Mingzhang Li
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View article: Blue light enhances the resistance to soft rot disease by inhibiting the activity of Botryosphaeria dothidea and inducing the expression of resistant genes in harvested kiwifruit
Blue light enhances the resistance to soft rot disease by inhibiting the activity of Botryosphaeria dothidea and inducing the expression of resistant genes in harvested kiwifruit Open
View article: Staphylococcus aureus SaeRS impairs macrophage immune functions through bacterial clumps formation in the early stage of infection
Staphylococcus aureus SaeRS impairs macrophage immune functions through bacterial clumps formation in the early stage of infection Open
View article: The mediating role of synovitis in meniscus pathology and knee osteoarthritis radiographic progression
The mediating role of synovitis in meniscus pathology and knee osteoarthritis radiographic progression Open
Meniscus pathologies (damage, extrusion) and synovitis are associated with knee osteoarthritis (KOA); however, whether synovitis mediates the relationship between meniscus pathologies and KOA radiographic progression remains unclear. We co…
View article: Diagnostic Role of Metagenomic Next-Generation Sequencing in Tubercular Orthopedic Implant-Associated Infection
Diagnostic Role of Metagenomic Next-Generation Sequencing in Tubercular Orthopedic Implant-Associated Infection Open
TB-IAI is a rare infection, which occurs after orthopedic surgery and hard to diagnose microbiologically. mNGS is a new detection technique not yet discussed in current literature as a means for TB-IAI diagnostics. Here we describe a cohor…
View article: Anti-osteoarthritis effects of injectable hyaluronic acid hydrogel loaded with platelet lysate and cerium oxide nanoparticle by regulating TNF-α: An in vitro model
Anti-osteoarthritis effects of injectable hyaluronic acid hydrogel loaded with platelet lysate and cerium oxide nanoparticle by regulating TNF-α: An in vitro model Open
The most prevalent type of joint illness is osteoarthritis, also known as OA. The inflammation of the joint is strongly linked to both the beginning and the progression of osteoarthritis. The use of hydrogels as an OA treatment has the pot…
View article: Adaptive evolution of the Clf-Sdr subfamily contributes to Staphylococcus aureus musculoskeletal infection: Evidence from comparative genomics
Adaptive evolution of the Clf-Sdr subfamily contributes to Staphylococcus aureus musculoskeletal infection: Evidence from comparative genomics Open
Persistent Staphylococcus aureus infections of the musculoskeletal system are a challenge in clinical practice. Although extensive studies on the genotypic changes in S. aureus in soft tissue and blood system infections have been conducted…
View article: Trends in microbiological epidemiology of orthopedic infections: a large retrospective study from 2008 to 2021
Trends in microbiological epidemiology of orthopedic infections: a large retrospective study from 2008 to 2021 Open
Background This study assessed the distribution characteristics of pathogens isolated from cases of orthopedic infections and focused on the antimicrobial susceptibility of the main pathogens. Methods This retrospective study involved pati…
View article: Identification of <i>Staphylococcus aureus</i> virulence-modulating RNA from transcriptomics data with machine learning
Identification of <i>Staphylococcus aureus</i> virulence-modulating RNA from transcriptomics data with machine learning Open
The virulence factors of Staphylococcus aureus are tightly controlled by two-component systems (TCSs) and small RNA (sRNA). TCSs have been well studied over the past several decades, but our understanding of sRNA functions lags far …
View article: Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface Open
View article: Chromosome-scale genome assembly of a natural diploid kiwifruit (Actinidia chinensis var. deliciosa)
Chromosome-scale genome assembly of a natural diploid kiwifruit (Actinidia chinensis var. deliciosa) Open
View article: Integrative Analysis of Metabolome and Transcriptome Reveals the Mechanism of Color Formation in Yellow-Fleshed Kiwifruit
Integrative Analysis of Metabolome and Transcriptome Reveals the Mechanism of Color Formation in Yellow-Fleshed Kiwifruit Open
During the development of yellow-fleshed kiwifruit (Actinidia chinensis), the flesh appeared light pink at the initial stage, the pink faded at the fastest growth stage, and gradually changed into green. At the maturity stage, it showed br…
View article: Interactions between Macrophages and Biofilm during <i>Staphylococcus aureus</i>-Associated Implant Infection: Difficulties and Solutions
Interactions between Macrophages and Biofilm during <i>Staphylococcus aureus</i>-Associated Implant Infection: Difficulties and Solutions Open
Staphylococcus aureus (S. aureus) biofilm is the major cause of failure of implant infection treatment that results in heavy social and economic burden on individuals, families, and communities. Planktonic S. aureus at…
View article: Identification of <i>Staphylococcus aureus</i> virulence-modulating RNA from transcriptomics data with machine learning
Identification of <i>Staphylococcus aureus</i> virulence-modulating RNA from transcriptomics data with machine learning Open
The virulence factors of Staphylococcus aureus are tightly controlled by two-component systems (TCSs) and small RNA (sRNA). TCSs have been well studied over the past several decades, but our understanding of sRNA functions lags far …
View article: Integration of transcriptomic and metabolomic data reveals new tetraploid kiwifruit hybrids with enhanced nutrients
Integration of transcriptomic and metabolomic data reveals new tetraploid kiwifruit hybrids with enhanced nutrients Open
Compared to traditional diploids, polyploid red-fleshed kiwifruit varieties usually present excellent characteristics such as larger fruit, storage resistance and strong stress resistance. In this study, the male seed progeny of the wild r…
View article: A novel method to detect the early warning signal of COVID-19 transmission
A novel method to detect the early warning signal of COVID-19 transmission Open
Background Infectious illness outbreaks, particularly the corona-virus disease 2019 (COVID-19) pandemics in recent years, have wreaked havoc on human society, and the growing number of infected patients has put a strain on medical faciliti…
View article: Short-term and oncological outcomes of natural orifice specimen extraction surgery (NOSES) for colorectal cancer in China: a national database study of 5055 patients
Short-term and oncological outcomes of natural orifice specimen extraction surgery (NOSES) for colorectal cancer in China: a national database study of 5055 patients Open
View article: A Novel Method to Detect the Early Warning Signal of Covid-19 Transmission
A Novel Method to Detect the Early Warning Signal of Covid-19 Transmission Open
Background: Infectious illness outbreaks, particularly the corona-virus 19 pandemics in recent years, have wreaked havoc on human society, and the growing number of infected patients has put a strain on medical facilities. It’s necessary t…
View article: Integrative Analysis of Metabolome and Transcriptome Reveals the Mechanism of Color Formation in Actinidia Chinensis Fruit
Integrative Analysis of Metabolome and Transcriptome Reveals the Mechanism of Color Formation in Actinidia Chinensis Fruit Open
View article: Multicenter analysis of gastrointestinal stromal tumors in inner Mongolia of China: A study of 804 cases
Multicenter analysis of gastrointestinal stromal tumors in inner Mongolia of China: A study of 804 cases Open
View article: Integrative analyses of metabolome and genome‐wide transcriptome reveal the regulatory network governing flavor formation in kiwifruit (<i>Actinidia chinensis</i>)
Integrative analyses of metabolome and genome‐wide transcriptome reveal the regulatory network governing flavor formation in kiwifruit (<i>Actinidia chinensis</i>) Open
Summary Soluble sugars, organic acids and volatiles are important components that determine unique fruit flavor and consumer preferences. However, the metabolic dynamics and underlying regulatory networks that modulate overall flavor forma…
View article: Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study
Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study Open
Introduction Gallbladder cancer (GBC), the sixth most common gastrointestinal tract cancer, poses a significant disease burden in China. However, no national representative data are available on the clinical characteristics, treatment and …
View article: Complete genome sequencing of Pseudomonas syringae pv. actinidiae Biovar 3, P155, kiwifruit pathogen originating from China
Complete genome sequencing of Pseudomonas syringae pv. actinidiae Biovar 3, P155, kiwifruit pathogen originating from China Open
Pseudomonas syringae pv. actinidiae is a bacterial pathogen of kiwifruit. Based on the results of the pathogenicity assay, we sequenced the strain Pseudomonas syringae (Psa3) P155 which possesses a series of virulence and resistance genes,…
View article: pUDK-HGF Gene Therapy to Relieve CLI Rest Pain and Ulcers: A Phase II, Double-Blind, Randomized Placebo-Controlled Trial
pUDK-HGF Gene Therapy to Relieve CLI Rest Pain and Ulcers: A Phase II, Double-Blind, Randomized Placebo-Controlled Trial Open
BackgroundCritical limb ischemia (CLI) has become a global problem. Less invasive therapy is needed. Hepatocyte growth factor (HGF) is one of the most potent angiogenic protein and the plasmid encoding human hepatocyte growth factor (HGF) …
View article: Generalised average modelling of grid‐connected three‐phase VSC with closed‐loop vector control and regular‐sampled modulation
Generalised average modelling of grid‐connected three‐phase VSC with closed‐loop vector control and regular‐sampled modulation Open
Based on the generalised averaging method, a comprehensive mathematical model for a three‐phase grid‐connected voltage source converter (VSC) with closed‐loop vector control and symmetrical regular‐sampled modulation is proposed here. The …
View article: Chromosome-scale genome assembly of kiwifruit <i>Actinidia eriantha</i> with single-molecule sequencing and chromatin interaction mapping
Chromosome-scale genome assembly of kiwifruit <i>Actinidia eriantha</i> with single-molecule sequencing and chromatin interaction mapping Open
Background Kiwifruit (Actinidia spp.) is a dioecious plant with fruits containing abundant vitamin C and minerals. A handful of kiwifruit species have been domesticated, among which Actinidiaeriantha is increasingly favored in breeding owi…
View article: Chromosome-scale genome assembly of kiwifruit Actinidia eriantha with single-molecule sequencing and chromatin interaction mapping v2
Chromosome-scale genome assembly of kiwifruit Actinidia eriantha with single-molecule sequencing and chromatin interaction mapping v2 Open
This protocol includes a computational pipeline used in assembly and annotation of Kiwifruit Actinidia eriantha genome.
View article: Differences of Ascorbic Acid Synthesis in Different Genotype of Red-fleshed Kiwifruits
Differences of Ascorbic Acid Synthesis in Different Genotype of Red-fleshed Kiwifruits Open
To investigate the ascorbic acid (AsA) content of different varieties of red-fleshed kiwifruit, four kinds of red flesh kiwifruit were used as materials to determine the content of AsA and glutathione (GSH). Results showed that there were …
View article: Oxidation resistance of exogenous melatonin on leaves of kiwifruit seedlings under copper stress
Oxidation resistance of exogenous melatonin on leaves of kiwifruit seedlings under copper stress Open
In this study, the wild kiwifruit seedlings were used as the research object to investigate the oxidation resistance of exogenous melatonin on leaves of kiwifruit seedlings under copper stress, adopting the root irrigation method.The resul…