Mingxing Tian
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View article: Pretreatment circulating tumor DNA and tissue genomic profiling concordance in ovarian cancer: a prospective observational study of influencing factors and clinical implications
Pretreatment circulating tumor DNA and tissue genomic profiling concordance in ovarian cancer: a prospective observational study of influencing factors and clinical implications Open
Background: Next-generation sequencing (NGS) of plasma circulating tumor DNA (ctDNA) shows promise as a minimally invasive alternative to tissue sequencing. However, concordance between genomic alterations in tumor tissue and plasma ctDNA …
View article: Pentatricopeptide repeat protein EspX1 facilitates the virulence of avian pathogenic Escherichia coli
Pentatricopeptide repeat protein EspX1 facilitates the virulence of avian pathogenic Escherichia coli Open
Avian pathogenic Escherichia coli (APEC) can infect poultry and cause colibacillosis, leading to significant economic losses in the poultry industry. APEC is similar to human Extraintestinal pathogenic Escherichia coli (ExPEC) in serotype,…
View article: Thermal Circuit Study of Magnetically Controlled Reactors
Thermal Circuit Study of Magnetically Controlled Reactors Open
Magnetic saturated controllable reactors are used a lot in power systems to balance dynamic reactive power, control voltage, and improve power quality, but their internal thermal field is more complicated due to the operating environment a…
View article: Biological Characterization and DIVA Potential of Three Rough Brucella melitensis Vaccine Strains
Biological Characterization and DIVA Potential of Three Rough Brucella melitensis Vaccine Strains Open
Background: Brucellosis is a zoonotic bacterial disease primarily controlled through quarantine, culling, and vaccination. Live attenuated vaccines remain the most effective countermeasure, yet their application is limited by residual viru…
View article: Development of an indirect ELISA based on a new specific lipoprotein LP53 for the detection of antibodies against Mycoplasma synoviae
Development of an indirect ELISA based on a new specific lipoprotein LP53 for the detection of antibodies against Mycoplasma synoviae Open
BACKGROUND: Mycoplasma synoviae (MS) is considered to be one of the main mycoplasma pathogens of poultry, causing arthritis, airsacculitis, eggshell apex abnormalities and production drops in chickens and turkeys. Infection by MS usually r…
View article: Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes
Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes Open
The biotransformation of nanoparticles plays a crucial role in determining their biological fate and responses. Although a few engineering strategies (e.g., surface functionalization and shape control) have been employed to regulate the fa…
View article: Using a novel gene site to develop a duplex real-time TaqMan MGB probe PCR method for the SNP detection and differentiation between the MS-H live vaccine strain and wild-type Mycoplasma synoviae strains
Using a novel gene site to develop a duplex real-time TaqMan MGB probe PCR method for the SNP detection and differentiation between the MS-H live vaccine strain and wild-type Mycoplasma synoviae strains Open
Mycoplasma synoviae (MS) is a globally prevalent avian pathogen responsible for airsacculitis and synovitis. The temperature-sensitive (ts)+ vaccine strain MS-H, a live attenuated variant, is the most effective and widely used vaccine for …
View article: PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE<sup>–/–</sup> Mice
PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE<sup>–/–</sup> Mice Open
Perfluorooctanesulfonate (PFOS), an emerging contaminant with widespread concern, has been associated with the pathogenesis of atherosclerosis (AS). As a substitute for PFOS, sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is extensive…
View article: In silico design of a multi-epitope vaccine against Mycobacterium avium subspecies paratuberculosis
In silico design of a multi-epitope vaccine against Mycobacterium avium subspecies paratuberculosis Open
The widespread chronic enteritis known as Paratuberculosis (PTB) or Johne's disease (JD) is caused by Mycobacterium avium subspecies paratuberculosis (MAP), posing a significant threat to global public health. Given the challenges associat…
View article: Identification of Brucella RS15060 as a novel type IV secretion system effector associated with bacterial virulence
Identification of Brucella RS15060 as a novel type IV secretion system effector associated with bacterial virulence Open
Brucella is an intracellular parasitic pathogen that causes the worldwide zoonotic disease brucellosis. The type IV secretion system (T4SS) is utilized to secrete various effectors to help Brucella form Brucella -containing vacuoles within…
View article: Development and Application of Colloidal Gold Test Strips for the Rapid Detection of Canine Brucellosis
Development and Application of Colloidal Gold Test Strips for the Rapid Detection of Canine Brucellosis Open
Brucellosis is a global problem, with the causative agent being the genus Brucella. B. canis can cause undulant fever in dogs, which is a zoonotic disease that can spread not only among dogs but also to humans. This poses a public health t…
View article: Spatio-temporal heterogeneity of ecological water level in Poyang Lake, China
Spatio-temporal heterogeneity of ecological water level in Poyang Lake, China Open
Anthropogenic activities and climate change have caused physical and ecological changes in lakes and have aggravated water level fluctuations, which are essential factors to consider for nutrient import, ecological protection, and biodiver…
View article: Brucella Manipulates Host Cell Ferroptosis to Facilitate Its Intracellular Replication and Egress in RAW264.7 Macrophages
Brucella Manipulates Host Cell Ferroptosis to Facilitate Its Intracellular Replication and Egress in RAW264.7 Macrophages Open
Brucella virulence relies on its successful intracellular life cycle. Modulating host cell death is a strategy for Brucella to survive and replicate intracellularly. Ferroptosis is a novel regulated cell death characterized by iron-trigger…
View article: The aroA and luxS Double-Gene Mutant Strain Has Potential to Be a Live Attenuated Vaccine against Salmonella Typhimurium
The aroA and luxS Double-Gene Mutant Strain Has Potential to Be a Live Attenuated Vaccine against Salmonella Typhimurium Open
Salmonella Typhimurium (S. Typhimurium) is a zoonotic pathogen posing a threat to animal husbandry and public health. Due to the emergence of antibiotic-resistant strains, alternative prevention and control strategies are needed. Live atte…
View article: Identification and characterization of a plasmid co-harboring blaCTX-M-55 and blaTEM-141 in Escherichia albertii from broiler in China
Identification and characterization of a plasmid co-harboring blaCTX-M-55 and blaTEM-141 in Escherichia albertii from broiler in China Open
The inappropriate use of cephalosporins lead to the occurrence and global spread of bacteria resistant to these antimicrobials. In this study, we isolated four Escherichia albertii strains from broilers in eastern China. The antimicrobial …
View article: Identification and Genomic Analyses of a Multidrug Resistant Avian Pathogenic <i>Escherichia coli</i> Coharboring <i>mcr-1</i>, <i>bla</i><sub>TEM-176</sub> and <i>bla</i><sub>CTX-M-14</sub> Genes
Identification and Genomic Analyses of a Multidrug Resistant Avian Pathogenic <i>Escherichia coli</i> Coharboring <i>mcr-1</i>, <i>bla</i><sub>TEM-176</sub> and <i>bla</i><sub>CTX-M-14</sub> Genes Open
The emergence and transmission of the colistin‐resistance gene mcr and extended‐spectrum β ‐lactamase (ESBL) encoding genes pose a significant threat to global public health. In recent years, it has been reported that mcr-1 and ESBL genes …
View article: The functions of EF-hand proteins from host and zoonotic pathogens
The functions of EF-hand proteins from host and zoonotic pathogens Open
EF-hand proteins not only regulate biological processes, but also influence immunity and infection. In this review, we summarize EF-hand proteins' functions in host and zoonotic pathogens, with details in structures, Ca2+ affinity, downstr…
View article: Research on the Relationship between Vibration Noise and Magnetic Saturation of Magnetic Saturated Controllable Reactor Based on COMSOL
Research on the Relationship between Vibration Noise and Magnetic Saturation of Magnetic Saturated Controllable Reactor Based on COMSOL Open
This article is based on a 2.2 kVar small magnetically saturated controllable reactor (MSCR) prototype and builds a three-dimensional three-field coupling model of its electromagnetic structure acoustics in the finite element simulation so…
View article: Brucella abortus Rough-Type Mutant Induces Ferroptosis and More Oxidative Stress in Infected Macrophages
Brucella abortus Rough-Type Mutant Induces Ferroptosis and More Oxidative Stress in Infected Macrophages Open
Brucella is an intracellular parasitic bacterium that uses multiple strategies to evade the host’s defense mechanisms. However, how Brucella manipulates the host-induced oxidative stress and relevant biological processes are still poorly u…
View article: A lytic phage to control multidrug-resistant avian pathogenic Escherichia coli (APEC) infection
A lytic phage to control multidrug-resistant avian pathogenic Escherichia coli (APEC) infection Open
The inappropriate use of antibiotics has led to the emergence of multidrug-resistant strains. Bacteriophages (phages) have gained renewed attention as promising alternatives or supplements to antibiotics. In this study, a lytic avian patho…
View article: Erythronate utilization activates VdtR regulating its metabolism to promote <i>Brucella</i> proliferation, inducing abortion in mice
Erythronate utilization activates VdtR regulating its metabolism to promote <i>Brucella</i> proliferation, inducing abortion in mice Open
Brucella is a facultative intracellular pathogen that preferentially colonizes reproductive organs and utilizes erythritol as a preferred carbon source for its survival and proliferation. In this study, we identified a v irulence-related D…
View article: AI-2 quorum sensing system contributes fluoroquinolones resistance of Salmonella typhimurium by regulating metabolism
AI-2 quorum sensing system contributes fluoroquinolones resistance of Salmonella typhimurium by regulating metabolism Open
The multidrug-resistant Salmonella is becoming major health threat due to inappropriate use of antibiotics. It is found that the metabolic changes contributed to bacterial drug resistance. AI-2 quorum sensing (QS) is involved in the regula…
View article: Characterization of Brucella abortus Mutant A19mut2, a Potential DIVA Vaccine Candidate with a Modification on Lipopolysaccharide
Characterization of Brucella abortus Mutant A19mut2, a Potential DIVA Vaccine Candidate with a Modification on Lipopolysaccharide Open
Background: Brucella abortus is the main causative agent for bovine brucellosis. B. abortus A19 is a widely used vaccine strain to protect cows from Brucella infection in China. However, A19 has a similar lipopolysaccharide (LPS) antigen t…
View article: Characteristics, pathogenic mechanism, zoonotic potential, drug resistance, and prevention of avian pathogenic Escherichia coli (APEC)
Characteristics, pathogenic mechanism, zoonotic potential, drug resistance, and prevention of avian pathogenic Escherichia coli (APEC) Open
Although most Escherichia coli ( E. coli ) strains are commensal and abundant, certain pathogenic strains cause severe diseases from gastroenteritis to extraintestinal infections. Extraintestinal pathogenic E . coli (ExPEC) contains newbor…