Mingzhu Liu
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View article: PLNMFG: Pseudo-label guided non-negative matrix factorization model with graph constraint for single-cell multi-omics data clustering
PLNMFG: Pseudo-label guided non-negative matrix factorization model with graph constraint for single-cell multi-omics data clustering Open
The development of single-cell multi-omics sequencing technologies has enabled the simultaneous analysis of multi-omics data within the same cell. Accurate clustering of these cells is crucial for downstream analyses of complex biological …
View article: Accelerating discovery of next-generation power electronics materials via high-throughput ab initio screening
Accelerating discovery of next-generation power electronics materials via high-throughput ab initio screening Open
Power electronics (PEs) play a pivotal role in electrical energy conversion and regulation for applications spanning from consumer devices to industrial infrastructure. Wide-bandgap (WBG) semiconductors such as SiC, GaN, and Ga2O3 have eme…
View article: Polyethylene terephthalate (PET) microplastics induced male reproductive toxicity in mice by activating the p38-MAPK pathway
Polyethylene terephthalate (PET) microplastics induced male reproductive toxicity in mice by activating the p38-MAPK pathway Open
View article: Gut microbiome dysregulation in noninfectious uveitis
Gut microbiome dysregulation in noninfectious uveitis Open
Noninfectious uveitis (NIU) is a vision-threatening autoimmune disease of the eye, but its pathogenesis is still not fully understood. Recently, accumulating evidence suggests that gut microbiome dysbiosis may affect the development and pr…
View article: Single-cell RNA sequencing reveals the immune cell landscape of head kidney in the Perciform fish (Micropterus salmoides)
Single-cell RNA sequencing reveals the immune cell landscape of head kidney in the Perciform fish (Micropterus salmoides) Open
View article: Alterations of the Enteric Virome in Vogt-Koyanagi-Harada Disease
Alterations of the Enteric Virome in Vogt-Koyanagi-Harada Disease Open
The gut virome of patients with VKH differs significantly from healthy controls, suggesting its disturbance may contribute to gut microbiome imbalance and VKH development.
View article: Development and validation of liquid–liquid phase separation-associated prognostic biomarkers in gastric cancer
Development and validation of liquid–liquid phase separation-associated prognostic biomarkers in gastric cancer Open
This work detected three LLPS-associated prognostic biomarkers (DACT1, PTPN6, and GLE1) for GC. These findings were expected to lead to the development of more precise and effective therapeutic strategies for GC in the future.
View article: The association of blood eosinophil levels with sepsis and mortality risk: An observational and Mendelian Randomization Study
The association of blood eosinophil levels with sepsis and mortality risk: An observational and Mendelian Randomization Study Open
Image, graphical abstract.
View article: Isolation and purification of Pleurotus ostreatus polysaccharides by corn distiller dried grains cultivation: Structural characterization and study the protective capacity against cells
Isolation and purification of Pleurotus ostreatus polysaccharides by corn distiller dried grains cultivation: Structural characterization and study the protective capacity against cells Open
View article: An Activable Aptamer Probe Q2c for Detection of Grouper Iridovirus
An Activable Aptamer Probe Q2c for Detection of Grouper Iridovirus Open
View article: Evaluation of a Tilapia Vaccine Against Streptococcus Agalactiae Epitopes Based on Phage Display Technology
Evaluation of a Tilapia Vaccine Against Streptococcus Agalactiae Epitopes Based on Phage Display Technology Open
View article: Antiviral Activity of Epicatechin Against Singapore Grouper Iridovirus in Vitro and in Vivo
Antiviral Activity of Epicatechin Against Singapore Grouper Iridovirus in Vitro and in Vivo Open
View article: Freeze-Thaw Driven Transport and Transformation of Hexavalent Chromium: Field Monitoring and Mechanistic Controls
Freeze-Thaw Driven Transport and Transformation of Hexavalent Chromium: Field Monitoring and Mechanistic Controls Open
View article: Ganoderma lucidum driven fermentation of Rosa roxburghii pomace: Effects on noodle physicochemical properties, digestion, and gut microbiota
Ganoderma lucidum driven fermentation of Rosa roxburghii pomace: Effects on noodle physicochemical properties, digestion, and gut microbiota Open
View article: Saccharomyces cerevisiae strains L7 contribute to flavor and deacidification in Suanyu, a Chinese traditional fermented fish
Saccharomyces cerevisiae strains L7 contribute to flavor and deacidification in Suanyu, a Chinese traditional fermented fish Open
View article: Tumor-related IGF2BP1-derived molecular subtypes to predict prognosis and immune microenvironment in head and neck squamous cell carcinoma
Tumor-related IGF2BP1-derived molecular subtypes to predict prognosis and immune microenvironment in head and neck squamous cell carcinoma Open
Background Recent studies have underscored the biological significance of RNA modifications in tumorigenicity and progression. However, the potential roles of RNA modifications in immune regulation and the formation of the tumor microenvir…
View article: Differential intestinal microbes and metabolites between Behcet's uveitis and Fuchs syndrome
Differential intestinal microbes and metabolites between Behcet's uveitis and Fuchs syndrome Open
View article: Establishment a cell line of splenic fibroblasts from golden pompano and its application in heavy metal toxicology and pathogen infection
Establishment a cell line of splenic fibroblasts from golden pompano and its application in heavy metal toxicology and pathogen infection Open
A cell line derived from golden pompano Trachinotus ovatus splenic fibroblasts (TOSF) was established, its application in toxicology and virus susceptibility was demonstrated in this study. The TOSF cells grew fastest with the L-15 medium …
View article: [Relationship between GTSE1 and Cell Cycle and Potential Regulatory Mechanisms
in Lung Cancer Cells].
[Relationship between GTSE1 and Cell Cycle and Potential Regulatory Mechanisms
in Lung Cancer Cells]. Open
The regulation of the cell cycle is essential for maintaining normal cellular function, especially in the development of diseases such as lung cancer. The cell cycle consists of four major phases (G1, S, G2 and M phases), which are charact…
View article: Ultrasensitive Ochratoxin A Detection in Cereal Products Using a Fluorescent Aptasensor Based on RecJf Exonuclease-Assisted Target Recycling
Ultrasensitive Ochratoxin A Detection in Cereal Products Using a Fluorescent Aptasensor Based on RecJf Exonuclease-Assisted Target Recycling Open
Ochratoxin A (OTA) is a mycotoxin widely found in foodstuffs such as cereal grains. It greatly threatens human health owing to its strong toxicity and high stability. Aptasensors have emerged as promising tools for the analysis of small mo…
View article: Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis
Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis Open
Pancreas development is tightly controlled by multilayer mechanisms. Despite years of effort, large gaps remain in understanding how histone modifications coordinate pancreas development. SETD2, a predominant histone methyltransferase of H…
View article: The Efficacy of Radiotherapy for Retroperitoneal Metastasis Upper Tract Urothelial Carcinoma: Patterns of Metastasis and Proposals for the Delineation of Clinical Target Volume
The Efficacy of Radiotherapy for Retroperitoneal Metastasis Upper Tract Urothelial Carcinoma: Patterns of Metastasis and Proposals for the Delineation of Clinical Target Volume Open
View article: The Inhibitory Activities and Antiviral Mechanism of Areca Catechu L. Nut Components Against Singapore Grouper Iridovirus Infection
The Inhibitory Activities and Antiviral Mechanism of Areca Catechu L. Nut Components Against Singapore Grouper Iridovirus Infection Open
View article: Antiviral Effect and Mechanism of Edaravone against Grouper Iridovirus Infection
Antiviral Effect and Mechanism of Edaravone against Grouper Iridovirus Infection Open
Singapore grouper iridovirus (SGIV) is a virus with high fatality rate in the grouper culture industry. The outbreak of SGIV is often accompanied by a large number of grouper deaths, which has a great impact on the economy. Therefore, it i…
View article: Non-O1/O139 Vibrio cholerae causes severe intestinal disease in bullfrogs (Rana catesbeiana)
Non-O1/O139 Vibrio cholerae causes severe intestinal disease in bullfrogs (Rana catesbeiana) Open
Bullfrogs ( Rana catesbeiana ) are amphibians with high economic value, but in recent years, bullfrog farming has encountered serious threats of bacterial diseases, and the “bullfrog economy” is facing a continuous decline. In this study, …
View article: Genome-wide analysis of RNA-binding proteins co-expression with alternative splicing events in mitral valve prolapse
Genome-wide analysis of RNA-binding proteins co-expression with alternative splicing events in mitral valve prolapse Open
Objectives We investigated the role and molecular mechanisms of RNA-binding proteins (RBPs) and their regulated alternative splicing events (RASEs) in the pathogenesis of mitral valve prolapse (MVP). Methods For RNA extraction, we obtained…
View article: Antisense Oligonucleotides Selectively Enter Human‐Derived Antibiotic‐Resistant Bacteria through Bacterial‐Specific ATP‐Binding Cassette Sugar Transporter
Antisense Oligonucleotides Selectively Enter Human‐Derived Antibiotic‐Resistant Bacteria through Bacterial‐Specific ATP‐Binding Cassette Sugar Transporter Open
Current vehicles used to deliver antisense oligonucleotides (ASOs) cannot distinguish between bacterial and mammalian cells, greatly hindering the preclinical or clinical treatment of bacterial infections, especially those caused by antibi…
View article: A cost-effective machine learning-based method for preeclampsia risk assessment and driver genes discovery
A cost-effective machine learning-based method for preeclampsia risk assessment and driver genes discovery Open
Background The placenta, as a unique exchange organ between mother and fetus, is essential for successful human pregnancy and fetal health. Preeclampsia (PE) caused by placental dysfunction contributes to both maternal and infant morbidity…
View article: Diagnosis and surgical management strategy for pediatric small bowel obstruction: Experience from a single medical center
Diagnosis and surgical management strategy for pediatric small bowel obstruction: Experience from a single medical center Open
Identifying Bowel strangulation and the approach and timing of surgical intervention for pediatric SBO are still uncertain. In this study, 75 consecutive pediatric patients with surgically confirmed SBO were retrospectively reviewed. The p…
View article: Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation
Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation Open
Emerging evidence shows that the biomechanical environment is required to support cancer stem cells (CSCs), which play a crucial role in drug resistance. However, how mechanotransduction signals regulate CSCs and its clinical significance …