Ming‐Rong Zhang
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View article: Evaluation of [11C]cyanide as a potential probe for imaging thiocyanate efflux system in the brain
Evaluation of [11C]cyanide as a potential probe for imaging thiocyanate efflux system in the brain Open
View article: Preparation and property of zirconium-89 radiolabeled IgG2-type antibody with hydrolyzed glycan moieties
Preparation and property of zirconium-89 radiolabeled IgG2-type antibody with hydrolyzed glycan moieties Open
View article: Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain
Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain Open
Histone deacetylase 6 (HDAC6) is a crucial target for the development of pharmaceuticals used in the treatment of neurodegenerative disorders. Here, we identified 16a as a candidate of positron emission tomography (PET) tracer for H…
View article: Pharmacological potentiation of Nav1.1 channels in interneurons mitigates tau depositions and neuronal death in a mouse model of neurodegenerative dementias
Pharmacological potentiation of Nav1.1 channels in interneurons mitigates tau depositions and neuronal death in a mouse model of neurodegenerative dementias Open
Epileptiform discharges and neuronal hyperexcitability are key pathophysiological features of Alzheimer’s disease and related tauopathies. We previously identified selective dynfuntion of parvalbumin-positive GABAergic interneurons (PV neu…
View article: Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging
Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging Open
Dysfunction of cyclic nucleotide phosphodiesterase 7 (PDE7) has been associated with excess intracellular cAMP concentrations, fueling pathogenic processes that are implicated in neurodegenerative disorders. This study aimed to develop a s…
View article: Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications
Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications Open
Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, a…
View article: Evaluation of myocardial fibrosis and wall motion abnormality with 68Ga-FAPI PET/MR in coronary heart disease
Evaluation of myocardial fibrosis and wall motion abnormality with 68Ga-FAPI PET/MR in coronary heart disease Open
View article: Trithiol ligand provides tumor-targeting 191Pt-complexes with high molar activity and promising in vivo properties
Trithiol ligand provides tumor-targeting 191Pt-complexes with high molar activity and promising in vivo properties Open
Purpose: The Auger electron-emitting radionuclide 191Pt is a promising candidate for radiopharmaceutical therapy. Herein, we explored novel labeling methods for 191Pt using thiol-containing ligands to improve the in vivo stability and targ…
View article: Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays
Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays Open
INTRODUCTION Late‐life mood disorders (LLMDs) may represent prodromal manifestations of neurodegenerative dementia; however, the neuropathological basis of LLMDs, including depression and bipolar disorder, remains unclear. We aimed to inve…
View article: A Cyclic Peptide‐Based Radiotheranostic Agent for Urokinase‐Type Plasminogen Activator in Tumors
A Cyclic Peptide‐Based Radiotheranostic Agent for Urokinase‐Type Plasminogen Activator in Tumors Open
The plasminogen activator system is critically involved in tumor progression regulation. Aberrant activation of urokinase‐type plasminogen activator (uPA) induces proteolytic degradation of cellular membranes and the extracellular matrix, …
View article: Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, 18F-SPAL-T-06 and 18F-C05-05
Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, 18F-SPAL-T-06 and 18F-C05-05 Open
View article: IN VIVO CLASSIFICATION OF TAU PATHOLOGIES BY POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH FRONTOTEMPORAL DEMENTIA
IN VIVO CLASSIFICATION OF TAU PATHOLOGIES BY POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH FRONTOTEMPORAL DEMENTIA Open
Background Frontotemporal dementia (FTD) is a group of neurodegenerative disorders with diverse clinical and neuropathological features. In vivo neuropathological assessments of FTD at an individual level have not hitherto been successful.…
View article: A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy
A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy Open
View article: Evaluation of the Gly-Phe-Lys Linker to Reduce the Renal Radioactivity of a [<sup>64</sup>Cu]Cu-Labeled Multimeric cRGD Peptide
Evaluation of the Gly-Phe-Lys Linker to Reduce the Renal Radioactivity of a [<sup>64</sup>Cu]Cu-Labeled Multimeric cRGD Peptide Open
Radiometal-labeled peptide-based radiopharmaceuticals (RLPB-radiopharmaceuticals) are promising for cancer imaging and targeted radiotherapy; however, their effectiveness is often compromised by the high retention of nonspecific radioactiv…
View article: <i>SLC9A6</i> -Linked Parkinson Syndrome in Female Heterozygotes Is Associated With PET-Detectable Tau Pathology
<i>SLC9A6</i> -Linked Parkinson Syndrome in Female Heterozygotes Is Associated With PET-Detectable Tau Pathology Open
Our 18F-florzolotau PET analysis revealed greater tau accumulation in the striatum of heterozygous women with SLC9A6 mutation associated with worsening extrapyramidal symptom severity. The heterozygosity of loss-of-functi…
View article: Mineral Reaction Kinetics During Water–Rock Interactions of Julong Hot Springs, Northern China
Mineral Reaction Kinetics During Water–Rock Interactions of Julong Hot Springs, Northern China Open
To elucidate the water–rock interaction mechanisms of the Julong Hot Springs in Changbai Mountain, this study first analyzed the leaching patterns of hydrochemical components in water–rock interactions. The PHREEQC software was then utiliz…
View article: Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models
Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models Open
Non-invasive determination of amyloid-β peptide (Aβ) and tau deposition are important for early diagnosis and therapeutic intervention for Alzheimer's disease (AD) and non-AD tauopathies. In the present study, we investigated the capacity …
View article: Comparative Analysis of Two Soybean Cultivars Revealed Tolerance Mechanisms Underlying Soybean Adaptation to Flooding
Comparative Analysis of Two Soybean Cultivars Revealed Tolerance Mechanisms Underlying Soybean Adaptation to Flooding Open
Flooding stress poses a significant challenge to soybean cultivation, impacting plant growth, development, and ultimately yield. In this study, we investigated the responses of two distinct soybean cultivars: flooding-tolerant Nanxiadou 38…
View article: Development of a Candidate <sup>11</sup>C-Labeled Selective Phosphodiesterase 1 Radioligand for Positron Emission Tomography
Development of a Candidate <sup>11</sup>C-Labeled Selective Phosphodiesterase 1 Radioligand for Positron Emission Tomography Open
Phosphodiesterases (PDEs) constitute a superfamily of phosphohydrolytic enzymes that regulate intracellular second messenger signaling by hydrolyzing cyclic adenosine monophosphate and cyclic guanosine monophosphate. Among the 11 subfamili…
View article: Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder
Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder Open
View article: SnoRNAs: The promising targets for anti-tumor therapy
SnoRNAs: The promising targets for anti-tumor therapy Open
Recently, small nucleolar RNAs (snoRNAs) have transcended the genomic "noise" to emerge as pivotal molecular markers due to their essential roles in tumor progression. Substantial evidence indicates a strong association between snoRNAs and…
View article: l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis
l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis Open
Inhibiting glutamine metabolism has been proposed as a potential treatment strategy for improving non-alcoholic steatohepatitis (NASH). However, effective methods for assessing dynamic metabolic responses during interventions targeting glu…
View article: Malic enzymes in cancer: Regulatory mechanisms, functions, and therapeutic implications
Malic enzymes in cancer: Regulatory mechanisms, functions, and therapeutic implications Open
Malic enzymes (MEs) are metabolic enzymes that catalyze the oxidation of malate to pyruvate and NAD(P)H. While researchers have well established the physiological metabolic roles of MEs in organisms, recent research has revealed a link bet…
View article: Enhanced radiotheranostic targeting of integrin α5β1 with PEGylation-enabled peptide multidisplay platform (PEGibody): A strategy for prolonged tumor retention with fast blood clearance
Enhanced radiotheranostic targeting of integrin α5β1 with PEGylation-enabled peptide multidisplay platform (PEGibody): A strategy for prolonged tumor retention with fast blood clearance Open
Peptide-based radiopharmaceuticals targeting integrin α5β1 show promise for precise tumor diagnosis and treatment. However, current peptide-based radioligands that target α5β1 demonstrate inadequate in vivo
View article: 64Cu2+ Complexes of Tripodal Amine Ligands’ In Vivo Tumor and Liver Uptakes and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line TFK-1: A Basic Comparative Study
64Cu2+ Complexes of Tripodal Amine Ligands’ In Vivo Tumor and Liver Uptakes and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line TFK-1: A Basic Comparative Study Open
Copper (Cu) is a critical element for cancer cell proliferation and considerably accumulates in the nucleus. 64Cu2+ is an anticancer radiopharmaceutical that targets the copper requirement of cancer cells. However, intravenously injected 6…
View article: Imaging α-synuclein pathologies in animal models and patients with Parkinson’s and related diseases
Imaging α-synuclein pathologies in animal models and patients with Parkinson’s and related diseases Open
View article: Frontispiece: Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers (EXP2 3/2024)
Frontispiece: Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers (EXP2 3/2024) Open
View article: <sup>64</sup>Cu<sup>2+ </sup>Complexes of Tripodal Amine Ligands on In Vivo Tumor and Liver Uptake and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line TFK-1: A Basic Comparative Study
<sup>64</sup>Cu<sup>2+ </sup>Complexes of Tripodal Amine Ligands on In Vivo Tumor and Liver Uptake and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line TFK-1: A Basic Comparative Study Open
Copper (Cu) is a critical element for cancer cell proliferation and considerably accumulates in the nucleus. 64Cu2+ is an anticancer radiopharmaceuticals targeting the copper requirement of cancer cells. However, intravenously injected 64C…
View article: <i>In Vivo</i> Assessment of Astrocyte Reactivity in Patients with Progressive Supranuclear Palsy
<i>In Vivo</i> Assessment of Astrocyte Reactivity in Patients with Progressive Supranuclear Palsy Open
Objective Although astrocytic pathology is a pathological hallmark of progressive supranuclear palsy (PSP), its pathophysiological role remains unclear. This study aimed to assess astrocyte reactivity in vivo in patients with PSP. Furtherm…
View article: Combined positron emission tomography‐guided modified black phosphorus nanosheet‐based photothermal therapy and anti programmed cell death protein ligand 1 therapy
Combined positron emission tomography‐guided modified black phosphorus nanosheet‐based photothermal therapy and anti programmed cell death protein ligand 1 therapy Open
Background Patients with cold tumors gain limited benefits from immune checkpoint blockade (ICB) therapy owing to low programmed cell death protein ligand 1 (PD‐L1) expression and minimal immune cell infiltration. Mild photothermal therapy…