Ming Liao
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View article: Global genomic survey of <i>Salmonella</i> Kentucky: discovery of a chromosomeborne <i>bla</i> <sub>NDM-5</sub> and the emergence of ST314, an MDR clone mediated by the IncR plasmid
Global genomic survey of <i>Salmonella</i> Kentucky: discovery of a chromosomeborne <i>bla</i> <sub>NDM-5</sub> and the emergence of ST314, an MDR clone mediated by the IncR plasmid Open
Antimicrobial resistance (AMR) in Salmonella enterica serotype Kentucky (S. Kentucky) is a global challenge, with increasing resistance to cephalosporins, ciprofloxacin, and carbapenems significantly limiting treatment strategies, yet its …
View article: In Vivo Ultrasonographic Assessment of Bone Mineral Density and Its Impact on Semen Quality in Boars
In Vivo Ultrasonographic Assessment of Bone Mineral Density and Its Impact on Semen Quality in Boars Open
Bone mineral density (BMD) is a key indicator of skeletal health in boars that influences their reproductive performance. Systematic research on the relationship between BMD and semen quality in adult boars of different breeds and ages is …
View article: AniMarkerDB: a comprehensive database for exploring cell types and marker genes in livestock and poultry at single-cell resolution
AniMarkerDB: a comprehensive database for exploring cell types and marker genes in livestock and poultry at single-cell resolution Open
Single-cell RNA sequencing (scRNA-seq) has dramatically advanced the understanding of cellular heterogeneity. While numerous marker gene databases are available for humans and mice, a lack of systematic resources for livestock and poultry …
View article: Investigation of the genome, taxonomy, and distribution of pigeon gammacoronavirus: insights into its relationships with other avian gammacoronaviruses
Investigation of the genome, taxonomy, and distribution of pigeon gammacoronavirus: insights into its relationships with other avian gammacoronaviruses Open
Introduction Various coronaviruses (CoVs) are pathogenic to humans and animals. Most pathogenic CoVs belong to the Orthocoronavirinae subfamily, which comprises the genera of Alphacoronavirus , Betacoronavirus , Gammacoronavirus , and Delt…
View article: Vulnerable Patient Intensified Protocol to Reduce Readmission Disparities After Coronary Artery Bypass Grafting: Design, Implementation, and Lessons Learned from a Quality Initiative
Vulnerable Patient Intensified Protocol to Reduce Readmission Disparities After Coronary Artery Bypass Grafting: Design, Implementation, and Lessons Learned from a Quality Initiative Open
Goal: In 2024, the Centers for Medicare & Medicaid Services (CMS) introduced equity metrics for healthcare systems to document social determinants of health (SDOH). Payment determinations were also linked to readmission performance measure…
View article: Identification and characterization of two putative novel genera of arteriviruses in shrews and rats
Identification and characterization of two putative novel genera of arteriviruses in shrews and rats Open
Introduction Certain arteriviruses causing severe diseases in domestic animals, such as porcine respiratory and reproductive syndrome viruses, could originate through viral spillover, and simian arteriviruses pose threats to public health …
View article: MRPL15 as a Key Gene in the Malignant Proliferation of LUAD
MRPL15 as a Key Gene in the Malignant Proliferation of LUAD Open
Lung adenocarcinoma (LUAD) accounts for 40% of lung cancers and the rate of clinical detection is increasing year by year. Mitochondrial ribosomal protein L15 (MRPL15) is a mitochondrial ribosomal protein whose high expression has been ass…
View article: Clade 2.3.4.4b highly pathogenic H5N1 influenza viruses from birds in China replicate effectively in bovine cells and pose potential public health risk
Clade 2.3.4.4b highly pathogenic H5N1 influenza viruses from birds in China replicate effectively in bovine cells and pose potential public health risk Open
In February 2024, H5N1 highly pathogenic avian influenza viruses (HPAIVs) of clade 2.3.4.4b were first reported in dairy cows in the USA. Subsequent multiple outbreaks on dairy farms and sporadic human infections have raised substantial pu…
View article: Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges
Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges Open
Since 2020, the clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 viruses have caused unprecedented outbreaks in wild birds and domestic poultry globally, resulting in significant ecological damage and economic losses due to the…
View article: Unique phenomenon of H5 highly pathogenic avian influenza virus in China: co-circulation of Clade 2.3.4.4b H5N1 and H5N6 results in diversity of H5 Virus
Unique phenomenon of H5 highly pathogenic avian influenza virus in China: co-circulation of Clade 2.3.4.4b H5N1 and H5N6 results in diversity of H5 Virus Open
Recently, Clade 2.3.4.4b H5N1 virus has been widely prevalent globally. Although no outbreaks of Avian Influenza have occurred in poultry in China recently, Clade 2.3.4.4b H5 virus can still be isolated from wild birds, live poultry market…
View article: Isolation, Characterization, and Comparative Analysis of Two Subtypes of Goose Astrovirus in Guangdong Province, China
Isolation, Characterization, and Comparative Analysis of Two Subtypes of Goose Astrovirus in Guangdong Province, China Open
Since 2017, an infectious disease characterized by gosling gout and caused by goose astrovirus (GAstV) has affected geese in most major goose-producing regions of China. In this study, a total of 385 geese displaying gout symptoms were sam…
View article: Genome-scale evolution and phylodynamics of swine influenza A viruses in China: a genomic epidemiology study
Genome-scale evolution and phylodynamics of swine influenza A viruses in China: a genomic epidemiology study Open
Scientific Innovation Strategy-Construction of High-Level Academy of Agriculture Science-Distinguished Scholar (R2020PY-JC001).
View article: Identification and characterization of a broadly neutralizing and protective nanobody against the HA1 domain of H5 avian influenza virus hemagglutinin
Identification and characterization of a broadly neutralizing and protective nanobody against the HA1 domain of H5 avian influenza virus hemagglutinin Open
The highly pathogenic avian influenza viruses (HPAIVs) of subtype H5, particularly those of the currently circulating clades 2.3.2.1 and 2.3.4.4, are largely responsible for the sporadic human infections that frequently present with a high…
View article: Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis
Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis Open
ObjectiveThis study aimed to systematically evaluate potential causal relationships between nine cathepsins and female infertility using Mendelian randomization (MR) methods.MethodsA bidirectional MR analysis was conducted utilizing single…
View article: A Smart Single‐Loop‐Mediated Isothermal Amplification Facilitates Flexible SNP Probe Design for On‐Site Rapid Differentiation of SARS‐CoV‐2 Omicron Variants
A Smart Single‐Loop‐Mediated Isothermal Amplification Facilitates Flexible SNP Probe Design for On‐Site Rapid Differentiation of SARS‐CoV‐2 Omicron Variants Open
Rapid on‐site typing methods for SARS‐CoV‐2 variants of concern are crucial for its effective surveillance and control. Herein, a smart single‐loop‐mediated isothermal amplification (ssLAMP) method with the absence of an inner primer but t…
View article: Development of a Monoclonal Antibody Against Duck IFN-γ Protein and the Application for Intracellular Cytokine Staining
Development of a Monoclonal Antibody Against Duck IFN-γ Protein and the Application for Intracellular Cytokine Staining Open
Interferon-γ (IFN-γ), a member of the Type II IFN family, is a crucial cytokine in the immune system and serves as an important indicator of immune response. Intracellular cytokine staining (ICS) is a technique used to analyze the producti…
View article: Survival Strategies and Color Preferences of Mandarin Fish (Siniperca chuatsi) and Mud Carp (Cirrhinus molitorella): Implications for Aquaculture
Survival Strategies and Color Preferences of Mandarin Fish (Siniperca chuatsi) and Mud Carp (Cirrhinus molitorella): Implications for Aquaculture Open
This study evaluated the habitat coloration preferences of Siniperca chuatsi and Cirrhinus molitorella in both solitary (n = 1) and group (n = 3) settings across six colors. The results indicated that both individual and group S. chuatsi s…
View article: Comparative Transcriptomics Analysis of Foot-and-Mouth Disease Virus-Infected Cell Model Systems
Comparative Transcriptomics Analysis of Foot-and-Mouth Disease Virus-Infected Cell Model Systems Open
The highly contagious FMDV is the agent responsible for foot-and-mouth disease, significantly impacting animals with cloven hooves and incurring substantial economic losses globally. The FMDV genome, composed of single-stranded RNA, consis…
View article: Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens
Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens Open
The vaccine developed in this study provides complete protection against divergent H5N1 AIV strains in chickens, offering a promising approach for the future development of mRNA vaccines against multivalent avian influenza subtypes.
View article: A survival prognostic model for gastro-intestinal lymphomas
A survival prognostic model for gastro-intestinal lymphomas Open
Primary gastro-intestinal lymphomas are the most common extra-nodal lymphomas but there is no widely-accepted survival prognosis model. We interrogated data from 1 023 consecutive newly-diagnosed people with primary gastro-intestinal lymph…
View article: The Comorbidity of Depression and Diabetes Is Involved in the Decidual Protein Induced by Progesterone 1 (Depp1) Dysfunction in the Medial Prefrontal Cortex
The Comorbidity of Depression and Diabetes Is Involved in the Decidual Protein Induced by Progesterone 1 (Depp1) Dysfunction in the Medial Prefrontal Cortex Open
Background: There is a high rate of depressive symptoms such as irritability, anhedonia, fatigue, and hypersomnia in patients with type 2 diabetes mellitus (T2DM). However, the causes and underlying mechanisms of the comorbidity of depress…
View article: T Regulatory and T Helper 17 Populations with Transcription Factors in Pig Tissues in Response to Chronic Heat Stress
T Regulatory and T Helper 17 Populations with Transcription Factors in Pig Tissues in Response to Chronic Heat Stress Open
Both Treg cells (CD4+ CD25+ FOXP3+) and Th17 cells are pivotal in sustaining the immune balance in most experimental animal models. But this is not clear in heat stressed pigs. The present study was aimed at determining if T regulatory and…
View article: Pathogenicity of the First Buffalo‐origin Senecavirus A in Conventional Piglets and Buffaloes
Pathogenicity of the First Buffalo‐origin Senecavirus A in Conventional Piglets and Buffaloes Open
As the only member of the genus Senecavirus within the family Picornaviridae , Senecavirus A (SVA) has posed an enormous challenge for the pig industry worldwide. In our previous study, a SVA strain was isolated from a buffalo with mouth u…