Mingcheng Xu
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View article: Intermittent fasting ameliorates resistant hypertension through modulation of gut microbiota
Intermittent fasting ameliorates resistant hypertension through modulation of gut microbiota Open
Resistant hypertension (RH) remains a major cardiovascular challenge despite optimal pharmacological treatment. Intermittent fasting (IF) has demonstrated beneficial effects in various diseases, but its impact on RH and the underlying mech…
View article: PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation
PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation Open
Increasing evidence has clarified that atrial fibrillation (AF) is associated with enhanced glycolysis, leading to lactate accumulation. However, whether glycolysis promotes AF remains unknown, as does whether histone lactylation plays a r…
View article: Selected new approaches and future perspectives in liquid chromatography for the analysis of emerging modalities
Selected new approaches and future perspectives in liquid chromatography for the analysis of emerging modalities Open
Emerging biopharmaceutical modalities, such as genetic medicines and RNA therapies, offer transformative potential for treating previously intractable diseases. However, these complex drugs present unique analytical challenges due to their…
View article: Association between the ratio of serum uric acid to high density lipoprotein cholesterol and depressive symptoms in middle-aged and elderly Chinese
Association between the ratio of serum uric acid to high density lipoprotein cholesterol and depressive symptoms in middle-aged and elderly Chinese Open
Background Previous studies have reported that metabolic syndrome is associated with depression. In recent years, the ratio of uric acid to high-density lipoprotein cholesterol (UHR) has been considered as a new effective marker of metabol…
View article: Cerebral Ischemia Increases the Distribution and Residence Time of 6-Hydroxykynurenic Acid in the Ischemic Cerebral Cortex of Mice
Cerebral Ischemia Increases the Distribution and Residence Time of 6-Hydroxykynurenic Acid in the Ischemic Cerebral Cortex of Mice Open
Background 6-hydroxykynurenic acid (6-HKA), isolated from Ginkgo biloba leaves, has demonstrated neurorestorative properties against cerebral ischemia in middle cerebral artery occlusion (MCAO) mice models. However, our previous studies sh…
View article: Lipopolyplex-formulated mRNA cancer vaccine elicits strong neoantigen-specific T cell responses and antitumor activity
Lipopolyplex-formulated mRNA cancer vaccine elicits strong neoantigen-specific T cell responses and antitumor activity Open
mRNA neoantigen cancer vaccine inducing neoantigen-specific T cell responses holds great promise for cancer immunotherapy; however, its clinical translation remains challenging because of suboptimal neoantigen prediction accuracy and low d…
View article: Bridged Ethylene Polyethylene Oxide Surfaces to Improve Packing Materials for Widepore Size Exclusion Chromatography
Bridged Ethylene Polyethylene Oxide Surfaces to Improve Packing Materials for Widepore Size Exclusion Chromatography Open
Here, we describe the preparation of bridged ethylene polyethylene oxide (BE‐PEO) surface‐modified silica packing materials for size exclusion chromatography. BE‐PEO surface‐modified silica was hydrolyzed and subsequent 1 H nuclear magneti…
View article: Site-specific detection of circulating tumor DNA methylation in biological samples utilizing phosphorothioated primer-based loop-mediated isothermal amplification
Site-specific detection of circulating tumor DNA methylation in biological samples utilizing phosphorothioated primer-based loop-mediated isothermal amplification Open
DNA methylation, a kind of epigenetic alteration, plays a vital role in tumorigenesis and offers a new class of targets for cancer treatment. DNA hypermethylation at the E-Box site (CACGTG, -288 bp) in the SLC22A2 promoter was related to m…
View article: Study on the Influence of Window Type on Natural Ventilation Effect Based on CFD Simulation
Study on the Influence of Window Type on Natural Ventilation Effect Based on CFD Simulation Open
Good natural ventilation is one of the basic conditions for people to be able to work and live indoors. In this paper, wind velocity, wind velocity non-uniformity coefficient and air age are taken as the evaluation indexes of indoor ventil…
View article: Clinical characteristics and management of hemodialysis patients with pre-dialysis hypertension: a multicenter observational study
Clinical characteristics and management of hemodialysis patients with pre-dialysis hypertension: a multicenter observational study Open
Pre-dialysis SBP ≥ 160 mmHg is common in clinical practice and most of the patients could diagnosed to be hypertensive according to their home SBP. Patients with pre-dialysis SBP ≥ 160 mmHg are more likely to be subjected to dialysis insuf…
View article: The Metabolic Stability of Antimicrobial Peptides IK8 in Plasma and Liver S9
The Metabolic Stability of Antimicrobial Peptides IK8 in Plasma and Liver S9 Open
In the face of mounting global antibiotic resistance, which has become a critical clinical problem, antimicrobial peptides (AMPs) have received considerable interest as new therapeutics with the efficacy for the treatment of multidrug-resi…
View article: Rolling Circle and Loop Mediated Isothermal Amplification Strategy for Ultrasensitive miRNA Detection
Rolling Circle and Loop Mediated Isothermal Amplification Strategy for Ultrasensitive miRNA Detection Open
Rolling circle amplification (RCA) and loop mediated isothermal amplification (LAMP) were combined to establish the rolling circle and loop mediated isothermal amplification (RC-LAMP) method for miRNA detection. With the participation of B…
View article: Pharmacokinetics and brain distribution studies of 6-hydroxykynurenic acid and its structural modified compounds
Pharmacokinetics and brain distribution studies of 6-hydroxykynurenic acid and its structural modified compounds Open
Objectives 6-Hydroxykynurenic acid (6-HKA) is an organic acid component in extracts of Ginkgo biloba leaves and acts as a major contributor to neurorestorative effects, while its oral bioavailability was low. Therefore, using prodrug metho…
View article: Research advances in the detection of miRNA
Research advances in the detection of miRNA Open
MicroRNAs (miRNAs) are a family of endogenous, small (approximately 22 nucleotides in length), noncoding, functional RNAs. With the development of molecular biology, the research of miRNA biological function has attracted significant inter…
View article: Reverse of Acute and Chronic Morphine Tolerance by Lithocholic Acid via Down-Regulating UGT2B7
Reverse of Acute and Chronic Morphine Tolerance by Lithocholic Acid via Down-Regulating UGT2B7 Open
Lithocholic acid (LCA) deposited in human livers always induces drastic pains which need analgesic drug, like morphine to release. Our research showed that LCA can effectively inhibit uridine 5'-diphospho-glucuronosyltransferase 2B7 (UGT2B…
View article: Simultaneous analysis of gemfibrozil, morphine, and its two active metabolites in different mouse brain structures using solid‐phase extraction with ultra‐high performance liquid chromatography and tandem mass spectrometry with a deuterated internal standard
Simultaneous analysis of gemfibrozil, morphine, and its two active metabolites in different mouse brain structures using solid‐phase extraction with ultra‐high performance liquid chromatography and tandem mass spectrometry with a deuterated internal standard Open
A rapid and sensitive bioassay was established and validated to simultaneously determine gemfibrozil, morphine, morphine‐3β‐glucuronide, and morphine‐6β‐glucuronide in mouse cerebrum, epencephalon, and hippocampus based on ultra‐high perfo…