Feng‐Ming Kong
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View article: Role of the PKA–PGC1α–BACE1 Signaling Pathway in Aluminum-Induced Neurotoxicity in PC12 Cells
Role of the PKA–PGC1α–BACE1 Signaling Pathway in Aluminum-Induced Neurotoxicity in PC12 Cells Open
View article: A novel relationship between Corticotropin-releasing hormone level and high-altitude hypoxia in human and rat model
A novel relationship between Corticotropin-releasing hormone level and high-altitude hypoxia in human and rat model Open
Background: Acute mountain sickness(AMS) strikes people who travel too quickly to high altitude, outstripping their ability to acclimatize. Individual susceptibility to AMS remains unpredictable. The aim of study was to investigate the neu…
View article: Phocaeicola vulgatus induces immunotherapy resistance in hepatocellular carcinoma via reducing indoleacetic acid production
Phocaeicola vulgatus induces immunotherapy resistance in hepatocellular carcinoma via reducing indoleacetic acid production Open
Immunotherapy has made remarkable achievements in various cancers, but response rates in hepatocellular carcinoma (HCC) remain highly variable. Understanding mechanisms behind this heterogeneity and identifying responsive patients are urge…
View article: Hemoglobin-to-red blood cell distribution width ratio in the relationship between occupational aluminum exposure and cognitive function impairment: a mediation analysis
Hemoglobin-to-red blood cell distribution width ratio in the relationship between occupational aluminum exposure and cognitive function impairment: a mediation analysis Open
Objective To investigate the partial mediating role of the inflammatory marker hemoglobin-to-red cell distribution width ratio (HRR) in the association between occupational aluminum exposure and cognitive function impairment, and its signi…
View article: Local FLASH Radiation Exhibits Double-Edged Effect in Mice Immune System
Local FLASH Radiation Exhibits Double-Edged Effect in Mice Immune System Open
View article: Adaptive vs. Non-Adaptive Radiation Dose Escalation in Locally Advanced Non-Small Cell Lung Cancer (LA-NSCLC): Indirect Comparison of NRG-RTOG 0617 and 1106 Individual Patient Data
Adaptive vs. Non-Adaptive Radiation Dose Escalation in Locally Advanced Non-Small Cell Lung Cancer (LA-NSCLC): Indirect Comparison of NRG-RTOG 0617 and 1106 Individual Patient Data Open
View article: InfinityHuman: Towards Long-Term Audio-Driven Human
InfinityHuman: Towards Long-Term Audio-Driven Human Open
Audio-driven human animation has attracted wide attention thanks to its practical applications. However, critical challenges remain in generating high-resolution, long-duration videos with consistent appearance and natural hand motions. Ex…
View article: A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028
A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028 Open
Background Neoantigen-based vaccines show promising therapeutic potential in solid tumors such as melanoma, GBM, NSCLC, and CRC. However, clinical responses remain suboptimal in stage IV patients, due to ineffective T-cell function and hig…
View article: Strategies for Enhancing the Commercial Value of Sports Films: A Multidimensional Analysis
Strategies for Enhancing the Commercial Value of Sports Films: A Multidimensional Analysis Open
There is a tremendous development in commercial sports films, both internationally and in China, as examples of Dangal and Leap can attest to. Such films attract audiences and have good ticket sales, proving that people are interested in s…
View article: Comparative effectiveness for early-stage NSCLC without lymph node involvement based on prospective studies
Comparative effectiveness for early-stage NSCLC without lymph node involvement based on prospective studies Open
Background: There is ongoing uncertainty in comparing surgical and nonsurgical therapies, with or without systemic options, in heterogeneous early-stage non-small cell lung cancer without lymph node involvement (eNSCLC-N0). Materials and m…
View article: A Statistical Approach to Assess Biological Equivalent Mean Organ Dose (MOD) for Different Fractionations in Thoracic Radiotherapy
A Statistical Approach to Assess Biological Equivalent Mean Organ Dose (MOD) for Different Fractionations in Thoracic Radiotherapy Open
Background: With advances in radiotherapy technology, there are more technological options and fractionation regiments for different stages of lung cancer. Evaluation of the possibility of severe organ toxicity for the organ-at-risks (OARs…
View article: Seaweed-7B: Cost-Effective Training of Video Generation Foundation Model
Seaweed-7B: Cost-Effective Training of Video Generation Foundation Model Open
This technical report presents a cost-efficient strategy for training a video generation foundation model. We present a mid-sized research model with approximately 7 billion parameters (7B) called Seaweed-7B trained from scratch using 665,…
View article: Anti-arthritic Activity of Citral Against Complete Freund’s Adjuvant-induced Arthritis in Rats Through NF-κB Signaling Pathway
Anti-arthritic Activity of Citral Against Complete Freund’s Adjuvant-induced Arthritis in Rats Through NF-κB Signaling Pathway Open
Background Citral is a bioactive compound found in lemongrass oil. It functions as an anti-oxidant and possesses anti-inflammatory qualities. Objective The purpose of this study was to assess the anti-arthritic benefits of citral using a r…
View article: Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine
Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine Open
Tumor cells often down‐regulate antigen presentation and mount an immunosuppressive microenvironment, hindering successful cancer immunotherapy and vaccine development. Additionally, due to genomic instability, tumor cells are usually hete…
View article: Global health inequalities in female-specific cancers from 1990 to 2021: insights from the Global Burden of Disease Study 2021
Global health inequalities in female-specific cancers from 1990 to 2021: insights from the Global Burden of Disease Study 2021 Open
View article: Artificial intelligence-powered innovations in radiotherapy: boosting efficiency and efficacy
Artificial intelligence-powered innovations in radiotherapy: boosting efficiency and efficacy Open
Cancer remains a substantial global health challenge, with steadily increasing incidence rates. Radiotherapy (RT) is a crucial component in cancer treatment. Nevertheless, due to limited resources, there is an urgent need to enhance both i…
View article: Development and Validation of a Prediction Model for Treatment-Related Toxicity (TRTRM) in Older Patients with Cancer
Development and Validation of a Prediction Model for Treatment-Related Toxicity (TRTRM) in Older Patients with Cancer Open
View article: Usp18–Hrd1 Erad Signaling Pathway Inhibits Nlrp3 Inflammasome Activation and Decelerates the Aging Process
Usp18–Hrd1 Erad Signaling Pathway Inhibits Nlrp3 Inflammasome Activation and Decelerates the Aging Process Open
View article: Lymphocyte Nadir and Recovery Dynamics for Locally Advanced Thoracic Malignancies Undergoing Concurrent Chemo-Irradiation: Establishment of Organs-at-Risk Constraints
Lymphocyte Nadir and Recovery Dynamics for Locally Advanced Thoracic Malignancies Undergoing Concurrent Chemo-Irradiation: Establishment of Organs-at-Risk Constraints Open
View article: Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer
Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer Open
View article: Development and validation of AI delineation of the thoracic RTOG organs at risk with deep learning on multi-institutional datasets
Development and validation of AI delineation of the thoracic RTOG organs at risk with deep learning on multi-institutional datasets Open
View article: Treatments of transarterial chemoembolization (TACE), stereotactic body radiotherapy (SBRT) and immunotherapy reshape the systemic tumor immune environment (STIE) in patients with unresectable hepatocellular carcinoma
Treatments of transarterial chemoembolization (TACE), stereotactic body radiotherapy (SBRT) and immunotherapy reshape the systemic tumor immune environment (STIE) in patients with unresectable hepatocellular carcinoma Open
STIE cells are significant for treatment response, can be reshaped differentially after TACE, SBRT, and IO. The most significant changes of T-lymphocyte lineage are SBRT associated modulations in CD25+CD8+ T cells, CD…
View article: Derivation of a comprehensive semi-empirical proton RBE model from published experimental cell survival data collected in the PIDE database
Derivation of a comprehensive semi-empirical proton RBE model from published experimental cell survival data collected in the PIDE database Open
We aimed to develop a comprehensive proton relative biological effectiveness (RBE) model based on accumulated cell survival data in the literature. Our approach includes four major components: (1) Eligible cell survival data with various l…
View article: Accelerated Hypofractionated Radiotherapy for Locally Advanced NSCLC: A Systematic Review From the International Association for the Study of Lung Cancer Advanced Radiation Technology Subcommittee
Accelerated Hypofractionated Radiotherapy for Locally Advanced NSCLC: A Systematic Review From the International Association for the Study of Lung Cancer Advanced Radiation Technology Subcommittee Open
View article: Addressing challenges in low-income and middle-income countries through novel radiotherapy research opportunities
Addressing challenges in low-income and middle-income countries through novel radiotherapy research opportunities Open
View article: Precision radiation therapy in the modern era of multidisciplinary care in oncology: What matters to our patients and beyond?
Precision radiation therapy in the modern era of multidisciplinary care in oncology: What matters to our patients and beyond? Open
View article: Dual-tracer PET/CT in the management of hepatocellular carcinoma
Dual-tracer PET/CT in the management of hepatocellular carcinoma Open
Compared to CT or MRI, dual-tracer positron-emission tomography/computed tomography (PET/CT) led to upstaging in 12% of patients with hepatocellular carcinoma (HCC) undergoing staging, resulting in treatment modification in 8% of cases and…
View article: Clinical factors and major pathological response after neoadjuvant chemoimmunotherapy in potentially resectable lung squamous cell carcinoma
Clinical factors and major pathological response after neoadjuvant chemoimmunotherapy in potentially resectable lung squamous cell carcinoma Open
Objective Major pathological response (MPR) helps evaluate the prognosis of patients with lung squamous cell carcinoma (LUSC). However, the clinical factors that affect the achievement of MPR after neoadjuvant chemoimmunotherapy (NCIO) in …
View article: Graphical Abstract: Angew. Chem. Int. Ed. 12/2024
Graphical Abstract: Angew. Chem. Int. Ed. 12/2024 Open
Lithium-Ion BatteriesIn their Communication (e202315628), De-en Jiang et al. reveal through machine-learning force field molecular dynamics simulations the superionic Li + transport in glassy LiTaCl 6 via adynamic "monkey bar" mechanism.
View article: Expert consensus on the evaluation and management of high-risk indeterminate pulmonary nodules
Expert consensus on the evaluation and management of high-risk indeterminate pulmonary nodules Open
Background: The most effective method for improving the prognosis of lung cancer is the application of low-dose computed tomography (LDCT) for pulmonary nodule screening in populations at high risk. Timely diagnosis and treatment of early-…