Thai Tran
YOU?
Author Swipe
View article: Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer’s disease
Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer’s disease Open
Aging populations face increasing incidence of neurological disorders, including Alzheimer’s disease (AD) and late-onset epilepsy (LOE), which demonstrate a bidirectional relationship where AD is a risk factor for LOE and LOE is a risk fac…
View article: 355. AGONISM HETEROGENEITY: ANTI-AMNESIC SIGMAR1 AGONISTS PRE-084 AND (+)PENTAZOCINE DIFFERENTIALLY TRANSLOCATE SIGMAR1 TO SUBSTRUCTURES OF ENDOPLASMIC RETICULUM IN NEURO2A CELLS
355. AGONISM HETEROGENEITY: ANTI-AMNESIC SIGMAR1 AGONISTS PRE-084 AND (+)PENTAZOCINE DIFFERENTIALLY TRANSLOCATE SIGMAR1 TO SUBSTRUCTURES OF ENDOPLASMIC RETICULUM IN NEURO2A CELLS Open
Background Sigma-1 receptor (SIGMAR1) is a ligand-operated CNS transmembrane chaperone implicated in psychiatric diseases such as addiction, depression, amnesia, and schizophrenia. SIGMAR1 normally co-locates with another chaperone BiP at …
View article: Diverse Genomes, Shared Health: Insights from a Health System Biobank
Diverse Genomes, Shared Health: Insights from a Health System Biobank Open
Coupling genetic profiling with electronic health records from hospital biobanks is a foundational resource for precision medicine. However, lack of ancestral heterogeneity limits discovery and generalizability. We leveraged the UCLA ATLAS…
View article: Vietnam Sets Bold Milestones for Elephant Conservation with New National Action Plan
Vietnam Sets Bold Milestones for Elephant Conservation with New National Action Plan Open
View article: TIA1 Is Required for Microglial Activation in Alzheimer’s Disease
TIA1 Is Required for Microglial Activation in Alzheimer’s Disease Open
View article: Ruminococcus‐based metagenomic‐brain signature linked to cognitive performance and Alzheimer’s disease markers
Ruminococcus‐based metagenomic‐brain signature linked to cognitive performance and Alzheimer’s disease markers Open
Background The aim of this study was to identify a gut microbial signature associated with patterns of gray matter volume in AD, and to validate the microbial signature by testing it against measures of AD pathology and cognitive performan…
View article: IMMUNOSTIMULATORY EFFECT OF JASMINUM SUBTRIPLINERVE BLUME LEAVES EXTRACT ON CYCLOPHOSPHAMIDE-INDUCED IMMUNOSUPPRESSION IN MICE
IMMUNOSTIMULATORY EFFECT OF JASMINUM SUBTRIPLINERVE BLUME LEAVES EXTRACT ON CYCLOPHOSPHAMIDE-INDUCED IMMUNOSUPPRESSION IN MICE Open
The objective of this study was to evaluate the immunostimulatory activity of Jasminum subtriplinerve Blume. extract (JM). We induced the immunosuppression in Swiss mice by cyclophosphamide (CP). Jasminum subtriplinerve Blume. extract 14.4…
View article: TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages
TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages Open
The RNA binding protein TIA1 is known to regulate stress responses. Here we show that TIA1 plays a much broader role in inflammatory cells, being required for the microglial sensome. We crossed TIA1 cKO mice (using a CX3CR1 driven cre elem…
View article: Differentiation of CD166-positive hPSC-derived lung progenitors into airway epithelial cells
Differentiation of CD166-positive hPSC-derived lung progenitors into airway epithelial cells Open
The generation of lung epithelial cells through the directed differentiation of human pluripotent stem cells (hPSCs) in vitro provides a platform to model both embryonic lung development and adult airway disease. Here, we describe a robust…
View article: Impact of <scp>CD151</scp> overexpression on prognosis and therapy in non‐small cell lung cancer patients lacking <scp>EGFR</scp> mutations
Impact of <span>CD151</span> overexpression on prognosis and therapy in non‐small cell lung cancer patients lacking <span>EGFR</span> mutations Open
This study investigates CD151, a protein linked to cancer progression, in non‐small cell lung cancer (NSCLC) patients without epidermal growth factor receptor (EGFR) mutations. These patients often have limited treatment options. The study…
View article: Dendritic cell‐targeted delivery of antigens using extracellular vesicles for anti‐cancer immunotherapy
Dendritic cell‐targeted delivery of antigens using extracellular vesicles for anti‐cancer immunotherapy Open
Neoantigen delivery using extracellular vesicles (EVs) has gained extensive interest in recent years. EVs derived from tumour cells or immune cells have been used to deliver tumour antigens or antitumor stimulation signals. However, potent…
View article: Multi-class Modeling Identifies Shared Genetic Risk for Late-onset Epilepsy and Alzheimer’s Disease
Multi-class Modeling Identifies Shared Genetic Risk for Late-onset Epilepsy and Alzheimer’s Disease Open
Background Previous studies have established a strong link between late-onset epilepsy (LOE) and Alzheimer’s disease (AD). However, their shared genetic risk beyond the APOE gene remains unclear. Our study sought to examine the shared gene…
View article: New radiochromic film densitometry system using commercially available digital camera and LEDs
New radiochromic film densitometry system using commercially available digital camera and LEDs Open
This project involved designing and building a radiochromic film (RCF) densitometer using a still digital camera as the light detector and light emitting diode, LED, as the light source. The behaviour of the LED and charged coupled device …
View article: Numerical Modeling of Water Flow in Permeable Friction Course Pavement During Rainfall Considering Rainfall Intensity and Suction Pressure
Numerical Modeling of Water Flow in Permeable Friction Course Pavement During Rainfall Considering Rainfall Intensity and Suction Pressure Open
This study developed a numerical model to observe the water flow in permeable friction course pavement (PFCP) during rainfall events. The model was established based on FeniCS, which is widely known as an open-source computing platform for…
View article: Latent diffusion augmentation enhances deep learning analysis of neuro-morphology in limbal stem cell deficiency
Latent diffusion augmentation enhances deep learning analysis of neuro-morphology in limbal stem cell deficiency Open
Introduction Limbal Stem Cell Deficiency (LSCD) is a blinding corneal disease characterized by the loss of function or deficiency in adult stem cells located at the junction between the cornea and the sclera (i.e., the limbus), namely the …
View article: Human neutrophils are a key target of glucocorticoids
Human neutrophils are a key target of glucocorticoids Open
Neutrophils play central roles in immunity and inflammation. Glucocorticoids (GCs) are the cornerstone of anti-inflammatory and immunosuppressive therapy. While GCs trigger an acute rise in circulating neutrophils, little is known about th…
View article: Influence of glycan structure on the colonization of <i>Streptococcus pneumoniae</i> on human respiratory epithelial cells
Influence of glycan structure on the colonization of <i>Streptococcus pneumoniae</i> on human respiratory epithelial cells Open
Virtually all living cells are encased in glycans. They perform key cellular functions such as immunomodulation and cell–cell recognition. Yet, how their composition and configuration affect their functions remains enigmatic. Here, we cons…
View article: Big data and artificial intelligence in ophthalmology - clinical application and future exploration
Big data and artificial intelligence in ophthalmology - clinical application and future exploration Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…
View article: GCgx: transcriptome-wide exploration of the response to glucocorticoids
GCgx: transcriptome-wide exploration of the response to glucocorticoids Open
Glucocorticoids are the cornerstone of immunosuppressive and anti-inflammatory therapy in humans, yet the mechanisms of glucocorticoid immunoregulation and toxicity remain unclear. The response to glucocorticoids is highly cell type-depend…
View article: Tetraspanins: Host Factors in Viral Infections
Tetraspanins: Host Factors in Viral Infections Open
Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and en…
View article: Editorial: Intra/Extracellular Dynamics of the Respiratory System and Global Airway Disease
Editorial: Intra/Extracellular Dynamics of the Respiratory System and Global Airway Disease Open
EDITORIAL article Front. Cell Dev. Biol., 09 July 2020 | https://doi.org/10.3389/fcell.2020.00523
View article: Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases
Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases Open
View article: FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD)
FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD) Open
The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF family. It plays a role in airway remodeling associated with chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary d…
View article: Editorial: Adaptor Protein Regulation in Immune Signalling
Editorial: Adaptor Protein Regulation in Immune Signalling Open
EDITORIAL article Front. Immunol., 13 March 2020Sec. Molecular Innate Immunity Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.00441
View article: CD151 in Respiratory Diseases
CD151 in Respiratory Diseases Open
The tetraspanin, Cluster of Differentiation 151 (CD151), is ubiquitously expressed in adult tissue, especially in the lungs where it has been implicated in lung cancer, asthma, influenza, and idiopathic pulmonary fibrosis (IPF). CD151 inte…
View article: Integrin α7 expression is increased in asthmatic patients and its inhibition reduces Kras protein abundance in airway smooth muscle cells
Integrin α7 expression is increased in asthmatic patients and its inhibition reduces Kras protein abundance in airway smooth muscle cells Open
View article: Comparative Transcriptomic and Metagenomic Analyses of Influenza Virus-Infected Nasal Epithelial Cells From Multiple Individuals Reveal Specific Nasal-Initiated Signatures
Comparative Transcriptomic and Metagenomic Analyses of Influenza Virus-Infected Nasal Epithelial Cells From Multiple Individuals Reveal Specific Nasal-Initiated Signatures Open
In vitro and in vivo research based on cell lines and animals are likely to be insufficient in elucidating authentic biological and physiological phenomena mimicking human systems, especially for generating pre-clinical data …
View article: CD151, a novel host factor of nuclear export signaling in influenza virus infection
CD151, a novel host factor of nuclear export signaling in influenza virus infection Open
View article: CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling
CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling Open
View article: Integrins as Therapeutic Targets for Respiratory Diseases
Integrins as Therapeutic Targets for Respiratory Diseases Open
Integrins are a large family of transmembrane heterodimeric proteins that constitute the main receptors for extracellular matrix components. Integrins were initially thought to be primarily involved in the maintenance of cell adhesion and …