: Circadian Rhythm Disruption and Its Association With Type 2 Diabetes Mellitus
Circadian Rhythm Disruption and Its Association With Type 2 Diabetes Mellitus Open
View article: Long Chain-of-Thought Fine-tuning via Understanding-to-Reasoning Transition
Long Chain-of-Thought Fine-tuning via Understanding-to-Reasoning Transition Open
View article: Origin-Destination Demand Prediction: An Urban Radiation and Attraction Perspective
Origin-Destination Demand Prediction: An Urban Radiation and Attraction Perspective Open
In recent years, origin-destination (OD) demand prediction has gained significant attention for its profound implications in urban development. Existing data-driven deep learning methods primarily focus on the spatial or temporal dependenc…
View article: New Mitochondrial Genomes of Ithonidae (Neuroptera) and Higher Phylogenetic Implications
New Mitochondrial Genomes of Ithonidae (Neuroptera) and Higher Phylogenetic Implications Open
Ithonidae (moth lacewings) are an enigmatic, small family of the insect order Neuroptera (lacewings). Its phylogenetic position within Neuroptera and internal subfamily relationships remain unresolved. In this study, the complete mitochond…
View article: A comprehensive analysis of genes associated with hypoxia and cuproptosis in pulmonary arterial hypertension using machine learning methods and immune infiltration analysis: AHR is a key gene in the cuproptosis process
A comprehensive analysis of genes associated with hypoxia and cuproptosis in pulmonary arterial hypertension using machine learning methods and immune infiltration analysis: AHR is a key gene in the cuproptosis process Open
Background Pulmonary arterial hypertension (PAH) is a serious condition characterized by elevated pulmonary artery pressure, leading to right heart failure and increased mortality. This study investigates the link between PAH and genes ass…
View article: In vitro shoot regeneration system from leaves wrapped by bud scales of a multipurpose tree (Neolamarckia cadamba)
In vitro shoot regeneration system from leaves wrapped by bud scales of a multipurpose tree (Neolamarckia cadamba) Open
Neolamarckia cadamba ( N. cadamba ) is an evergreen tree species known for its rapid growth, remarkable wood properties, and significant value in medicine, feeding, and landscape. In order to clone a N. cadamba individual with excellent ge…
View article: WITHDRAWN: Establishment of regeneration system from leaves wrapped by bud scales of Neolamarckia cadamba in the wild
WITHDRAWN: Establishment of regeneration system from leaves wrapped by bud scales of Neolamarckia cadamba in the wild Open
The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
View article: Painless thyroiditis induced by pembrolizumab leading to depleted pituitary hypothyroidism: a case report and literature review
Painless thyroiditis induced by pembrolizumab leading to depleted pituitary hypothyroidism: a case report and literature review Open
Introduction Cases of hypothyroidism (referred to as hypothyroidism) induced by PD-1 inhibitor therapy are common in clinical practice, but cases of pituitary hypothyroidism induced by thyrotoxicosis have not been reported. Case Report We …
View article: Exostoisns (EXT1/2) in Head and Neck Cancers: An In Silico Analysis and Clinical Correlates
Exostoisns (EXT1/2) in Head and Neck Cancers: An In Silico Analysis and Clinical Correlates Open
View article: WITHDRAWN: Establishment of regeneration system from leaves wrapped by bud scales of Neolamarckia cadamba in the wild
WITHDRAWN: Establishment of regeneration system from leaves wrapped by bud scales of Neolamarckia cadamba in the wild Open
Neolamarckia cadamba is an evergreen tree species growing fast, with not only good wood properties, but also great value in medicine, feeding and landscape. In order to clone an excellent genotype individual of N. cadamba , the plant regen…
View article: Genome of Alectoris chukar provide insights into its domestication, adaptation, and origin
Genome of Alectoris chukar provide insights into its domestication, adaptation, and origin Open
Alectoris chukar (chukar) is the most widespread partridge species in the world, adapting well to a variety of ecological settings. Like chickens and other poultries, chukars have been domesticated in recent decades to provide meat and egg…
View article: Deep Vein Thrombosis Is Facilitated by Endothelial-Derived Extracellular Vesicles via the PDI–GRP94–GPIIb/IIIa Pathway in Mice
Deep Vein Thrombosis Is Facilitated by Endothelial-Derived Extracellular Vesicles via the PDI–GRP94–GPIIb/IIIa Pathway in Mice Open
Aims: Deep vein thrombosis (DVT) is a prevalent cardiovascular condition. Endothelial-derived extracellular vesicles (EVs) may play a crucial role in platelet-dependent DVT development via platelet activation, but the mechanism is not clea…
View article: Efficacy and safety of glucocorticoids use in patients with COVID- 19: a systematic review and network meta‑analysis
Efficacy and safety of glucocorticoids use in patients with COVID- 19: a systematic review and network meta‑analysis Open
Background Currently, some meta-analyses on COVID-19 have suggested that glucocorticoids use can reduce the mortality rate of COVID-19 patients, utilization rate of invasive ventilation, and improve the prognosis of patients. However, opti…
View article: Inhibition of Fatty Acid β-Oxidation by Fatty Acid Binding Protein 4 Induces Ferroptosis in HK2 Cells Under High Glucose Conditions
Inhibition of Fatty Acid β-Oxidation by Fatty Acid Binding Protein 4 Induces Ferroptosis in HK2 Cells Under High Glucose Conditions Open
Background: Ferroptosis, which is caused by an iron-dependent accumulation of lipid hydroperoxides, is a type of cell death linked to diabetic kidney disease (DKD). Previous research has shown that fatty acid binding protein 4 (FABP4) is i…
View article: Serum Response Factor-Regulated IDO1/Kyn-Ahr Pathway Promotes Tumorigenesis of Oral Squamous Cell Carcinoma
Serum Response Factor-Regulated IDO1/Kyn-Ahr Pathway Promotes Tumorigenesis of Oral Squamous Cell Carcinoma Open
Serum response factor (SRF) regulates pro-carcinogenic genes in various cancers, but its role in oral squamous cell carcinoma (OSCC) remains unclear. SRF expression in 70 OSCC samples was detected via immunohistochemistry. Abundant SRF exp…
View article: Functional characterization and development of novel human kinase insert domain receptor chimeric antigen receptor T-cells for immunotherapy of non-small cell lung cancer
Functional characterization and development of novel human kinase insert domain receptor chimeric antigen receptor T-cells for immunotherapy of non-small cell lung cancer Open
CAR-T cell therapy, in which T cells are transfected or transduced with a chimeric antigen receptor (CAR), is a transformative type of cancer immunotherapy. Despite outstanding success in hematological malignancies, their efficacy against …
View article: New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1
New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1 Open
View article: STAMP2 Attenuates Cardiac Dysfunction and Insulin Resistance in Diabetic Cardiomyopathy via NMRAL1-Mediated NF-κB Inhibition in Type 2 Diabetic Rats
STAMP2 Attenuates Cardiac Dysfunction and Insulin Resistance in Diabetic Cardiomyopathy via NMRAL1-Mediated NF-κB Inhibition in Type 2 Diabetic Rats Open
STAMP2 attenuates cardiac dysfunction and insulin resistance in diabetic cardiomyopathy, likely by promoting NMRAL1 retranslocation and NF-κB signaling inhibition.
View article: Effects and mechanism of Aβ1−42 on EV-A71 replication
Effects and mechanism of Aβ1−42 on EV-A71 replication Open
Background β-Amyloid (Aβ) protein is a pivotal pathogenetic factor in Alzheimer’s disease (AD). However, increasing evidence suggests that the brain has to continuously produce excessive Aβ to efficaciously prevent pathogenic micro-organis…
View article: β-sheets in serum protein are independent risk factors for coronary lesions besides LDL-C in coronary heart disease patients
β-sheets in serum protein are independent risk factors for coronary lesions besides LDL-C in coronary heart disease patients Open
Background Coronary heart disease (CHD) patients with standard low-density lipoprotein cholesterol (LDL-C) remain at risk of cardiovascular events, making it critical to explore new targets to reduce the residual risk. The relationship bet…
View article: TBXAS1 Gene Polymorphism Is Associated with the Risk of Ischemic Stroke of Metabolic Syndrome in a Chinese Han Population
TBXAS1 Gene Polymorphism Is Associated with the Risk of Ischemic Stroke of Metabolic Syndrome in a Chinese Han Population Open
Objective. To investigate the association between thromboxane A synthase 1 (TBXAS1) gene polymorphism and metabolic syndrome (MS) and explore whether gene polymorphism could act as biomarkers in MS and its components or whether it could pl…
View article: Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats
Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats Open
Activin receptor-like kinase 7 (ALK7) is associated with lipometabolism and insulin sensitivity. Our previous study demonstrated that ALK7 participated in high glucose-induced cardiomyocyte apoptosis. The aim of our study was to investigat…
View article: Integrated Bioinformatics Analysis Identifies microRNA-200a-5p as a New Plasma Marker in Patients with Venous Thromboembolism
Integrated Bioinformatics Analysis Identifies microRNA-200a-5p as a New Plasma Marker in Patients with Venous Thromboembolism Open
We anticipate that the miR-200a-5p-COX7C pair might be involved in the progression of VTE. Moreover, miR-200a-5p might be a therapeutic target for VTE.
View article: Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle Open
Background Patients suffering from chronic heart failure (CHF) show an increased prevalence of sarcopenia. Levosimendan is an effective drug for the treatment of heart failure, but its effect on sarcopenia is still unclear. We aimed to exp…
View article: PGF2<i>α</i>‐FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI‐1 Signal Pathway
PGF2<i>α</i>‐FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI‐1 Signal Pathway Open
Senescence in vascular smooth muscle cells (VSMCs) is involved in vascular remodeling of aged mice. ProstaglandinF2 α- (PGF2 α ‐) FP receptor plays a critical role in cardiovascular diseases (CVDs), hypertension, and cardiac fibrosis. Howe…
View article: NOTCH4 Single-Nucleotide Polymorphism Is Associated With Brain Arteriovenous Malformation in a Chinese Han Population
NOTCH4 Single-Nucleotide Polymorphism Is Associated With Brain Arteriovenous Malformation in a Chinese Han Population Open
Background: Brain arteriovenous malformations (BAVMs) are high-flow intracranial vascular malformations characterized by the direct connection of arteries to veins without an intervening capillary bed. It is one of the main causes of intra…