Mindaugas Jonikas
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View article: Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1
Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1 Open
Objective Defective mitochondrial function attributed to optic atrophy 1 ( OPA1 ) mutations causes primarily optic atrophy and, less commonly, neurodegenerative syndromes. The pathomechanism by which OPA1 mutations trigger diffuse loss of …
View article: Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration
Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration Open
The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a promising treatment strategy. Here, we characterize cone differentiation in retina…
View article: An Atlas of Human Kinase Regulation
An Atlas of Human Kinase Regulation Open
The coordinated regulation of protein kinases is a rapid mechanism that integrates diverse cues and swiftly determines appropriate cellular responses. However, our understanding of cellular decision-making has been limited by the small num…