Mingxia Gu
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View article: Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems
Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems Open
Increasing evidence strongly links neuroinflammation to Alzheimer’s disease (AD) pathogenesis. Peripheral monocytes are crucial components of the human immune system, but their contribution to AD pathogenesis is still largely understudied …
View article: Isoform-Specific Roles of NTRK2 in Pulmonary Vascular Regeneration
Isoform-Specific Roles of NTRK2 in Pulmonary Vascular Regeneration Open
SUMMARY Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants with no curative therapy, characterized by impaired alveologenesis and capillary formation. However, the molecular mechanisms underlying endothelial dy…
View article: Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human brain organoid microphysiological systems
Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human brain organoid microphysiological systems Open
Increasing evidence suggests that Alzheimer’s disease (AD) pathogenesis strongly correlates with neuroinflammation. Peripheral monocytes are crucial components of the human immune system that may play a role in neuroinflammation, but their…
View article: Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart
Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart Open
Congenital heart defects (CHD) arise in part due to inherited genetic variants that alter genes and noncoding regulatory elements in the human genome. These variants are thought to act during fetal development to influence the formation of…
View article: Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study
Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study Open
Previous studies have suggested a link between the gut microbiome and hypertension‐related traits like blood pressure. However, these reports are often limited by weak causal evidence. This study investigates the potential causal associati…
View article: Induced pluripotent stem cell (iPSC) modeling validates reduced GBE1 enzyme activity due to a novel variant, p.Ile694Asn, found in a patient with suspected glycogen storage disease IV
Induced pluripotent stem cell (iPSC) modeling validates reduced GBE1 enzyme activity due to a novel variant, p.Ile694Asn, found in a patient with suspected glycogen storage disease IV Open
iPSC-based disease modeling supported a loss of function effect of p.Ile694Asn in GBE1. The modeling of GBE1 enzyme deficiency in iHep and iCM cell lines had multi-organ findings, demonstrating iPSC-based modeling usefulness in elucidating…
View article: Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids
Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids Open
Summary To investigate the co-development of vasculature, mesenchyme, and epithelium crucial for organogenesis and the acquisition of organ-specific characteristics, we constructed a human pluripotent stem cell-derived organoid system comp…
View article: Functional Neural Networks in Human Brain Organoids
Functional Neural Networks in Human Brain Organoids Open
Human brain organoids are 3-dimensional brain-like tissues derived from human pluripotent stem cells and hold promising potential for modeling neurological, psychiatric, and developmental disorders. While the molecular and cellular aspects…
View article: Feeder-free generation and characterization of endocardial and cardiac valve cells from human pluripotent stem cells
Feeder-free generation and characterization of endocardial and cardiac valve cells from human pluripotent stem cells Open
Valvular heart disease presents a significant health burden, yet advancements in valve biology and therapeutics have been hindered by the lack of accessibility to human valve cells. In this study, we have developed a scalable and feeder-fr…
View article: Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia
Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia Open
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal developmental disorder of lung morphogenesis caused by insufficiency of FOXF1 (forkhead box F1) transcription factor function. The cellular a…
View article: APOE-NOTCH Axis Governs Elastogenesis During Human Cardiac Valve Remodeling
APOE-NOTCH Axis Governs Elastogenesis During Human Cardiac Valve Remodeling Open
Background Valve remodeling is a complex process involving extracellular matrix organization, development of trilaminar structures, and physical elongation of valve leaflets. However, the cellular and molecular mechanisms regulating valve …
View article: Brain Organoid Computing for Artificial Intelligence
Brain Organoid Computing for Artificial Intelligence Open
Brain-inspired hardware emulates the structure and working principles of a biological brain and may address the hardware bottleneck for fast-growing artificial intelligence (AI). Current brain-inspired silicon chips are promising but still…
View article: Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension
Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension Open
Objective: Mutations in BMPR2 (bone morphogenetic protein receptor 2) are associated with familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular link between loss of BMPR2 in pulmonary artery smooth muscl…
View article: Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia
Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia Open
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is linked to heterozygous mutations in the FOXF1 (Forkhead Box F1) gene, a key transcriptional regulator of pulmonary vascular development. There are no …
View article: Endocardium in Hypoplastic Left Heart Syndrome: Implications from In Vitro Study
Endocardium in Hypoplastic Left Heart Syndrome: Implications from In Vitro Study Open
Endocardium lines the inner layer of the heart ventricle and serves as the source of valve endothelial cells and interstitial cells. Previously, endocardium-associated abnormalities in hypoplastic left heart syndrome (HLHS) have been repor…
View article: Engineering human spinal microphysiological systems to model opioid-induced tolerance
Engineering human spinal microphysiological systems to model opioid-induced tolerance Open
pioids are commonly used for treating chronic pain. However, with continued use, they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human mechanisms of opioid-induced tolerance and hyperalgesia are signif…
View article: TMEM100, a Lung-Specific Endothelium Gene
TMEM100, a Lung-Specific Endothelium Gene Open
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View article: Engineering human spinal microphysiological systems to model opioid-induced tolerance
Engineering human spinal microphysiological systems to model opioid-induced tolerance Open
Opioids are commonly used for treating chronic pain. However, with continued use, they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human mechanisms of opioid-induced hyperalgesia are significantly under…
View article: TMEM100, a Lung-Specific Endothelium Gene
TMEM100, a Lung-Specific Endothelium Gene Open
The heterogeneity of endothelium across different organs was recently explored using single-cell RNA-sequencing analysis. Compared to other organs, the lung exhibits a distinct structure composed of a thin layer of capillary for efficient …
View article: Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function
Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function Open
Deficiency of iron-sulfur (Fe-S) clusters promotes metabolic rewiring of the endothelium and the development of pulmonary hypertension (PH) in vivo . Joining a growing number of Fe-S biogenesis proteins critical to pulmonary endothelial fu…
View article: Understanding Immune‐Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform
Understanding Immune‐Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform Open
The aging of the immune system drives systemic aging and the pathogenesis of age‐related diseases. However, a significant knowledge gap remains in understanding immune‐driven aging, especially in brain aging, due to the limited current in …
View article: Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease Open
Summary Congenital heart defects, the most common birth disorders, are the clinical manifestation of anomalies in fetal heart development - a complex process involving dynamic spatiotemporal coordination among various precursor cell lineag…