Xin Gu
YOU?
Author Swipe
View article: Cerebrospinal fluid profile associated with the incidence and outcomes of patients with chronic graft-versus-host disease after haploidentical hematopoietic stem cell transplantation
Cerebrospinal fluid profile associated with the incidence and outcomes of patients with chronic graft-versus-host disease after haploidentical hematopoietic stem cell transplantation Open
Chronic graft-versus-host disease (cGVHD) is a major complication of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). In our previous studies, we speculated that cGVHD might be closely related to immune-mediated encepha…
View article: Insights from a multicenter study on the outcomes of liver abscess after allogeneic hematopoietic stem cell transplantation
Insights from a multicenter study on the outcomes of liver abscess after allogeneic hematopoietic stem cell transplantation Open
Introduction: Liver abscess (LA), a severe and potentially life-threatening infection, is characterized by the formation of purulent material within the liver parenchyma, often resulting from bacterial, fungal, or parasitic infections. In …
View article: Clinical manifestations and outcomes of EBV-related secondary hemophagocytic lymphohistiocytosis
Clinical manifestations and outcomes of EBV-related secondary hemophagocytic lymphohistiocytosis Open
In summary, our study firstly reported the clinical manifestations and outcomes of EBV-related sHLH following allo-HSCT in the largest cohort at present.
View article: Breaking the heterogeneity barrier: a robust prognostic signature for survival stratification and immune profiling in triple-negative breast cancer
Breaking the heterogeneity barrier: a robust prognostic signature for survival stratification and immune profiling in triple-negative breast cancer Open
Background Triple-negative breast cancer (TNBC), a highly heterogeneous breast cancer subtype, poses significant challenges to human health. Intra-tumor heterogeneity (ITH) limits the reliability of conventional prognostic models. Methods …
View article: Intra-tumor heterogeneity-resistant gene signature predicts prognosis and immune infiltration in breast cancer
Intra-tumor heterogeneity-resistant gene signature predicts prognosis and immune infiltration in breast cancer Open
Background Breast cancer (BC) remains a significant threat to human health, with substantial variations in prognosis and treatment responses. Intra-tumor heterogeneity (ITH) presents a critical challenge in developing reliable prognostic m…
View article: Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and female infertility: insights from a cross-sectional study
Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and female infertility: insights from a cross-sectional study Open
The findings demonstrated significant linear associations between elevated UHR levels and increased odds of female infertility. UHR may serve as a potential biomarker for infertility that requires validation. Future studies should remedy t…
View article: Commensal bacterial glycosylation at the interface of host–bacteria interactions
Commensal bacterial glycosylation at the interface of host–bacteria interactions Open
Commensal bacteria produce a diverse array of glycosylated molecules, including glycoproteins, glycolipids, peptidoglycan, capsular polysaccharides, and exopolysaccharides, which play fundamental roles in host-microbe interactions. Recent …
View article: White matter changes in recovered COVID-19 patients: insights from DTI, DKI, and NODDI metrics
White matter changes in recovered COVID-19 patients: insights from DTI, DKI, and NODDI metrics Open
Background COVID-19 affects not only the respiratory system but also the central nervous system, resulting in symptoms such as anosmia and confusion. Understanding the long-term neurological effects of COVID-19 is critical for comprehensiv…
View article: Impact of the Western Tibetan Vortex on Springtime Snow Cover Over the Western Tibetan Plateau
Impact of the Western Tibetan Vortex on Springtime Snow Cover Over the Western Tibetan Plateau Open
Snow cover changes are of great importance to the hydrological cycle of the western Tibetan Plateau (TP). However, the influence of the atmospheric circulation on snow cover over the western TP is still unclear. This study finds that sprin…
View article: Effects of electroacupuncture on central insulin signal transduction-related proteins in insulin resistance model rats via the mTORC1/S6K1 pathway
Effects of electroacupuncture on central insulin signal transduction-related proteins in insulin resistance model rats via the mTORC1/S6K1 pathway Open
Objective: To investigate the effects of electroacupuncture (EA) on the expression and phosphorylation of insulin signal transduction-related proteins in the hypothalamus of insulin resistance (IR) rats. Methods: There were totally seventy…
View article: Recognition of Strawberry Powdery Mildew in Complex Backgrounds: A Comparative Study of Deep Learning Models
Recognition of Strawberry Powdery Mildew in Complex Backgrounds: A Comparative Study of Deep Learning Models Open
Powdery mildew is one of the most common diseases affecting strawberry yield and quality. Accurate and timely detection is essential to reduce pesticide usage and labor costs. However, recognizing strawberry powdery mildew in complex field…
View article: Artificial intelligence-based predictive model for relapse in acute myeloid leukemia patients following haploidentical hematopoietic cell transplantation
Artificial intelligence-based predictive model for relapse in acute myeloid leukemia patients following haploidentical hematopoietic cell transplantation Open
Background and Objectives Relapse is one of the most critical causes of transplant failure in patients with acute myeloid leukemia (AML) receiving haploidentical-related donor (HID) hematopoietic stem cell transplantation (HSCT). We aimed …
View article: Multi-omics Mendelian Randomization Reveals Immunometabolic Signatures of the Gut Microbiota in Optic Neuritis and the Potential Therapeutic Role of Vitamin B6
Multi-omics Mendelian Randomization Reveals Immunometabolic Signatures of the Gut Microbiota in Optic Neuritis and the Potential Therapeutic Role of Vitamin B6 Open
Optic neuritis (ON) is an inflammatory condition often linked to autoimmune disorders like multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Despite its low incidence, ON can lead to severe, irreversible visual im…
View article: Exploring the association between 91 circulating inflammatory proteins and the risk of carcinoid syndrome: a Mendelian randomization analysis
Exploring the association between 91 circulating inflammatory proteins and the risk of carcinoid syndrome: a Mendelian randomization analysis Open
This study aims to explore the potential correlation between circulating inflammatory proteins and carcinoid syndrome (CS). Using summary data from genome-wide association studies (GWAS), we conducted a Mendelian randomization (MR) analysi…
View article: Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer
Comprehensive pan-cancer analysis indicates key gene of p53-independent apoptosis is a novel biomarker for clinical application and chemotherapy in colorectal cancer Open
Background Schlafen11 (SLFN11) is a key gene in p53-independent apoptosis through ribosome stalling; however, systematic research has been conducted on its role in the tumor immune microenvironment, clinical application, and immunotherapy …
View article: Clinical features and prognostic nomogram for therapy-related acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
Clinical features and prognostic nomogram for therapy-related acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation Open
Therapy-related acute myeloid leukemia (t-AML), which develops after cytotoxic therapy, has a poorer prognosis. Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potential cure, its efficacy varies among patients…
View article: Prognostic value of post-transplantation measurable residual disease in patients with myelodysplastic syndrome: A prospective cohort study
Prognostic value of post-transplantation measurable residual disease in patients with myelodysplastic syndrome: A prospective cohort study Open
Our results demonstrated both post-HSCT MRD and IPSS-R scores were independent prognostic factors for OS, DFS, and relapse for MDS patients after allo-HSCT. The risk score system could better predict transplant outcomes and refine the risk…
View article: Short-, medium- and long-chain chlorinated paraffins from indoor/outdoor air in Guanzhong Plain, China: Characteristics, distribution and human exposure risks
Short-, medium- and long-chain chlorinated paraffins from indoor/outdoor air in Guanzhong Plain, China: Characteristics, distribution and human exposure risks Open
Research on the environment of long chain chlorinated paraffins (LCCPs) in the fine particulate matter (PM2.5) and gas phase is still scarce, particularly in indoors. It limits the comprehensive investigation into the gas-particle partitio…
View article: Expression and mechanism of endogenous relaxin in hypertensive patients
Expression and mechanism of endogenous relaxin in hypertensive patients Open
Objective This study aimed to investigate the role of endogenous relaxin in the development of hypertension by examining its expression in hypertensive patients and various hypertensive rat models. Methods In this study, 61 hypertensive pa…
View article: Electroacupuncture improves cognitive function in high-fat diet/streptozocin-induced type 2 diabetic mice by inhibiting autophagy-related ferroptosis
Electroacupuncture improves cognitive function in high-fat diet/streptozocin-induced type 2 diabetic mice by inhibiting autophagy-related ferroptosis Open
At present, there lacks a definitive pharmaceutical intervention or therapeutic approach for diabetes-associated cognitive impairment. Herein, we delved into the impact of electroacupuncture on cognitive function in high-fat diet/streptozo…
View article: Large-Scale Simulated Storage Tank Settlement and Strain Simulation
Large-Scale Simulated Storage Tank Settlement and Strain Simulation Open
Under the action of hydraulic pressure, the storage tanks built on soft soil foundation are prone to produce various settlement and deformation. The stability of the tank is very sensitive to settlement deformation, and the uneven settleme…
View article: Comparison of Two Conditioning Regimens for Haploidentical Stem Cell Transplantation in Patients with Severe Aplastic Anemia
Comparison of Two Conditioning Regimens for Haploidentical Stem Cell Transplantation in Patients with Severe Aplastic Anemia Open
Allogeneic hematopoietic cell transplantation (HCT) is the best curative approach for patients with severe aplastic anemia (SAA). The outcomes of haploidentical donor HCT (haplo-HCT) have improved, making it a favorable option for patients…
View article: Causal effect of immune cells, metabolites, cathepsins, and vitamin therapy in diabetic retinopathy: a Mendelian randomization and cross-sectional study
Causal effect of immune cells, metabolites, cathepsins, and vitamin therapy in diabetic retinopathy: a Mendelian randomization and cross-sectional study Open
Background Diabetic retinopathy (DR) is a major microvascular complication of diabetes and a leading cause of blindness worldwide. The pathogenesis of DR involves complex interactions between metabolic disturbances, immune cells, and prote…