Explanipedia

Bragg-peak FLASH biological optimization enables enhanced normal tissue sparing and dose escalation for ocular stereotactic body radiation therapy Open

Muhammad Hamza, Balaji Selvaraj, Xingyi Zhao, Chingyun Cheng, Tyler Kaulfers , et al. · 2025

Objective. To evaluate proton Bragg peak FLASH for ocular treatments to enhance normal tissue sparing and enable dose escalation via FLASH biological optimization (FBO). Approach. The FLASH-sparing factors for normal tissues were derived f…

First experience with third‐party validations: A robust calibration and QA procedure for proton FLASH delivery Open

Cai Chang, Balaji Selvaraj, Xingyi Zhao, Jacob Rembish, Paige A. Taylor , et al. · 2025

Background Proton FLASH radiotherapy, delivering ultra‐high dose rates, shows promise in reducing normal tissue toxicity while maintaining tumor control. However, accurate dosimetry and quality assurance (QA) for FLASH remain challenging d…

Feasibility Study of Bragg Peak Proton FLASH Radiotherapy in Pediatric Brain Tumors Open

S. Hiltner, K. Canikligil, Winston C. Vaughan, Brett A. Morris, K.A. Bradley , et al. · 2025

Free-Breathing Spirometer-Gated Proton Pencil Beam Scanning Radiotherapy - Maintain Tumor Coverage with Improved Organ-at-Risk Sparing Open

H. Qi, Anmin Zheng, Sheng Huang, U. Aura, Feng Yu , et al. · 2025

NRG Oncology Liver Proton SBRT and Hypofractionated Radiation Therapy: Current Treatment Technical Assessment and Practice Patterns Open

Minglei Kang, Paige A. Taylor, Jiajian Shen, Jun Zhou, Jatinder Saini , et al. · 2025

Background/Objectives: Proton therapy delivers highly conformal doses to the target area without producing an exit dose, minimizing cumulative doses to healthy liver tissue. This study aims to evaluate current practices, challenges, and va…

Proton Therapy for Uveal Melanoma on a Pencil Beam Scanning Gantry Open

Hang Qi, Lei Hu, Sheng Huang, Yen-Po Lee, Qing Chen , et al. · 2025

424P Chemotherapy (SOX) plus tisleizumab in gastric cancer patients with liver metastasis: The first report from a multi-center phase II study Open

Minglei Kang, Guowei Chen, Xin Jin, Qisen Guo, Deqing Wu , et al. · 2025

Implementation of a novel pencil beam scanning Bragg peak FLASH technique to a commercial treatment planning system Open

Alexander Bookbinder, Miriam Krieger, P. Lansonneur, Anthony Magliari, Xingyi Zhao , et al. · 2025

Background Ultra‐high dose rate, or FLASH, radiotherapy has shown promise in preclinical experiments of sparing healthy tissue without compromising tumor control. This “FLASH effect” can compound with dosimetric sparing of the proton Bragg…

FLASH Stereotactic Body Radiation Therapy for Spine Tumors Using a Single-Energy Proton Pristine Bragg Peak Delivery Technique Open

Balaji Selvaraj, Xingyi Zhao, Lin Haibo, Jiajian Shen, Chingyun Cheng , et al. · 2025

BP-FLASH SBRT is a promising treatment for challenging spinal cord cancers, which achieved ultra-high-dose rates for FLASH effect and maintained the same dosimetry quality as the CONV-IMPT plans.

Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy Open

Hang Qi, Lei Hu, Sheng Huang, Yen-Po Lee, Francis T. S. Yu , et al. · 2025

Dose escalation in lung cancer re-irradiation using biological optimization of Bragg peak FLASH therapy Open

Balaji Selvaraj, Xiangyi Zhao, Chingyun Cheng, Dongdong Meng, J. Isabelle Choi , et al. · 2025

Validation and reproducibility of in vivo dosimetry for pencil beam scanned FLASH proton treatment in mice Open

Alexander Bookbinder, Balaji Selvaraj, Brett I. Bell, Michael Pennock, Pingfang Tsai , et al. · 2025

Bragg-peak FLASH biological optimization with dose escalation in ocular SBRT Open

Muhammad Hamza, Balaji Selvaraj, Grant Lattery, Chingyun Cheng, Xingyi Zhao , et al. · 2025

Benchmarking the performance of a prototype commercial TPS with novel pencil beam scanning Bragg Peak FLASH technique and scorecard-based optimization Open

Alexander Bookbinder, Miriam Krieger, P. Lansonneur, Anthony Magliari, Xingyi Zhao , et al. · 2025

FLASH stereotactic body radiation therapy for spine tumors using a single-energy proton pristine Bragg peak delivery technique Open

Balaji Selvaraj, Xingyi Zhao, Lin Haibo, Jiajian Shen, Chingyun Cheng , et al. · 2025

A comprehensive comparative study of the two predominant techniques for delivering conformal proton pencil beam scanning FLASH radiotherapy Open

Xingyi Zhao, Chingyun Cheng, Jenghwa Chang, J. Isabelle Choi, Charles B. Simone , et al. · 2025

Camera-based monitoring and tracking system to advance the ocular proton therapy Open

Siyu Yang, Hang Qi, Yen-Po Lee, Francis T. S. Yu, M. A. Vermeulen , et al. · 2025

Gantry-based Pencil Beam Scanning (PBS) proton therapy for uveal melanoma: IMPT versus proton arc therapy Open

Hang Qi, Lei Hu, Sheng Huang, Yen-Po Lee, Francis T. S. Yu , et al. · 2025

Ensuring high passing rates for third-party credentialing: An effective calibration and QA procedure for proton FLASH delivery Open

Cai Chang, Jacob Rembish, Balaji Selvaraj, Paige A. Taylor, Xingyi Zhao , et al. · 2025

Novel Bragg-Peak Flash Radiotherapy: Safe and Precise Treatment of Base-of-Skull Tumors within Existing Clinical Guidelines Open

Michael Pennock, Balaji Selvaraj, C.C. Chen, Alex Kyler, Lin Haibo , et al. · 2025

The Potential and Challenges of Proton FLASH in Head and Neck Cancer Reirradiation Open

Chingyun Cheng, Liming Xu, Hao Jing, Balaji Selvaraj, Haibo Lin , et al. · 2024

Ultrahigh-dose-rate therapy, also known as FLASH radiotherapy (RT), is an emerging technique that is garnering significant interest in cancer treatment due to its potential to revolutionize therapy. This method can achieve comparable tumor…

Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality Open

Brett I. Bell, Christian Velten, Michael Pennock, Minglei Kang, Kathryn E. Tanaka , et al. · 2024

A CHROMATIC ABERRATION AND DISPERSION EFFECTS SYSTEM UTILIZED FOR LASER-DRIVEN PROTON RADIOTHERAPY Open

Yiyu Fang, Kai Wang, Kedong Wang, Haoyang Lan, Minglei Kang , et al. · 2024

A NOVEL PROTON FLASH STEREOTACTIC RADIOSURGERY TECHNIQUE: ACHIEVING CYBERKNIFE-EQUIVALENT DOSIMETRY FOR RECURRENT GLIOBLASTOMA - A PROOF-OF-CONCEPT STUDY Open

Hui Wu, Xingyi Zhao, Chingyun Cheng, Wei Guo, Longfei Diao , et al. · 2024

SIMULTANEOUS INTENSITY ENERGY MODULATION AND COMPENSATION (SIEMAC) OPTIMIZATION FRAMEWORK FOR PROTON FLASH TREATMENT PLANNING Open

N. Harrison, Minglei Kang, Ruirui Liu, Serdar Charyyev, Niklas Wahl , et al. · 2024

A NOVEL OPTIMIZATION FRAMEWORK FOR PROTON FLASH TREATMENT PLANNING ALLOWS DOSE, DOSE RATE, AND LET OPTIMIZATION USING PATIENT-SPECIFIC RIDGE FILTERS Open

Ruirui Liu, Serdar Charyyev, Niklas Wahl, Wei Liu, Minglei Kang , et al. · 2024

PENCIL BEAM SCANNING PROTON THERAPY FOR UVEAL MELANOMA: MODULATED MULTIBEAM SOLUTION IN A REGULAR GANTRY ROOM Open

Lei Hu, Sheng Huang, Yen-Po Lee, Francis T. S. Yu, Qing Chen , et al. · 2024

BRAGG PEAK PROTON FLASH RADIOTHERAPY IN PANCREATIC CANCER TREATMENT: ENHANCING TARGET DOSE ESCALATION WITH FLASH SPARING EFFECT VIA BIOLOGICAL OPTIMIZATION Open

Chingyun Cheng, Xingyi Zhao, Yin Zhang, I.J. Choi, Charles B. Simone , et al. · 2024

FLASH STEREOTACTIC BODY RADIATION THERAPY FOR SPINE TUMORS USING A SINGLE-ENERGY PROTON PRISTINE BRAGG PEAK DELIVERY TECHNIQUE Open

Balaji Selvaraj, Xingyi Zhao, Lin Haibo, Jiajian Shan, Alex Bookbinder , et al. · 2024

Commissioning a 250 MeV research beamline for proton FLASH radiotherapy preclinical experiments Open

Y. Y. Yang, Minglei Kang, C.C. Chen, Liqun Hu, Feng Yu , et al. · 2024

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