Minami Tokuyama
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View article: Making housestaff feel at home: impact of workspace interventions on anatomic pathology trainee wellness
Making housestaff feel at home: impact of workspace interventions on anatomic pathology trainee wellness Open
View article: Gastrointestinal germinal center B cell depletion and reduction in IgA <sup>+</sup> plasma cells in HIV-1 infection
Gastrointestinal germinal center B cell depletion and reduction in IgA <sup>+</sup> plasma cells in HIV-1 infection Open
Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and the host response to HIV-1 infection. Here, high-resolution mapping of human B cells and PCs sampled from the colon and ileum during both viremic …
View article: Gastrointestinal germinal center B cell depletion and reduction in IgA<sup>+</sup>plasma cells in HIV-1 infection
Gastrointestinal germinal center B cell depletion and reduction in IgA<sup>+</sup>plasma cells in HIV-1 infection Open
Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and the host response to HIV-1 infection. Here, high resolution mapping of human B cells and PCs sampled from the colon and ileum during both viremic …
View article: Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis
Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis Open
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct coho…
View article: EP203/#368 Characterization of folate receptor alpha expression in non-high-grade serous gynecologic tumors
EP203/#368 Characterization of folate receptor alpha expression in non-high-grade serous gynecologic tumors Open
Introduction Mirvetuximab soravtansine (MIRV) is an anti-folate receptor alpha (FOLR1)-drug conjugate. Following the results of the SORAYA trail, MIRV was approved for the treatment of FOLR1-positive, platinum-resistant epithelial ovarian,…
View article: Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis
Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis Open
Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of the colon with sharply rising global prevalence. Dysfunctional epithelial compartment (EC) dynamics are implicated in UC pathogenesis although EC-specific studies are…
View article: P061 Response to anti-α4β7 therapy in Ulcerative colitis is associated with lymphoid aggregate attrition through impaired recruitment of naïve lymphocytes
P061 Response to anti-α4β7 therapy in Ulcerative colitis is associated with lymphoid aggregate attrition through impaired recruitment of naïve lymphocytes Open
Background Vedolizumab (VDZ) is a frontline drug for Ulcerative colitis (UC) and Crohn’s disease (CD) that targets integrin α4β7, a gut-homing receptor. Despite significant use, the mechanism(s) of action (MOA) of VDZ remain unclear. Metho…
View article: Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis
Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis Open
Targeting the α4β7-MAdCAM-1 axis with vedolizumab (VDZ) is a front-line therapeutic paradigm in ulcerative colitis (UC). However, mechanism(s) of action (MOA) of VDZ remain relatively undefined. Here, we examined three distinct cohorts of …
View article: Radiation-Induced Morphea of the Breast Treated With Wide Local Excision and Abdominal Free Flap Breast Reconstruction.
Radiation-Induced Morphea of the Breast Treated With Wide Local Excision and Abdominal Free Flap Breast Reconstruction. Open
Radiation-induced morphea (RIM) associated with breast cancer treatment is a rare and underdiagnosed skin complication of radiotherapy that can lead to severe and painful contractures, resulting in disfigurement, failure of reconstruction,…
View article: 1161: PERSISTENT IMMUNE CELL ABNORMALITIES IN THE INTESTINAL MUCOSA OF PATIENTS AFTER RECOVERY FROM COVID-19 INFECTION
1161: PERSISTENT IMMUNE CELL ABNORMALITIES IN THE INTESTINAL MUCOSA OF PATIENTS AFTER RECOVERY FROM COVID-19 INFECTION Open
View article: Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity Open
View article: DOP19 Myeloid and lymphoid cell abnormalities persist in the intestinal mucosa of patients who recover from COVID-19 infection
DOP19 Myeloid and lymphoid cell abnormalities persist in the intestinal mucosa of patients who recover from COVID-19 infection Open
Background Although respiratory failure is the hallmark of severe disease, it is increasingly clear that Coronavirus Disease 2019 (COVID-19) is a multi-system disorder. The presence of gastrointestinal (Gl) involvement by Severe acute resp…
View article: Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension
Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension Open
View article: Fr137 FIRST HIGH DIMENSIONAL EXAMINATION OF INTESTINAL BIOPSIES IN PATIENTS WITH COVID-19
Fr137 FIRST HIGH DIMENSIONAL EXAMINATION OF INTESTINAL BIOPSIES IN PATIENTS WITH COVID-19 Open
View article: Fr492 SIGNIFICANTLY REDUCED MORTALITY IN COVID-19 PATIENTS WITH GASTROINTESTINAL MANIFESTATIONS
Fr492 SIGNIFICANTLY REDUCED MORTALITY IN COVID-19 PATIENTS WITH GASTROINTESTINAL MANIFESTATIONS Open
View article: 785 SARS-COV-2 INFECTS ENTEROCYTES IN VIVO AND CAN PERSIST UP TO 7 MONTHS FOLLOWING RESOLUTION OF SYMPTOMS
785 SARS-COV-2 INFECTS ENTEROCYTES IN VIVO AND CAN PERSIST UP TO 7 MONTHS FOLLOWING RESOLUTION OF SYMPTOMS Open
View article: Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms
Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms Open
View article: Evolution of antibody immunity to SARS-CoV-2
Evolution of antibody immunity to SARS-CoV-2 Open
View article: Evolution of Antibody Immunity to SARS-CoV-2
Evolution of Antibody Immunity to SARS-CoV-2 Open
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with development of variable levels of antibodies with neutral…
View article: Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease
Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease Open
View article: Gastrointestinal involvement attenuates COVID-19 severity and mortality
Gastrointestinal involvement attenuates COVID-19 severity and mortality Open
Given that gastrointestinal (GI) symptoms are a prominent extrapulmonary manifestation of coronavirus disease 2019 (COVID-19), we investigated the impact of GI infection on disease pathogenesis in three large cohorts of patients in the Uni…
View article: Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease
Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease Open
Immune dysregulation and cytokine release syndrome have emerged as pathological hallmarks of severe Coronavirus Disease 2019 (COVID-19), leading to the evaluation of cytokine antagonists as therapeutic agents. A number of immune-directed t…
View article: Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies
Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies Open
View article: Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals Open
Anti-α4β7 integrin therapy results in attrition of lymphoid aggregates within the gastrointestinal tract of HIV-1–infected individuals with IBD.
View article: Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals Open
Herein, we present the first human study of anti-α4β7 therapy in a cohort of HIV-1 infected subjects with mild inflammatory bowel disease. α4β7 + gut homing CD4 + T cells are early viral targets and contribute to HIV-1 pathogenesis, likely…