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View article: Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing
Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing Open
Recurrent synovial bleeding is the major cause of Hemophilic Arthritis (HA). Up to now, the transcriptomic profiles of bleeding syvonium in HA patient have largely remained unknown. Exploring the transcriptomic characteristics of synovium …
View article: Mimicking DOUGONG brackets orchestrate regulating inflammation and mechanical stimuli for osteochondral regeneration using 3D printing
Mimicking DOUGONG brackets orchestrate regulating inflammation and mechanical stimuli for osteochondral regeneration using 3D printing Open
The microstructure of scaffolds is essential for enhancing cell‐extracellular matrix interactions, which are critical for osteochondral regeneration. This study investigates the innovative use of 3D printing to mimic DOUGONG brackets to ac…
View article: Single-cell RNA-seq reveals a repair pattern in cystic lesions in steroid induced osteonecrosis of the femoral head
Single-cell RNA-seq reveals a repair pattern in cystic lesions in steroid induced osteonecrosis of the femoral head Open
Background Studies have indicated that cystic lesions play a crucial role in the repair processes of steroid-induced osteonecrosis of the femoral head and its subsequent collapse. Here, we employed single-cell RNA sequencing (scRNA-seq) te…
View article: Tectorigenin Ameliorates Glucocorticoid‐Induced Osteoporosis by Inhibiting the <scp>NF</scp>‐<scp>κB</scp> Signal Pathway and Modulating Treg‐Th17 Cell Balance
Tectorigenin Ameliorates Glucocorticoid‐Induced Osteoporosis by Inhibiting the <span>NF</span>‐<span>κB</span> Signal Pathway and Modulating Treg‐Th17 Cell Balance Open
Glucocorticoid‐induced osteoporosis is a common clinical orthopaedic disease, primarily due to excessive use of hormones. Tectorigenin has shown a certain efficacy in treating osteoporosis, but its underlying mechanisms are not yet fully u…
View article: Is Osteoarthritis a State of Joint Dysbiosis?
Is Osteoarthritis a State of Joint Dysbiosis? Open
Osteoarthritis (OA) has traditionally been defined as a degenerative joint disease driven by mechanical wear, aging, and metabolic disturbances. However, emerging evidence suggests that joint dysbiosis, a dysregulation in the joint microbi…
View article: [Finite element analysis of impact of bone mass and volume in low-density zone beneath tibial plateau on cartilage and meniscus in knee joint].
[Finite element analysis of impact of bone mass and volume in low-density zone beneath tibial plateau on cartilage and meniscus in knee joint]. Open
The presence of subtalar plateau low-density zone may aggravate joint degeneration. In clinical practice, it is necessary to pay attention to the changes in the subtalar plateau low-density zone and actively take effective measures to stre…
View article: Plasma SQSTM1/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head
Plasma SQSTM1/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head Open
View article: [Finite element analysis of the impact of bone mass and volume of low-density area under tibial plateau on lower limb alignment].
[Finite element analysis of the impact of bone mass and volume of low-density area under tibial plateau on lower limb alignment]. Open
The existence of a low-density area under tibial plateau suggests a heightened likelihood of knee varus and inward movement of the lower limb force line. Both the volume and reduction in bone mass of the low-density area serve as critical …
View article: Plasma SQSTM1/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head
Plasma SQSTM1/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head Open
Background: Autophagy is closely associated with the onset and progression of steroid-induced osteonecrosis of the femoral head (SIONFH). SQSTM1/p62 is an important indicator of autophagic activity. The aim of this study was to investigate…
View article: m6A methylation modification and immune infiltration analysis in osteonecrosis of the femoral head
m6A methylation modification and immune infiltration analysis in osteonecrosis of the femoral head Open
Osteonecrosis of the femoral head (ONFH) is a elaborate hip disease characterized by collapse of femoral head and osteoarthritis. RNA N6-methyladenosine (m6A) plays a crucial role in a lot of biological processes within eukaryotic cells. H…
View article: Osteotomy for treating knee osteoarthritis from 2012 to 2023: Bibliometric analysis and global trends
Osteotomy for treating knee osteoarthritis from 2012 to 2023: Bibliometric analysis and global trends Open
Background: Numerous surgical interventions are available for the treatment of knee osteoarthritis (KOA). In recent years, knee-preserving surgery, specifically osteotomy, has gained significant attention from patients, particularly those …
View article: Association between sarcopenia and osteoarthritis among the US adults: a cross-sectional study
Association between sarcopenia and osteoarthritis among the US adults: a cross-sectional study Open
The association between sarcopenia and OA still presents many uncertainties. We aimed to assess whether sarcopenia is associated with occurrence of OA in US adults. We conducted a cross-sectional study consisting of 11,456 participants fro…
View article: [Finite element analysis for predicting osteonecrosis of the femoral head collapse based on the preserved angles].
[Finite element analysis for predicting osteonecrosis of the femoral head collapse based on the preserved angles]. Open
From the perspective of biomechanics, when a preserved angle of ONFH is less than its critical value, the stress concentration phenomenon in the femoral head is more pronounced, suggesting that the necrotic femoral head may have a higher r…
View article: Association between gut microbiota and osteoporosis from 2012 to 2023: Bibliometric analysis and global trends
Association between gut microbiota and osteoporosis from 2012 to 2023: Bibliometric analysis and global trends Open
Background Osteoporosis (OP) is a chronic systemic metabolic bone disease. As the population ages, the prevalence of OP is gradually increasing, making it one of the significant public health problems worldwide. The gut microbiota (GM) is …
View article: Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head
Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head Open
Background Oxidative stress was closely related to the occurrence and development of Steroid-induced osteonecrosis of the femoral head (SIONFH). 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a important index of oxidative stress. The aim of this…
View article: Effect of whole body vibration therapy in the rat model of steroid-induced osteonecrosis of the femoral head
Effect of whole body vibration therapy in the rat model of steroid-induced osteonecrosis of the femoral head Open
Background: Steroid-induced Osteonecrosis of the Femoral Head (SIONFH) is a skeletal disease with a high incidence and a poor prognosis. Whole body vibration therapy (WBVT), a new type of physical training, is known to promote bone formati…
View article: Mechanical properties of trabeculae and osteocyte morphology change significantly in different areas of the necrotic femoral head
Mechanical properties of trabeculae and osteocyte morphology change significantly in different areas of the necrotic femoral head Open
Background: Osteonecrosis of the femoral head is a complex hip ailment. The precise changes in bone tissue during the disease’s onset remain unclear. It is vital to assess both the quantity and quality of the trabecular state in a necrotic…
View article: Lateral classification system predicts the collapse of JIC type C1 nontraumatic osteonecrosis of the femoral head: a retrospective study
Lateral classification system predicts the collapse of JIC type C1 nontraumatic osteonecrosis of the femoral head: a retrospective study Open
View article: Incidence of periprosthetic joint infection after primary total hip arthroplasty is underestimated: a synthesis of meta-analysis and bibliometric analysis
Incidence of periprosthetic joint infection after primary total hip arthroplasty is underestimated: a synthesis of meta-analysis and bibliometric analysis Open
The American Musculoskeletal Society updated the diagnostic criteria for periprosthetic joint infection (PJI) in 2011 and 2018. However, the overall incidence of PJI since the introduction of these new standards has not been assessed. In o…
View article: A bibliometric analysis and visualization of research trends on periacetabular osteotomy
A bibliometric analysis and visualization of research trends on periacetabular osteotomy Open
Bernese periacetabular osteotomy (PAO) is a practical and safe acetabular reorientation technique used to correct structural hip deformities, and much relevant literature has been published over the past decades. This bibliometric study ai…
View article: Association between sarcopenia and risk of osteoarthritis among the US adults
Association between sarcopenia and risk of osteoarthritis among the US adults Open
Background: The association between sarcopenia and the risk of OA still presents many uncertainties. We aimed to assess whether sarcopenia is associated with a higher risk of OA in US adults. Methods: We conducted a cross-sectional study c…
View article: Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head
Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head Open
Background: 4-hydroxynonenal (4-HNE) is a common marker of oxidative stress. this study aim to study the potential role of 4-HNE in the progression of steroid-induced osteonecrosis of the femoral head (SIONFH). Method: Between April 2021 a…
View article: [A novel lateral classification of osteonecrosis of femoral head based on CT recons-truction of necrotic area and its clinical verification].
[A novel lateral classification of osteonecrosis of femoral head based on CT recons-truction of necrotic area and its clinical verification]. Open
JIC types A and B can be treated by non-surgical treatment, while type C2 can be treated by surgical treatment with hip preservation. Type C1 was classified into 5 subtypes by CT lateral classification, type 3 has the highest risk of femor…
View article: Association of macronutrients intake distribution with osteoarthritis risk among adults in NHANES, 2013–2016
Association of macronutrients intake distribution with osteoarthritis risk among adults in NHANES, 2013–2016 Open
The association between dietary macronutrient distribution and the risk of OA remains unknown. We aimed to evaluate how dietary macronutrient distribution was correlated with the risk of OA in US adults. We performed a cross-sectional stud…
View article: Global research trends and hotspots in calcaneal fracture: A bibliometric analysis (2000–2021)
Global research trends and hotspots in calcaneal fracture: A bibliometric analysis (2000–2021) Open
Background Calcaneal fracture is common and carries high morbidity and disability. Its treatment is therefore of vital concern. Many topics concerning calcaneal fracture remain controversial, and the subject has not yet been well-researche…
View article: Bibliometric and visualized analysis of research relating to minimally invasive spine surgery reported over the period 2000–2022
Bibliometric and visualized analysis of research relating to minimally invasive spine surgery reported over the period 2000–2022 Open
Background Since entering the 21 st century, there has been an increasing interest in minimally invasive surgery for spinal diseases, which has led to the continued development of minimally invasive spine surgery (MISS), with major breakth…
View article: Global prevalence and incidence of hallux valgus: a systematic review and meta‐analysis
Global prevalence and incidence of hallux valgus: a systematic review and meta‐analysis Open
Background Though hallux valgus is a common foot deformity, the integrated information on its global prevalence and incidence is relatively lacking. The aim of this research was to assess the global prevalence and incidence of hallux valgu…
View article: A bibliometric analysis and visualization of research trends on surgical hip dislocation
A bibliometric analysis and visualization of research trends on surgical hip dislocation Open
Surgical hip dislocation (SHD) is a powerful and safe approach used to address pathologic lesions around the hip joint, and therefore, many studies have been conducted in this field. However, no bibliometric studies regarding the global re…
View article: A negative association between total cholesterol and bone mineral density in US adult women
A negative association between total cholesterol and bone mineral density in US adult women Open
Background The association between serum total cholesterol (TC) and bone mineral density (BMD) is still controversial. We aimed to evaluate the association of serum TC with BMD in general US adult women. Methods A cross-sectional study con…
View article: Global Research Status and Trends of Femoral Neck Fracture Over the Past 27 Years: A Historical Review and Bibliometric Analysis
Global Research Status and Trends of Femoral Neck Fracture Over the Past 27 Years: A Historical Review and Bibliometric Analysis Open
Background Femoral neck fracture (FNF) is a commonly encountered injury in orthopedic practice, and many studies have been conducted in this field. However, no bibliometric studies regarding the global research trend concerning FNF have be…