Min‐Bin Chen
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View article: Curcumin in colorectal cancer: mechanistic insights, pharmacological limitations, and translational perspectives
Curcumin in colorectal cancer: mechanistic insights, pharmacological limitations, and translational perspectives Open
Curcumin, a natural polyphenolic compound from Curcuma longa , has been extensively investigated for its potential role in colorectal cancer (CRC) prevention and therapy. Preclinical studies suggest that curcumin can modulate gut microbiot…
View article: Insights into recent findings and therapeutic potential of nonhistone lactylation in cancer
Insights into recent findings and therapeutic potential of nonhistone lactylation in cancer Open
Lactylation, a recently identified post-translational modification, has become a crucial regulatory mechanism beyond its conventional metabolic role. Unlike histone lactylation, which regulates gene expression, nonhistone lactylation direc…
View article: Strain-Level Genetic Heterogeneity and Colonization Dynamics Drive Microbiome Therapeutic Efficacy
Strain-Level Genetic Heterogeneity and Colonization Dynamics Drive Microbiome Therapeutic Efficacy Open
Fecal microbiota transplantation (FMT) has shown immunotherapeutic promise across multiple malignancies, yet its clinical efficacy in non-small-cell lung cancer (NSCLC) remains unexplored. Here, we report results from a single-arm trial de…
View article: A Dual Radiomic and Dosiomic Filtering Technique for Locoregional Radiation Pneumonitis Prediction in Breast Cancer Patients
A Dual Radiomic and Dosiomic Filtering Technique for Locoregional Radiation Pneumonitis Prediction in Breast Cancer Patients Open
Purpose: Radiation pneumonitis (RP) is a serious complication of intensity-modulated radiation therapy (IMRT) for breast cancer patients, underscoring the need for precise and explainable predictive models. This study presents an Explainab…
View article: A Voxel-Wise Uncertainty-Guided Framework for Glioma Segmentation Using Spherical Projection-Based U-Net and Localized Refinement in Multi-Parametric MRI
A Voxel-Wise Uncertainty-Guided Framework for Glioma Segmentation Using Spherical Projection-Based U-Net and Localized Refinement in Multi-Parametric MRI Open
Purpose: Accurate segmentation of glioma subregions in multi-parametric MRI (MP-MRI) is essential for diagnosis and treatment planning but remains challenging due to tumor heterogeneity and ambiguous boundaries. This study proposes an unce…
View article: The Prognostic Value of Combined Systemic Immune-Inflammatory Index (SII) and Prognostic Nutritional Index (PNI) in Solid Tumor
The Prognostic Value of Combined Systemic Immune-Inflammatory Index (SII) and Prognostic Nutritional Index (PNI) in Solid Tumor Open
High level of pretreatment SII may be an independent prognostic factor for cancer patients. Patients with both high SII and low PNI had the worst prognosis.
View article: Identification of PRRG1 as a possible molecular target of pancreatic cancer
Identification of PRRG1 as a possible molecular target of pancreatic cancer Open
Pancreatic cancer (PC) remains one of the most lethal malignancies with limited treatment options and poor patient outcomes. The identification of novel therapeutic targets is therefore urgently needed. In this study, we investigated the e…
View article: Exosome-mediated ferroptosis in the tumor microenvironment: from molecular mechanisms to clinical application
Exosome-mediated ferroptosis in the tumor microenvironment: from molecular mechanisms to clinical application Open
Ferroptosis in the tumor microenvironment (TME) plays a crucial role in the development, metastasis, immune escape, and drug resistance of various types of cancer. A better understanding of ferroptosis in the TME could illuminate novel asp…
View article: Embedding Radiomics into Vision Transformers for Multimodal Medical Image Classification
Embedding Radiomics into Vision Transformers for Multimodal Medical Image Classification Open
Background: Deep learning has significantly advanced medical image analysis, with Vision Transformers (ViTs) offering a powerful alternative to convolutional models by modeling long-range dependencies through self-attention. However, ViTs …
View article: Mitochondrial transcription elongation factor TEFM promotes malignant progression of gliomas
Mitochondrial transcription elongation factor TEFM promotes malignant progression of gliomas Open
Gliomas are the most common tumors of the central nervous system, with glioblastoma (GBM) being particularly aggressive and fatal. Current treatments for GBM, including surgery and chemotherapy, are limited by tumor aggressiveness and the …
View article: Safety and efficacy of mecapegfilgrastim in preventing neutropenia in patients with head and neck cancer: a multicenter, prospective, observational, real-world study
Safety and efficacy of mecapegfilgrastim in preventing neutropenia in patients with head and neck cancer: a multicenter, prospective, observational, real-world study Open
Mecapegfilgrastim demonstrated promising efficacy and safety in preventing neutropenia in patients with head and neck cancer, particularly those undergoing chemoradiotherapy or chemoimmunotherapy. Mecapegfilgrastim was well tolerated, with…
View article: A dual-radiomics model for overall survival prediction in early-stage NSCLC patient using pre-treatment CT images
A dual-radiomics model for overall survival prediction in early-stage NSCLC patient using pre-treatment CT images Open
Introduction Radiation therapy (RT) is one of the primary treatment options for early-stage non-small cell lung cancer (ES-NSCLC). Therefore, accurately predicting the overall survival (OS) rate following radiotherapy is crucial for implem…
View article: A multicenter, prospective, non‐interventional real‐world study to assess the effectiveness of mecapegfilgrastim in preventing neutropenia in patients with gastrointestinal cancer
A multicenter, prospective, non‐interventional real‐world study to assess the effectiveness of mecapegfilgrastim in preventing neutropenia in patients with gastrointestinal cancer Open
Background Mecapegfilgrastim, a long‐acting granulocyte‐colony stimulating factor has been approved for reducing the incidence of infection, particularly febrile neutropenia (FN), in China. Objective We conducted a multicenter prospective …
View article: The Role of CDCA3 in Disulfidptosis: Implications for Breast Cancer Cell Viability and Treatment
The Role of CDCA3 in Disulfidptosis: Implications for Breast Cancer Cell Viability and Treatment Open
"Disulfidptosis" is a novel concept, primarily characterized by the depletion of intracellular NADPH during glucose deprivation, leading to the accumulation of disulfides. This accumulation triggers disulfide stress, breakdown of the actin…
View article: Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application
Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application Open
Ferroptosis and cuproptosis, regulated forms of cell death resulting from metal ion accumulation, are closely related in terms of occurrence, cell metabolism, signaling pathways, and drug resistance. Notably, it is now understood that thes…
View article: Figure S2 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
Figure S2 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation Open
Figure S2. TE-1 cells, expressing AMPKα1 shRNA ("sh-AMPKα1") or scramble control shRNA ("shRNA-Ctrl"), as well as the parental control TE-1 cells ("No shRNA"), were treated with itraconazole ("Itra", 3.0 μg/mL) for indicated time, and w…
View article: Figure S3 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
Figure S3 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation Open
Figure S3. Stable Eca-109 cells (5Ã-106 cells per mouse), expressing scramble control shRNA ("shRNA-C") or AMPKα1 shRNA ("sh-AMPKα1"), were inoculated (s.c. injection) to the SCID mice, with 8 mice per group. When the volume of each tumo…
View article: Figure S1 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
Figure S1 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation Open
Figure S1. Eca-109 cells were pre-treated for 1 hour with 50 μM of necrostatin-1 ("Nec-1"), or 5 μM of Ferrostatin-1 ("Fer-1"), followed by itraconazole ("Itra", 3.0 μg/mL) treatment for 72 hours; Cell viability (MTT assay, A) and cell …
View article: Figure S3 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
Figure S3 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation Open
Figure S3. Stable Eca-109 cells (5Ã-106 cells per mouse), expressing scramble control shRNA ("shRNA-C") or AMPKα1 shRNA ("sh-AMPKα1"), were inoculated (s.c. injection) to the SCID mice, with 8 mice per group. When the volume of each tumo…
View article: Data from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
Data from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation Open
We here evaluated the antiesophageal cancer cell activity by the antifungal drug itraconazole. Our results show that μg/mL concentrations of itraconazole potently inhibited survival and proliferation of established (TE-1 and Eca-109) and p…
View article: Figure S1 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
Figure S1 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation Open
Figure S1. Eca-109 cells were pre-treated for 1 hour with 50 μM of necrostatin-1 ("Nec-1"), or 5 μM of Ferrostatin-1 ("Fer-1"), followed by itraconazole ("Itra", 3.0 μg/mL) treatment for 72 hours; Cell viability (MTT assay, A) and cell …
View article: Data from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
Data from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation Open
We here evaluated the antiesophageal cancer cell activity by the antifungal drug itraconazole. Our results show that μg/mL concentrations of itraconazole potently inhibited survival and proliferation of established (TE-1 and Eca-109) and p…
View article: Figure S2 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
Figure S2 from Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation Open
Figure S2. TE-1 cells, expressing AMPKα1 shRNA ("sh-AMPKα1") or scramble control shRNA ("shRNA-Ctrl"), as well as the parental control TE-1 cells ("No shRNA"), were treated with itraconazole ("Itra", 3.0 μg/mL) for indicated time, and w…
View article: Identification of matrix-remodeling associated 5 as a possible molecular oncotarget of pancreatic cancer
Identification of matrix-remodeling associated 5 as a possible molecular oncotarget of pancreatic cancer Open
Pancreatic cancer has an extremely poor prognosis. Here we examined expression, potential functions and underlying mechanisms of MXRA5 (matrix remodeling associated 5) in pancreatic cancer. Bioinformatics studies revealed that MXRA5 transc…