Mingye Wang
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View article: Tongxinluo alleviates myocardial ischemia–reperfusion injury by inhibiting the pyroptosis of endothelial cells via the NLRP3/Caspase-1/GSDMD signaling pathway
Tongxinluo alleviates myocardial ischemia–reperfusion injury by inhibiting the pyroptosis of endothelial cells via the NLRP3/Caspase-1/GSDMD signaling pathway Open
Numerous people experiencing acute myocardial infarction are also experiencing myocardial ischemia-reperfusion injury (MIRI). Pyroptosis is a core mechanism in MIRI. Tongxinluo (TXL) has a significant protective effect on endothelial cell …
View article: Deciphering the molecular mechanisms of QLQX capsules in heart failure: A multi-omics perspective
Deciphering the molecular mechanisms of QLQX capsules in heart failure: A multi-omics perspective Open
QLQX exerts multifaceted therapeutic effects on HFpEF by modulating gene expression, protein function, and metabolic pathways, particularly through the cGMP-PKG signaling pathway. These findings support QLQX as a promising therapeutic inte…
View article: Hypoxia-conditioned cardiomyocyte-derived exosomes attenuate myocardial injury via ANP-mediated M2 macrophage polarization
Hypoxia-conditioned cardiomyocyte-derived exosomes attenuate myocardial injury via ANP-mediated M2 macrophage polarization Open
Exosomes derived from various cells have been demonstrated to contribute to cardiac repair by regulating macrophage polarization in myocardial infarction. However, how exosomes secreted from cardiomyocytes under hypoxia-ischemia (Hypo-Exo)…
View article: Emerging Perspectives in Anti-aging Treatments Using Anti-Fibrotic Strategies
Emerging Perspectives in Anti-aging Treatments Using Anti-Fibrotic Strategies Open
Aging involves chronic organ degeneration, characterized by a continued decline in cellular regenerative ability and excessive buildup of extracellular matrix (ECM), leading to organ fibrosis. Fibrosis is now widely recognized as a key sig…
View article: Driving and suppressing the human language network using large language models
Driving and suppressing the human language network using large language models Open
Transformer models such as GPT generate human-like language and are highly predictive of human brain responses to language. Here, using fMRI-measured brain responses to 1,000 diverse sentences, we first show that a GPT-based encoding model…
View article: Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect
Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect Open
Cardiac glycosides (CGs) are candidate anticancer agents that function by increasing [Ca2+]i to induce apoptotic cell death in several types of cancer cells. However, new findings have shown that the anti‑cancer effects of CGs involve comp…
View article: Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects
Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects Open
Our results indicated that SR manifested as a multiple ion-channel blocker in the electrophysiological properties and exerts antiarrhythmic effects ex vivo and in vivo. Meanwhile, due to the low pro-arrhythmic risk in the hERG inhibition a…
View article: Scalp Electroacupuncture Promotes Angiogenesis after Stroke in Rats by Activation of Wnt/β-Catenin Signal Pathway
Scalp Electroacupuncture Promotes Angiogenesis after Stroke in Rats by Activation of Wnt/β-Catenin Signal Pathway Open
Background. Scalp acupuncture is a contemporary acupuncture method based on the fundamental theories of traditional acupuncture, which has been widely used in patients with stroke in China. However, the effectiveness is controversial due t…
View article: Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis
Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis Open
JLD has a protective effect against NAFLD, which may be related to its anti-pyroptosis, suggesting that JLD has the potential as a novel agent in the treatment of NAFLD.
View article: Inhibition of Autophagy Facilitates XY03‐EA‐Mediated Neuroprotection against the Cerebral Ischemia/Reperfusion Injury in Rats
Inhibition of Autophagy Facilitates XY03‐EA‐Mediated Neuroprotection against the Cerebral Ischemia/Reperfusion Injury in Rats Open
Objective . L‐3‐n‐Butylphthalide (NBP) is used to treat moderate and severe acute ischemia stroke. A previous screening study indicates that XY03‐EA, a novel derivative of NBP, is more potent than NBP in the oxyradical scavenging capacity.…
View article: Si-Miao-Yong-An Decoction Maintains the Cardiac Function and Protects Cardiomyocytes from Myocardial Ischemia and Reperfusion Injury
Si-Miao-Yong-An Decoction Maintains the Cardiac Function and Protects Cardiomyocytes from Myocardial Ischemia and Reperfusion Injury Open
Objective. The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD) could protect cardiomyocytes from ischemia/reperfusion (I/R) injury and its underlying mechanisms. Methods. C57BL/6 mice were used to establish a m…
View article: Si-Miao-Yong-An Decoction maintains the cardiac function and protects cardiomyocytes from myocardial ischemia and reperfusion injury
Si-Miao-Yong-An Decoction maintains the cardiac function and protects cardiomyocytes from myocardial ischemia and reperfusion injury Open
Objective ：The aim of this study was to determine whether Si-Miao-Yong-An decoction (SMYAD) could protect cardiomyocytes from ischemia/reperfusion (I/R) injury and its underlying mechanisms. Methods: C57BL/6 mice were used to establish a m…
View article: Analysis of Resibufogenin on Cardiac conduction reveals a species difference in the cardiac electrophysiology: Rats versus guinea pigs.
Analysis of Resibufogenin on Cardiac conduction reveals a species difference in the cardiac electrophysiology: Rats versus guinea pigs. Open
Resibufogenin (RBG) is a chemical ingredient of Chan Su. In our research, we found RBG affected cardiac rhythm in a negative chronotropic way in vivo. The cardiac Mapping system ex vivo and the patch clamp in vitro were used to explore how…
View article: Bufei Decoction Alleviated Bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Mice by Anti‐Inflammation
Bufei Decoction Alleviated Bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Mice by Anti‐Inflammation Open
Objective . This study aimed to investigate the mechanistic action and therapeutic effects of Bufei decoction on idiopathic pulmonary fibrosis (IPF) after inhalation of bleomycin. Methods . Pulmonary fibrosis model in mice was prepared by …