Mingming Jin
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View article: Deep Node Embeddings for the Graph Coloring Problem
Deep Node Embeddings for the Graph Coloring Problem Open
In recent years, there has been a growing trend in utilizing deep learning techniques to solve various NP-hard combinatorial optimization problems, mostly using deep neural networks to generate the solutions directly. In this work, we addr…
View article: Circ-AARS plays an important role during the odontogenic differentiation of dental pulp stem cells by modulating miR-24-3p/KLF6 expression
Circ-AARS plays an important role during the odontogenic differentiation of dental pulp stem cells by modulating miR-24-3p/KLF6 expression Open
The present study showed that circ-AARS can promote the odontoblastic differentiation of DPSCs by increasing KLF6 expression and sponging miR-24-3p. Taken together, the results indicate that circ-AARS may be a potential positive regulator …
View article: Gambogenic Acid Suppresses Malignant Progression of Non-Small Cell Lung Cancer via GCH1-Mediated Ferroptosis
Gambogenic Acid Suppresses Malignant Progression of Non-Small Cell Lung Cancer via GCH1-Mediated Ferroptosis Open
Introduction: Non-small cell lung cancer (NSCLC) is a lethal type of lung cancer (LC) with a 5-year survival rate of 19%. Because drug resistance typically develops following chemotherapy, radiotherapy, and immunotherapy, a novel NSCLC the…
View article: HPV11 targeting KDM4A regulates the polarization of macrophage M1 and promotes the development of nasal inverted papilloma
HPV11 targeting KDM4A regulates the polarization of macrophage M1 and promotes the development of nasal inverted papilloma Open
The development of nasal inverted papilloma (NIP) is closely related to human papillomavirus (HPV) infection. Previous studies indicated that HPV11 shows the highest expression in NIP tissues. However, the mechanisms following its integrat…
View article: Melittin suppresses aerobic glycolysis by regulating HSF1/PDK3 to increase chemosensitivity of NSCLC
Melittin suppresses aerobic glycolysis by regulating HSF1/PDK3 to increase chemosensitivity of NSCLC Open
Non-small cell lung cancer (NSCLC), although considered non-immunogenic, is often resistant to chemotherapy agents during the course of treatment in clinical patients. Melittin (C131H229N39O31, CAS: 20449-79-0), the major component of hone…
View article: Melittin treatment suppressed malignant NSCLC progression through enhancing CTSB-mediated hyperautophagy
Melittin treatment suppressed malignant NSCLC progression through enhancing CTSB-mediated hyperautophagy Open
Melittin is preclinically investigated as anticancer agent in multiple tumor types. But its regulation role and regulatory mechanism regarding NSCLC is unknown. In our investigation, Proteomic test was employed to identify proteins that ex…
View article: Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation
Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation Open
Lactylation, a newly identified post-translational modification, is uncertain in its implication in triple-negative breast cancer (TNBC). In this study, we analyzed 60 TNBC samples using immunohistochemical staining and revealed elevated l…
View article: Corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis
Corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis Open
The data suggested that corosolic acid delivered by exosomes from Eriobotrya japonica decreased pancreatic cancer cell proliferation and invasion by inducing SAT1-mediated ferroptosis.
View article: KD-Club: An Efficient Exact Algorithm with New Coloring-Based Upper Bound for the Maximum k-Defective Clique Problem
KD-Club: An Efficient Exact Algorithm with New Coloring-Based Upper Bound for the Maximum k-Defective Clique Problem Open
The Maximum k-Defective Clique Problem (MDCP) aims to find a maximum k-defective clique in a given graph, where a k-defective clique is a relaxation clique missing at most k edges. MDCP is NP-hard and finds many real-world applications in …
View article: Hypoxic Exosomal circPLEKHM1‐Mediated Crosstalk between Tumor Cells and Macrophages Drives Lung Cancer Metastasis
Hypoxic Exosomal circPLEKHM1‐Mediated Crosstalk between Tumor Cells and Macrophages Drives Lung Cancer Metastasis Open
Intercellular communication often relies on exosomes as messengers and is critical for cancer metastasis in hypoxic tumor microenvironment. Some circular RNAs (circRNAs) are enriched in cancer cell‐derived exosomes, but little is known abo…
View article: The Impact of Forestry Industry Integration on the Forest Farmers' Income in China: A Theoretical and Empirical Study
The Impact of Forestry Industry Integration on the Forest Farmers' Income in China: A Theoretical and Empirical Study Open
Transforming the forestry development model and promoting the integrated development of the forestry industry has become an important way for forestry to break through development bottlenecks and achieve efficiency enhancement, prosperity …
View article: An Effective Branch-and-Bound Algorithm with New Bounding Methods for the Maximum $s$-Bundle Problem
An Effective Branch-and-Bound Algorithm with New Bounding Methods for the Maximum $s$-Bundle Problem Open
The Maximum s-Bundle Problem (MBP) addresses the task of identifying a maximum s-bundle in a given graph. A graph G=(V, E) is called an s-bundle if its vertex connectivity is at least |V|-s, where the vertex connectivity equals the minimum…
View article: Comprehensive analysis of mitophagy-related genes in NSCLC diagnosis and immune scenery: based on bulk and single-cell RNA sequencing data
Comprehensive analysis of mitophagy-related genes in NSCLC diagnosis and immune scenery: based on bulk and single-cell RNA sequencing data Open
Lung cancer is the main cause of cancer-related deaths, and non-small cell lung cancer (NSCLC) is the most common type. Understanding the potential mechanisms, prognosis, and treatment aspects of NSCLC is essential. This study systematical…
View article: Performance Analysis of the Maximum Likelihood Estimation of Signal Period Length and Its Application in Heart Rate Estimation with Reduced Respiratory Influence
Performance Analysis of the Maximum Likelihood Estimation of Signal Period Length and Its Application in Heart Rate Estimation with Reduced Respiratory Influence Open
The remote and non-contact monitoring of human respiration and heartbeat based on radars is a safe and convenient practice. However, how to accurately estimate the heart rate is still an open issue, because the heartbeat information in rad…
View article: Downregulation hsa_circ_0006620 inhibit the malignant progression of prostate cancer by regulation miR-502-3p/HK2 axis mediated aerobic glycolysis
Downregulation hsa_circ_0006620 inhibit the malignant progression of prostate cancer by regulation miR-502-3p/HK2 axis mediated aerobic glycolysis Open
Background: Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have been implicated in cancer progression by regulation metabolism. But, the circRNA roles in prostate cancer remains unknown. Methods: This re…
View article: KD-Club: An Efficient Exact Algorithm with New Coloring-based Upper Bound for the Maximum k-Defective Clique Problem
KD-Club: An Efficient Exact Algorithm with New Coloring-based Upper Bound for the Maximum k-Defective Clique Problem Open
The Maximum k-Defective Clique Problem (MDCP) aims to find a maximum k-defective clique in a given graph, where a k-defective clique is a relaxation clique missing at most k edges. MDCP is NP-hard and finds many real-world applications in …
View article: Integrative analysis reveals an enhancer based prognostic risk model for non-small cell lung cancer
Integrative analysis reveals an enhancer based prognostic risk model for non-small cell lung cancer Open
The study used integratively analyzed methylation data and expression data on non-small cell lung cancer (NSCLC). From the methylation data, we obtained 19,784 differentially methylated probes (DMPs) and studied the distribution of these D…