Minglong Liu
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View article: Molecular determinants for recognition of serotonylated chromatin
Molecular determinants for recognition of serotonylated chromatin Open
Post-translational modifications of histone tails constitute a key epigenetic mechanism controlling chromatin environment and gene transcription. Serotonylation of histone H3Q5 (H3Q5ser) is a recently discovered mark associated with active…
View article: Influence of <scp>COVID</scp>‐19 Vaccination on Treatment‐Related Adverse Events and Oncologic Outcomes of Nonmetastatic Nasopharyngeal Carcinoma
Influence of <span>COVID</span>‐19 Vaccination on Treatment‐Related Adverse Events and Oncologic Outcomes of Nonmetastatic Nasopharyngeal Carcinoma Open
Background The influence of COVID‐19 vaccination before chemoradiotherapy on nonmetastatic nasopharyngeal carcinoma (NPC) is not known. Methods Propensity score matching was used to minimize potential selection bias between groups. Primary…
View article: Influence of COVID-19 Vaccination on Treatment-Related Adverse Events and Oncologic Outcomes of Non-metastatic Nasopharyngeal Carcinoma
Influence of COVID-19 Vaccination on Treatment-Related Adverse Events and Oncologic Outcomes of Non-metastatic Nasopharyngeal Carcinoma Open
Background: The influence of COVID-19 vaccination on treatment of non-metastatic nasopharyngeal carcinoma (NPC) who were newly diagnosed after the widespread vaccination against COVID-19 and subsequently treated withchemoradiotherapy is no…
View article: A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein
A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein Open
The ongoing COVID-19 pandemic has had great societal and health consequences. Despite the availability of vaccines, infection rates remain high due to immune evasive Omicron sublineages. Broad-spectrum antivirals are needed to safeguard ag…
View article: An N-terminal selective thiazoline peptide macrocyclisation compatible with mRNA display and efficient SPPS
An N-terminal selective thiazoline peptide macrocyclisation compatible with mRNA display and efficient SPPS Open
Discovery of new to nature ‘de novo’ macrocyclic peptides has been greatly facilitated by the integration of genetic recoding approaches with peptide display technologies. Perhaps most important among the changes that can made to a peptide…
View article: Peroxiredoxin 6 alleviates high glucose-induced inflammation and apoptosis in HK-2 cells by inhibiting TLR4/NF-κB signaling
Peroxiredoxin 6 alleviates high glucose-induced inflammation and apoptosis in HK-2 cells by inhibiting TLR4/NF-κB signaling Open
To conclude, PRDX6 appears to protect HG-exposed HK-2 cells against inflammation and apoptosis by inhibiting TLR4/NF-κB signaling.
View article: Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis
Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis Open
A new tool for peptide discovery. Pyridine-nitrile based macrocyclisation in mRNA display format, provides novel conformational constraints and allows construction of controlled bicyclic structures.
View article: An Efficient, Site‐Selective and Spontaneous Peptide Macrocyclisation During in vitro Translation
An Efficient, Site‐Selective and Spontaneous Peptide Macrocyclisation During in vitro Translation Open
Macrocyclisation provides a means of stabilising the conformation of peptides, often resulting in improved stability, selectivity, affinity, and cell permeability. In this work, a new approach to peptide macrocyclisation is reported, using…
View article: A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein
A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein Open
The ongoing COVID-19 pandemic has had great societal and health consequences. Despite the availability of vaccines, infection rates remain high due to immune evasive Omicron sublineages. Broad-spectrum antivirals are needed to safeguard ag…
View article: Phosphine addition to dehydroalanine for peptide modification
Phosphine addition to dehydroalanine for peptide modification Open
Thiols are commonly exploited as nucleophiles in biomolecules, but phosphines less so. In this work we show that conjugate addition of phosphines into dehydroalanine is a practical approach to peptide modification to form a phosphonium ion…
View article: Expanding Chemical and Structural Space in mRNA Display
Expanding Chemical and Structural Space in mRNA Display Open
In vitro translation provides a useful toolbox for the chemical biologist because of its multiple applications, such as protein/peptide synthesis, protein folding studies and rapid identification of genes. By reprogramming the genetic code…
View article: Suppression of Formylation Provides an Alternative Approach to Vacant Codon Creation in Bacterial In Vitro Translation
Suppression of Formylation Provides an Alternative Approach to Vacant Codon Creation in Bacterial In Vitro Translation Open
Genetic code reprogramming is a powerful approach to controlled protein modification. A remaining challenge, however, is the generation of vacant codons. We targeted the initiation machinery of E. coli, showing that restriction of the form…
View article: Suppression of Formylation Provides an Alternative Approach to Vacant Codon Creation in Bacterial In Vitro Translation
Suppression of Formylation Provides an Alternative Approach to Vacant Codon Creation in Bacterial In Vitro Translation Open
Genetic code reprogramming is a powerful approach to controlled protein modification. A remaining challenge, however, is the generation of vacant codons. We targeted the initiation machinery of E. coli, showing that restriction of the form…
View article: Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display
Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display Open
Targeting chemokine signaling is an attractive avenue for the treatment of inflammatory disorders. Tyrosine sulfation is an important post-translational modification (PTM) that enhances chemokine-receptor binding and is also utilized by a …
View article: Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase
Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase Open
De novo macrocyclic peptides, derived using selection technologies such as phage and mRNA display, present unique and unexpected solutions to challenging biological problems. This is due in part to their unusual folds, which are able to pr…
View article: Exenatide Inhibits the K
Exenatide Inhibits the K Open
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