Minghan Wang
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View article: HA protein acetylation modulates replication, pathogenicity, and immunogenicity of influenza virus and facilitates live-attenuated vaccine design
HA protein acetylation modulates replication, pathogenicity, and immunogenicity of influenza virus and facilitates live-attenuated vaccine design Open
Lysine acetylation, a form of protein post-translational modifications (PTM), is known to play crucial roles in regulating cellular and physiological processes. In this study, for the first time, lysine acetylation sites were identified on…
View article: Towards Inference-time Scaling for Continuous Space Reasoning
Towards Inference-time Scaling for Continuous Space Reasoning Open
Inference-time scaling through multiple sample generation in combination with Process- or Outcome-Reward Model (PRM or ORM) re-ranking has proven effective for text-based reasoning in large language models. This paper investigates whether …
View article: Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway
Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway Open
Our study proposes a novel AhR-mediated gut microbiota-eye axis in glaucoma pathogenesis and demonstrates that IAA serves as an effective neuroprotective strategy with clinical potential for managing RGCs neurodegeneration.
View article: Changes in influenza-associated excess mortality in China between 2012–2019 and 2020–2021: a population-based statistical modelling study
Changes in influenza-associated excess mortality in China between 2012–2019 and 2020–2021: a population-based statistical modelling study Open
Background The seasonal cycle of the influenza virus causes substantial morbidity and mortality globally. The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the circulation of influenza viruses can influence infl…
View article: MAPLE: Multi-Agent Adaptive Planning with Long-Term Memory for Table Reasoning
MAPLE: Multi-Agent Adaptive Planning with Long-Term Memory for Table Reasoning Open
Table-based question answering requires complex reasoning capabilities that current LLMs struggle to achieve with single-pass inference. Existing approaches, such as Chain-of-Thought reasoning and question decomposition, lack error detecti…
View article: Qorgau: Evaluating LLM Safety in Kazakh-Russian Bilingual Contexts
Qorgau: Evaluating LLM Safety in Kazakh-Russian Bilingual Contexts Open
Large language models (LLMs) are known to have the potential to generate harmful content, posing risks to users. While significant progress has been made in developing taxonomies for LLM risks and safety evaluation prompts, most studies ha…
View article: Against The Achilles' Heel: A Survey on Red Teaming for Generative Models
Against The Achilles' Heel: A Survey on Red Teaming for Generative Models Open
Generative models are rapidly gaining popularity and being integrated into everyday applications, raising concerns over their safe use as various vulnerabilities are exposed. In light of this, the field of red teaming is undergoing fast-pa…
View article: A multicenter study of neurofibromatosis type 1 utilizing deep learning for whole body tumor identification
A multicenter study of neurofibromatosis type 1 utilizing deep learning for whole body tumor identification Open
Deep-learning models have shown promise in differentiating between benign and malignant lesions. Previous studies have primarily focused on specific anatomical regions, overlooking tumors occurring throughout the body with highly heterogen…
View article: Proverbs Run in Pairs: Evaluating Proverb Translation Capability of Large Language Model
Proverbs Run in Pairs: Evaluating Proverb Translation Capability of Large Language Model Open
Despite achieving remarkable performance, machine translation (MT) research remains underexplored in terms of translating cultural elements in languages, such as idioms, proverbs, and colloquial expressions. This paper investigates the cap…
View article: Cell-Cycle-Related and Expression Elevated Protein in Tumor Upregulates the Antioxidant Genes via Activation of NF-κB/Nrf2 in Acute Liver Injury
Cell-Cycle-Related and Expression Elevated Protein in Tumor Upregulates the Antioxidant Genes via Activation of NF-κB/Nrf2 in Acute Liver Injury Open
Background and aims: Cell-cycle-related and expression elevated protein in tumor (CREPT, also named RPRD1B) is highly expressed in tumors and functions to promote tumorigenesis. However, the role of CREPT in the pathophysiology of acute li…
View article: Loki: An Open-Source Tool for Fact Verification
Loki: An Open-Source Tool for Fact Verification Open
We introduce Loki, an open-source tool designed to address the growing problem of misinformation. Loki adopts a human-centered approach, striking a balance between the quality of fact-checking and the cost of human involvement. It decompos…
View article: How Does Plastic Litter Accumulate in Submarine Canyons?
How Does Plastic Litter Accumulate in Submarine Canyons? Open
Manned submersible dives in the northwest South China Sea encountered substantial amounts of plastic litter accumulated at the base of scours along the floor of a submarine canyon, which may associate with the depositional behaviors of tur…
View article: CREPT is required for pulmonary fibrosis induced by bleomycin
CREPT is required for pulmonary fibrosis induced by bleomycin Open
Background Pulmonary fibrosis is a chronic and progressive disease that originates from interstitial lung diseases and ultimately exhibits respiratory failure in patients. The disease is characterized by focal accumulation and excessive pr…
View article: The Combination of Exercise and Konjac Glucomannan More Effectively Prevents Antibiotics-Induced Dysbiosis in Mice Compared with Singular Intervention
The Combination of Exercise and Konjac Glucomannan More Effectively Prevents Antibiotics-Induced Dysbiosis in Mice Compared with Singular Intervention Open
Our previous studies have demonstrated that konjac glucomannan (KGM) can prevent dysbiosis induced by antibiotics. While exercise may also impact the gut microbiome, there are limited studies reporting its protective effect on antibiotic-i…
View article: OpenFactCheck: A Unified Framework for Factuality Evaluation of LLMs
OpenFactCheck: A Unified Framework for Factuality Evaluation of LLMs Open
The increased use of large language models (LLMs) across a variety of real-world applications calls for automatic tools to check the factual accuracy of their outputs, as LLMs often hallucinate. This is difficult as it requires assessing t…
View article: Can Machines Resonate with Humans? Evaluating the Emotional and Empathic Comprehension of LMs
Can Machines Resonate with Humans? Evaluating the Emotional and Empathic Comprehension of LMs Open
Empathy plays a pivotal role in fostering prosocial behavior, often triggered by the sharing of personal experiences through narratives. However, modeling empathy using NLP approaches remains challenging due to its deep interconnection wit…
View article: Exploring the Potential of Multimodal LLM with Knowledge-Intensive Multimodal ASR
Exploring the Potential of Multimodal LLM with Knowledge-Intensive Multimodal ASR Open
Recent advancements in multimodal large language models (MLLMs) have made significant progress in integrating information across various modalities, yet real-world applications in educational and scientific domains remain challenging. This…
View article: How does plastic litter accumulate in submarine canyons?
How does plastic litter accumulate in submarine canyons? Open
The numerical simulation data of turbidity currents.
View article: The Improvement and Related Mechanism of Microecologics on the Sports Performance and Post-Exercise Recovery of Athletes: A Narrative Review
The Improvement and Related Mechanism of Microecologics on the Sports Performance and Post-Exercise Recovery of Athletes: A Narrative Review Open
The diversity and functionality of gut microbiota may play a crucial role in the function of human motor-related systems. In addition to traditional nutritional supplements, there is growing interest in microecologics due to their potentia…
View article: OpenFactCheck: Building, Benchmarking Customized Fact-Checking Systems and Evaluating the Factuality of Claims and LLMs
OpenFactCheck: Building, Benchmarking Customized Fact-Checking Systems and Evaluating the Factuality of Claims and LLMs Open
The increased use of large language models (LLMs) across a variety of real-world applications calls for mechanisms to verify the factual accuracy of their outputs. Difficulties lie in assessing the factuality of free-form responses in open…
View article: Proteomic analysis of DEN and CCl4-induced hepatocellular carcinoma mouse model
Proteomic analysis of DEN and CCl4-induced hepatocellular carcinoma mouse model Open
Hepatocellular carcinoma (HCC) seriously threatens human health, mostly developed from liver fibrosis or cirrhosis. Since diethylnitrosamine (DEN) and carbon tetrachloride (CCl 4 )-induced HCC mouse model almost recapitulates the character…
View article: Against The Achilles' Heel: A Survey on Red Teaming for Generative Models
Against The Achilles' Heel: A Survey on Red Teaming for Generative Models Open
Generative models are rapidly gaining popularity and being integrated into everyday applications, raising concerns over their safe use as various vulnerabilities are exposed. In light of this, the field of red teaming is undergoing fast-pa…
View article: Conversational SimulMT: Efficient Simultaneous Translation with Large Language Models
Conversational SimulMT: Efficient Simultaneous Translation with Large Language Models Open
Simultaneous machine translation (SimulMT) presents a challenging trade-off between translation quality and latency. Recent studies have shown that LLMs can achieve good performance in SimulMT tasks. However, this often comes at the expens…
View article: Factuality of Large Language Models: A Survey
Factuality of Large Language Models: A Survey Open
Large language models (LLMs), especially when instruction-tuned for chat, have become part of our daily lives, freeing people from the process of searching, extracting, and integrating information from multiple sources by offering a straig…
View article: How does plastic litter accumulate in submarine canyons?
How does plastic litter accumulate in submarine canyons? Open
The numerical simulation data of turbidity currents.