Zhen Li
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View article: Comparative molecular profiling of Helicobacter pylori infection and antibiotic genotypic resistance in paired gastric mucosa, gastric juice, and stool samples
Comparative molecular profiling of Helicobacter pylori infection and antibiotic genotypic resistance in paired gastric mucosa, gastric juice, and stool samples Open
Increasing antibiotic resistance in Helicobacter pylori (H. pylori) is undermining empirical eradication therapies. Non-invasive methods for resistance profiling are urgently needed to guide precision treatment. This study aimed to compare…
View article: Overcoming drug resistance microspheres combined with photothermal ablation reinforce transcatheter arterial chemoembolization of hepatocellular carcinoma
Overcoming drug resistance microspheres combined with photothermal ablation reinforce transcatheter arterial chemoembolization of hepatocellular carcinoma Open
Drug-eluting microspheres (DEMs) are key for transcatheter arterial chemoembolization (TACE) in advanced hepatocellular carcinoma (HCC), but face challenges like tumor multidrug resistance (MDR) and poor post-TACE outcomes. Here we show a …
View article: One-stop early noninvasive evaluation of renal allograft rejection and fibrosis: microstructural mapping via time-dependent diffusion MRI
One-stop early noninvasive evaluation of renal allograft rejection and fibrosis: microstructural mapping via time-dependent diffusion MRI Open
This study has received funding from the National Natural Science Foundation of China. (Nos. 82371942, U24A200313, and 32427802). The funders had no role in study design, data collection, data analysis, interpretation of results, or writin…
View article: Efficacy of left subclavian artery laser in situ fenestration combined with hybrid arch debranching surgery for aortic arch reconstruction in patients with Stanford type A aortic dissection
Efficacy of left subclavian artery laser in situ fenestration combined with hybrid arch debranching surgery for aortic arch reconstruction in patients with Stanford type A aortic dissection Open
Objective To investigate the early and mid-term outcomes of in situ laser fenestration (ISLF) of the left subclavian artery (LSA) combined with hybrid aortic arch debranching for aortic arch reconstruction in Stanford type A aortic dissect…
View article: An automatic severity grading system using confocal laser endomicroscopy to evaluate inflammatory activity of ulcerative colitis: a prospective study
An automatic severity grading system using confocal laser endomicroscopy to evaluate inflammatory activity of ulcerative colitis: a prospective study Open
In the treatment of ulcerative colitis (UC), persistent inflammatory activity increases the risk of recurrence and poor prognosis. Probe-based confocal laser endomicroscopy (pCLE) can accurately assess the UC inflammation than conventional…
View article: YOLO-Citrus: a lightweight and efficient model for citrus leaf disease detection in complex agricultural environments
YOLO-Citrus: a lightweight and efficient model for citrus leaf disease detection in complex agricultural environments Open
Accurate and efficient detection of citrus leaf diseases is crucial for ensuring the quality and yield of global citrus production. However, many existing agricultural disease detection methods face significant challenges, including overla…
View article: The risk of radiation-associated second cancer in patients with cervical cancer following radiotherapy from 1975 to 2019
The risk of radiation-associated second cancer in patients with cervical cancer following radiotherapy from 1975 to 2019 Open
Background Radiation-associated second primary malignancies (SPMs) are a significant risk factor affecting the quality of life in long-term cervical cancer survivors. However, the impact of brachytherapy-boost and advanced radiotherapy tec…
View article: Sleep disturbances in patients with myasthenia gravis: A cross-sectional study
Sleep disturbances in patients with myasthenia gravis: A cross-sectional study Open
Objective: To explore sleep dysfunction in clinically stable patients with myasthenia gravis (MG) and to identify sleep disturbances and uncover their associated risk factors. Methods: A cross-sectional study was conducted, involving the r…
View article: Proteomic Characteristics Of GCF In Periodontitis Treated With Er:Yaglaser
Proteomic Characteristics Of GCF In Periodontitis Treated With Er:Yaglaser Open
Aim or purpose: This study employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology to analyze the proteomic changes in gingival crevicular fluid (GCF) of patients with chronic periodontitis before and after Er:YAG las…
View article: Effects of Deep Shading on Agronomic Traits, Coloration, and Antioxidant Properties in Sweetpotato Leaves
Effects of Deep Shading on Agronomic Traits, Coloration, and Antioxidant Properties in Sweetpotato Leaves Open
The vegetable sweetpotato (Ipomoea batatas L.) is a novel, specialized type, cultivated for its tender stems and leaves, which are rich in nutrients and bioactive compounds. To clarify its growth adaptation to weak light conditions often e…
View article: The experience and discharge readiness of patients undergoing metabolic and bariatric surgery: a qualitative study
The experience and discharge readiness of patients undergoing metabolic and bariatric surgery: a qualitative study Open
Background The discharge readiness for metabolic and bariatric surgery (MBS) patients are designed to facilitate their transition from hospital to home and support early rehabilitation, ultimately improving discharge quality and outcomes. …
View article: High coverage with delayed doses: Cross-sectional study of parental acceptance and uptake of varicella vaccination in children aged 4–12 years in Chaoyang District, Beijing
High coverage with delayed doses: Cross-sectional study of parental acceptance and uptake of varicella vaccination in children aged 4–12 years in Chaoyang District, Beijing Open
Regional disparities exist in China's varicella vaccination policies, with Beijing's voluntary two-dose program requiring self-payment having been implemented for more than a decade. In this study, we investigated parental acceptance and v…
View article: Solid pseudopapillary neoplasm of the pancreas with elevated β-HCG levels: A case report
Solid pseudopapillary neoplasm of the pancreas with elevated β-HCG levels: A case report Open
Rationale: Solid pseudopapillary neoplasm of the pancreas, first classified as a malignant epithelial tumor of the pancreas in 2019, is rare and usually occurs in young women, with a high incidence at approximately 30 years of age. Herein,…
View article: Development and validation of a nomogram-based predictive model for recurrence risk of uterine leiomyoma after myomectomy
Development and validation of a nomogram-based predictive model for recurrence risk of uterine leiomyoma after myomectomy Open
Uterine fibroids are common among women of reproductive age and often recur after treatment. Accurate recurrence prediction is essential for guiding clinical decisions, yet existing models remain inadequate. This study aimed to develop a n…
View article: Familial Carney complex with embolic ischemic stroke: a case report and literature review
Familial Carney complex with embolic ischemic stroke: a case report and literature review Open
Background Carney complex (CNC) is a rare autosomal dominant multiple neoplasia syndrome characterized by cutaneous and mucosal pigmented lesions, cardiac myxomas, and various endocrine and non-endocrine tumors. Methods We report a familia…
View article: High-Resolution C-arm Computed Tomography for Evaluation of Stent Expansion and Apposition after Intracranial Stent Implantation
High-Resolution C-arm Computed Tomography for Evaluation of Stent Expansion and Apposition after Intracranial Stent Implantation Open
Objective : C-arm computed tomography (CT) has always played an important role in neurointerventional surgery, in this study, we aimed to investigate the value of high-resolution C-arm CT in evaluating stent expansion and apposition in car…
View article: Exploring the Correlation Between the Serum Homocysteine to Apolipoprotein A1 Ratio and the Severity of Coronary Artery Disease Based on Multicenter Data: A Novel Risk Assessment Parameter
Exploring the Correlation Between the Serum Homocysteine to Apolipoprotein A1 Ratio and the Severity of Coronary Artery Disease Based on Multicenter Data: A Novel Risk Assessment Parameter Open
There is a discernible correlation between HAR and coronary artery disease (CAD), demonstrating predictive value for both CAD and severe CAD, thereby serving as a useful tool in the diagnosis and assessment of coronary heart disease.
View article: Transarterial chemoembolization combined with apatinib in the treatment of advanced hepatocellular carcinoma: a prospective, multi-center, real-world study (Ahend-HAP02)
Transarterial chemoembolization combined with apatinib in the treatment of advanced hepatocellular carcinoma: a prospective, multi-center, real-world study (Ahend-HAP02) Open
Purpose To analyze the efficacy and safety of transarterial chemoembolization (TACE) with apatinib (TACE-A) for the treatment of advanced hepatocellular carcinoma (HCC). Methods Data from advanced HCC patients treated with TACE-A between J…
View article: CCDC 2428701: Experimental Crystal Structure Determination
CCDC 2428701: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Quantitative assessment of liver graft function using functional automated whole-liver score derived from gadoxetic acid-enhanced MRI: a prospective cohort study
Quantitative assessment of liver graft function using functional automated whole-liver score derived from gadoxetic acid-enhanced MRI: a prospective cohort study Open
Objectives: Accurate and timely assessment of liver graft function is of great significance for the survival of liver grafts and liver transplant recipients. This study aimed to investigate the correlation between the functional automated …
View article: Breaking the premetastatic niche barrier: the role of endothelial cells and therapeutic strategies
Breaking the premetastatic niche barrier: the role of endothelial cells and therapeutic strategies Open
The premetastatic niche (PMN) represents a metastasis-facilitative microenvironment established prior to tumor dissemination, initiated by vascular leakage and endothelial cell (EC) functional remodeling. ECs play pivotal roles as bridges …
View article: Global burden and health inequality of atrial fibrillation/atrial flutter from 1990 to 2021
Global burden and health inequality of atrial fibrillation/atrial flutter from 1990 to 2021 Open
Introduction Atrial fibrillation (AF) and atrial flutter (AFL) are the most prevalent tachyarrhythmias worldwide, leading to severe complications such as stroke and heart failure. Despite advancements in diagnosis and management, the globa…
View article: Impaired Respiratory Function as an Auxiliary Marker for Disease Progression in Different Motor Subtypes of Parkinson's Disease
Impaired Respiratory Function as an Auxiliary Marker for Disease Progression in Different Motor Subtypes of Parkinson's Disease Open
Background The mechanisms underlying respiratory function impairments in different motor subtypes of Parkinson's disease (PD) remain poorly understood. Objectives This study aims to elucidate the differences in respiratory function between…