Mingguang He
YOU?
Author Swipe
View article: Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases
Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases Open
Retinal nerve fibre layer (RNFL) is a non-invasive structural biomarker of cardiometabolic health, yet its biological underpinnings remain unknown. Here, we integrate advanced retinal optical biopsy and artificial intelligence (AI) algorit…
View article: AI driven quantitative analysis of meibomian glands in children and adolescents: a benchmark dataset study
AI driven quantitative analysis of meibomian glands in children and adolescents: a benchmark dataset study Open
Background Due to the lack of quality-controlled quantitative data on meibomian gland (MG) morphology in children and adolescents, this study aims to establish a Children and Adolescents Meibomian Gland (CAMG) dataset. Methods A total of 1…
View article: Association between systemic immune-inflammation index and sleep disorder among US adults: A cross-sectional study based on NHANES 2005 to 2020
Association between systemic immune-inflammation index and sleep disorder among US adults: A cross-sectional study based on NHANES 2005 to 2020 Open
The relationship between the Systemic Immune-Inflammation Index (SII) and sleep disorders remains poorly characterized. This cross-sectional study investigated this association utilizing data from the National Health and Nutrition Examinat…
View article: Acceleration of Myopic Shifts in Refraction and Axial Elongation Begins in the Premyopia Stage
Acceleration of Myopic Shifts in Refraction and Axial Elongation Begins in the Premyopia Stage Open
Myopia acceleration starts in mild hyperopia. Public health interventions should aim to keep refractions over +1.00 D to delay entry into the premyopic range.
View article: Differences in quadriceps but not hamstrings strength in runners with varying durations of patellofemoral pain
Differences in quadriceps but not hamstrings strength in runners with varying durations of patellofemoral pain Open
Background Patellofemoral pain (PFP) is a common injury among runners. The quadriceps and hamstrings strength in patients with different durations of PFP is still unclear. The purpose of this study is to evaluate the isokinetic strength ch…
View article: Macular Optical Coherence Tomography Parameters and Incident Glaucoma Among Myopic Eyes
Macular Optical Coherence Tomography Parameters and Incident Glaucoma Among Myopic Eyes Open
Our study highlighted the potential of OCT-derived indicators for early glaucoma risk assessment and clinical monitoring.
View article: Photoreceptor Layer Thinning as Biomarker for Circulatory Premature Mortality: UK Biobank Cohort Study
Photoreceptor Layer Thinning as Biomarker for Circulatory Premature Mortality: UK Biobank Cohort Study Open
These findings suggest that specific OCT parameters could serve as noninvasive biomarkers for mortality risk assessment, potentially enhancing early identification of individuals at higher risk of premature death, particularly from circula…
View article: Neurotoxic effects of Cis-bifenthrin on microbe-gut-brain axis: Disruption of neurolipid balance in Xenopus laevis
Neurotoxic effects of Cis-bifenthrin on microbe-gut-brain axis: Disruption of neurolipid balance in Xenopus laevis Open
The neurotoxic effects of cis-bifenthrin (cis-BF) on amphibians and its molecular mechanisms are unclear despite its common presence in aquatic environments. In present study, female Xenopus laevis were subjected to a three-month treatment…
View article: Interpretable machine learning model for predicting early recurrence of pancreatic cancer: integrating intratumoral and peritumoral radiomics with body composition
Interpretable machine learning model for predicting early recurrence of pancreatic cancer: integrating intratumoral and peritumoral radiomics with body composition Open
Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a high rate of early recurrence (ER) after radical resection, which significantly affects long-term survival. Currently, no reliable system exists for predicting ER in …
View article: Development and multicenter validation of an AI driven model for quantitative meibomian gland evaluation
Development and multicenter validation of an AI driven model for quantitative meibomian gland evaluation Open
This multicenter retrospective study developed and validated an AI driven model for automated segmentation and quantitative evaluation of meibomian glands using infrared meibography images acquired by the Keratograph 5M device. A total of …
View article: Controversies, consensuses, and guidelines for acute primary angle closure attack (APACA) by the Asia-Pacific Glaucoma Society (APGS) and the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO)
Controversies, consensuses, and guidelines for acute primary angle closure attack (APACA) by the Asia-Pacific Glaucoma Society (APGS) and the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO) Open
The Asia-Pacific Glaucoma Society (APGS), in collaboration with the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO), convened a panel of 18 international experts from 10 countries/territories to identify areas of controversy an…
View article: Underlying brain and genetic mechanisms linking historic phone use patterns, visual decline, and dementia risk in middle‐aged and older adults
Underlying brain and genetic mechanisms linking historic phone use patterns, visual decline, and dementia risk in middle‐aged and older adults Open
BACKGROUND This study aimed to investigate associations between historic phone use, visual decline, and risk of dementia, as well as underlying biological mechanisms. METHODS A total of 494,359 participants from UK Biobank were included in…
View article: Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-Release Tablets on Somatic Symptoms of Major Depressive Disorder: A Prospective, Single-Arm, Multicenter Clinical Study
Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-Release Tablets on Somatic Symptoms of Major Depressive Disorder: A Prospective, Single-Arm, Multicenter Clinical Study Open
NCT05849272.
View article: A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium Open
The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually dec…
View article: Structural and causal links between retinal vascular geometry and neural layer thickness
Structural and causal links between retinal vascular geometry and neural layer thickness Open
GC-IPL and INL were positively associated with vascular Density and Caliber. Multidimensional relationships indicate a complementary nature between retinal vascular and neural parameters, highlighting their value as a composite biomarker. …
View article: Similarity = Value? Consultation Value Assessment and Alignment for Personalized Search
Similarity = Value? Consultation Value Assessment and Alignment for Personalized Search Open
Personalized search systems in e-commerce platforms increasingly involve user interactions with AI assistants, where users consult about products, usage scenarios, and more. Leveraging consultation to personalize search services is trendin…
View article: Incidence and risk factors for glaucoma and its clinical, mental health and economic impact in an elderly population: a longitudinal study
Incidence and risk factors for glaucoma and its clinical, mental health and economic impact in an elderly population: a longitudinal study Open
Objectives To investigate the incidence and determinants of glaucoma in an elderly Chinese population, and clinical, mental health and economic impacts. Design This nationally representative, longitudinal study assessed self-reported 6-yea…
View article: Myopia and high myopia trends in Chinese children and adolescents over 25 years: a nationwide study with projections to 2050
Myopia and high myopia trends in Chinese children and adolescents over 25 years: a nationwide study with projections to 2050 Open
National Natural Science Foundation of China (#82271086; #82388101; #72495123).
View article: Chronic Low-Dose Phoxim Exposure Impairs Silk Production in Bombyx mori L. (Lepidoptera: Bombycidae) by Disrupting Juvenile Hormone Signaling-Mediated Fibroin Synthesis
Chronic Low-Dose Phoxim Exposure Impairs Silk Production in Bombyx mori L. (Lepidoptera: Bombycidae) by Disrupting Juvenile Hormone Signaling-Mediated Fibroin Synthesis Open
Phoxim is a pesticide extensively applied in mulberry fields, and residues may persist on leaves even after the recommended pre-harvest interval. However, the potential risks of these residues to Bombyx mori L. (Lepidoptera: Bombycidae) ha…