Miao He
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View article: Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation
Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation Open
Metabolic syndrome increases the risk of endometrial cancer development and progression, but the mechanism remains unclear. We find that polyamine metabolites are notably elevated in the sera and tumor tissues of endometrial cancer patient…
View article: Impact of meteorological factors on influenza incidence in Wuxi from 2014 to 2019: a time series and comprehensive analysis
Impact of meteorological factors on influenza incidence in Wuxi from 2014 to 2019: a time series and comprehensive analysis Open
Background Although the association between meteorological factors and influenza was numerously documented, the results are inconsistent, requiring a meta-analysis for synthesis. A recent analysis of the association between influenza and m…
View article: Enhanced anti-cancer effect of AMTB hydrochloride via chitosan nanoparticles in pancreatic cancer
Enhanced anti-cancer effect of AMTB hydrochloride via chitosan nanoparticles in pancreatic cancer Open
Pancreatic cancer is a malignancy with poor prognosis and high mortality. This study investigated the use of chitosan nanoparticles (CS-NPs) to encapsulate AMTB, a TRPM8 inhibitor, as a novel strategy to enhance therapeutic efficacy in pan…
View article: Impact of meteorological factors on influenza incidence in Wuxi from 2014 to 2019: a time series and comprehensive analysis
Impact of meteorological factors on influenza incidence in Wuxi from 2014 to 2019: a time series and comprehensive analysis Open
Background Although the association between meteorological factors and influenza was numerously documented, it has not been comprehensively studied. A recent analysis of the association between influenza and meteorological factors was cond…
View article: Cytogenetics and genomics analysis of cold‐hardy perennial wheatgrass: insights into agronomic performance, chromosome composition, and gene expression
Cytogenetics and genomics analysis of cold‐hardy perennial wheatgrass: insights into agronomic performance, chromosome composition, and gene expression Open
SUMMARY Intermedium wheatgrass ( Thinopyrum intermedium ), a perennial species with extensive root systems and high tolerance to cold, drought, and salinity, is a valuable genetic resource for the development of perennial crops. Over a dec…
View article: Identification and Functional Analysis of Novel Mutations in <i>AXIN2</i> and <i>LRP6</i> Linked With Non‐Syndromic Tooth Agenesis
Identification and Functional Analysis of Novel Mutations in <i>AXIN2</i> and <i>LRP6</i> Linked With Non‐Syndromic Tooth Agenesis Open
Background Tooth agenesis (TA) ranks among the most common dental abnormalities. This study aimed to explore the etiology and pathogenesis in Chinese families with non‐syndromic TA. Methods Chinese families exhibiting non‐syndromic TA were…
View article: GenCLS++: Pushing the Boundaries of Generative Classification in LLMs Through Comprehensive SFT and RL Studies Across Diverse Datasets
GenCLS++: Pushing the Boundaries of Generative Classification in LLMs Through Comprehensive SFT and RL Studies Across Diverse Datasets Open
As a fundamental task in machine learning, text classification plays a crucial role in many areas. With the rapid scaling of Large Language Models (LLMs), particularly through reinforcement learning (RL), there is a growing need for more c…
View article: Budesonide/glycopyrronium/formoterol fumarate co-suspension metered dose inhaler relieves cough after lobectomy: a randomized controlled study
Budesonide/glycopyrronium/formoterol fumarate co-suspension metered dose inhaler relieves cough after lobectomy: a randomized controlled study Open
Clinicaltrials.gov. Clinical Trial Registry Number: NCT05472350.
View article: Exome analyses unravel the genetic architecture of Mendelian dominant nonsyndromic orofacial clefts
Exome analyses unravel the genetic architecture of Mendelian dominant nonsyndromic orofacial clefts Open
Nonsyndromic orofacial clefts (NSOFC) represents a prevalent congenital anomalies, the etiology of which likely involves a complex interplay between genetic and environmental factors. To elucidate potential pathogenic variants, exome seque…
View article: Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21<sup>+</sup>CD86<sup>+</sup> Microglia
Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21<sup>+</sup>CD86<sup>+</sup> Microglia Open
Stroke remains the leading cause of neurological mortality and disability worldwide, with post‐stroke inflammation significantly hindering neural repair. Despite its critical impact, mechanism‐based therapeutic strategies are scarce. In th…
View article: Improved split prime editors enable efficient in vivo genome editing
Improved split prime editors enable efficient in vivo genome editing Open
Efficient prime editor (PE) delivery in vivo is critical for realizing its full potential in disease modeling and therapeutic correction. Although PE has been divided into two halves and delivered using dual adeno-associated viruses (AAVs)…
View article: Research on Virtual Screening of Natural Compounds Against Protozoan Parasites Using Comparative Genomics and Molecular Docking Techniques
Research on Virtual Screening of Natural Compounds Against Protozoan Parasites Using Comparative Genomics and Molecular Docking Techniques Open
This study aims to identify conserved drug targets in protozoan parasites through genomic data mining and use computational virtual screening to discover small molecule inhibitors from the TCMSP database that target these conserved drug ta…
View article: Improved split prime editors enable efficient in vivo genome editing
Improved split prime editors enable efficient in vivo genome editing Open
Prime editor (PE) is a precise genome-editing tool that enables all 12 possible base-to-base conversions, as well as insertions and deletions, that does not require DSBs or donor DNA. The efficient delivery of prime editors in vivo is crit…
View article: Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections
Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections Open
Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate the formation of TLS. However, the role of TLS in immune respons…
View article: Anxiety disorders: Treatments, models, and circuitry mechanisms
Anxiety disorders: Treatments, models, and circuitry mechanisms Open
Anxiety disorders are one of the most prevalent mental health conditions worldwide, imposing a significant burden on individuals affected by them and society in general. Current research endeavors aim to enhance the effectiveness of existi…
View article: Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity Open
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wi…
View article: A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure Open
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–s…
View article: Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids Open
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wi…
View article: Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries Open
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for…
View article: Reconstitution of RNA cap methylation reveals different features of SARS‐CoV‐2 and SARS‐CoV methyltransferases
Reconstitution of RNA cap methylation reveals different features of SARS‐CoV‐2 and SARS‐CoV methyltransferases Open
Cap RNA methylations play important roles in the replication, evasion of host RNA sensor recognition, and pathogenesis. Coronaviruses possess both guanine N7‐ and 2′‐O‐ribose methyltransferases (N7‐MTase and 2′‐O‐MTase) encoded by nonstruc…
View article: Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator
Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator Open
A dual-enzyme-responsive indicator for the non-invasive diagnosis of bacterial and non-bacterial inflammations has been developed. This indicator responds to NAD(P)H and NTR in inflammations, emitting two distinct turn-on fluorescence sign…
View article: NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication
NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication Open
Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and liver cancer, despite strong prevention and treatment efforts. The study of the epigenetic modification of HBV has become a research hotspot, including the N…
View article: Genome‐wide meta‐analyses identify five new risk loci for nonsyndromic orofacial clefts in the Chinese Han population
Genome‐wide meta‐analyses identify five new risk loci for nonsyndromic orofacial clefts in the Chinese Han population Open
Background Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial birth malformations in humans and are generally classified as nonsyndromic cleft lip with or without cleft palate (NSCL/P) and nonsyndromic cleft palate onl…
View article: Mutation analysis in patients with nonsyndromic tooth agenesis using exome sequencing
Mutation analysis in patients with nonsyndromic tooth agenesis using exome sequencing Open
Background Tooth agenesis (TA) is a congenital abnormality that may present as syndromic or nonsyndromic. Considering its complex genetic aetiology, the aim of this study was to uncover the pathogenic mutants in patients with nonsyndromic …
View article: Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice
Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice Open
Background Commitment of mouse dental papilla cells (mDPCs) to the odontoblast lineage is critical for dentin formation, and this biological process is regulated by a complex transcription factor network. The transcription factor Mycn is a…