Mingfang Lu
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View article: A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide
A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide Open
The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has been increasing worldwide. Since gut-derived bacterial lipopolysaccharides (LPS) can travel via the portal vein to the liver and play an important role i…
View article: A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide
A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide Open
The incidence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has been increasing world-wide. Since gut-derived bacterial lipopolysaccharides (LPS) can travel via the portal vein to the liver and play an important role …
View article: A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide
A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide Open
The incidence of Non-alcoholic Fatty Liver Disease (NAFLD) has been increasing world-wide. Since gut-derived bacterial lipopolysaccharides (LPS) can travel via the portal vein to the liver and play an important role in producing hepatic pa…
View article: A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide
A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide Open
The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has been increasing worldwide. Since gut-derived bacterial lipopolysaccharides (LPS) can travel via the portal vein to the liver and play an important role i…
View article: A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide
A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide Open
The incidence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has been increasing world-wide. Since gut-derived bacterial lipopolysaccharides (LPS) can travel via the portal vein to the liver and play an important role …
View article: FAP expression in adipose tissue macrophages promotes obesity and metabolic inflammation
FAP expression in adipose tissue macrophages promotes obesity and metabolic inflammation Open
Adipose tissue macrophages (ATM) are key players in the development of obesity and associated metabolic inflammation which contributes to systemic metabolic dysfunction. We here found that fibroblast activation protein α (FAP), a well-know…
View article: Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance
Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance Open
Although alveolar macrophages (AMs) play important roles in preventing and eliminating pulmonary infections, little is known about their regulation in healthy animals. Since exposure to LPS often renders cells hyporesponsive to subsequent …
View article: Anlotinib Combined with Anti‐PD1 Potentiates Anti‐Tumor Immunity via Immunogenic Cell Death and Macrophage Reprogramming
Anlotinib Combined with Anti‐PD1 Potentiates Anti‐Tumor Immunity via Immunogenic Cell Death and Macrophage Reprogramming Open
The combination therapy of targeted drugs and immune checkpoint inhibitors has shown prominent success. In addition to blocking mutated oncogene downstream signaling, the immunological mechanism(s) underlying the anti‐tumor effect of targe…
View article: Intestinal CD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A
Intestinal CD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A Open
The intestinal mucosal immune environment requires multiple immune cells to maintain homeostasis. Although intestinal B cells are among the most important immune cells, little is known about the mechanism that they employ to regulate immun…
View article: Author response: A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice
Author response: A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Oxidized phospholipids…
View article: A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury
A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury Open
Oxidized phospholipids have diverse biological activities, many of which can be pathological, yet how they are inactivated in vivo is not fully understood. Here we present evidence that a previously unsuspected host lipase, acyloxyacyl hyd…
View article: Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain
Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain Open
Glioma microenvironment contains numerous myeloid cells, including brain-resident microglia and recruited monocytes and macrophages (Mo/Mφ). When studied collectively, these cells presented pro-tumor effects. Yet, little is known about the…
View article: Extracellular Acidity Reprograms Macrophage Metabolism and Innate Responsiveness
Extracellular Acidity Reprograms Macrophage Metabolism and Innate Responsiveness Open
Although organ hypofunction and immunosuppression are life-threatening features of severe sepsis, the hypofunctioning organs and immune cells usually regain normal functionality if patients survive. Because tissue interstitial fluid can be…
View article: CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity
CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity Open
Dendritic cells (DCs), as professional antigen‑presenting cells are essential for the initial activation of adaptive antitumor immunity. CD1d is considered to present phospholipid and glycosphingolipid antigens to NKT cells. However, it is…
View article: Temporal modulation of host aerobic glycolysis determines the outcome of M. marinum infection
Temporal modulation of host aerobic glycolysis determines the outcome of M. marinum infection Open
Macrophages are the first-line host defense where the invading Mycobacterium tuberculosis (Mtb) encounters. It has been recently reported that host aerobic glycolysis was elevated post the infection by a couple of virulent mycobacterial sp…
View article: LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma
LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma Open
Allergic asthma is a chronic inflammatory disease primarily mediated by Th2 immune mechanisms. Numerous studies have suggested that early life exposure to lipopolysaccharide (LPS) is negatively associated with allergic asthma. One proposed…
View article: Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury
Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury Open
Pulmonary infection is the most common risk factor for acute lung injury (ALI). Innate immune responses induced by Microbe-Associated Molecular Pattern (MAMP) molecules are essential for lung defense but can lead to tissue injury. Little i…