Mingcong Fan
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View article: Protective Mechanism of Broad Bean Extract on Parkinson’s Disease Model Cells
Protective Mechanism of Broad Bean Extract on Parkinson’s Disease Model Cells Open
Broad beans, natural sources of L-DOPA and bioactive phenolics show promise for Parkinson’s disease intervention. This study investigated broad bean extracts’ protective mechanisms against PD pathogenesis. Among screened varieties, QC25 ex…
View article: Effects and Mechanisms of Long-Term Lycium barbarum Water Consumption on Skeletal Muscle Function in Aged Mice
Effects and Mechanisms of Long-Term Lycium barbarum Water Consumption on Skeletal Muscle Function in Aged Mice Open
With the global aging population, skeletal muscle aging has threatened to elderly health, making dietary interventions for age-related muscle decline a research priority. Lycium barbarum, a traditional food and medicinal herb, was used in …
View article: Water-extractable arabinoxylan improves the properties of gluten during freeze-thaw cycles in steamed bread
Water-extractable arabinoxylan improves the properties of gluten during freeze-thaw cycles in steamed bread Open
View article: Gallic Acid Ameliorates Skeletal Muscle Metabolic Inflexibility by Regulating Lactate Metabolism and Promoting Mitochondrial Function
Gallic Acid Ameliorates Skeletal Muscle Metabolic Inflexibility by Regulating Lactate Metabolism and Promoting Mitochondrial Function Open
Obesity‐induced mitochondrial dysfunction impairs skeletal muscle metabolic flexibility. Gallic acid possesses the ability to modulate metabolic homeostasis. This study aimed to investigate the impact of gallic acid on high‐fat diet (HFD)‐…
View article: Effect of germination time on <i>in vitro</i> extractability, and bioavailability of γ-aminobutyric acid, total phenolic compounds, and antioxidant activity of highland barley bread
Effect of germination time on <i>in vitro</i> extractability, and bioavailability of γ-aminobutyric acid, total phenolic compounds, and antioxidant activity of highland barley bread Open
This study assessed the impact of the duration of highland barley germination on the in vitro extractability, and bioavailability of γ-aminobutyric acid (GABA), total phenolic compounds (TPC), and antioxidants in highland barley bread. The…
View article: Boiling Outperforms Other Thermal Treatments in Enhancing Bioaccessibility and Absorption of Ferulic Acid in Triticale Bran for Aging Populations
Boiling Outperforms Other Thermal Treatments in Enhancing Bioaccessibility and Absorption of Ferulic Acid in Triticale Bran for Aging Populations Open
View article: Exploring the transformative effects of solid-state fermentation on the structure, texture, and metabolism of oat-based dough
Exploring the transformative effects of solid-state fermentation on the structure, texture, and metabolism of oat-based dough Open
This study examines the impact of mixed strains solid-state fermentation on the properties of oat flour dough. Specifically, it focuses on the changes in rheological, thermomechanical, structural, and metabolic characteristics. By utilisin…
View article: Sirtuin 3 reinforces acylcarnitine metabolism and maintains thermogenesis in brown adipose tissue of aging mice
Sirtuin 3 reinforces acylcarnitine metabolism and maintains thermogenesis in brown adipose tissue of aging mice Open
Acylcarnitine (ACar) is a novel fuel source for activating thermogenesis in brown adipose tissue (BAT). However, whether ACar metabolism underlies BAT thermogenesis decline with aging remain unclear. Here, the L‐carnitine‐treated young and…
View article: Quinoa Polyphenol Extract Alleviates Non-Alcoholic Fatty Liver Disease via Inhibiting Lipid Accumulation, Inflammation and Oxidative Stress
Quinoa Polyphenol Extract Alleviates Non-Alcoholic Fatty Liver Disease via Inhibiting Lipid Accumulation, Inflammation and Oxidative Stress Open
Recently, the incidence of NAFLD has exploded globally, but there are currently no officially approved medications for treating the condition. The regulation of NAFLD through plant-derived active substances has become a new area of interes…
View article: Maternal Dietary Carbohydrate and Pregnancy Outcomes: Quality over Quantity
Maternal Dietary Carbohydrate and Pregnancy Outcomes: Quality over Quantity Open
Dietary nutrition plays a crucial role in determining pregnancy outcomes, with poor diet being a major contributor to pregnancy metabolic syndrome and metabolic disorders in offspring. While carbohydrates are essential for fetal developmen…
View article: Long-term consumption of highland barley tea promotes healthy aging of skeletal muscle
Long-term consumption of highland barley tea promotes healthy aging of skeletal muscle Open
Highland barley tea (HBT) is made from roasted barley seeds and is abundant in β-glucan, amino acids, minerals, phenolics, and other natural active ingredients. These natural compounds found in whole grains have been shown to slow aging an…
View article: Unraveling the transepithelial absorption of novel dark blue pigment from <i>Vaccinium bracteatum</i> Thunb. leaves on the Caco-2 intestinal cell
Unraveling the transepithelial absorption of novel dark blue pigment from <i>Vaccinium bracteatum</i> Thunb. leaves on the Caco-2 intestinal cell Open
The dark blue pigment (DBP) is a health ingredient from Vaccinium bracteatum Thunb. leaves used as a functional food supplement. However, the details of transepithelial absorption on the intestinal epithelial cells are barely understood. T…
View article: 5-Heptadecylresorcinol Improves Aging-Associated Hepatic Fatty Acid Oxidation Dysfunction via Regulating Adipose Sirtuin 3
5-Heptadecylresorcinol Improves Aging-Associated Hepatic Fatty Acid Oxidation Dysfunction via Regulating Adipose Sirtuin 3 Open
Aging-associated hepatic fatty acid (FA) oxidation dysfunction contributes to impaired adaptive thermogenesis. 5-Heptadecylresorcinol (AR-C17) is a prominent functional component of whole wheat and rye, and has been demonstrated to improve…
View article: Effects of whole wheat flour on frozen dough and steamed bread during freeze-thaw cycles
Effects of whole wheat flour on frozen dough and steamed bread during freeze-thaw cycles Open
The research on Chinese steamed bread (CSB) with whole wheat flour (WWF) is limited and has not been discussed during freeze-thaw. This study investigated the effects of WWF addition on the dough and CSB quality during freeze-thaw cycles. …
View article: The Enhancement of Acylcarnitine Metabolism by 5-Heptadecylresorcinol in Brown Adipose Tissue Contributes to Improving Glucose and Lipid Levels in Aging Male Mice
The Enhancement of Acylcarnitine Metabolism by 5-Heptadecylresorcinol in Brown Adipose Tissue Contributes to Improving Glucose and Lipid Levels in Aging Male Mice Open
5-Heptadecylresorcinol (AR-C17), a primary biomarker of whole grain (WG) consumption, has been demonstrated to improve the thermogenic activity of aging mice. However, the intricate regulatory mechanism is not fully understood. This study …
View article: Effect of Lactylated Gluten and Freeze-Thaw Cycles on Frozen Dough: From Water State and Microstructure
Effect of Lactylated Gluten and Freeze-Thaw Cycles on Frozen Dough: From Water State and Microstructure Open
The influence of lactylated gluten and Freeze-Thaw Cycles on the water state, microstructure, and quality of frozen steamed bread dough was investigated. After three freeze-thaw cycles (3F/T), the specific volume of steamed bread with sodi…
View article: Entanglement between Water Un-Extractable Arabinoxylan and Gliadin or Glutenins Induced a More Fragile and Soft Gluten Network Structure
Entanglement between Water Un-Extractable Arabinoxylan and Gliadin or Glutenins Induced a More Fragile and Soft Gluten Network Structure Open
This study aimed to investigate the effects of water-unextractable arabinoxylan (WUAX) on the gluten network structure, especially on gliadins and glutenins. The results indicated that the free sulfhydryl (free SH) of gliadins increased by…
View article: Low-Carbohydrate Diet Modulates Glucose–Lipid Utilization in Skeletal Muscle of Diabetic Mice
Low-Carbohydrate Diet Modulates Glucose–Lipid Utilization in Skeletal Muscle of Diabetic Mice Open
Type 2 diabetes is associated with many complications, including skeletal muscle atrophy. Ketogenic diets and low-carbohydrate diets (LCD) have recently been introduced as dietary interventions in patients with diabetes, but their effects …
View article: Unraveling the Deterioration Mechanism of Dough During Whole Wheat Flour Processing: A Case Study of Gluten Protein Containing Arabinoxylan with Different Molecular Weights
Unraveling the Deterioration Mechanism of Dough During Whole Wheat Flour Processing: A Case Study of Gluten Protein Containing Arabinoxylan with Different Molecular Weights Open
View article: MRTCM: A comprehensive dataset for probabilistic risk assessment of metals and metalloids in traditional Chinese medicine
MRTCM: A comprehensive dataset for probabilistic risk assessment of metals and metalloids in traditional Chinese medicine Open
Traditional Chinese medicine (TCM) is still considered a global complementary or alternative medical system, but exogenous hazardous contaminants remain in TCM even after decocting. Besides, it is time-consuming to conduct a risk assessmen…
View article: Effect of lactylation on functional and structural properties of gluten
Effect of lactylation on functional and structural properties of gluten Open
Gluten is widely used as a high-quality protein material in the food industry, however, low solubility restricts its development and applications. In this study, gluten was treated with lactate and sodium lactate for lactylation. Lactylati…
View article: Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring
Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring Open
View article: l-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice
l-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice Open
View article: Influence of germination on bread-making behaviors, functional and shelf-life properties, and overall quality of highland barley bread
Influence of germination on bread-making behaviors, functional and shelf-life properties, and overall quality of highland barley bread Open
In this study, the impact of highland barley germination on bread-making performance, shelf-life, and nutritional value was evaluated. Highland barley was germinated for 24, 48, and 72 h. Results showed that germination produced a function…
View article: Development of Steamed Bread Fortified with Gardenia Fruit Pomace: An Evaluation of its Bioactive Compounds and Quality Characteristics
Development of Steamed Bread Fortified with Gardenia Fruit Pomace: An Evaluation of its Bioactive Compounds and Quality Characteristics Open
View article: Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4
Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4 Open
Rationale: The molecular mechanisms underlying the pathogenesis of systemic insulin resistance in type 2 diabetes remain elusive. Growth hormone receptor (GHR) deficiency has long been known to improved insulin sensitivity. However,…
View article: Geniposide Improves Cholesterol Homeostasis by Regulating FXR-Mediated Liver-Gut Crosstalk of Bile Acids
Geniposide Improves Cholesterol Homeostasis by Regulating FXR-Mediated Liver-Gut Crosstalk of Bile Acids Open
View article: Discussion and Analysis of <em>Flammulina velutipes Polysaccharides</em> Compositions, Molecular Weight and Monosaccharide Composition
Discussion and Analysis of <em>Flammulina velutipes Polysaccharides</em> Compositions, Molecular Weight and Monosaccharide Composition Open
The aim of the present work was to explore the composition, molecular weight and monosaccharide composition of ,Flammulina velutipes polysaccharides by DEAE Cellulose-52, High Performance Gel Filtration Chromatography (HPGFC) and …
View article: Effects of Micro-vacuum Storage on Post-harvest Physiological and Physicochemical Characteristics of Laiyang Pear (<em>Pyrus bretschneideri</em> Reld)
Effects of Micro-vacuum Storage on Post-harvest Physiological and Physicochemical Characteristics of Laiyang Pear (<em>Pyrus bretschneideri</em> Reld) Open
The aim of this study was to compare the physiological and physicochemical characteristics of Laiyang pears after 40 days of storage at 3±1°C under both MV and CA storage systems. During the storage period, physiological and physicochemica…