Mingwei Chen
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View article: Deciphering oligomeric proanthocyanidins’ dual osteoprotective mechanisms at single-cell resolution: NR4A1-mediated PTGS2 suppression and β-catenin-Runx2 activation
Deciphering oligomeric proanthocyanidins’ dual osteoprotective mechanisms at single-cell resolution: NR4A1-mediated PTGS2 suppression and β-catenin-Runx2 activation Open
Background Osteoporosis (OP), as a systemic bone disorder, has a complex pathogenesis and faces significant challenges in clinical treatment. Oligomeric proanthocyanidin (OPC), a type of natural polyphenolic flavonoid compound, demonstrate…
View article: Solvent‐Rich Pre‐Coagulation Bath for Tunable Liquid‐State Fusion Enables Robust Two‐Step Polymer Embedded Printing
Solvent‐Rich Pre‐Coagulation Bath for Tunable Liquid‐State Fusion Enables Robust Two‐Step Polymer Embedded Printing Open
Effective interlayer fusion is a critical step enabling a 3D printing process. For engineering polymer printing, interlayer fusion is usually either heat‐enabled or binder‐based, which may introduce thermal residual stress, warpage, and un…
View article: Investigation into the Influence of Alkyl Thioureas with Varying Steric Hindrance on the Tensile Strength of Electrolytic Copper Foil
Investigation into the Influence of Alkyl Thioureas with Varying Steric Hindrance on the Tensile Strength of Electrolytic Copper Foil Open
Thiourea derivatives are typical additives that exert different steric hindrance effects on the tensile strength of electrolytic copper foil (ECF). However, the underlying mechanisms remain unclear. Herein, thioureas with methyl, isopropyl…
View article: Ni-doped 3D-printed honeycomb carbon microlattices: Sustainable fabrication and functionalization of microarchitected carbon
Ni-doped 3D-printed honeycomb carbon microlattices: Sustainable fabrication and functionalization of microarchitected carbon Open
We developed composite photoresins for sustainable production of microarchitected carbon electrodes via stereolithography (SLA) 3D printing. The composite resins contain 20-25 mass% water that decreases the amount of organic waste. After p…
View article: Magnetization Dependent In-plane Anomalous Hall Effect in a Low-dimensional System
Magnetization Dependent In-plane Anomalous Hall Effect in a Low-dimensional System Open
Anomalous Hall Effect (AHE) response in magnetic systems is typically proportional to an out-of-plane magnetization component because of the restriction imposed by system symmetries, which demands that the magnetization, applied electric f…
View article: On-Chip Quantum Sensing of Kondo Spins in a High-Mobility Quasi-One-Dimensional Nanoconstriction
On-Chip Quantum Sensing of Kondo Spins in a High-Mobility Quasi-One-Dimensional Nanoconstriction Open
The precise nature of Kondo spins has remained enigmatic when extended to multiple spin impurities or, more intriguingly, when the localized spin itself may already be the consequence of many-body interactions in a presumably delocalized o…
View article: Construction of a risk prediction model for hypertension in type 2 diabetes: Independent risk factors and nomogram
Construction of a risk prediction model for hypertension in type 2 diabetes: Independent risk factors and nomogram Open
BACKGROUND Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder increasingly linked with hypertension, posing significant health risks. The need for a predictive model tailored for T2DM patients is evident, as current tools ma…
View article: Crystal plane orientation-dependent surface atom diffusion in sub–10-nm Au nanocrystals
Crystal plane orientation-dependent surface atom diffusion in sub–10-nm Au nanocrystals Open
Surface atom diffusion is a ubiquitous phenomenon in nanostructured metals with ultrahigh surface-to-volume ratios. However, the fundamental atomic mechanism of surface atom diffusion remains elusive. Here, we report in situ atomic-scale o…
View article: 241P Development and characterization of a novel DLL3-targeting antibody drug conjugate (ADC) for the treatment of solid tumors
241P Development and characterization of a novel DLL3-targeting antibody drug conjugate (ADC) for the treatment of solid tumors Open
DLL3, a type I transmembrane protein that serves as an inhibitor in the Notch pathway, is a validated target for direct therapy. It exhibits significant upregulation and abnormal expression on the cell surface in small cell lung cancer (SC…
View article: Electrodeposition, microstructure and characterization of high-strength, low-roughness copper foils with polyethylene glycol additives
Electrodeposition, microstructure and characterization of high-strength, low-roughness copper foils with polyethylene glycol additives Open
High-quality copper foils with high tensile strength (433.2 MPa) and low surface roughness (1.7 μm) were electrodeposited with PEG, exhibiting high (220) crystal plane orientation, high density of twin grain boundaries and stacking faults.
View article: Identification of the target genes of AhTWRKY24 and AhTWRKY106 transcription factors reveals their regulatory network in Arachis hypogaea cv. Tifrunner using DAP-seq
Identification of the target genes of AhTWRKY24 and AhTWRKY106 transcription factors reveals their regulatory network in Arachis hypogaea cv. Tifrunner using DAP-seq Open
WRKY transcription factors (TFs) have been identified as important core regulators in the responses of plants to biotic and abiotic stresses. Cultivated peanut (Arachis hypogaea) is an important oil and protein crop. Previous studies have …
View article: Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial
Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial Open
EMERGING-CTONG 1103 showed improved progression-free survival (PFS) with neoadjuvant erlotinib vs. chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell lung cancer (NSCLC) (NCT0140782…
View article: Metal-carbide eutectics with multiprincipal elements make superrefractory alloys
Metal-carbide eutectics with multiprincipal elements make superrefractory alloys Open
Materials with excellent high-temperature strength are now sought for applications in hypersonics, fusion reactors, and aerospace technologies. Conventional alloys and eutectic multiprincipal-element alloys (MPEAs) exhibit insufficient str…
View article: Lack of Association Between Helicobacter pylori Infection and the Risk of Thyroid Nodule Types: A Multicenter Case-Control Studyin China
Lack of Association Between Helicobacter pylori Infection and the Risk of Thyroid Nodule Types: A Multicenter Case-Control Studyin China Open
The prevalence of Helicobacter pylori infection is high worldwide, while numerous research has focused on unraveling the relationship between H. pylori infection and extragastric diseases. Although H. pylori infection has been associated w…
View article: Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer
Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer Open
Significance Pancreatic cancer treatments remain challenging due to late diagnosis and intrinsic resistance to conventional treatments. In this study, we demonstrate the use of the homogeneous SSEA-4 antibody and CAR-T cells for effective …
View article: Structural Origin of Boson Peak in Glasses
Structural Origin of Boson Peak in Glasses Open
Boson peak, the excess low energy excitations in the terahertz regime, is one of the most unique features of disordered systems and has been linked to many anomalous properties of glass materials. The nature and structural origin of the bo…
View article: In Situ Atomic-Scale Observation of Dislocation Climb and Grain Boundary Transformation in Nanostructured Metal
In Situ Atomic-Scale Observation of Dislocation Climb and Grain Boundary Transformation in Nanostructured Metal Open
We report atomic-scale observations of grain boundary (GB) dislocation climb in nanostructured Au during in situ straining at room temperature. Climb of a dislocation occurs by stress-induced reconstruction of two atomic columns at the edg…