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View article: Photon-counting CT for Pancreatic Cancer: Advancing Precision Imaging and Virtual Surgical Navigation
Photon-counting CT for Pancreatic Cancer: Advancing Precision Imaging and Virtual Surgical Navigation Open
Pancreatic cancer remains highly lethal, with 5-year survival below 15%. While surgical resection is the only potentially curative approach, conventional imaging often fails to clearly delineate tumor boundaries and adjacent anatomy, compr…
View article: A new peptide inhibitor of C1QBP exhibits potent anti‐tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombination repair
A new peptide inhibitor of C1QBP exhibits potent anti‐tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombination repair Open
C1QBP exhibits heightened expression across a spectrum of tumours, thereby fostering their proliferation and metastasis, rendering it a pivotal therapeutic target. Nevertheless, to date, no pharmacological agents capable of directly target…
View article: Commensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor
Commensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor Open
Background The gastrointestinal tract contains a wide range of microorganisms that have evolved alongside the immune system of the host. The intestinal mucosa maintains balance within the intestines by utilizing the mucosal immune system, …
View article: LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145-5p
LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145-5p Open
Background Long-non-coding RNA PVT1 (lncRNA PVT1) can be used as an oncogenic regulatory non-coding RNA (ncRNA) for many cancers. However, its function and mechanism in breast cancer (BRCA) are still not clearly elucidated. Objective We at…
View article: Surgical anatomy of the lingual lymph nodes. Systematic literature analysis and proposition for topographic classification.
Surgical anatomy of the lingual lymph nodes. Systematic literature analysis and proposition for topographic classification. Open
Purpose: Metastatic involvement of the lingual lymph nodes (LLNs) in oral cavity squamous cell cancer has recently been proven to significantly reduce locoregional control and survival. Despite recent refinements in the detection of these …
View article: P753: DYSFUNCTIONAL BONE MARROW ENDOTHELIAL PROGENITOR CELLS ARE INVOLVED IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES
P753: DYSFUNCTIONAL BONE MARROW ENDOTHELIAL PROGENITOR CELLS ARE INVOLVED IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES Open
Background: Myelodysplastic syndromes(MDS) are a group of heterogeneous myeloid clonal disorders characterized by ineffective haematopoiesis and immune deregulation. Emerging evidence has shown important roles of the bone marrow(BM) microe…
View article: On terminology and topographic classification of the lingual lymph nodes
On terminology and topographic classification of the lingual lymph nodes Open
A review of accumulated international clinical experience and prognostic significance calculations of metastatic involvement of the lingual lymph nodes is given. Anatomical terminology of lingual lymph nodes and its contradictive aspects a…
View article: The Regulation Network and Clinical Significance of Circular RNAs in Breast Cancer
The Regulation Network and Clinical Significance of Circular RNAs in Breast Cancer Open
Breast cancer is one of the most common malignant tumors in women worldwide. Circular RNA (circRNA) is a class of structurally stable non-coding RNA with a covalently closed circular structure. In recent years, with the development of high…
View article: Comprehensive Analysis of lncRNA and miRNA Regulatory Network Reveals Potential Prognostic Non-coding RNA Involved in Breast Cancer Progression
Comprehensive Analysis of lncRNA and miRNA Regulatory Network Reveals Potential Prognostic Non-coding RNA Involved in Breast Cancer Progression Open
Breast cancer is one of the most common malignant tumors in women and is the second leading cause of cancer deaths among women. The tumorigenesis and progression of breast cancer are not well understood. The existing researches have indica…
View article: Assessment of Bidirectional Relationships Between Polycystic Ovary Syndrome and Periodontitis: Insights From a Mendelian Randomization Analysis
Assessment of Bidirectional Relationships Between Polycystic Ovary Syndrome and Periodontitis: Insights From a Mendelian Randomization Analysis Open
Background Observational studies have indicated an association between polycystic ovary syndrome (PCOS) and periodontitis, but it is unclear whether the association is cofounded or causal. We conducted a two-sample Mendelian randomization …
View article: Novel Long Noncoding RNA 005620 Induces Epirubicin Resistance in Triple-Negative Breast Cancer by Regulating ITGB1 Expression
Novel Long Noncoding RNA 005620 Induces Epirubicin Resistance in Triple-Negative Breast Cancer by Regulating ITGB1 Expression Open
Triple-negative breast cancer (TNBC) is often treated with anthracyclines (e.g., epirubicin or doxorubicin), but very little is known about anthracycline resistance, especially epirubicin resistance in TNBC. To identify novel long noncodin…
View article: Genes That Predict Poor Prognosis in Breast Cancer via Bioinformatical Analysis
Genes That Predict Poor Prognosis in Breast Cancer via Bioinformatical Analysis Open
Background . Breast cancer is one of the most commonly diagnosed cancers all over the world, and it is now the leading cause of cancer death among females. The aim of this study was to find DEGs (differentially expressed genes) which can p…
View article: Oncological safety of submental island flap for reconstruction of pathologically node-negative and node-positive T1–2 oral squamous cell carcinoma-related defects: A retrospective study and comparison of outcomes
Oncological safety of submental island flap for reconstruction of pathologically node-negative and node-positive T1–2 oral squamous cell carcinoma-related defects: A retrospective study and comparison of outcomes Open
SIF is a reliable flap for the reconstruction of OSCC-related small- and medium-sized soft tissue defect. With careful neck dissection and appropriate postoperative adjuvant treatment, the application of SIF did not increase the risk of lo…
View article: [Erratum] Chemoresistance‑related long non‑coding RNA expression profiles in human breast cancer cells
[Erratum] Chemoresistance‑related long non‑coding RNA expression profiles in human breast cancer cells Open
Subsequently to the publication of this article, the authors have noted that the second and third named authors on the paper, Lihua Zeng and Jiahui Chu, were not accredited as being joint first authors on this paper, and equal contributors…
View article: Extranodal intraosseous Rosai–Dorfman disease in the lower jaw: a case report and review of the literature
Extranodal intraosseous Rosai–Dorfman disease in the lower jaw: a case report and review of the literature Open
Rosai–Dorfman disease or sinus histiocytosis is a rare entity which may affect various lymph node groups. Extranodal form is observed in 45 % of cases, facial bone involvement is especially rare. A 62-year old male presented with complaint…
View article: Chemoresistance‑related long non‑coding RNA expression profiles in human breast cancer cells
Chemoresistance‑related long non‑coding RNA expression profiles in human breast cancer cells Open
Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death in females worldwide. Chemoresistance has been a major reason for the drug therapy failure. The present study performed a microarray analysis between…
View article: Contrast-enhanced ultrasound mapping of sentinel lymph nodes in oral tongue cancer—a pilot study
Contrast-enhanced ultrasound mapping of sentinel lymph nodes in oral tongue cancer—a pilot study Open
For oral tongue tumours, CEUS is a feasible and potentially widely available approach of sentinel node mapping. Further clinical research is required to establish the position of CEUS detection of the sentinel nodes in oral cavity cancers.
View article: Imaging diagnostic methods for identification of sentinel lymph nodes in patients with early squamous cell carcinoma of the oral cavity mucosa: a literature review
Imaging diagnostic methods for identification of sentinel lymph nodes in patients with early squamous cell carcinoma of the oral cavity mucosa: a literature review Open
The paper describes properties of clinical visualization approaches which are applied for detection of sentinel lymph nodes in patients suffering from oral cavity squamous cell cancer. Diagnostic efficiency results and technological featur…
View article: LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer
LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer Open
Long noncoding RNA (lncRNA) has been recognized as a regulator of gene expression, and the dysregulation of lncRNAs is involved in the progression of many types of cancer, including epithelial ovarian cancer (EOC). To explore the potential…
View article: Distinct expression profile of lncRNA in endometrial carcinoma
Distinct expression profile of lncRNA in endometrial carcinoma Open
Endometrial carcinoma (EC) is the most common malignancy in women. Dispite its prevalence, the prognosis of endometrial carcinoma still relies on conventional histological type, grade and invasion information. Its morbidity is still increa…
View article: LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer
LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer Open
Triple negative breast cancer (TNBC) is an aggressive type of breast cancer with high heterogeneity. To date, there is no efficient therapy for TNBC patients and the prognosis is poor. It is urgent to find new biomarkers for the diagnosis …
View article: Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer
Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer Open
Introduction Previous studies have produced controversial results regarding whether mesenchymal stem cells (MSCs) promote or inhibit tumor development. Given the dual role of MSCs in inflammation and cancer, in this study the colitis-assoc…