Mingyu Sun
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View article: Bench-to-bedside translation of podophyllotoxin-based nanomedicines for cancer treatment: utopias and reality?
Bench-to-bedside translation of podophyllotoxin-based nanomedicines for cancer treatment: utopias and reality? Open
Cancers represent a complex and multifaceted health challenge, marked by elevated disease burden and fatality rates stemming from both genetic alterations and epigenetic modifications. Nanomedicine, as an emerging field in oncological inve…
View article: Challenges and advances in clinical cure of chronic hepatitis B
Challenges and advances in clinical cure of chronic hepatitis B Open
View article: Enhancing luminescence of QD thin films, polymer composite films, and LED devices by nanostructures
Enhancing luminescence of QD thin films, polymer composite films, and LED devices by nanostructures Open
View article: Knowledge, attitude and practice regarding scars in patients who had orthopaedic surgery: a cross-sectional study in China
Knowledge, attitude and practice regarding scars in patients who had orthopaedic surgery: a cross-sectional study in China Open
Objectives This study aims to describe the knowledge, attitude and practice (KAP) regarding surgical scars among patients who had postorthopaedic surgery, and to explore correlations between these factors. Design A multicentre, cross-secti…
View article: Knowledge, Attitude, and Practice Toward Breast Reconstruction Among Breast Surgery Healthcare Professionals in China
Knowledge, Attitude, and Practice Toward Breast Reconstruction Among Breast Surgery Healthcare Professionals in China Open
While attitudes and practices were generally positive, significant gaps remain in routine recommendation and education practices. Targeted educational programs may enhance their knowledge and improve clinical practices.
View article: Unveiling distribution and drivers of soil organic carbon in coastal China: Salt marshes and tidal flats as major carbon storage contributors
Unveiling distribution and drivers of soil organic carbon in coastal China: Salt marshes and tidal flats as major carbon storage contributors Open
Understanding the characteristics, distribution and drivers of soil organic carbon (SOC) stock in coastal wetlands are of great significance to effective management and sustainable development of blue carbon ecosystems (BCEs). However, cur…
View article: ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis
ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis Open
Lipid peroxidation stands as a prominent hallmark and a prerequisite for the onset of ferroptosis. Lipid metabolism holds a pivotal role in regulating this process, forming the metabolic foundation for cellular sensitivity to ferroptosis. …
View article: The short-term effect of laparoscopic sleeve gastrectomy with his angle reconstruction (LSG-His) on gastroesophageal reflux disease
The short-term effect of laparoscopic sleeve gastrectomy with his angle reconstruction (LSG-His) on gastroesophageal reflux disease Open
In this retrospective observational study, LSG-His was associated with lower rates of GERD symptoms and higher %EWL compared to standard LSG, but with comparable %TWL in 24 month outcomes. However, these preliminary results are limited to …
View article: Machine learning based CAGIB score predicts in-hospital mortality of cirrhotic patients with acute gastrointestinal bleeding
Machine learning based CAGIB score predicts in-hospital mortality of cirrhotic patients with acute gastrointestinal bleeding Open
Acute gastrointestinal bleeding (AGIB) is a potentially lethal complication in cirrhosis. In this prospective international multi-center study, the performance of CAGIB score for predicting the risk of in-hospital death in 2467 cirrhotic p…
View article: The Effect of Corn Stalks and <em>Salix psammophila</em> on the Fermentation Quality and Microbial Community of <em>Caragana korshinskii </em>Silage
The Effect of Corn Stalks and <em>Salix psammophila</em> on the Fermentation Quality and Microbial Community of <em>Caragana korshinskii </em>Silage Open
To expand the utilization of waste from the coppicing of xerophytic shrubs, such as Caragana korshinskii (C. korshinskii). This study aimed to evaluate the effects of Salix psammophila (S. psammophila) and corn stalks on C. korshinskii sil…
View article: Nutrient Effects and Dietary Pattern Strategies in the Management of Type 2 Diabetes
Nutrient Effects and Dietary Pattern Strategies in the Management of Type 2 Diabetes Open
Type 2 diabetes (T2D) is a metabolic disorder affected by dietary patterns and nutrient intake. It is well established that macronutrients, such as carbohydrates, proteins, and fats, influence glycemic control and insulin sensitivity. Simi…
View article: Game Changers: Blockbuster Small-Molecule Drugs Approved by the FDA in 2024
Game Changers: Blockbuster Small-Molecule Drugs Approved by the FDA in 2024 Open
This article profiles 27 innovative advancements in small-molecule drugs approved by the U.S. Food and Drug Administration (FDA) in 2024. These drugs target various therapeutic areas including non-small cell lung cancer, advanced or metast…
View article: Precise Electromagnetic Modulation of the Cell Cycle and Its Applications in Cancer Therapy
Precise Electromagnetic Modulation of the Cell Cycle and Its Applications in Cancer Therapy Open
Precise modulation of the cell cycle via electromagnetic (EM) control presents a groundbreaking approach for cancer therapy, especially in the development of personalized treatment strategies. EM fields can precisely regulate key cellular …
View article: Impact of thrombocytopenia on failure of endoscopic variceal treatment in cirrhotic patients with acute variceal bleeding
Impact of thrombocytopenia on failure of endoscopic variceal treatment in cirrhotic patients with acute variceal bleeding Open
Background: Acute variceal bleeding (AVB), a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is a risk of early rebleeding after endoscopic variceal treatment (EVT). Thrombocytopenia is …
View article: Sugar and organic acid metabolism and accumulation in different cultivars during fruit development in hawthorn (<i>Crataegus pinnatifida</i>)
Sugar and organic acid metabolism and accumulation in different cultivars during fruit development in hawthorn (<i>Crataegus pinnatifida</i>) Open
Objectives: Hawthorn fruit is beneficial for human health; however, the consumption of fresh hawthorn fruit is severely limited because of its extreme acidity. Elucidating the metabolic patterns of sugar and organic acid in fruits is cruci…
View article: Atmospheric Nitrogen Deposition Controls Interannual Variability of Net Primary Production in the Bohai Sea
Atmospheric Nitrogen Deposition Controls Interannual Variability of Net Primary Production in the Bohai Sea Open
Increasing human activities and climate change have resulted in significant changes in net primary production (NPP) of the marginal sea in the past several decades. The Bohai Sea (BHS) is a shallow semi‐enclosed marginal sea of North China…
View article: Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4
Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4 Open
Background Ferroptosis, a novel iron-ion-dependent metabolic cell death mode with lipid peroxides as the main driving substrate, plays an irreplaceable role in the development and preventive treatment of hepatocellular carcinoma. Curcumin …
View article: SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure Open
SARS-CoV-2 spike protein (SARS-2-S) induced cell–cell fusion in uninfected cells may occur in long COVID-19 syndrome, as circulating SARS-2-S or extracellular vesicles containing SARS-2-S (S-EVs) were found to be prevalent in post-acute se…
View article: Correction: Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer
Correction: Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer Open
View article: SLC7A11: the Achilles heel of tumor?
SLC7A11: the Achilles heel of tumor? Open
The non-natriuretic-dependent glutamate/cystine inverse transporter-system Xc- is composed of two protein subunits, SLC7A11 and SLC3A2, with SLC7A11 serving as the primary functional component responsible for cystine uptake and glutathione…
View article: Ginsenoside RK1 Induces Ferroptosis in Hepatocellular Carcinoma Cells through an FSP1-Dependent Pathway
Ginsenoside RK1 Induces Ferroptosis in Hepatocellular Carcinoma Cells through an FSP1-Dependent Pathway Open
Background: Hepatocellular carcinoma (HCC), currently ranking as the third most lethal malignancy, poses a grave threat to human health. Ferroptosis, a form of programmed cell demise, has emerged as a promising therapeutic target in HCC tr…
View article: GSH and Ferroptosis: Side-by-Side Partners in the Fight against Tumors
GSH and Ferroptosis: Side-by-Side Partners in the Fight against Tumors Open
Glutathione (GSH), a prominent antioxidant in organisms, exhibits diverse biological functions and is crucial in safeguarding cells against oxidative harm and upholding a stable redox milieu. The metabolism of GSH is implicated in numerous…
View article: Causal relationship between gut microbiota and differentiated thyroid cancer: a two-sample Mendelian randomization study
Causal relationship between gut microbiota and differentiated thyroid cancer: a two-sample Mendelian randomization study Open
Background The gut microbiota has been significantly associated with differentiated thyroid cancer (DTC). However, the causal relationship between the gut microbiota and DTC remains unexplored. Methods Genome-wide association study (GWAS) …
View article: CCL20 and CD8A as potential diagnostic biomarkers for HBV-induced liver fibrosis in chronic hepatitis B
CCL20 and CD8A as potential diagnostic biomarkers for HBV-induced liver fibrosis in chronic hepatitis B Open
View article: Study of Laser-Induced Multi-Exciton Generation and Dynamics by Multi-Photon Absorption in CdSe Quantum Dots
Study of Laser-Induced Multi-Exciton Generation and Dynamics by Multi-Photon Absorption in CdSe Quantum Dots Open
Multi-exciton generation by multi-photon absorption under low-energy photons can be thought a reasonable method to reduce the risk of optical damage, especially in photoelectric quantum dot (QD) devices. The lifetime of the multi-exciton s…
View article: Ferroptosis: a new hunter of hepatocellular carcinoma
Ferroptosis: a new hunter of hepatocellular carcinoma Open
Ferroptosis is an iron ion-dependent, regulatory cell death modality driven by intracellular lipid peroxidation that plays a key role in the development of HCC. Studies have shown that various clinical agents (e.g., sorafenib) have ferropt…
View article: Synergism of non-thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells
Synergism of non-thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells Open
Background Though (1S, 3R)-RSL3 has been used widely in basic research as a small molecular inducer of ferroptosis, the toxicity on normal cells and poor pharmacokinetic properties of RSL3 limited its clinical application. Here, we investi…
View article: Progress in research of type 2 diabetes with nonalcoholic fatty liver in traditional Chinese and Western medicine
Progress in research of type 2 diabetes with nonalcoholic fatty liver in traditional Chinese and Western medicine Open
View article: Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer
Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer Open
The gas therapy is drawing increasing attention in the treatment of many diseases including cancer. As one of gas signaling molecules, carbon monoxide (CO) has been proved to exert anti-cancer effects via triggering multiple cell death typ…
View article: LINC01234 promoted malignant behaviors of breast cancer cells via hsa-miR-30c-2-3p/CCT4/mTOR signaling pathway
LINC01234 promoted malignant behaviors of breast cancer cells via hsa-miR-30c-2-3p/CCT4/mTOR signaling pathway Open
The LINC01234/hsa-miR-30c-2-3p/CCT4/mTOR axis was identified as a potential ceRNA regulatory mechanism in BC. These findings established the foundation for systematically unveiling the pathological mechanisms of BC and provided new insight…