Hung‐Ming Wang
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View article: UFUR maintenance therapy significantly improves survival in locally advanced head and neck squamous cell carcinoma following definitive chemoradiotherapy
UFUR maintenance therapy significantly improves survival in locally advanced head and neck squamous cell carcinoma following definitive chemoradiotherapy Open
UFUR maintenance therapy significantly improves survival outcomes in patients with advanced HNSCC following definitive chemoradiotherapy, particularly through enhanced locoregional control, and should be considered a key component of perso…
View article: Outcome of T2 Glottic Cancer Treated with Radiotherapy Alone or Concurrent Chemo-Radiotherapy
Outcome of T2 Glottic Cancer Treated with Radiotherapy Alone or Concurrent Chemo-Radiotherapy Open
Laryngeal cancer accounts for 10% of head and neck cancers, with glottic cancers comprising two-thirds of cases in our country [...]
View article: Prognostic significance of diagnosis-to-surgery interval in oral cavity squamous cell carcinoma: A nationwide study
Prognostic significance of diagnosis-to-surgery interval in oral cavity squamous cell carcinoma: A nationwide study Open
Our findings indicate that DSI is an independent predictor of 5-year DSS and OS in patients with OCSCC. A DSI exceeding 31 days, or even 21 days, may potentially decrease survival outcomes.
View article: Margin-to-depth ratio as an independent prognostic factor in resected oral cavity squamous cell carcinoma: A nationwide cohort study
Margin-to-depth ratio as an independent prognostic factor in resected oral cavity squamous cell carcinoma: A nationwide cohort study Open
An MDR (cutoff: 0.6) is independently associated with prognosis in OCSCC, offering improved risk stratification compared to margin status alone. While MDR may guide surgical margin modification, further research is needed to determine whet…
View article: Prognostic significance of adjuvant therapy and specific radiation dosages in Taiwanese patients with oral cavity cancer and extra-nodal extension: a nationwide cohort study
Prognostic significance of adjuvant therapy and specific radiation dosages in Taiwanese patients with oral cavity cancer and extra-nodal extension: a nationwide cohort study Open
For OCSCC patients with ENE, our study shows CRT improved survivals than RT alone, underscoring the clinical significance of chemotherapy. Patients undergoing CRT with irradiation doses ranging from 6000 to 6500 cGy exhibited comparable su…
View article: Prognostic factors and risk-stratification model of recurrent or metastatic head and neck squamous cell carcinoma treated with cetuximab containing regimen
Prognostic factors and risk-stratification model of recurrent or metastatic head and neck squamous cell carcinoma treated with cetuximab containing regimen Open
Background In recent years, the addition of cetuximab to chemotherapy has improved treatment outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). In this study, we present the real-world surviv…
View article: Prognostic impact of elective tracheotomy in resected oral cavity squamous cell carcinoma: A nationwide cohort study
Prognostic impact of elective tracheotomy in resected oral cavity squamous cell carcinoma: A nationwide cohort study Open
Background Elective tracheotomy is commonly performed in resected oral squamous cell carcinoma (OCSCC) to maintain airway patency. However, the indications for this procedure vary among surgeons. This nationwide study evaluated the impact …
View article: Comparing the clinical outcomes of initial surgery and primary definitive radiotherapy with a dosage of 6600 <scp>cGy</scp> or higher in <scp>cT1</scp>−<scp>2N0M0</scp> oral cavity squamous cell carcinoma: A nationwide cohort study
Comparing the clinical outcomes of initial surgery and primary definitive radiotherapy with a dosage of 6600 <span>cGy</span> or higher in <span>cT1</span>−<span>2N0M0</span> oral cavity squamous cell carcinoma: A nationwide cohort study Open
Background To compare the clinical outcomes of two treatment modalities, initial surgery and primary definitive radiotherapy (RT), in Taiwanese patients diagnosed with cT1−2N0M0 oral cavity squamous cell carcinoma (OCSCC). Methods Between …
View article: Impact of pretreatment quality of life on tolerance and survival outcome in head and neck cancer patients undergoing definitive CCRT
Impact of pretreatment quality of life on tolerance and survival outcome in head and neck cancer patients undergoing definitive CCRT Open
In patients with HNC planned for definitive CCRT, pre-treatment HRQoL was significantly associated with treatment-related complications, tolerance, and survival outcomes. Furthermore, our results validated the clinical value of QLQ-HN35 as…
View article: Is elective neck dissection justified in cT2N0M0 oral cavity cancer defined according to the AJCC eighth edition staging system?
Is elective neck dissection justified in cT2N0M0 oral cavity cancer defined according to the AJCC eighth edition staging system? Open
Background The current NCCN guidelines recommend considering elective neck dissection (END) for early‐stage oral cavity squamous cell carcinoma (OCSCC) with a depth of invasion (DOI) exceeding 3 mm. However, this DOI threshold, determined …
View article: Are all high-volume surgeons equally good outcome? A survival analysis of patients with oral cavity squamous cell carcinoma in relation to surgical margin status based on propensity score matching analysis
Are all high-volume surgeons equally good outcome? A survival analysis of patients with oral cavity squamous cell carcinoma in relation to surgical margin status based on propensity score matching analysis Open
Background In this retrospective study, we assessed whether Taiwanese high-volume surgeons performing oral cavity squamous cell carcinoma (OCSCC) removal may differ in terms of margin status, and examined how this variable – as a quality s…
View article: Supplementary Data from Methylation of <i>RASSF1A, RASSF2A</i>, and <i>HIN-1</i> Is Associated with Poor Outcome after Radiotherapy, but not Surgery, in Oral Squamous Cell Carcinoma
Supplementary Data from Methylation of <i>RASSF1A, RASSF2A</i>, and <i>HIN-1</i> Is Associated with Poor Outcome after Radiotherapy, but not Surgery, in Oral Squamous Cell Carcinoma Open
Supplementary Data from Methylation of RASSF1A, RASSF2A, and HIN-1 Is Associated with Poor Outcome after Radiotherapy, but not Surgery, in Oral Squamous Cell Carcinoma
View article: Supplementary Figures 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
Supplementary Figures 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer Open
Supplementary Figures 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
View article: Supplementary Data from Methylation of <i>RASSF1A, RASSF2A</i>, and <i>HIN-1</i> Is Associated with Poor Outcome after Radiotherapy, but not Surgery, in Oral Squamous Cell Carcinoma
Supplementary Data from Methylation of <i>RASSF1A, RASSF2A</i>, and <i>HIN-1</i> Is Associated with Poor Outcome after Radiotherapy, but not Surgery, in Oral Squamous Cell Carcinoma Open
Supplementary Data from Methylation of RASSF1A, RASSF2A, and HIN-1 Is Associated with Poor Outcome after Radiotherapy, but not Surgery, in Oral Squamous Cell Carcinoma
View article: Supplementary Figures 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
Supplementary Figures 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer Open
Supplementary Figures 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
View article: Data from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
Data from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer Open
Purpose: The goal of this study was to establish a common set of molecules that regulate cell invasion in head and neck cancer (HNC).Experimental Design: Five invasive sublines derived from HNC cell lines were established using the Matrige…
View article: Supplementary Tables 1-3, Figure Legends 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
Supplementary Tables 1-3, Figure Legends 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer Open
Supplementary Tables 1-3, Figure Legends 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
View article: Supplementary Tables 1-3, Figure Legends 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
Supplementary Tables 1-3, Figure Legends 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer Open
Supplementary Tables 1-3, Figure Legends 1-6 from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
View article: Data from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
Data from Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer Open
Purpose: The goal of this study was to establish a common set of molecules that regulate cell invasion in head and neck cancer (HNC).Experimental Design: Five invasive sublines derived from HNC cell lines were established using the Matrige…
View article: Early relapse is an adverse prognostic factor for survival outcomes in patients with oral cavity squamous cell carcinoma: results from a nationwide registry study
Early relapse is an adverse prognostic factor for survival outcomes in patients with oral cavity squamous cell carcinoma: results from a nationwide registry study Open
Background The prognostic significance of the relapse interval in patients with resected oral cavity squamous cell carcinoma (OCSCC) is a matter of ongoing debate. In this large-scale, registry-based, nationwide study, we examined whether …
View article: Quantitative Measurement of Perineural Invasion for Prognosis Analysis of Oral Cavity Cancer Treated by Radical Surgery With or Without Adjuvant Therapy
Quantitative Measurement of Perineural Invasion for Prognosis Analysis of Oral Cavity Cancer Treated by Radical Surgery With or Without Adjuvant Therapy Open
Objectives: Perineural invasion (PNI) was quantitatively analyzed in oral squamous cell carcinoma (OSCC) specimens obtained by radical surgery to correlate with survival outcomes. Methods: This is a retrospective study that reviewed the Ca…
View article: Optimizing margin status for improving prognosis in patients with oral cavity squamous cell carcinoma: A retrospective study from the two highest-volume Taiwanese hospitals
Optimizing margin status for improving prognosis in patients with oral cavity squamous cell carcinoma: A retrospective study from the two highest-volume Taiwanese hospitals Open
Background In the treatment of oral cavity squamous cell carcinoma (OCSCC), surgical quality measures which are expected to affect outcomes, including the achievement of a clear margin, are surgeon-dependent but might not be invariably ass…
View article: Maintenance tegafur-plus-uracil after adjuvant concurrent chemoradiotherapy may improve outcome for resected oral cavity squamous cell carcinoma with extranodal extension
Maintenance tegafur-plus-uracil after adjuvant concurrent chemoradiotherapy may improve outcome for resected oral cavity squamous cell carcinoma with extranodal extension Open
Objectives To evaluate whether tegafur-uracil maintenance (UFTm) following postoperation adjuvant cisplatin-based concurrent chemoradiotherapy (CCRT) may reduce distant metastasis in patients with resected oral cavity squamous cell carcino…
View article: Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1/T2 Tongue Cancer
Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1/T2 Tongue Cancer Open
Background: Patients affected by oral tongue squamous cell carcinoma (OTSCC) underwent a supraomohyoid neck dissection (SOHND) or modified radical neck dissection (mRND) according to the clinical nodal status (cN0 vs. cN+). We investigate …
View article: Early relapse is an adverse prognostic factor for survival outcomes in patients with oral cavity squamous cell carcinoma: Results from a nationwide registry study
Early relapse is an adverse prognostic factor for survival outcomes in patients with oral cavity squamous cell carcinoma: Results from a nationwide registry study Open
Background To investigate whether the time interval between surgery and first relapse affects survival outcomes in Taiwanese patients with oral cavity squamous cell carcinoma (OCSCC). The prognostic significance of the relapse interval in …
View article: Towards an Improved Pathological Node Classification for Prognostic Stratification of Patients With Oral Cavity Squamous Cell Carcinoma: Results From a Nationwide Registry Study
Towards an Improved Pathological Node Classification for Prognostic Stratification of Patients With Oral Cavity Squamous Cell Carcinoma: Results From a Nationwide Registry Study Open
Background To assess the prognostic significance of different nodal parameters [i.e., number of pathologically positive nodes, log odds of positive lymph nodes, lymph node ratio (LNR), and extra-nodal extension (ENE)] in Taiwanese patients…
View article: Predictive Value of Albumin and Neutrophil-to-Lymphocyte Ratio Score for Treatment Completeness and Safety Profiles in Patients With Head and Neck Cancer Receiving Definitive Concurrent Chemoradiotherapy
Predictive Value of Albumin and Neutrophil-to-Lymphocyte Ratio Score for Treatment Completeness and Safety Profiles in Patients With Head and Neck Cancer Receiving Definitive Concurrent Chemoradiotherapy Open
Our study showed that the ANS can accurately predict the treatment completeness of CCRT in patients with HNC and can be widely used as a simple predictor of treatment tolerance and safety profiles in patients with HNC undergoing CCRT.