Mingqi Zhao
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View article: Dihydro-R demonstrates innate immunity against Adenovirus-7 by suppressing the NF-κB/JAK-STAT pathway in a SIRT1-dependent manner
Dihydro-R demonstrates innate immunity against Adenovirus-7 by suppressing the NF-κB/JAK-STAT pathway in a SIRT1-dependent manner Open
Severe adenovirus infections pose significant health challenges, particularly in immunocompromised individuals. This study characterizes the antiviral activity of dihydro-resveratrol (Dihydro-R) against adenovirus type 7 and reveals a SIRT…
View article: Burn scar pain: from mechanisms to treatments
Burn scar pain: from mechanisms to treatments Open
Chronic scars and pain following burns not only impair patients’ quality of life but also resist current empirical treatments, highlighting an urgent need for mechanism-based therapies. Early studies have characterized key mediators of sca…
View article: Selenomethionine Inhibited RSV Infection-Induced Apoptosis and Inflammatory Response through ROS-Mediated Signaling Pathway
Selenomethionine Inhibited RSV Infection-Induced Apoptosis and Inflammatory Response through ROS-Mediated Signaling Pathway Open
Respiratory syncytial virus (RSV) is the leading pathogen of acute lower respiratory tract infections in children under 5 years of age worldwide. Respiratory syncytial virus pneumonia in infants and children causes more deaths than influen…
View article: Elevated IL-8 and abnormal Lymphocytes in pediatric primary Sjögren's syndrome: A single-center study
Elevated IL-8 and abnormal Lymphocytes in pediatric primary Sjögren's syndrome: A single-center study Open
Background: Cytokines and lymphocytes orchestrating the pathophysiological landscape have been well explored in adults but are rare in children with Sjögren's syndrome. We aimed to assess their potential as biomarkers in pediatric Sjögren'…
View article: Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis
Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis Open
Liver fibrosis is induced by persistent stimulation of various factors, resulting from complex multicellular interactions and multifactorial networks. Without intervention, it can progress to cirrhosis and even liver cancer. Current unders…
View article: A Water‐Triggered Sensor for Self‐Powered Flood Alarming
A Water‐Triggered Sensor for Self‐Powered Flood Alarming Open
Devastating natural disasters are prompting the need for effective early warning systems. The warning systems relying on cables or batteries are much expensive and not suitable for low‐lying areas or remote environments. This research prop…
View article: A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1
A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1 Open
Our data show that METTL3-mediated m6A modification of YY1 plays a crucial role in RILI pathogenesis, and IGF2BP1 serves as an essential mediator for the stability of YY1 mRNA.
View article: GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity
GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity Open
GTPase IMAP family member 8 (GIMAP8) plays a key role in pathophysiology of several malignancies. The objective of this current research endeavor was to investigate the prognosis value of GIMAP8 in lung adenocarcinoma and examine how it re…
View article: Prefrontal Internal Event‐Driven Analysis of Dynamical Electroencephalographic Biomarkers in Depression During Emotional Auditory Task
Prefrontal Internal Event‐Driven Analysis of Dynamical Electroencephalographic Biomarkers in Depression During Emotional Auditory Task Open
Aims This study for the first time proposed a novel prefrontal internal event‐driven analytic framework for electroencepalography (EEG) data, which aim to dynamically resolve neural processes during natural emotional auditory tasks. Method…
View article: E-DANN: An Enhanced Domain Adaptation Network for Audio-EEG Feature Decoupling in Explainable Depression Recognition
E-DANN: An Enhanced Domain Adaptation Network for Audio-EEG Feature Decoupling in Explainable Depression Recognition Open
Given the significant global health burden caused by depression, numerous studies have utilized artificial intelligence techniques to objectively and automatically detect depression. However, existing research primarily focuses on improvin…
View article: Correction: Li et al. Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway. Nutrients 2024, 16, 1966
Correction: Li et al. Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway. Nutrients 2024, 16, 1966 Open
In the original publication [...]
View article: Radiation-induced YAP/TEAD4 binding confers non-small cell lung cancer radioresistance via promoting NRP1 transcription
Radiation-induced YAP/TEAD4 binding confers non-small cell lung cancer radioresistance via promoting NRP1 transcription Open
Despite the importance of radiation therapy as a non-surgical treatment for non-small cell lung cancer (NSCLC), radiation resistance has always been a concern, due to poor patient response and prognosis. Therefore, it is crucial to uncover…
View article: Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway
Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway Open
Adenovirus (HAdV) can cause severe respiratory infections in children and immunocompromised patients. There is a lack of specific therapeutic drugs for HAdV infection, and the study of anti-adenoviral drugs has far-reaching clinical implic…
View article: Brain Networks Modulation during Simple and Complex Gait: A “Mobile Brain/Body Imaging” Study
Brain Networks Modulation during Simple and Complex Gait: A “Mobile Brain/Body Imaging” Study Open
Walking encompasses a complex interplay of neuromuscular coordination and cognitive processes. Disruptions in gait can impact personal independence and quality of life, especially among the elderly and neurodegenerative patients. While tra…
View article: Enhancement of the Tumor Suppression Effect of High-dose Radiation by Low-dose Pre-radiation Through Inhibition of DNA Damage Repair and Increased Pyroptosis
Enhancement of the Tumor Suppression Effect of High-dose Radiation by Low-dose Pre-radiation Through Inhibition of DNA Damage Repair and Increased Pyroptosis Open
Radiation therapy has been a critical and effective treatment for cancer. However, not all cells are destroyed by radiation due to the presence of tumor cell radioresistance. In the current study, we investigated the effect of low-dose rad…
View article: Selenadiazole Inhibited Adenovirus-Induced Apoptosis through the Oxidative-Damage-Mediated Bcl-2/Stat 3/NF-κB Signaling Pathway
Selenadiazole Inhibited Adenovirus-Induced Apoptosis through the Oxidative-Damage-Mediated Bcl-2/Stat 3/NF-κB Signaling Pathway Open
Human adenovirus type 7 (HAdV7) infection causes severe pneumonia, yet there are still no breakthroughs in treatment options for adenovirus, and the road to antiviral drug development faces major challenges. We attempted to find new drugs …
View article: Early modulations of neural oscillations during the processing of emotional body language
Early modulations of neural oscillations during the processing of emotional body language Open
The processing of threat‐related emotional body language (EBL) has been shown to engage sensorimotor cortical areas early on and induce freezing in the observers' motor system, particularly when observing fearful EBL. To provide insights i…
View article: Resveratrol Demonstrates Innate Immunity Against Adenovirus-7 by Suppressing the NF-κB/JAK-STAT Pathway in a SIRT1-Dependent Manner
Resveratrol Demonstrates Innate Immunity Against Adenovirus-7 by Suppressing the NF-κB/JAK-STAT Pathway in a SIRT1-Dependent Manner Open
The increasing incidence of severe adenovirus cases underscores the imperative for efficacious anti-adenovirus medications, given the current absence of targeted therapeutic options. This study explores the potential antiviral effects of t…
View article: 5‐Nitrobenzo[c][1, 2, 5]selenadiazole as therapeutic agents in the regulation of oxidative stress and inflammation induced by influenza A(H1N1)pdm09 in vitro and in vivo
5‐Nitrobenzo[c][1, 2, 5]selenadiazole as therapeutic agents in the regulation of oxidative stress and inflammation induced by influenza A(H1N1)pdm09 in vitro and in vivo Open
Currently, various problems are being faced in the treatment of influenza, so the development of new safe and effective drugs is crucial. Selenadiazole, an important component of selenium heterocyclic compounds, has received wide attention…
View article: Inhibition of H3N2 Influenza Virus Induced Apoptosis by Selenium Nanoparticles with Chitosan through ROS-Mediated Signaling Pathways
Inhibition of H3N2 Influenza Virus Induced Apoptosis by Selenium Nanoparticles with Chitosan through ROS-Mediated Signaling Pathways Open
In recent years, nanotechnology has received more and more attention in the antiviral field. Among them, selenium nanoparticles (SeNPs) have received a lot of attention. Chitosan, as a substance with antiviral effect, is limited by water s…