Mingyue Tan
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View article: Is there a relationship between serum uric acid and prostate-specific antigen in middle-aged and elderly Chinese men?
Is there a relationship between serum uric acid and prostate-specific antigen in middle-aged and elderly Chinese men? Open
View article: Loss of OBSCN expression promotes bladder cancer progression but enhances the efficacy of PD-L1 inhibitors
Loss of OBSCN expression promotes bladder cancer progression but enhances the efficacy of PD-L1 inhibitors Open
View article: Single-port transvesical robot-assisted simple prostatectomy with total urethral preservation for patients unable to adopt the lithotomy position: A case report
Single-port transvesical robot-assisted simple prostatectomy with total urethral preservation for patients unable to adopt the lithotomy position: A case report Open
Benign prostatic hyperplasia (BPH), prevalent in the aging male population, presented a unique surgical challenge in a 58-year-old patient with a history of multiple pelvic and hip surgeries, precluding conventional lithotomy and transuret…
View article: Oroxylin A alleviates myocardial ischemia–reperfusion injury by quelling ferroptosis via activating the <scp>DUSP10</scp>/<scp>MAPK</scp>‐Nrf2 pathway
Oroxylin A alleviates myocardial ischemia–reperfusion injury by quelling ferroptosis via activating the <span>DUSP10</span>/<span>MAPK</span>‐Nrf2 pathway Open
Reperfusion therapy is the primary treatment strategy for acute myocardial infarction (AMI). Paradoxically, it can lead to myocardial damage, namely myocardial ischemia/reperfusion injury (MIRI). This study explored whether oroxylin A (OA)…
View article: Comprehensive macro and micro views on immune cells in ischemic heart disease
Comprehensive macro and micro views on immune cells in ischemic heart disease Open
Ischemic heart disease (IHD) is a prevalent cardiovascular condition that remains the primary cause of death due to its adverse ventricular remodelling and pathological changes in end‐stage heart failure. As a complex pathologic condition,…
View article: Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway
Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway Open
Despite advances in treatment, myocardial infarction remains the leading cause of heart failure and death worldwide, and the restoration of coronary blood flow can also cause heart damage. In this study, we found that corosolic acid (CA), …
View article: Global burden of bladder cancer attributable to smoking in 204 countries and territories, 1990–2019
Global burden of bladder cancer attributable to smoking in 204 countries and territories, 1990–2019 Open
Bladder cancer (BCa) poses a significant medical burden worldwide. However, the epidemiological pattern of the global smoking-induced BCa burden is unclear. Our analysis of the 2019 Global Burden of Disease (GBD) database showed a signific…
View article: The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs: A multicenter retrospective real-world study
The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs: A multicenter retrospective real-world study Open
Objective The objective of this study is to assess the effectiveness and safety of ureteroscopic lithotripsy and flexible ureteroscopy (fURS) for treating patients on anticoagulant (AC) or antiplatelet (AP) medications. Patients and Method…
View article: Investigation of ENO2 as a promising novel marker for the progression of colorectal cancer with microsatellite instability-high
Investigation of ENO2 as a promising novel marker for the progression of colorectal cancer with microsatellite instability-high Open
View article: PIGT promotes cell growth, glycolysis, and metastasis in bladder cancer by modulating GLUT1 glycosylation and membrane trafficking
PIGT promotes cell growth, glycolysis, and metastasis in bladder cancer by modulating GLUT1 glycosylation and membrane trafficking Open
View article: In Vivo Tracking of Leaf-Delivered Titanium Dioxide Nanopesticide in Ginseng Plant Using Surface - Enhanced Raman Scattering - Labeled Techniques
In Vivo Tracking of Leaf-Delivered Titanium Dioxide Nanopesticide in Ginseng Plant Using Surface - Enhanced Raman Scattering - Labeled Techniques Open
View article: Trimetazidine Attenuates Ischemia/Reperfusion-Induced Myocardial Ferroptosis by Modulating the Sirt3/Nrf2-GSH System and Reducing Mitochondrial Oxidative Stress
Trimetazidine Attenuates Ischemia/Reperfusion-Induced Myocardial Ferroptosis by Modulating the Sirt3/Nrf2-GSH System and Reducing Mitochondrial Oxidative Stress Open
Background and Purpose: Ferroptosis is a newly defined mode of cellular demise. Increasing investigatieon supports the hypothesis that ferroptosis is a crucial factor in the complex mechanisms of myocardial ischemia-reperfusion(I/R) injury…
View article: The stratification and prognostic importance of molecular and immune landscapes in clear cell renal cell carcinoma
The stratification and prognostic importance of molecular and immune landscapes in clear cell renal cell carcinoma Open
The aim of our research is to explore the various characteristics and genetic profiles of clear cell renal cell carcinoma (ccRCC) in order to discover possible predictors of prognosis and targets for treatment. By utilizing ssGSEA scores, …
View article: Super-enhancer-associated SNHG15 cooperating with FOSL1 contributes to bladder cancer progression through the WNT pathway
Super-enhancer-associated SNHG15 cooperating with FOSL1 contributes to bladder cancer progression through the WNT pathway Open
Small nucleolar RNA host gene 15 (SNHG15) plays an oncogenic role in many cancers. However, the role of SNHG15 in bladder cancer (BLCA) remains unclear. In this study, the regulation of SNHG15 on the activities of BLCA cells (T24 and RT112…
View article: Comprehensive view of macrophage autophagy and its application in cardiovascular diseases
Comprehensive view of macrophage autophagy and its application in cardiovascular diseases Open
Cardiovascular diseases (CVDs) are the primary drivers of the growing public health epidemic and the leading cause of premature mortality and economic burden worldwide. With decades of research, CVDs have been proven to be associated with …
View article: Identification of the novel therapeutic targets and biomarkers associated of prostate cancer with cancer-associated fibroblasts (CAFs)
Identification of the novel therapeutic targets and biomarkers associated of prostate cancer with cancer-associated fibroblasts (CAFs) Open
Globally, prostate cancer remains a leading cause of mortality and morbidity despite advances in treatment. Research on prostate cancer has primarily focused on the malignant epithelium, but the tumor microenvironment has recently been rec…
View article: Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition
Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition Open
Reperfusion is essential for ischemic myocardium but paradoxically leads to myocardial damage that worsens cardiac functions. Ferroptosis often occurs in cardiomyocytes during ischemia/reperfusion (I/R). The SGLT2 inhibitor dapagliflozin (…
View article: Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis
Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Open
View article: The hippo kinases MST1/2 in cardiovascular and metabolic diseases: A promising therapeutic target option for pharmacotherapy
The hippo kinases MST1/2 in cardiovascular and metabolic diseases: A promising therapeutic target option for pharmacotherapy Open
View article: Molecular Targets of Shenqi Dihuang, A Traditional Chinese HerbalMedicine, and Its Potential Role in Renal Cell Carcinoma Therapy
Molecular Targets of Shenqi Dihuang, A Traditional Chinese HerbalMedicine, and Its Potential Role in Renal Cell Carcinoma Therapy Open
Chinese herbal medicine (CHM), which includes herbal slices and proprietary products, is widely used in China. Shenqi Dihuang (SQDH) is a traditional Chinese medicine (TCM) formula with ingredients that affect tumor growth. Despite recent …
View article: A novel cuproptosis-related lncRNA signature predicts prognosis and therapeutic response in bladder cancer
A novel cuproptosis-related lncRNA signature predicts prognosis and therapeutic response in bladder cancer Open
Bladder cancer (BC) ranks the tenth in the incidence of global tumor epidemiology. LncRNAs and cuproptosis were discovered to regulate the cell death. Herein, we downloaded transcriptome profiling, mutational data, and clinical data on pat…
View article: Identifying tumor antigens and immune subtypes of renal cell carcinoma for immunotherapy development
Identifying tumor antigens and immune subtypes of renal cell carcinoma for immunotherapy development Open
Renal cell carcinoma (RCC) is one of the leading causes of death in men. Messenger ribonucleic acid (mRNA) vaccines may be an attractive means to achieve satisfactory results. Cancer immunotherapy is a promising cancer treatment strategy. …
View article: Establishment of an optimized orthotopic bladder cancer model in mice
Establishment of an optimized orthotopic bladder cancer model in mice Open
View article: The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development
The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development Open
Bone sialoprotein (gene: Ibsp; protein: BSP) is a multifunctional extracellular matrix protein present in bone, cementum, and dentin. Accumulating evidence supports BSP as a key regulator of mineralized tissue formation via evolutionarily …
View article: Overexpression of RNF180 Inhibits Progression and Metastasis by Epithelial Mesenchymal Transformation and Immune Infiltration in Renal Cancer
Overexpression of RNF180 Inhibits Progression and Metastasis by Epithelial Mesenchymal Transformation and Immune Infiltration in Renal Cancer Open
Background : Molecular biomarkers combined with histopathological examination are of critical importance in the diagnosis and treatment of clear cell renal cell carcinoma (ccRCC). The occurrence and development of ccRCC is closely related …
View article: Qici Sanling Decoction Suppresses Glutamine Consumption and Bladder Cancer Cell Growth through Inhibiting c-Myc Expression
Qici Sanling Decoction Suppresses Glutamine Consumption and Bladder Cancer Cell Growth through Inhibiting c-Myc Expression Open
Traditional Chinese medicine (TCM) is widely used as an alternative therapy for cancer treatment in China. Glutamine catabolism plays an important role in cancer development. Qici Sanling decoction (QCSL) suppresses bladder cancer growth. …
View article: Comprehensive overview of Nrf2-related epigenetic regulations involved in ischemia-reperfusion injury
Comprehensive overview of Nrf2-related epigenetic regulations involved in ischemia-reperfusion injury Open
Ischemic disease is a class of diseases in which an organ is ischemic due to vascular occlusion, a major contributor to death and disability worldwide. However, when the blood flow is restored, more severe damage occurs than ischemia alone…
View article: PDE4B Induces Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Is Transcriptionally Suppressed by CBX7
PDE4B Induces Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Is Transcriptionally Suppressed by CBX7 Open
Urinary bladder cancer (UBC) is a common malignant tumor with high incidence. Advances in the diagnosis and treatment of this disease demand the identification of novel therapeutic targets. Multiple studies demonstrated that PDE4B level wa…
View article: CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma
CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma Open
Recent studies have reported that MLST8 is upregulated in many malignant tumors. Nevertheless, the underlying molecular mechanism is still unclear. The aim of this work was to investigate how MLST8 contributes to the development and progre…
View article: CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10–ERK signaling
CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10–ERK signaling Open