Duc M. Duong
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View article: Symptom clusters and their influencing factors among Vietnamese women after cancer treatment
Symptom clusters and their influencing factors among Vietnamese women after cancer treatment Open
This study aimed to (1) identify symptom clusters in Vietnamese women with cancer and (2) examine the factors influencing those identified clusters. A cross-sectional study was conducted in 5 hospitals across Vietnam from September to Dece…
View article: Integrated phenotypic and proteomic screening identifies top‐tier Alzheimer's disease therapeutic targets
Integrated phenotypic and proteomic screening identifies top‐tier Alzheimer's disease therapeutic targets Open
INTRODUCTION Alzheimer's disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi‐omic studies, but effective prioritization remains a major bottleneck. METHODS We …
View article: Label-free viability assessment of <i>ex vivo</i> mouse kidneys for transplant applications using dynamic optical coherence tomography
Label-free viability assessment of <i>ex vivo</i> mouse kidneys for transplant applications using dynamic optical coherence tomography Open
Kidney transplantation remains the preferred treatment for patients with end-stage kidney disease. However, the ongoing shortage of donor organs continues to limit the availability of transplant treatments. Existing evaluation methods, suc…
View article: Integrated phenotypic and proteomic screening identifies top-tier Alzheimer’s disease therapeutic targets
Integrated phenotypic and proteomic screening identifies top-tier Alzheimer’s disease therapeutic targets Open
Introduction Alzheimer’s disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi-omic studies, but effective prioritization remains a major bottleneck. Methods We …
View article: Neuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons
Neuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons Open
Background: Understanding synapse-specific effects of neuroinflammation can provide mechanistic and therapeutically relevant insights across the spectrum of neurological diseases. Methods: We applied neuron-specific proteomic biotinylation…
View article: Real-Time Viability Assessment of Ex Vivo Mouse Kidneys for Transplant Applications Using Dynamic Optical Coherence Tomography
Real-Time Viability Assessment of Ex Vivo Mouse Kidneys for Transplant Applications Using Dynamic Optical Coherence Tomography Open
Kidney transplantation remains the preferred treatment for patients with end-stage kidney disease. However, the ongoing shortage of donor organs continues to limit the availability of transplant treatments. Existing evaluation methods, suc…
View article: Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions
Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions Open
To understand shared and ancestry-specific genetic control of brain protein expression and its ramifications for disease, we mapped protein quantitative trait loci (pQTLs) in 1,362 brain proteomes from African American, Hispanic/Latin Amer…
View article: Blood plasma сytokine levels in patients with chronic viral hepatitis B stage-dependent liver fibrosis
Blood plasma сytokine levels in patients with chronic viral hepatitis B stage-dependent liver fibrosis Open
Introduction. Hepatitis B is an infectious inflammatory liver disease resulting from hepatitis B virus infection. According to the WHO estimates, 254 million people with chronic hepatitis B (CHB) were recorded worldwide in 2022. CHB is acc…
View article: Engineering a cell-based orthogonal ubiquitin transfer cascade for profiling the substrates of RBR E3 Parkin
Engineering a cell-based orthogonal ubiquitin transfer cascade for profiling the substrates of RBR E3 Parkin Open
The E3 ubiquitin (UB) ligase Parkin utilizes a Ring-Between-Ring (RBR) domain to mediate UB transfer to substrate proteins, and mutations affecting Parkin catalysis promote cancer and are associated with Parkinson's disease. An essential r…
View article: Exploring technology access, knowledge, and preferences for detection, monitoring, and support of cognitive health in rural communities
Exploring technology access, knowledge, and preferences for detection, monitoring, and support of cognitive health in rural communities Open
Approximately 25% of adults in the United States aged 60 years and older experience Mild Cognitive Impairment (MCI) or Subjective Cognitive Decline (SCD) which may be precursors to Alzheimer’s Disease. Families living in rural areas and co…
View article: Proteomic Subtyping of Alzheimer’s Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic Biomarkers
Proteomic Subtyping of Alzheimer’s Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic Biomarkers Open
Alzheimer’s disease (AD) is characterized by significant clinical and molecular heterogeneity, influenced by genetic and demographic factors. Using an unbiased, network-driven approach, we analyzed the cerebrospinal fluid (CSF) proteome fr…
View article: Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease
Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease Open
Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants are associated with genes highly expressed in astrocytes. However, the contribution of genetic risk within astrocytes to cellular proces…
View article: Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration Open
Rare inherited diseases caused by mutations in the copper transporters SLC31A1 (CTR1) or ATP7A induce copper deficiency in the brain, causing seizures and neurodegeneration in infancy through poorly understood mechanisms. Here, we used mul…
View article: CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment
CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment Open
INTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cogni…
View article: Exploratory CSF proteomics biomarker outcomes of the the phase 2 clinical trial shine to assess the effects of CT1812 in Alzheimer’s patients
Exploratory CSF proteomics biomarker outcomes of the the phase 2 clinical trial shine to assess the effects of CT1812 in Alzheimer’s patients Open
Background SHINE (NCT03507790, COG0201) is a Phase 2 randomized, double‐blind, placebo‐controlled 6‐month trial, conducted to study the effect of the sigma‐2 receptor (S2R) modulator CT1812 in patients with Alzheimer’s disease (AD). An unb…
View article: Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons
Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons Open
Background Neuroinflammation plays a critical role in Alzheimer’s disease pathogenesis. Neurons are anatomically divided in subcellular compartments (axons, soma, and synapses), which may be distinctly impacted by neuroinflammation. This s…
View article: Matched Proteomics of Cerebrospinal Fluid and Brain Reveals Conserved and Discordant Mechanisms of Progressive Aβ Pathology in Mice
Matched Proteomics of Cerebrospinal Fluid and Brain Reveals Conserved and Discordant Mechanisms of Progressive Aβ Pathology in Mice Open
Background Cerebrospinal fluid (CSF) is an important source of protein biomarkers for diagnosis, risk stratification, and predicting treatment response in Alzheimer's disease (AD). Proximity to brain parenchyma suggests that CSF proteomic …
View article: Marmosets as model systems for the study of Alzheimer's disease and related dementias: Substantiation of physiological tau 3R and 4R isoform expression and phosphorylation
Marmosets as model systems for the study of Alzheimer's disease and related dementias: Substantiation of physiological tau 3R and 4R isoform expression and phosphorylation Open
INTRODUCTION Marmosets spontaneously develop pathological hallmarks of Alzheimer's disease (AD) including amyloid beta plaques. However, tau expression in the marmoset brain has been understudied. METHODS Isoforms of tau were examined by w…
View article: Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology Open
Preventative treatment for Alzheimer's Disease (AD) is dire, yet mechanisms underlying early regional vulnerability remain unknown. In AD, one of the earliest pathophysiological correlates to cognitive decline is hyperexcitability, which i…
View article: Alzheimer’s disease risk gene <i>CD2AP</i> is a dose-sensitive determinant of synaptic structure and plasticity
Alzheimer’s disease risk gene <i>CD2AP</i> is a dose-sensitive determinant of synaptic structure and plasticity Open
CD2-Associated protein (CD2AP) is a candidate susceptibility gene for Alzheimer’s disease, but its role in the mammalian central nervous system remains largely unknown. We show that CD2AP protein is broadly expressed in the adult mouse bra…
View article: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease Open
Lewy body dementia (LBD), a class of disorders comprising Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), features substantial clinical and pathological overlap with Alzheimer’s disease (AD). The identification of b…
View article: Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer’s disease
Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer’s disease Open
Reactive astrocytes are associated with Alzheimer’s disease (AD), and several AD genetic risk variants are associated with genes highly expressed in astrocytes. However, the contribution of genetic risk within astrocytes to cellular proces…
View article: Proteomic analysis of Alzheimer’s disease cerebrospinal fluid reveals alterations associated with <i>APOE</i> ε4 and atomoxetine treatment
Proteomic analysis of Alzheimer’s disease cerebrospinal fluid reveals alterations associated with <i>APOE</i> ε4 and atomoxetine treatment Open
Alzheimer’s disease (AD) is currently defined by the aggregation of amyloid-β (Aβ) and tau proteins in the brain. Although biofluid biomarkers are available to measure Aβ and tau pathology, few markers are available to measure the complex …
View article: Psychosocial experiences are associated with human brain mitochondrial biology
Psychosocial experiences are associated with human brain mitochondrial biology Open
Psychosocial experiences affect brain health and aging trajectories, but the molecular pathways underlying these associations remain unclear. Normal brain function relies on energy transformation by mitochondria oxidative phosphorylation (…