Mingyu Pan
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View article: EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation
EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation Open
Lung cancer, 85% of which is non‐small cell lung cancer (NSCLC), is the cancer with the highest incidence and mortality rate worldwide. Despite recent advancements in therapeutic approaches, the efficacy of conventional radiotherapy and ch…
View article: Centrosome‐Signaling Pathway Crosstalk: A Core Hub From Cellular Homeostasis to Disease
Centrosome‐Signaling Pathway Crosstalk: A Core Hub From Cellular Homeostasis to Disease Open
The centrosome, an evolutionarily conserved organelle in most animal cells, plays a pivotal role in fundamental processes such as cell division and ciliogenesis. Recent evidence increasingly highlights active crosstalk between the centroso…
View article: PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation
PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation Open
Virus infection stimulates proto‐oncoprotein PIM1 kinase expression, but its importance and the biological functions of this process are poorly understood. Herein, PIM1 promotes IFNAR1 degradation to attenuate cellular innate immunity duri…
View article: New insight in treating autoimmune diseases by targeting autophagy
New insight in treating autoimmune diseases by targeting autophagy Open
Autophagy is a highly conserved biological process in eukaryotes, which degrades cellular misfolded proteins, damaged organelles and invasive pathogens in the lysosome-dependent manner. Autoimmune diseases caused by genetic elements, envir…
View article: Res-DFNN: An NN-Based Device Fingerprint Extraction Method Using Network Packet Data
Res-DFNN: An NN-Based Device Fingerprint Extraction Method Using Network Packet Data Open
The past few years have witnessed a wider adoption of Internet of Things (IoT) devices. Since IoT devices are usually deployed in an open and uncertain environment, device authentication is of great importance. However, traditional device …
View article: CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling
CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling Open
STING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and eliciting innate immunity. Nevertheless, …
View article: Study on the Kinematics of Key Components of Film Bidirectional Synchronous Stretching Equipment
Study on the Kinematics of Key Components of Film Bidirectional Synchronous Stretching Equipment Open
In this paper, the stretching chain clamp model in the film synchronous biaxial stretching equipment is simplified. And we establish the kinematic model. The variation rule of kinematic parameters of each joint of the chain clamp during th…
View article: UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation
UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation Open
STING1 (stimulator of interferon response cGAMP interactor 1), the pivotal adaptor protein of CGAS (cyclic GMP-AMP synthase)-STING1 signaling, is critical for type I IFN production of innate immunity. However, excessive or prolonged activa…
View article: UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation
UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation Open
STING1 (stimulator of interferon response cGAMP interactor 1), the pivotal adaptor protein of CGAS (cyclic GMP-AMP synthase)-STING1 signaling, is critical for type I IFN production of innate immunity. However, excessive or prolonged activa…
View article: The Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion
The Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion Open
Virus infection has been consistently threatening public health. The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian c…
View article: NEAT1 silencing alleviates pulmonary arterial smooth muscle cell migration and proliferation under hypoxia through regulation of miR‑34a‑5p/KLF4<i>in vitro</i>
NEAT1 silencing alleviates pulmonary arterial smooth muscle cell migration and proliferation under hypoxia through regulation of miR‑34a‑5p/KLF4<i>in vitro</i> Open
Pulmonary arterial hypertension (PAH) is a severe vascular disease that adversely affects patient health and can be life threatening. The present study aimed to investigate the detailed role of nuclear paraspeckle assembly transcript 1 (NE…
View article: Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation
Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation Open
UXT (ubiquitously expressed prefoldin like chaperone), a small chaperone-like protein, is widely expressed in diverse human and mouse tissues and is more abundant in retina and kidney. However, the functional characterization of UXT at tis…
View article: Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation
Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation Open
UXT (ubiquitously expressed prefoldin like chaperone), a small chaperone-like protein, is widely expressed in diverse human and mouse tissues and is more abundant in retina and kidney. However, the functional characterization of UXT at tis…
View article: JNK1 Induces Notch1 Expression to Regulate Genes Governing Photoreceptor Production
JNK1 Induces Notch1 Expression to Regulate Genes Governing Photoreceptor Production Open
c-Jun N-terminal kinases (JNKs) regulate cell proliferation and differentiation via phosphorylating such transcription factors as c-Jun. The function of JNKs in retinogenesis remains to be elucidated. Here, we report that knocking out Jnk1…