Mingyuan Tian
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View article: Generative AI-Based Night Scene Design of Historic Districts: Value Transition from Basic Lighting to Cultural Narrative
Generative AI-Based Night Scene Design of Historic Districts: Value Transition from Basic Lighting to Cultural Narrative Open
As a cultural medium that facilitates the renewal and adaptive reuse of historic neighborhoods, nightscape design is undergoing an evolution from basic illumination to the conveyance of rich cultural narratives. The advent of generative ar…
View article: Sitagliptin ameliorates microbial dysbiosis and enhances gut barrier integrity in streptozotocin-induced type 2 diabetic rats
Sitagliptin ameliorates microbial dysbiosis and enhances gut barrier integrity in streptozotocin-induced type 2 diabetic rats Open
Background Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, has demonstrated efficacy in the management of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of sitagliptin on gut microbial composition and…
View article: Hypothalamic BCL6 signaling modulates energy homeostasis and metabolism by inhibiting STAT3 transcription
Hypothalamic BCL6 signaling modulates energy homeostasis and metabolism by inhibiting STAT3 transcription Open
Our findings demonstrate that BCL6 in hypothalamic POMC neurons acts as a key regulator of energy metabolism.
View article: Alterations of the paired maternal fecal microbiota and neonatal meconium microbiota in newborns from pregnant women with hypertensive disorders
Alterations of the paired maternal fecal microbiota and neonatal meconium microbiota in newborns from pregnant women with hypertensive disorders Open
Background Hypertensive disorders of pregnancy (HDP) pose significant risks to both maternal and fetal health and have been associated with alterations in the maternal gut microbiota. However, the impact of HDP on neonatal microbiota remai…
View article: Effect of Thyroid Peroxidase Antibody Titers Trajectories during Pregnancy and Postpartum on Postpartum Thyroid Dysfunction
Effect of Thyroid Peroxidase Antibody Titers Trajectories during Pregnancy and Postpartum on Postpartum Thyroid Dysfunction Open
Objective To identify risk factors contributing to the development of postpartum hypothyroidism in women newly diagnosed with subclinical hypothyroidism (SCH) during the first trimester of pregnancy (T1). Additionally, this study aimed to …
View article: Combined serum CTRP7 and CTRP15 levels as a novel biomarker for insulin resistance and type 2 diabetes mellitus
Combined serum CTRP7 and CTRP15 levels as a novel biomarker for insulin resistance and type 2 diabetes mellitus Open
Log10 (CTRP7+CTRP15) may serve as a valuable diagnostic marker for the management of metabolic-related diseases, particularly T2DM and IR.
View article: Hypothalamic P62 (SQSTM1) regulates energy balance by modulating leptin signaling
Hypothalamic P62 (SQSTM1) regulates energy balance by modulating leptin signaling Open
This study demonstrated the capacity of p62 to monogenically regulate the obesity phenotype and emphasized its dual role in managing energy homeostasis through direct modulation of STAT3/POMC signaling and amplification of leptin sensitivi…
View article: Fulminant Type 1 Diabetes Mellitus Associated With Drug Hypersensitivity and Epstein–Barr Virus Infection: A Case Report
Fulminant Type 1 Diabetes Mellitus Associated With Drug Hypersensitivity and Epstein–Barr Virus Infection: A Case Report Open
Background: Fulminant type 1 diabetes mellitus (FT1DM) is a new subtype of type 1 diabetes, first proposed by Japanese scholars in 2000. Herein, the functions of the islets are rapidly destroyed. Its pathogenesis is related to viral infect…
View article: The Relationships among Plasma Fetuin-B, Thyroid Autoimmunity, and Fertilization Rate In Vitro Fertilization and Embryo Transfer
The Relationships among Plasma Fetuin-B, Thyroid Autoimmunity, and Fertilization Rate In Vitro Fertilization and Embryo Transfer Open
Objective. The objective of the study is to investigate the relationships between fetuin-B, thyroid autoimmunity (TAI), and pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Design, Patients, and M…
View article: CTRP7 Is a Biomarker Related to Insulin Resistance and Oxidative Stress: Cross‐Sectional and Intervention Studies In <i>Vivo</i> and In <i>Vitro</i>
CTRP7 Is a Biomarker Related to Insulin Resistance and Oxidative Stress: Cross‐Sectional and Intervention Studies In <i>Vivo</i> and In <i>Vitro</i> Open
Objective . CTRP7 is a cytokine that is known to be associated with obesity. However, its relationship with insulin resistance (IR) and metabolic diseases remains unknown. The aim of this study is to investigate the relationship between CT…
View article: Curcumin ameliorates lipid metabolic disorder and cognitive dysfunction via the ABCA1 transmembrane transport system in APP/PS1 double transgenic mice
Curcumin ameliorates lipid metabolic disorder and cognitive dysfunction via the ABCA1 transmembrane transport system in APP/PS1 double transgenic mice Open
The disorder of lipid metabolism, especially cholesterol metabolism, can promote Alzheimer’s Disease. Curcumin can ameliorate lipid metabolic disorder in the brain of Alzheimer’s Disease patients, while the mechanism is not clear. APP/PS1 …
View article: Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice
Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice Open
Autophagosome accumulation is observed in the distal axons of Alzheimer disease (AD) patients and AD animal models, suggesting that deficient retrograde transport and impaired autophagic clearance of beta-amyloid (A β) contribute to AD pat…
View article: Protein Expression Profile in IVF Follicular Fluid and Pregnancy Outcome Analysis in Euthyroid Women with Thyroid Autoimmunity
Protein Expression Profile in IVF Follicular Fluid and Pregnancy Outcome Analysis in Euthyroid Women with Thyroid Autoimmunity Open
The objective of this study is to investigate the influence of the thyroid autoantibodies on the protein expression in follicular fluid and the clinical outcome of assisted reproductive technology. A total of 602 patients treated for infer…
View article: The DPP-4 inhibitor sitagliptin alters the gut microbiota and prevents neuronal damage of hippocampus in STZ induced type 2 diabetic rats
The DPP-4 inhibitor sitagliptin alters the gut microbiota and prevents neuronal damage of hippocampus in STZ induced type 2 diabetic rats Open
Background : Type 2 Diabetes mellitus is characterized by impaired glucose metabolism and insulin resistance with increasing risk of specific complication, including central neuropathy. Dipeptidyl peptidase 4 (DPP-4) inhibitors are agents …
View article: Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion
Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion Open
The present study demonstrates that central Sfrp5 signaling activates a previously unappreciated InsR-Akt-PI3k-KATP channel pathway in the hypothalamus and brain-hepatic vagus neurocircuitry to decrease HGP and VLDL-TG secretion.
View article: Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study
Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study Open
Rui Ren,1,2 Yu Ma,2 Fang Deng,1 Tao Li,1 Hongyan Wang,2 Jing Wei,3 Xiaoyan Jiang,2 Min He,1 Mingyuan Tian,4 Dongfang Liu,4 Bing Chen,1 Wuquan Deng1,21Department of Endocrinology and Nephrology, Chongqing University Central Hospital, Chongq…
View article: <p>Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study</p>
Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study Open
This large population-based study demonstrates a significant interaction between metabolic factors and TSH levels. An adverse weight status, high blood pressure levels, blood lipid metabolism disorder and excessive iodine intake may be ear…
View article: Erratum: The Functional IgE-Blocking Factor Induced by Allergen-Specific Immunotherapy Correlates with IgG4 Antibodies and a Decrease of Symptoms in House Dust Mite-Allergic Children
Erratum: The Functional IgE-Blocking Factor Induced by Allergen-Specific Immunotherapy Correlates with IgG4 Antibodies and a Decrease of Symptoms in House Dust Mite-Allergic Children Open
Background: At present, there are no validated biomarkers reflecting or predicting the clinical efficacy of allergen-specific immunotherapy (AIT) . We aimed to investigate the correlations between clinical and immunological responses of pa…