Ming‐Yang Chang
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View article: Cellular senescence links severe Leptospira infection to chronic kidney disease progression
Cellular senescence links severe Leptospira infection to chronic kidney disease progression Open
Severe Leptospira infection drives maladaptive kidney repair through senescence and fibrosis, promoting CKD progression. Targeting cellular senescence may represent a promising strategy to prevent chronic renal damage after leptospirosis.
View article: A Basic Overview of Cellulose Nanocrystals
A Basic Overview of Cellulose Nanocrystals Open
This paper discusses the various aspects of cellulose nanocrystals, including its extraction, mechanical properties, surface modifications, and medical applications. Cellulose nanocrystals are extracted from cellulose, one of the most comm…
View article: A double-layer PLGA/CoI-MeHA tissue engineering scaffold for urethral reconstruction
A double-layer PLGA/CoI-MeHA tissue engineering scaffold for urethral reconstruction Open
Introduction Urethral injury caused by various reasons usually leads to urethral stricture. And severe urethral stricture can further induce complications such as bladder stones, fistulas, sepsis, and even renal failure. At present, surgic…
View article: Uncovering latent infections in kidneys: A novel molecular approach for differential Leptospira detection
Uncovering latent infections in kidneys: A novel molecular approach for differential Leptospira detection Open
Leptospirosis, a re-emerging zoonotic disease caused by Leptospira spp., poses significant global health and veterinary challenges. Long-term colonization of renal tubules by Leptospira in asymptomatic hosts highlights the ne…
View article: Hydrogel-based formulations for urothelial cancer therapy
Hydrogel-based formulations for urothelial cancer therapy Open
Drug infusion therapy after surgery for urothelial carcinoma is an effective measure to reduce cancer recurrence rate. Hydrogels are drug carriers with good biocompatibility and high drug loading capacity, which can optimize the pharmacoki…
View article: Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment
Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment Open
View article: Interferon-alpha and MxA inhibit BK polyomavirus replication by interaction with polyomavirus large T antigen
Interferon-alpha and MxA inhibit BK polyomavirus replication by interaction with polyomavirus large T antigen Open
IFNα and its downstream protein, MxA, have potent antiviral properties against BKPyV. Furthermore, our findings indicate that the interaction between MxA and BKVPyV TAg plays a crucial role in determining the anti-BKPyV effects of MxA.
View article: A Novel 3 chemotactic activity-related gene signature for Predicting prognosis of bladder Cancer
A Novel 3 chemotactic activity-related gene signature for Predicting prognosis of bladder Cancer Open
Background Bladder cancer is one of the most common malignant tumors of the urinary system. Both cancer and stromal cells, including bladder cancer, express chemokines and their corresponding receptors. Their altered expression controls an…
View article: High-performance cost efficient simultaneous wireless information and power transfers deploying jointly modulated amplifying programmable metasurface
High-performance cost efficient simultaneous wireless information and power transfers deploying jointly modulated amplifying programmable metasurface Open
View article: The essential role of the ERK activation in large T antigen of BK polyomavirus regulated cell migration
The essential role of the ERK activation in large T antigen of BK polyomavirus regulated cell migration Open
View article: Clinical Benefits of Laparoscopic Adhesiolysis during Peritoneal Dialysis Catheter Insertion: A Single-Center Experience
Clinical Benefits of Laparoscopic Adhesiolysis during Peritoneal Dialysis Catheter Insertion: A Single-Center Experience Open
Background and Objectives: In peritoneal dialysis (PD) therapy, intra-abdominal adhesions (IAAs) can cause catheter insertion failure, poor dialysis function, and decreased PD adequacy. Unfortunately, IAAs are not readily visible to curren…
View article: Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury
Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury Open
Leptospirosis can cause chronic kidney damage, putting patients at risk of additional kidney injury due to other factors that can lead to renal failure. To understand the combined effect, the transcriptome profiles of kidneys of mice with …
View article: Tuberculous peritonitis in patients on peritoneal dialysis: a 35-year experience from a large medical center in Northern Taiwan
Tuberculous peritonitis in patients on peritoneal dialysis: a 35-year experience from a large medical center in Northern Taiwan Open
Physicians should pay attention to the unusual presentations of peritonitis, especially if symptoms include fever or an initial low PDE WBC count. Catheter removal is not mandatory if early diagnosis and appropriate therapy are available.
View article: The Essential Role of the Erk Activation in Large T Antigen of Bk Polyomavirus Regulated Cell Migration
The Essential Role of the Erk Activation in Large T Antigen of Bk Polyomavirus Regulated Cell Migration Open
View article: Effects of Suramin on Polycystic Kidney Disease in a Mouse Model of Polycystin-1 Deficiency
Effects of Suramin on Polycystic Kidney Disease in a Mouse Model of Polycystin-1 Deficiency Open
The aberrant activation of the purinergic signaling pathway has been shown to promote cyst growth and fluid secretion in autosomal dominant polycystic kidney disease (ADPKD). Suramin is an anti-parasitic drug that has strong anti-purinergi…
View article: Implication of the IL-10-Expression Signature in the Pathogenicity of <i>Leptospira</i> -Infected Macrophages
Implication of the IL-10-Expression Signature in the Pathogenicity of <i>Leptospira</i> -Infected Macrophages Open
Activation of macrophages by Leptospira spp. infection is thought to be involved in the pathogenesis of leptospirosis. To evaluate the innate macrophage responses to Leptospira spp., specifically pathogenic versus nonpathogenic Leptospira …
View article: Study on protection measures of lightning electromagnetic pulse in automatic weather station
Study on protection measures of lightning electromagnetic pulse in automatic weather station Open
Due to automatic meteorological station, the distribution of the unique geographical location and environment, the equipment has a large number of sensors and electronic components, and a highly integrated, combined with the electronic com…
View article: Crosstalk between E-Cadherin/β-Catenin and NF-κB Signaling Pathways: The Regulation of Host-Pathogen Interaction during Leptospirosis
Crosstalk between E-Cadherin/β-Catenin and NF-κB Signaling Pathways: The Regulation of Host-Pathogen Interaction during Leptospirosis Open
Approximately 1 million cases of leptospirosis, an emerging infectious zoonotic disease, are reported each year. Pathogenic Leptospira species express leucine-rich repeat (LRR) proteins that are rarely expressed in non-pathogenic Leptospir…
View article: Challenges for the Applications of Human Pluripotent Stem Cell-Derived Liver Organoids
Challenges for the Applications of Human Pluripotent Stem Cell-Derived Liver Organoids Open
The current organoid culture systems allow pluripotent and adult stem cells to self-organize to form three-dimensional (3D) structures that provide a faithful recapitulation of the architecture and function of in vivo organs. In particular…
View article: Ultrafiltration in Patients on Automated Peritoneal Dialysis with Homechoice Claria connected to Sharesource: A Pilot Study
Ultrafiltration in Patients on Automated Peritoneal Dialysis with Homechoice Claria connected to Sharesource: A Pilot Study Open
Introduction: Fluid overload is an unavoidable problem in patients on peritoneal dialysis (PD) and is associated with poor outcomes. The aim of our study was to estimate ultrafiltration (UF) under different dextrose concentrations and clar…
View article: LncRNA OIP5-AS1 reduces renal epithelial cell apoptosis in cisplatin-induced AKI by regulating the miR-144-5p/PKM2 axis
LncRNA OIP5-AS1 reduces renal epithelial cell apoptosis in cisplatin-induced AKI by regulating the miR-144-5p/PKM2 axis Open
View article: Changes in anti-müllerian hormone after ultrasound guided aspiration and ethanol sclerotic therapy of ovarian cyst
Changes in anti-müllerian hormone after ultrasound guided aspiration and ethanol sclerotic therapy of ovarian cyst Open
View article: Low central blood pressure and sympathetic activity predispose for the development of intradialytic hypotension
Low central blood pressure and sympathetic activity predispose for the development of intradialytic hypotension Open
Intradialytic hypotension (IDH) may lead to a poor life quality and was associated with cardiovascular mortality in patients under hemodialysis. This study investigated the autonomic nerve and cardiovascular function in the IDH episodes. I…
View article: Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities
Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities Open
Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and …
View article: Peptidoglycan mediates Leptospira outer membrane protein Loa22 to toll-like receptor 2 for inflammatory interaction: a novel innate immune recognition
Peptidoglycan mediates Leptospira outer membrane protein Loa22 to toll-like receptor 2 for inflammatory interaction: a novel innate immune recognition Open
Leptospirosis is an overlooked zoonotic disease caused by pathogenic Leptospira depended on virulence of Leptospira and the host–pathogen interaction. Kidney is the major organ infected by Leptospira which causes tubulointerstitial nephrit…
View article: Human primary epidermal organoids enable modeling of dermatophyte infections
Human primary epidermal organoids enable modeling of dermatophyte infections Open
View article: The protective effect of beta-hydroxybutyric acid on renal glomerular epithelial cells in adriamycin-induced injury.
The protective effect of beta-hydroxybutyric acid on renal glomerular epithelial cells in adriamycin-induced injury. Open
Beta-hydroxybutyric acid (BHB) exerts a protective effect in experimental of kidney disease models. However, the mechanisms underlying this activity are not well defined. BHB stands out for its ability to inhibit the Nε-lysine acetylation …
View article: Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase
Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase Open
View article: Crystal structure of <i>Leptospira</i> leucine-rich repeat 20 reveals a novel E-cadherin binding protein to induce NGAL expression in HK2 cells
Crystal structure of <i>Leptospira</i> leucine-rich repeat 20 reveals a novel E-cadherin binding protein to induce NGAL expression in HK2 cells Open
Leptospirosis is the most common zoonotic disease caused by pathogenic Leptospira, which is classified into three groups according to virulence. Its pathogenic and intermediate species contain leucine-rich repeat (LRR) proteins that are ra…
View article: Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase
Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase Open
Background: Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes. Three-dimensional (3D) culture is important for the acquisition of mature…