Min Peng
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View article: Persistent Leukoencephalopathy Following <scp>H</scp> 1 <scp>N</scp> 1 Infection Associated With a Novel <scp>MYRF</scp> Variant (p. <scp>G</scp> ly735 <scp>A</scp> sp)
Persistent Leukoencephalopathy Following <span>H</span> 1 <span>N</span> 1 Infection Associated With a Novel <span>MYRF</span> Variant (p. <span>G</span> ly735 <span>A</span> sp) Open
Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical …
View article: RAD51 is chromatin enriched and targetable in BRCA1-deficient cells
RAD51 is chromatin enriched and targetable in BRCA1-deficient cells Open
BRCA1 mutant cancers are homologous recombination (HR) deficient, and their sensitivity to anti-cancer therapies such as poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) has long been attributed to this defect. Accordingly, the HR ma…
View article: Volatile organic compounds in exhaled human breath for the diagnosis of malignant pleural mesothelioma: a meta-analysis
Volatile organic compounds in exhaled human breath for the diagnosis of malignant pleural mesothelioma: a meta-analysis Open
Objective Malignant pleural mesothelioma (MPM) is a relatively rare thoracic tumor with a high mortality rate, making early diagnosis and treatment challenging. The present study evaluated the utility of exhaled volatile organic compounds …
View article: BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells
BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells Open
In chronic viral infections, sustained CD8+ T cell response relies on TCF1+ precursor-exhausted T cells (TPEX) exhibiting stem-like properties. TPEX self-renew and respond to PD-1 blockade, underscoring their paramount importance. However,…
View article: TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness
TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness Open
In mammalian cells, endoplasmic reticulum (ER) passively releases Ca 2+ under steady state, but channels involved remain elusive. Here, we report that TMEM41B, an ER-resident membrane protein critical for autophagy, lipid metabolism, and v…
View article: One Size doesn't Fit All: A Personalized Conversational Tutoring Agent for Mathematics Instruction
One Size doesn't Fit All: A Personalized Conversational Tutoring Agent for Mathematics Instruction Open
Large language models (LLMs) have been increasingly employed in various intelligent educational systems, simulating human tutors to facilitate effective human-machine interaction. However, previous studies often overlook the significance o…
View article: Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disease zebrafish models.
Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disease zebrafish models. Open
Preclinical evaluation of zag demonstrated its safety, significant protection of neuromuscular dysfunction and/or acute RC stressor-induced decompensation, and improved mitochondrial physiology across multiple different genetic and/or phar…
View article: Association Between Blood Urea Nitrogen and Delirium in Critically Ill Elderly Patients Without Kidney Diseases: A Retrospective Study and Mendelian Randomization Analysis
Association Between Blood Urea Nitrogen and Delirium in Critically Ill Elderly Patients Without Kidney Diseases: A Retrospective Study and Mendelian Randomization Analysis Open
Objective This study investigates the association between blood urea nitrogen (BUN) levels and the risk of delirium in critically ill elderly patients without kidney disease. Methods A retrospective analysis was conducted using data from t…
View article: Targeted protein degradation via CAR endocytosis of antigen in T cells
Targeted protein degradation via CAR endocytosis of antigen in T cells Open
Targeted protein degradation (TPD) relies on molecules engaging host protein degradation machinery. Here, we developed a novel TPD platform based on antigen endocytosis and degradation by chimeric antigen receptor (CAR) T cells. T cells ex…
View article: FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron Open
Small extracellular vesicles (sEVs) contain abundant circular RNAs (circRNAs) and are involved in cellular processes, particularly hypoxia. However, the process that packaging of circRNAs into neuronal sEVs under hypoxia is unclear. This s…
View article: Reconciling host-microbiota metabolic incompatibility safeguards male fertility
Reconciling host-microbiota metabolic incompatibility safeguards male fertility Open
The symbiotic relationship between the host and microbiota is widely acknowledged as mutually beneficial. However, due to significant differences in metabolic substrates and products between prokaryotic bacteria and mammalian cells, mechan…
View article: Fire acupuncture for plaque psoriasis case series
Fire acupuncture for plaque psoriasis case series Open
Objective: To investigate the clinical efficacy of fire acupuncture (FA) on plaque psoriasis (PP), exploring its suitable syndrome types, in order to achieve better therapeutic effects, accelerate the possibility of psoriasis skin lesion r…
View article: Case report: A germline CHEK1 c.613 + 2T>C leads to a splicing error in a family with multiple cancer patients
Case report: A germline CHEK1 c.613 + 2T>C leads to a splicing error in a family with multiple cancer patients Open
Background Genome instability plays a crucial role in promoting tumor development. Germline mutations in genes responsible for DNA repair are often associated with familial cancer syndromes. A noticeable exception is the CHEK1 gene. Despit…
View article: FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells
FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells Open
The effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi) in creating single-stranded DNA gaps and inducing sensitivity requires the FANCJ DNA helicase. Yet, how FANCJ relates to PARP1 inhibition or trapping, which contribute to…
View article: No Language is an Island: Unifying Chinese and English in Financial Large Language Models, Instruction Data, and Benchmarks
No Language is an Island: Unifying Chinese and English in Financial Large Language Models, Instruction Data, and Benchmarks Open
While the progression of Large Language Models (LLMs) has notably propelled financial analysis, their application has largely been confined to singular language realms, leaving untapped the potential of bilingual Chinese-English capacity. …
View article: Induction of immortal-like and functional CAR T cells by defined factors
Induction of immortal-like and functional CAR T cells by defined factors Open
Long-term antitumor efficacy of chimeric antigen receptor (CAR) T cells depends on their functional persistence in vivo. T cells with stem-like properties show better persistence, but factors conferring bona fide stemness to T cells remain…
View article: FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells
FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells Open
SUMMARY Single-stranded DNA gaps are postulated to be fundamental to the mechanism of anti-cancer drugs. Gaining insights into their induction could therefore be pivotal for advancing therapeutic strategies. For poly (ADP-ribose) polymeras…
View article: TMEM41B is an endoplasmic reticulum Ca<sup>2+</sup>release channel maintaining T cell metabolic quiescence and responsiveness
TMEM41B is an endoplasmic reticulum Ca<sup>2+</sup>release channel maintaining T cell metabolic quiescence and responsiveness Open
SUMMARY Naive T cells are metabolically quiescent. Here, we report an unexpected role of endoplasmic reticulum (ER) Ca 2+ in preserving T cell metabolic quiescence. TMEM41B, an ER-resident membrane protein previously known for its crucial …
View article: Induction of immortal-like and functional CAR-T cells by defined factors
Induction of immortal-like and functional CAR-T cells by defined factors Open
Long-term antitumor efficacy of chimeric antigen receptor (CAR)-T cells depends on their functional persistence in vivo. T cells with stem-like property show better persistence, but factors conferring T cells bona fide stemness remain to b…
View article: One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice
One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice Open
Summary The majority of common chronic human diseases are incurable, which affect a large portion of population and require life-long treatments that impose huge disease, economic and social burden. For example, asthma is the most common r…
View article: VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival
VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival Open
Ca2+ in endoplasmic reticulum (ER) dictates T cell activation, proliferation, and function via store-operated Ca2+ entry. How naive T cells maintain an appropriate level of Ca2+ in ER remains poorly understood. Here, we show that the ER tr…
View article: Corrigendum: Microbiological and clinical characteristics of bloodstream infections in general intensive care unit: A retrospective study
Corrigendum: Microbiological and clinical characteristics of bloodstream infections in general intensive care unit: A retrospective study Open
[This corrects the article DOI: 10.3389/fmed.2022.876207.].
View article: Development and validation of a genomic nomogram based on a ceRNA network for comprehensive analysis of obstructive sleep apnea
Development and validation of a genomic nomogram based on a ceRNA network for comprehensive analysis of obstructive sleep apnea Open
Objectives: Some ceRNA associated with lncRNA have been considered as possible diagnostic and therapeutic biomarkers for obstructive sleep apnea (OSA). We intend to identify the potential hub genes for the development of OSA, which will pr…
View article: Influenza A Virus-Induced circRNA circMerTK Negatively Regulates Innate Antiviral Responses
Influenza A Virus-Induced circRNA circMerTK Negatively Regulates Innate Antiviral Responses Open
CircRNAs are an important class of noncoding RNAs characterized by a covalently closed circular structure. CircRNAs have been proven to impact numerous cellular processes, where they conduct specialized biological activities.
View article: Metabolism along the life journey of T cells
Metabolism along the life journey of T cells Open
T cells are one of few cell types in adult mammals that can proliferate extensively and differentiate diversely upon stimulation, which serves as an excellent example to dissect the metabolic basis of cell fate decisions. During the last d…