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View article: Computational design of superstable proteins through maximized hydrogen bonding
Computational design of superstable proteins through maximized hydrogen bonding Open
Hydrogen bonds are fundamental chemical interactions that stabilize protein structures, particularly in β sheets, enabling resistance to mechanical stress and environmental extremes. Here, inspired by natural mechanostable proteins with sh…
View article: How eHealth use and cancer information-seeking influence older adults’ acceptance of genetic testing: Mediating roles of PIGI and cancer worry
How eHealth use and cancer information-seeking influence older adults’ acceptance of genetic testing: Mediating roles of PIGI and cancer worry Open
Objective This study aims to investigate how eHealth use and information-seeking behavior affect older adults’ acceptance of genetic testing, focusing on their participation in genetic tests and their willingness to adopt lifestyle changes…
View article: Rücktitelbild: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. 39/2024)
Rücktitelbild: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. 39/2024) Open
A synapse-mimicking nanopipette method was developed to electrochemically monitor single vesicle dynamics induced by lipid-tau interactions. To mimic the lipid environment in synapses, model vesicles and a modified lipid layer were confine…
View article: Back Cover: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. Int. Ed. 39/2024)
Back Cover: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. Int. Ed. 39/2024) Open
A synapse-mimicking nanopipette method was developed to electrochemically monitor single vesicle dynamics induced by lipid-tau interactions. To mimic the lipid environment in synapses, model vesicles and a modified lipid layer were confine…
View article: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette
Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette Open
The microtubule‐associated protein tau participates in neurotransmission regulation via its interaction with synaptic vesicles (SVs). The precise nature and mechanics of tau‘s engagement with SVs, especially regarding alterations in vesicl…
View article: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette
Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette Open
The microtubule‐associated protein tau participates in neurotransmission regulation via its interaction with synaptic vesicles (SVs). The precise nature and mechanics of tau‘s engagement with SVs, especially regarding alterations in vesicl…
View article: Ultrahigh-potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration
Ultrahigh-potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration Open
Despite substantial progress in antiretroviral therapy (ART) effectively suppressing HIV-1 replication in the bloodstream, a cure for HIV remains elusive. Existing antiviral drugs pose limitations, including lifelong medication, frequent a…