Min Zhang
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View article: Interactions between LncRNAs and MAPK signaling pathways in the pathogenesis of breast cancer
Interactions between LncRNAs and MAPK signaling pathways in the pathogenesis of breast cancer Open
Long non-coding RNAs (lncRNAs) are increasingly recognized as key modulators of gene expression and cellular processes, playing pivotal roles in cancer biology. In breast cancer, a multifaceted malignancy driven by diverse genetic and epig…
View article: Tumor-activated nanocomplex reprograms cancer and macrophage metabolism in opposite directions to overcome immune suppression
Tumor-activated nanocomplex reprograms cancer and macrophage metabolism in opposite directions to overcome immune suppression Open
Immunotherapy efficacy is hindered by the immunosuppressive metabolism of cancer cells and tumor-associated macrophages (TAMs), yet their opposite metabolic programs complicate synchronized modulation of tumor microenvironment. Here, we re…
View article: Stem cell and gene therapies for leukodystrophies
Stem cell and gene therapies for leukodystrophies Open
Leukodystrophies form a group of rare genetic disorders characterized by the progressive degeneration of white matter in the brain, often presenting in childhood with life-threatening consequences. Current therapeutic options are limited, …
View article: Influence of COVID-19 pandemic on the distribution and drug resistance of pathogens in patients with bloodstream infection
Influence of COVID-19 pandemic on the distribution and drug resistance of pathogens in patients with bloodstream infection Open
Background The pandemic of Coronavirus Disease 2019 (COVID-19) significantly impacted healthcare systems worldwide, especially improving awareness of infection prevention and control in medical institutions. However, it remains unclear to …
View article: Meta-analysis of the prognostic efficacy of daratumumab combined with standard therapy in high-risk multiple myeloma
Meta-analysis of the prognostic efficacy of daratumumab combined with standard therapy in high-risk multiple myeloma Open
The combination of DAR with standard therapy significantly enhances clinical outcomes in HRMM patients, resulting in prolonged PFS and OS, with manageable adverse effects.
View article: SREBF1 mediates immunoparalysis of dendritic cells in sepsis by regulating lipid metabolism and endoplasmic reticulum stress
SREBF1 mediates immunoparalysis of dendritic cells in sepsis by regulating lipid metabolism and endoplasmic reticulum stress Open
Background Lipid metabolic reprogramming is a key feature of sepsis, with increased lipid storage contributing to disease progression. Although lipid metabolism dysregulation has been implicated in sepsis pathogenesis, how lipid biosynthes…
View article: A three-layer digital twin architecture for granular bed profile prediction in rotary kiln
A three-layer digital twin architecture for granular bed profile prediction in rotary kiln Open
View article: Editorial: Autophagy and lung cancer therapy: targeted drug development and new emerging technology
Editorial: Autophagy and lung cancer therapy: targeted drug development and new emerging technology Open
View article: Increased cardiac macrophages in Sorbs2-deficient hearts: revealing a potential role for macrophage in responding to embryonic myocardial abnormalities
Increased cardiac macrophages in Sorbs2-deficient hearts: revealing a potential role for macrophage in responding to embryonic myocardial abnormalities Open
Macrophages are known to support cardiac development and homeostasis, contributing to tissue remodeling and repair in the adult heart. However, it remains unclear whether embryonic macrophages also respond to abnormalities in the developin…
View article: Genome-Wide Structural Variation Analysis and Breed Comparison of Local Domestic Ducks in Shandong Province, China
Genome-Wide Structural Variation Analysis and Breed Comparison of Local Domestic Ducks in Shandong Province, China Open
Structural variations in the duck genome significantly impact the environmental adaptability and phenotypic diversity of duck populations. Characterizing these SVs in local domestic duck breeds from Shandong province offers valuable insigh…
View article: Whole-Transcriptome Analysis Reveals the Regulatory Network of Immune Response in Dapulian Pig
Whole-Transcriptome Analysis Reveals the Regulatory Network of Immune Response in Dapulian Pig Open
There is a consensus that indigenous pigs in China are more resistant than modern commercial pigs in terms of disease resistance. Generally, the immune response is an important part of anti-disease capability; however, the related mechanis…
View article: A duplex HiFi-LAMP assay for screening of two novel human circoviruses HCirV-1 and HCirV-2
A duplex HiFi-LAMP assay for screening of two novel human circoviruses HCirV-1 and HCirV-2 Open
View article: Early senescence of pancreatic β cells induced by unfolded protein response deficiency prevents type 1 diabetes
Early senescence of pancreatic β cells induced by unfolded protein response deficiency prevents type 1 diabetes Open
Type 1 diabetes (T1D) is a T lymphocyte-mediated autoimmune disease caused by pancreatic β-cell destruction, which eventually leads to reduced insulin level and increased blood glucose level (Syed, 2022). As a multifactorial disease, T1D …
View article: Leech <i>Poecilobdella manillensis</i> protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites
Leech <i>Poecilobdella manillensis</i> protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites Open
BACKGROUND Hyperuricemia (HUA) is a public health concern that needs to be solved urgently. The lyophilized powder of Poecilobdella manillensis has been shown to significantly alleviate HUA; however, its underlying metabolic regulation rem…
View article: Endoscopic treatments versus TIPS for patients with cirrhosis and variceal bleeding: Comparison of long-term outcomes using meta-analysis
Endoscopic treatments versus TIPS for patients with cirrhosis and variceal bleeding: Comparison of long-term outcomes using meta-analysis Open
Subgroup analysis Subgroup analysis revealed no difference in mortality between the TIPS and ETs groups when follow-up was ≤ 24 months.Sensitivity analysis Publication bias was assessed using funnel plots.Sensitivity analyses were also per…
View article: Gene therapy by virus-like self-spooling toroidal DNA condensates for revascularization of hindlimb ischemia
Gene therapy by virus-like self-spooling toroidal DNA condensates for revascularization of hindlimb ischemia Open
View article: Traditional Chinese Medicine nursing of a patient with type 2 diabetes complicated with hypertension
Traditional Chinese Medicine nursing of a patient with type 2 diabetes complicated with hypertension Open
This article summarized the Traditional Chinese Medicine nursing practice of a case of type 2 diabetes with hypertension during hospitalization. On the basis of western medicine treatment, the intervention was carried out in combination wi…
View article: Prevalence and transmission of pretreatment drug resistance in people living with HIV-1 in Shanghai China, 2017–2021
Prevalence and transmission of pretreatment drug resistance in people living with HIV-1 in Shanghai China, 2017–2021 Open
The implementation of pretreatment drug-resistance (PDR) surveillance among people living with HIV-1 (PLWH) is a top priority in countries using efavirenz (EFV)/nevirapine (NVP) for first-line ART. In this study, we assessed the prevalence…
View article: Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives
Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives Open
View article: Application of Monte Carlo simulation to optimise the dosage regimen of meropenem in patients with augmented renal clearance for Pseudomonas aeruginosa infection
Application of Monte Carlo simulation to optimise the dosage regimen of meropenem in patients with augmented renal clearance for Pseudomonas aeruginosa infection Open
Tailored dosing based on bacterial MIC values is crucial for patients with ARC. Prolonged infusion time alone does not enhance efficacy. Empirical treatment in patients with ARC should consider MIC distribution; a dosage of 2 g q 6 h achie…
View article: Natural GmACO1 allelic variations confer drought tolerance and influence nodule formation in soybean
Natural GmACO1 allelic variations confer drought tolerance and influence nodule formation in soybean Open
Soybean [ Glycine max (L.) Merr.] is one of the most important, but a drought-sensitive, crops. Identifying the genes controlling drought tolerance is important in soybean breeding. Here, through a genome-wide association study, we identif…
View article: A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus
A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus Open
Marburg virus (MARV) is one of the filovirus species that cause deadly hemorrhagic fever in humans, with mortality rates up to 90%. Neutralizing antibodies represent ideal candidates to prevent or treat virus disease. However, no antibody …
View article: A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus
A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus Open
Marburg virus (MARV) is one of the filovirus species that cause deadly hemorrhagic fever in humans, with mortality rates up to 90%. Neutralizing antibodies represent ideal candidates to prevent or treat virus disease. However, no antibody …
View article: Author Response: A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus
Author Response: A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus Open
Marburg virus (MARV) is one of the filovirus species that cause deadly hemorrhagic fever in humans, with mortality rates up to 90%. Neutralizing antibodies represent ideal candidates to prevent or treat virus disease. However, no antibody …
View article: MicroRNA-153 Restrains Cell Metastasis and Epithelial–Mesenchymal Transition in Cervical Carcinoma by Targeting SATB1 and Regulating Wnt/<i>β</i>-Catenin Pathway
MicroRNA-153 Restrains Cell Metastasis and Epithelial–Mesenchymal Transition in Cervical Carcinoma by Targeting SATB1 and Regulating Wnt/<i>β</i>-Catenin Pathway Open
As a malignant tumor, cervical cancer (CC) seriously affects women’s life and health. Various microRNAs (miRNAs) are involved in tumorigenesis of CC. Here, we mainly paid attention to the effect of miR-153 in CC. RT-qPCR or Western blot wa…
View article: The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021
The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021 Open
Background HIV-1 drug resistance is a huge challenge in the era of ART. Objectives To investigate the prevalence and characteristics of acquired HIV-1 drug resistance (ADR) in Shanghai, China. Methods An epidemiological study was performed…
View article: Design and Synthesis of 6-C-Alkyl-Dmdp Type Nanomolar Inhibitors of Β-Galactosidase and Β-Glucosidase Based on Broussonetine S and Related Derivatives
Design and Synthesis of 6-C-Alkyl-Dmdp Type Nanomolar Inhibitors of Β-Galactosidase and Β-Glucosidase Based on Broussonetine S and Related Derivatives Open
View article: Astrocyte-Derived IL11 Modulates Astrocytes-Microglia Crosstalk Via NF-κB Signaling Pathway in Sepsis-Associated Encephalopathy
Astrocyte-Derived IL11 Modulates Astrocytes-Microglia Crosstalk Via NF-κB Signaling Pathway in Sepsis-Associated Encephalopathy Open
View article: Glass Transition Features of Frozen Dough Regulated by Lentinan Molecular Weight and Their Correlation with Dough Structural and Rheological Properties
Glass Transition Features of Frozen Dough Regulated by Lentinan Molecular Weight and Their Correlation with Dough Structural and Rheological Properties Open
View article: Advancements in Gastric Cancer Resection Techniques: Current Status and Future Directions
Advancements in Gastric Cancer Resection Techniques: Current Status and Future Directions Open