Ming‐De Lu
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View article: Complete biotransformation of cellulose to starch <i>in vitro</i>
Complete biotransformation of cellulose to starch <i>in vitro</i> Open
A multi-enzyme molecular machine enables the complete conversion of cellulose into starch, potentially unlocking agricultural residues and grass as a new feed and food source for non-ruminant animals and humans.
View article: Nab-paclitaxel plus bevacizumab for patients with metastatic extrapulmonary neuroendocrine carcinoma: a phase 2 single-arm study
Nab-paclitaxel plus bevacizumab for patients with metastatic extrapulmonary neuroendocrine carcinoma: a phase 2 single-arm study Open
This study was partially supported by Qilu Pharmaceutical Co., Ltd. This work is supported by the Beijing Municipal Science & Technology Commission (No. Z231100007223002).
View article: Targeting FADS1-mediated lipid metabolism and signaling: a novel therapeutic strategy for precision oncology in colorectal and esophageal cancers
Targeting FADS1-mediated lipid metabolism and signaling: a novel therapeutic strategy for precision oncology in colorectal and esophageal cancers Open
Gastrointestinal (GI) cancers exhibit aberrant lipid metabolism, yet the causal mechanisms remain elusive. Here, we integrated Mendelian randomization (MR) and multi-omics data to dissect metabolic drivers of 20 GI diseases. Focusing on co…
View article: Prediction of acute pancreatitis severity using a nomogram based on clinical features and body composition
Prediction of acute pancreatitis severity using a nomogram based on clinical features and body composition Open
This study aimed to construct a new model based on quantitative computed tomography (QCT) body composition and clinical features for early prediction of acute pancreatitis (AP) severity. The clinical features and body composition of patien…
View article: A bispecific antibody–drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial
A bispecific antibody–drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial Open
Research on patients with advanced esophageal squamous cell carcinoma (ESCC) who have progressed on immunotherapy remains limited. BL-B01D1 is a first-in-class antibody-drug conjugate consisting of an EGFR-HER3 bispecific antibody bound to…
View article: Towards Loss-Resilient Image Coding for Unstable Satellite Networks
Towards Loss-Resilient Image Coding for Unstable Satellite Networks Open
Geostationary Earth Orbit (GEO) satellite communication demonstrates significant advantages in emergency short burst data services. However, unstable satellite networks, particularly those with frequent packet loss, present a severe challe…
View article: PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial
PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial Open
Alpha-fetoprotein-producing gastric or gastro-esophageal junction (AFP-G/GEJ) cancer, a rare gastric cancer subtype, exhibits increased angiogenesis and more immunosuppression than non-AFP-G/GEJ cancer. The potential benefits of anti-angio…
View article: Radiogenomics of intrahepatic cholangiocarcinoma predicts immunochemotherapy response and identifies therapeutic target
Radiogenomics of intrahepatic cholangiocarcinoma predicts immunochemotherapy response and identifies therapeutic target Open
Background/Aims: Identifying patients with intrahepatic cholangiocarcinoma (ICC) likely to benefit from immunochemotherapy, the new front-line treatment, remains challenging. We aimed to unveil a novel radiotranscriptomic signature that ca…
View article: Towards Loss-Resilient Image Coding for Unstable Satellite Networks
Towards Loss-Resilient Image Coding for Unstable Satellite Networks Open
Geostationary Earth Orbit (GEO) satellite communication demonstrates significant advantages in emergency short burst data services. However, unstable satellite networks, particularly those with frequent packet loss, present a severe challe…
View article: High-Efficiency Neural Video Compression via Hierarchical Predictive Learning
High-Efficiency Neural Video Compression via Hierarchical Predictive Learning Open
The enhanced Deep Hierarchical Video Compression-DHVC 2.0-has been introduced. This single-model neural video codec operates across a broad range of bitrates, delivering not only superior compression performance to representative methods b…
View article: Thromboelastography in Long-Term Antiplatelet Therapy for Patients Diagnosed with Benign Prostate Hyperplasia Undergoing Holmium Laser Enucleation of the Prostate: A Retrospective Study
Thromboelastography in Long-Term Antiplatelet Therapy for Patients Diagnosed with Benign Prostate Hyperplasia Undergoing Holmium Laser Enucleation of the Prostate: A Retrospective Study Open
Compared to HP-HoLEP, LP-HoLEP effectively reduces surgical and subsequent processing times, decreases hospital stay duration, and diminishes hemoglobin decline, offering a viable option without discontinuing AP therapy.
View article: Complementary Role of CEUS and CT/MR LI-RADS for Diagnosis of Recurrent HCC
Complementary Role of CEUS and CT/MR LI-RADS for Diagnosis of Recurrent HCC Open
Purpose: We retrospectively compared the diagnostic performance of contrast-enhanced ultrasonography (CEUS) and contrast-enhanced computer tomography–magnetic resonance imaging (CT/MRI) for recurrent hepatocellular carcinoma (HCC) after cu…
View article: Development and Assessment of Nomogram Based on AFP Response for Patients with Unresectable Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors
Development and Assessment of Nomogram Based on AFP Response for Patients with Unresectable Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors Open
Background: Immune checkpoint inhibitors (ICIs) have been increasingly used to treat hepatocellular carcinoma (HCC). Prognostic biomarkers are an unmet need. We aimed to develop a prognostic nomogram for patients with unresectable HCC rece…
View article: Integration of Artificial Intelligence Decision Aids to Reduce Workload and Enhance Efficiency in Thyroid Nodule Management
Integration of Artificial Intelligence Decision Aids to Reduce Workload and Enhance Efficiency in Thyroid Nodule Management Open
Importance To optimize the integration of artificial intelligence (AI) decision aids and reduce workload in thyroid nodule management, it is critical to incorporate personalized AI into the decision-making processes of radiologists with va…
View article: SeisDeNet: an intelligent seismic data Denoising network for the internet of things
SeisDeNet: an intelligent seismic data Denoising network for the internet of things Open
Deep learning (DL) has attracted tremendous interest in various fields in last few years. Convolutional neural networks (CNNs) based DL architectures have been successfully applied in computer vision, medical image processing, remote sensi…
View article: Bleeding after Ultrasound-Guided Percutaneous Transhepatic Biliary Drainage in Patients with Coagulopathy: A Single Center Experience
Bleeding after Ultrasound-Guided Percutaneous Transhepatic Biliary Drainage in Patients with Coagulopathy: A Single Center Experience Open
Background To compare the rate of bleeding for ultrasound-guided Percutaneous Transhepatic Biliary Drainage (PTBD) in patients with coagulopathy to that in patients with normal coagulation. Methods This retrospective study included a total…
View article: Supplementary Material for: Somatostatin Receptor Imaging in Mice with Difference Positive Rate of SSTR2
Supplementary Material for: Somatostatin Receptor Imaging in Mice with Difference Positive Rate of SSTR2 Open
Introduction: Imaging with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11 and [18F]AlF-NOTA-JR11 was performed to analyze differences among the three probes, and to analyze the correlation between the image and pathology parameters. Method: Tumor …
View article: Circulating tumour cell counts and ultrasomics signature-based nomogram for preoperative prediction of early recurrence of hepatocellular carcinoma after radical treatment
Circulating tumour cell counts and ultrasomics signature-based nomogram for preoperative prediction of early recurrence of hepatocellular carcinoma after radical treatment Open
To develop and validate a nomogram incorporating circulating tumour cell counts (CTCs) and the ultrasomics signatures of contrast-enhancement ultrasound (CEUS) for predicting postoperative early recurrence (ER) of HCC after radical treatme…
View article: Preoperative prognostic value of alfa-fetoprotein density in patients with hepatocellular carcinoma undergoing radiofrequency ablation
Preoperative prognostic value of alfa-fetoprotein density in patients with hepatocellular carcinoma undergoing radiofrequency ablation Open
Serum AFP density may serve as a promising predictor of survival in patients with HCC undergoing RFA. High AFP density could identify patients who might be prone to recurrence or progression and need close surveillance.
View article: Application of the CT/MRI LI-RADS Treatment Response Algorithm to Contrast-Enhanced Ultrasound: A Feasibility Study
Application of the CT/MRI LI-RADS Treatment Response Algorithm to Contrast-Enhanced Ultrasound: A Feasibility Study Open
The CT/MRI LI-RADS TRA features were applicable to CEUS TRA for liver locoregional therapy. The CEUS TRA for liver locoregional therapy has sufficiently high specificity and PPV to diagnose the viability of lesions after ablation.
View article: Feasibility research of enhanced recovery after surgery implemented in esophageal cancer patients who underwent neoadjuvant chemotherapy
Feasibility research of enhanced recovery after surgery implemented in esophageal cancer patients who underwent neoadjuvant chemotherapy Open
Background: Enhanced recovery after surgery (ERAS) is a perioperative management protocol to accelerate patient recovery. This study aimed to evaluate the feasibility of ERAS protocols implemented in patients who underwent neoadjuvant chem…
View article: ACOT12-mediated acetyl-CoA hydrolysis suppresses intrahepatic cholangiocarcinoma metastasis by inhibiting epithelial-mesenchymal transition
ACOT12-mediated acetyl-CoA hydrolysis suppresses intrahepatic cholangiocarcinoma metastasis by inhibiting epithelial-mesenchymal transition Open
Intrahepatic cholangiocarcinoma (ICC) is the most common malignant bile duct tumor in the liver and the second most common primary liver cancer with increasing morbidity and poor prognosis. Metabolic aberration plays key roles in cancer pr…