Mingming Xiao
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View article: CPT2 inhibition enhances selective autophagy and proliferation in colorectal cancer via GPAT4-dependent glycerophospholipid biosynthesis
CPT2 inhibition enhances selective autophagy and proliferation in colorectal cancer via GPAT4-dependent glycerophospholipid biosynthesis Open
Metabolic reprogramming is one of the hallmark events in colorectal cancer. Tumor cells adapt to microenvironmental changes by regulating energy and biomaterial metabolism. This study identifys abnormal lipid accumulation and significant d…
View article: Tumor microenvironment phenotyping guides precision therapy in unresectable pancreatic cancer
Tumor microenvironment phenotyping guides precision therapy in unresectable pancreatic cancer Open
Treatment of locally advanced unresectable pancreatic cancer remains a major clinical challenge due to pronounced heterogeneity and resistance to standard regimens. Increasing evidence highlights the critical role of the tumor microenviron…
View article: Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation
Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation Open
Complex microbial interactions occur on the surfaces within the oral cavity, where biofilms form highly organized ecosystems composed of diverse microbial communities and their metabolic products. These biofilms, typically located on the t…
View article: Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer
Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer Open
Background Pancreatic cancer exhibits limited clinical responses to immunotherapy, highlighting the need for new strategies to counteract its immunosuppressive microenvironment. Although metabolic reprogramming and epigenetic changes contr…
View article: Prediction of Seronegative Hashimoto's thyroiditis using machine learning models based on ultrasound radiomics: a multicenter study
Prediction of Seronegative Hashimoto's thyroiditis using machine learning models based on ultrasound radiomics: a multicenter study Open
No. [2023] H013 TRIAL REGISTRATION: Chinese Clinical Trial Registry;CTR2400092179; 12 November 2024.
View article: TPX2 serves as a novel target for expanding the utility of PARPi in pancreatic cancer through conferring synthetic lethality
TPX2 serves as a novel target for expanding the utility of PARPi in pancreatic cancer through conferring synthetic lethality Open
Background PARP inhibitors (PARPi) have been licensed for the maintenance therapy of patients with metastatic pancreatic cancer carrying pathogenic germline BRCA1/2 mutations. However, mutations in BRCA1/2 are notably rare in pancreatic ca…
View article: Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response
Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response Open
Background The activation of the DNA damage response (DDR) heavily relies on post-translational modifications (PTMs) of proteins, which play a crucial role in the prevention of genetic instability and tumorigenesis. Among these PTMs, palmi…
View article: gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination
gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination Open
Adjuvant radiation therapy is a common treatment for breast cancer, yet its effectiveness is often limited by radioresistance in patients. Identifying novel targets to combat this radioresistance is imperative. Recent investigations show t…
View article: Cognition, Attitudes, and Utilization of Artificial Intelligence among Oncologists in China: Cross-Sectional Questionnaire Study (Preprint)
Cognition, Attitudes, and Utilization of Artificial Intelligence among Oncologists in China: Cross-Sectional Questionnaire Study (Preprint) Open
BACKGROUND As cancer incidence continues to rise, oncologists are experiencing escalating work pressure and challenges. In recent years, China has made notable progress in using Artificial Intelligence (AI) technologies, particularly in t…
View article: PP2A complex disruptor SET prompts widespread hypertranscription of growth-essential genes in the pancreatic cancer cells
PP2A complex disruptor SET prompts widespread hypertranscription of growth-essential genes in the pancreatic cancer cells Open
Hyperactivation of the oncogenic transcription reflects the epigenetic plasticity of the cancer cells. Su(var)3-9, enhancer of zeste, Trithorax (SET) was described as a nuclear factor that stimulated transcription from the chromatin templa…
View article: AI-Assisted Ultrasound for the Early Diagnosis of Antibody-Negative Autoimmune Thyroiditis
AI-Assisted Ultrasound for the Early Diagnosis of Antibody-Negative Autoimmune Thyroiditis Open
The prevalence of antibody-negative chronic autoimmune thyroiditis (SN-CAT) is increasing. The early diagnosis of SN-CAT can effectively prevent its further development. Thyroid ultrasound can diagnose autoimmune thyroiditis and predict hy…
View article: The Accurate Interpretation and Clinical Significance of Morphological Features of Fine Needle Aspiration Cells in Papillary Thyroid Carcinoma
The Accurate Interpretation and Clinical Significance of Morphological Features of Fine Needle Aspiration Cells in Papillary Thyroid Carcinoma Open
Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid gland; fine needle aspiration cytology is the most basic and reliable diagnostic method before PTC operation. However, it is not clear which cell morpho…
View article: Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy
Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy Open
Protein palmitoylation is an increasingly investigated form of post-translational lipid modification that affects protein localization, accumulation, secretion and function. Recently, emerging findings have revealed that protein palmitoyla…
View article: Comparison of nickle release and cytocompatibility between porous and dense NiTi alloy
Comparison of nickle release and cytocompatibility between porous and dense NiTi alloy Open
The porous NiTi (pNiTi) samples were produced by sintering evaporation using Ti−50.8Ni (at.%) gas-atomized powders. The samples were analyzed by metallographic microscope and X-ray dispersive spectroscopy (XRD). A comparison of nickel (Ni)…
View article: Role of BCLAF‐1 in PD‐L1 stabilization in response to ionizing irradiation
Role of BCLAF‐1 in PD‐L1 stabilization in response to ionizing irradiation Open
Programmed cell death ligand 1 (PD‐L1) is a major immunosuppressive checkpoint protein expressed by tumor cells to subvert anticancer immunity. Recent studies have shown that ionizing radiation (IR) upregulates the expression of PD‐L1 in t…
View article: Uncovering the Subtype-Specific Molecular Characteristics of Breast Cancer by Multiomics Analysis of Prognosis-Associated Genes, Driver Genes, Signaling Pathways, and Immune Activity
Uncovering the Subtype-Specific Molecular Characteristics of Breast Cancer by Multiomics Analysis of Prognosis-Associated Genes, Driver Genes, Signaling Pathways, and Immune Activity Open
Breast cancer is a heterogeneous malignant disease with different prognoses and has been divided into four molecular subtypes. It is believed that molecular events occurring in breast stem/progenitor cells contribute to the carcinogenesis …
View article: The prognostic value and immunological role of the small mother against decapentaplegic proteins in kidney renal clear cell carcinoma
The prognostic value and immunological role of the small mother against decapentaplegic proteins in kidney renal clear cell carcinoma Open
Our findings indicate that SMAD1, 2, 3, 4 and 6 were potent biomarkers for predicting the prognosis and immune cell infiltration of KIRC patients.
View article: A deep learning algorithm using CT images to screen for Corona virus disease (COVID-19)
A deep learning algorithm using CT images to screen for Corona virus disease (COVID-19) Open
Objective The outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has caused more than 26 million cases of Corona virus disease (COVID-19) in the world so far. To control the spread of the disease, screening large numb…
View article: Bioinformatics Analysis of the Prognostic and Biological Significance of ZDHHC-Protein Acyltransferases in Kidney Renal Clear Cell Carcinoma
Bioinformatics Analysis of the Prognostic and Biological Significance of ZDHHC-Protein Acyltransferases in Kidney Renal Clear Cell Carcinoma Open
ZDHHC-protein acyltransferases (ZDHHCs) are a family of 23 signature Asp-His-His-Cys (DHHC) domain-containing enzymes that mediate palmitoylation by covalent attachment of the 16-carbon fatty acid palmitate to thiol groups of specific cyst…