Mi Zhou
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View article: Tregs with High <scp>CD29</scp> Expression Promote Cell Adhesion and Contribute to the Malignant Transformation of <scp>MASLD</scp>
Tregs with High <span>CD29</span> Expression Promote Cell Adhesion and Contribute to the Malignant Transformation of <span>MASLD</span> Open
Background and Aim Regulatory T cells (Tregs) are highly enriched in the metabolic dysfunction‐associated steatotic liver disease (MASLD) microenvironment, but their role in driving metabolic dysfunction‐associated steatohepatitis (MASH) p…
View article: Association Betweenn Preoperative RDW and Postoperative Pulmonary Embolism in Trauma Patients: A Propensity Score-Matched Multicenter Cohort Study
Association Betweenn Preoperative RDW and Postoperative Pulmonary Embolism in Trauma Patients: A Propensity Score-Matched Multicenter Cohort Study Open
Background Although red cell distribution width (RDW) has been linked to venous thromboembolism, its predictive value for postoperative pulmonary embolism (PE) in surgical trauma patients remains ambiguous. This study aimed to investigate …
View article: Artificial intelligence in inflammatory bowel disease
Artificial intelligence in inflammatory bowel disease Open
Inflammatory bowel disease (IBD) is a complex condition influenced by various intestinal factors. Advances in next-generation sequencing, high-throughput omics, and molecular network technologies have significantly accelerated research in …
View article: Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF‐β Pathway Inhibition
Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF‐β Pathway Inhibition Open
Background Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the Fibrillin‐1 gene, which encodes the extracellular matrix protein fibrillin‐1. Patients with MFS are predisposed to aortic aneurysms and d…
View article: Effect of intraoperative intravenous remimazolam on the postoperative quality of recovery after noncardiac surgery: A meta-analysis of randomized controlled trials
Effect of intraoperative intravenous remimazolam on the postoperative quality of recovery after noncardiac surgery: A meta-analysis of randomized controlled trials Open
Objectives The postoperative quality of recovery holds significant economic and prognostic implications. Numerous studies have investigated the postoperative quality of recovery following surgery. However, the impact of intraoperative intr…
View article: Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis
Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis Open
The immune‐inflammatory responses in the brain represent a key therapeutic target to ameliorate brain injury following intracerebral hemorrhage (ICH), where pro‐inflammatory microglia and its mitochondrial dysfunction plays a pivotal role.…
View article: Deciphering the secret codes in N<sup>7</sup>‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases
Deciphering the secret codes in N<sup>7</sup>‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases Open
N 7 ‐methylguanosine (m 7 G) is one of the most prevalent post‐transcriptional modifications of RNA and plays a critical role in RNA translation and stability. As a pivotal m 7 G regulator, methyltransferase‐like 1 (METTL1) is responsible …
View article: Two-photon absorption of BODIPY, BIDIPY, GADIPY, and SBDIPY
Two-photon absorption of BODIPY, BIDIPY, GADIPY, and SBDIPY Open
Two-photon absorption (2PA) properties of BODIPY, BIDIPY, GADIPY, and SBDIPY were investigated using TD-DFT and RI-CC2. Core substitution (Ga, Sb, Bi) has minimal impact on 2PA cross-sections, while extended conjugation significantly enhan…
View article: Thirdhand Smoke As a Risk Factor for Pediatric Lymphoblastic Leukemia: Accelerated Leukemia in Female <i>Pax5</i>-P80R Mice
Thirdhand Smoke As a Risk Factor for Pediatric Lymphoblastic Leukemia: Accelerated Leukemia in Female <i>Pax5</i>-P80R Mice Open
Acute lymphoblastic leukemia (ALL) is the most common cancer of childhood. The development of ALL involves genetic and epigenetic processes, but how these factors are influenced by prenatal and early life exposures is poorly understood. Ep…
View article: Two-Photon Absorption of BODIPY, BIDIPY, GADIPY, and SBDIPY
Two-Photon Absorption of BODIPY, BIDIPY, GADIPY, and SBDIPY Open
Substituted boron-dipyrromethene compounds (BODIPYs) have gained significant attention due to their tunable photophysical properties, including two-photon absorption (2PA), a nonlinear optical process where two photons are absorbed simulta…
View article: Ten Machine Learning Models for Predicting Preoperative and Postoperative Coagulopathy in Patients With Trauma: Multicenter Cohort Study (Preprint)
Ten Machine Learning Models for Predicting Preoperative and Postoperative Coagulopathy in Patients With Trauma: Multicenter Cohort Study (Preprint) Open
BACKGROUND Recent research has revealed the potential value of machine learning (ML) models in improving prognostic prediction for patients with trauma. ML can enhance predictions and identify which factors contribute the most to posttrau…
View article: PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner Open
Clear cell renal cell carcinoma (ccRCC) is considered an immunotherapy-responsive disease; however, the reasons for this remain unclear. Studies have variably implicated PBRM1 mutations as a predictive biomarker of immune checkpoint blocka…
View article: Early plasma exchange and continuous renal replacement therapy improve puerperal prognosis in hepatitis B virus-related acute-on-chronic liver failure in pregnancy
Early plasma exchange and continuous renal replacement therapy improve puerperal prognosis in hepatitis B virus-related acute-on-chronic liver failure in pregnancy Open
Early PE and CRRT conducted within three days post-childbirth, enhance puerperal prognosis for HBV-related gestational ACLF.
View article: FGFR inhibition augments anti–PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression
FGFR inhibition augments anti–PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression Open
The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) inhibition with ICI in urothelial carcinoma (UC) of the blad…
View article: TGF-β1 inhibits apoptosis of cardiomyocytes H9c2 by regulating autophagy and ERK pathway
TGF-β1 inhibits apoptosis of cardiomyocytes H9c2 by regulating autophagy and ERK pathway Open
This study aimed to explore the expression and mechanism of transforming growth factor β1 (TGF-β1) in oxygen glucose deprivation reperfusion (OGD/R)-induced ischemia/reperfusion (I/R) injury. An OGD/R model was established in cardiomyocyte…
View article: 848 Predictions of endogenous neoantigens from varied genomic sources in a syngeneic murine cancer model
848 Predictions of endogenous neoantigens from varied genomic sources in a syngeneic murine cancer model Open
Background Current immune checkpoint inhibitor immunotherapy relies on the presence of a pool of pre-existing neoantigen-specific T cells that can be unsuppressed and leveraged to eliminate cancer cells. However, in many patients in many c…
View article: Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of <i>ETV6::RUNX1</i>
Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of <i>ETV6::RUNX1</i> Open
Not available.
View article: Supplementary Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Supplementary Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner Open
Supplementary Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
View article: Supplementary Figure from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Supplementary Figure from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner Open
Supplementary Figure from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
View article: Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner Open
Clear cell renal cell carcinoma (ccRCC) is considered an immunotherapy-responsive disease; however, the reasons for this remain unclear. Studies have variably implicated PBRM1 mutations as a predictive biomarker of immune checkpoint blocka…
View article: Supplementary Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Supplementary Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner Open
Supplementary Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
View article: Supplementary Figure from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Supplementary Figure from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner Open
Supplementary Figure from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
View article: Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner Open
Clear cell renal cell carcinoma (ccRCC) is considered an immunotherapy-responsive disease; however, the reasons for this remain unclear. Studies have variably implicated PBRM1 mutations as a predictive biomarker of immune checkpoint blocka…
View article: SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers Open
Adult liver malignancies, including intrahepatic cholangiocarcinoma and hepatocellular carcinoma, are the second leading cause of cancer-related deaths worldwide. Most individuals are treated with either combination chemotherapy or immunot…
View article: Gene profiling reveals the role of inflammation, abnormal uterine muscle contraction and vascularity in recurrent implantation failure
Gene profiling reveals the role of inflammation, abnormal uterine muscle contraction and vascularity in recurrent implantation failure Open
Objective: Recurrent implantation failure (RIF) is now disturbing numerous infertile couples accepting assisted reproductive technology (ART). And the endometrial factors are crucial causes of recurrent implantation failure. However, its m…
View article: Viewing RCC with a DNA Methylation Lens ENHANCES Understanding of ICI Resistance
Viewing RCC with a DNA Methylation Lens ENHANCES Understanding of ICI Resistance Open
Summary Clear-cell renal cell carcinoma tumors with an enhancer demethylator phenotype (TED) harbor a worse prognosis and derive less clinical benefit from immunotherapy. The TED phenotype may help predict immunotherapy resistance. See rel…
View article: Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer
Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer Open
Urothelial Cancer - Genomic Analysis to Improve Patient Outcomes and Research (NCT02643043), UC-GENOME, is a genomic analysis and biospecimen repository study in 218 patients with metastatic urothelial carcinoma. Here we report on the prim…