Mingcai Li
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View article: Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU
Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU Open
Finding novel compounds and drug targets is crucial for antibiotic development. The nucleoid‐associated protein HU plays a significant role in bacterial DNA metabolism, supercoiling, and biofilm formation, making it a promising new target.…
View article: Association between the geriatric nutritional risk index and all-cause mortality in older critically ill patients with community-acquired pneumonia
Association between the geriatric nutritional risk index and all-cause mortality in older critically ill patients with community-acquired pneumonia Open
Our study indicates that the GNRI has a significant association with all-cause mortality in critically ill older patients with CAP. However, further confirmation of these findings requires larger prospective studies.
View article: Efficient MPC-Based Energy Management System for Secure and Cost-Effective Microgrid Operations
Efficient MPC-Based Energy Management System for Secure and Cost-Effective Microgrid Operations Open
Model predictive control (MPC)-based energy management systems (EMS) are essential for ensuring optimal, secure, and stable operation in microgrids with high penetrations of distributed energy resources. However, due to the high computatio…
View article: Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis
Elevated serum interleukin-41 levels as a potential biomarker in ankylosing spondylitis Open
This study indicates that serum IL-41 levels are elevated in both active and inactive AS patients, suggesting that IL-41 may be a novel biomarker for AS.
View article: Association between advanced lung cancer inflammation index and all-cause mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database
Association between advanced lung cancer inflammation index and all-cause mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database Open
This study aimed to explore the association between the advanced lung cancer inflammation (ALI) index and the risk of mortality in critically ill patients with sepsis. This retrospective study included 6489 critically ill patients with sep…
View article: Characterization of the C2H2 Zinc Finger Protein Family in Setosphaeria turcica
Characterization of the C2H2 Zinc Finger Protein Family in Setosphaeria turcica Open
C2H2 zinc finger (C2H2-ZF) transcription factors, characterized by the presence of a conserved ZnF-C2H2 domain, are widespread among plant-pathogenic fungi such as Magnaporthe oryzae, Fusarium graminearum, and Sclerotinia sclerotiorum and …
View article: A human behavior-based model for respiratory infectious diseases prediction
A human behavior-based model for respiratory infectious diseases prediction Open
Objectives The research aims to develop a human behavior-based model to predict respiratory infectious diseases. Methods This research employs semi-supervised machine learning techniques in conjunction with an RGB-depth camera to collect m…
View article: Trans-Kingdom RNA Dialogues: miRNA and milRNA Networks as Biotechnological Tools for Sustainable Crop Defense and Pathogen Control
Trans-Kingdom RNA Dialogues: miRNA and milRNA Networks as Biotechnological Tools for Sustainable Crop Defense and Pathogen Control Open
MicroRNAs (miRNAs) are a class of non-coding RNAs approximately 20–24 nucleotides in length, which play a crucial role during gene regulation in plant–pathogen interaction. They negatively regulate the expression of target genes, primarily…
View article: Interleukin −39 Expression in Pleural Effusion and Its Diagnostic Value for Tuberculous Pleurisy
Interleukin −39 Expression in Pleural Effusion and Its Diagnostic Value for Tuberculous Pleurisy Open
IL-39 demonstrated good diagnostic and differential diagnostic value for TPE. Furthermore, the multivariate diagnostic model, as well as the joint detection of IL-39 with other tuberculosis biomarkers, can further increased the sensitivity…
View article: Construction of the Competency Index System for Nursing Staff in Tertiary General Hospitals to Respond to Emerging Infectious Diseases
Construction of the Competency Index System for Nursing Staff in Tertiary General Hospitals to Respond to Emerging Infectious Diseases Open
Background: The outbreak of emerging infectious diseases represents a crisis event that poses a threat to human beings. Nursing staff in the tertiary hospital, especially clinical nurses and nursing managers, serve as the frontline personn…
View article: Predicting Treatment Response of Repetitive Transcranial Magnetic Stimulation in Major Depressive Disorder Using an Explainable Machine Learning Model Based on Electroencephalography and Clinical Features
Predicting Treatment Response of Repetitive Transcranial Magnetic Stimulation in Major Depressive Disorder Using an Explainable Machine Learning Model Based on Electroencephalography and Clinical Features Open
Major depressive disorder (MDD) is highly heterogeneous in response to repetitive transcranial magnetic stimulation (rTMS), and identifying predictive biomarkers is essential for personalized treatment. However, most prior research studies…
View article: Association between Advanced lung cancer inflammation index and all- cause mortality in critically ill patients with sepsis: analysis of the MIMIC- IV database
Association between Advanced lung cancer inflammation index and all- cause mortality in critically ill patients with sepsis: analysis of the MIMIC- IV database Open
Background This study aimed to explore the association between the advanced lung cancer inflammation (ALI) index and the risk of mortality in critically ill patients with sepsis. Methods This retrospective study included 6489 critically il…
View article: The decreased serum levels of interleukin-38 in patients with gout and its clinical significance
The decreased serum levels of interleukin-38 in patients with gout and its clinical significance Open
Background Interleukin (IL)-38 is a newly discovered anti-inflammatory cytokine. However, its concentration and clinical significance in patients with gout remain unclear. This study aimed to investigate the levels of IL-38 in patients wit…
View article: Establishment and Verification of a Risk Prediction Model for Chronic Rhinosinusitis
Establishment and Verification of a Risk Prediction Model for Chronic Rhinosinusitis Open
Objective: Factors influencing chronic rhinosinusitis (CRS) are usually studied in terms of genetics and environment; however, clinical indicators have not been reported. This case-control study was conducted in Ningbo, China, to explore n…
View article: Investigating cortical complexity and connectivity in rats with schizophrenia
Investigating cortical complexity and connectivity in rats with schizophrenia Open
Background The above studies indicate that the SCZ animal model has abnormal gamma oscillations and abnormal functional coupling ability of brain regions at the cortical level. However, few researchers have focused on the correlation betwe…
View article: Analysis of the integrated role of the Yangtze River Delta based on the industrial economic resilience of cities during COVID-19
Analysis of the integrated role of the Yangtze River Delta based on the industrial economic resilience of cities during COVID-19 Open
The enhancement of regional comprehensive development ability is significantly impacted by the study on the implementation effect of regional integration strategies. The integration strategy's impact on urban development during COVID-19 in…
View article: Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease
Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease Open
Interleukin (IL)-41 is a novel immunomodulatory cytokine involved in the pathogenesis of several inflammatory and metabolic illnesses. However, it remains unclear how IL-41 contributes to the pathogenesis of chronic obstructive pulmonary d…
View article: [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics].
[PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics]. Open
PDCD4 knockdown protects vascular endothelial cells against LPS-induced damages by repressing mitochondrial fission and oxidative stress, promoting mitochondrial fusion, and maintaining normal mitochondrial function.
View article: A Heart Rate Matched Patch for Mechano-Chemical Treatment of Myocardial Infarction: Optimal Design and Transspecies Application
A Heart Rate Matched Patch for Mechano-Chemical Treatment of Myocardial Infarction: Optimal Design and Transspecies Application Open
After myocardial infarction (MI), ventricular dilation and the microscopic passive stretching of the infarcted border zone is the meaning contributor to the continuous expansion of myocardial fibrosis. Epicardial hydrogel patches have been…
View article: Serum IL-38 levels in patients with type 2 diabetes mellitus
Serum IL-38 levels in patients with type 2 diabetes mellitus Open
The results suggest that IL-38 may be a new biomarker of T2DM.
View article: Development and internal validation of a risk model for hyperuricemia in diabetic kidney disease patients
Development and internal validation of a risk model for hyperuricemia in diabetic kidney disease patients Open
Purpose This research aimed to identify independent risk factors for hyperuricemia (HUA) in diabetic kidney disease (DKD) patients and develop an HUA risk model based on a retrospective study in Ningbo, China. Patients and methods Six hund…
View article: Decreased serum interleukin‐41/Metrnl levels in patients with Graves' disease
Decreased serum interleukin‐41/Metrnl levels in patients with Graves' disease Open
Background Interleukin (IL)‐41, also known as Metrnl, is a novel immunomodulatory cytokine, which is involved in the pathogenesis of many inflammatory and metabolic diseases, but its role in thyroid autoimmune diseases is not clear. The ai…
View article: Protective Effects of Interleukin-37 Expression against Acetaminophen-Induced Hepatotoxicity in Mice
Protective Effects of Interleukin-37 Expression against Acetaminophen-Induced Hepatotoxicity in Mice Open
Aim. Interleukin (IL)-37 is a new anti-inflammatory cytokine of the IL-1 family. This study aimed to determine the effects of IL-37 on acetaminophen (APAP)-induced liver injury. Materials and Methods. IL-37 plasmids were injected into mice…
View article: Low levels of serum IL‐39 are associated with autoimmune thyroid disease
Low levels of serum IL‐39 are associated with autoimmune thyroid disease Open
Background Interleukin (IL)‐39 is a novel member of IL‐12 cytokine family, but its role in autoimmune thyroid diseases (AITD) is unclear. The aim of the present study was to determine serum levels of IL‐39 in Hashimoto's thyroiditis (HT) a…
View article: Low serum interleukin‐38 levels in patients with Graves’ disease and Hashimoto’s thyroiditis
Low serum interleukin‐38 levels in patients with Graves’ disease and Hashimoto’s thyroiditis Open
Background Autoimmune thyroid disease (AITD) mainly includes Graves’ disease (GD) and Hashimoto's thyroiditis (HT), which is caused by individual genetics, autoimmune dysfunction, and a variety of external environmental factors. Interleuki…
View article: Serum IL‐36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation
Serum IL‐36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation Open
Background The interleukin (IL)‐36 cytokines include IL‐36α, IL‐36β, IL‐36γ, and IL‐36Ra. Little was known about their roles in type 2 diabetes mellitus (T2DM). Methods The study included 40 T2DM patients and 42 healthy control subjects. T…