Minhee Park
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View article: Defining the factors that control differentiation of conventional monocytes into macrophages during early metastasis in the lung 9370
Defining the factors that control differentiation of conventional monocytes into macrophages during early metastasis in the lung 9370 Open
Description Conventional monocytes (cMonos) and their progeny, macrophages, support metastasis by priming pre-metastatic niches and aiding tumor colonization. While cMonos recruited to the metastatic lung differentiate into metastasis-asso…
View article: Beneficial effect of consuming milk containing only A2 beta-casein on gut microbiota: A single-center, randomized, double-blind, cross-over study
Beneficial effect of consuming milk containing only A2 beta-casein on gut microbiota: A single-center, randomized, double-blind, cross-over study Open
Cow milk contains essential nutrients, with β-casein existing in A1 and A2 forms. Studies suggest that A2 milk (containing only A2 β-casein) may offer gastrointestinal (GI) benefits compared to A1/A2 milk (containing both forms). This stud…
View article: Effects of Oral supplementation with eggshell membrane (Ovoderm®-AS) on skin health: A randomized, double-blind, placebo-controlled trial
Effects of Oral supplementation with eggshell membrane (Ovoderm®-AS) on skin health: A randomized, double-blind, placebo-controlled trial Open
Eggshell membrane (ESM, Ovoderm®-AS) contains bioactive compounds like collagen, elastin, hyaluronic acid, glucosamine, and chondroitin sulfate, which promote cellular activity, enhance collagen production, and reduce UV-induced damage. Th…
View article: Variations in metabolites content and bioactivity to regulate biomarkers of benign prostatic hyperplasia according to the growth stages of Sida rhombifolia
Variations in metabolites content and bioactivity to regulate biomarkers of benign prostatic hyperplasia according to the growth stages of Sida rhombifolia Open
It has been reported that the secondary metabolites produced by plants are influenced by genetic diversity and growth conditions, resulting in significant variations in chemical content even within the same species. In the previous study s…
View article: Repositioning of aripiprazole, an anti‑psychotic drug, to sensitize the chemotherapy of pancreatic cancer
Repositioning of aripiprazole, an anti‑psychotic drug, to sensitize the chemotherapy of pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited therapeutic options. Cisplatin is a primary chemotherapeutic agent utilized in combination with other drugs or radiotherapy for PDAC treatment. However, the severe…
View article: Construction, Purification, and Biological Characterization of Plant-Made Human Recombinant Irisin
Construction, Purification, and Biological Characterization of Plant-Made Human Recombinant Irisin Open
Irisin is a myokine primarily expressed in skeletal muscle, known to mediate the beneficial effects of exercise.Irisin was first reported to induce adipocyte browning by increasing the expression of uncoupling protein 1 (UCP1), and subsequ…
View article: 3D spheroid model of adipose-derived stem cell and breast cancer cell co- culture for mimicking cell migration and the cancer environment
3D spheroid model of adipose-derived stem cell and breast cancer cell co- culture for mimicking cell migration and the cancer environment Open
Traditional two-dimensional (2D) cell culture methodologies exhibit significant limitations, notably their failure to replicate the intricate three-dimensional (3D) milieu of human tissue architecture. This discrepancy has catalyzed the ex…
View article: Analysis of Visual Attention on Korean Essay Book Covers Using Eye-tracking Devices
Analysis of Visual Attention on Korean Essay Book Covers Using Eye-tracking Devices Open
Today, with the advent of various communication media, the importance of the visual component of the book cover is increasing as the purchasing behavior pattern changes from paper books to e-books and from offline to online and mobile chan…
View article: Suppressing Src-Mediated EGFR Signaling by Sustained Calcium Supply Targeting Triple-Negative Breast Cancer
Suppressing Src-Mediated EGFR Signaling by Sustained Calcium Supply Targeting Triple-Negative Breast Cancer Open
Src is emerging as a promising target in triple-negative breast cancer (TNBC) treatment because it activates survival signaling linked to the epidermal growth factor receptor. In this study, the effect of calcium supply on Src degradation …
View article: Supplementary Tables from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer
Supplementary Tables from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer Open
PDF file, 160K, Supplementary Table 1. Primer and siRNA sequences Supplementary Table 2. Clinicopathological characteristics of 250 colorectal cancers according to KIT expression.
View article: Supplementary Figures from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer
Supplementary Figures from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer Open
PDF file, 779K, Figure S1. Expressionofp-KIT,p-AKT,andp-ERK increased according to the increased SCF concentrationin two KIT-expressingcelllines. Figure S2. Expression of KIT, p-KIT, p-AKT, and p-ERK after SCF treatment in two tumor cell l…
View article: Supplementary Figures from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer
Supplementary Figures from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer Open
PDF file, 779K, Figure S1. Expressionofp-KIT,p-AKT,andp-ERK increased according to the increased SCF concentrationin two KIT-expressingcelllines. Figure S2. Expression of KIT, p-KIT, p-AKT, and p-ERK after SCF treatment in two tumor cell l…
View article: Data from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer
Data from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer Open
Purpose: Abnormal signaling through receptor tyrosine kinase (RTK) moieties is important in tumorigenesis and drug targeting of colorectal cancers. Wild-type KIT (WT-KIT), a RTK that is activated upon binding with stem cell factor (SCF), i…
View article: Data from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer
Data from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer Open
Purpose: Abnormal signaling through receptor tyrosine kinase (RTK) moieties is important in tumorigenesis and drug targeting of colorectal cancers. Wild-type KIT (WT-KIT), a RTK that is activated upon binding with stem cell factor (SCF), i…
View article: Supplementary Tables from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer
Supplementary Tables from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer Open
PDF file, 160K, Supplementary Table 1. Primer and siRNA sequences Supplementary Table 2. Clinicopathological characteristics of 250 colorectal cancers according to KIT expression.
View article: A Plant-Produced Porcine Parvovirus 1-82 VP2 Subunit Vaccine Protects Pregnant Sows against Challenge with a Genetically Heterologous PPV1 Strain
A Plant-Produced Porcine Parvovirus 1-82 VP2 Subunit Vaccine Protects Pregnant Sows against Challenge with a Genetically Heterologous PPV1 Strain Open
Porcine parvovirus (PPV) causes reproductive failure in sows, and vaccination remains the most effective means of preventing infection. The NADL-2 strain has been used as a vaccine for ~50 years; however, it does not protect animals agains…
View article: Accumulation of poly (adenosine diphosphate-ribose) by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells
Accumulation of poly (adenosine diphosphate-ribose) by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells Open
This study visualized the potential anticancer effects of excessive PAR accumulation by sustained calcium supply on pancreatic cancer, however elucidating a clear mode of action remains a challenge, and it should be accompanied by further …
View article: Poly adenosine diphosphate-ribosylation, a promising target for colorectal cancer treatment
Poly adenosine diphosphate-ribosylation, a promising target for colorectal cancer treatment Open
The development of colorectal cancer (CRC) can result from changes in a variety of cellular systems within the tumor microenvironment. Particularly, it is primarily associated with genomic instability that is the gradual accumulation of ge…
View article: The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm
The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm Open
Genome-wide studies focusing on elucidating the effects on cancer progression have enabled the consequent identification of a distinct subpopulation of pancreatic cancer cells with unstable genomic characteristics. Based on this background…
View article: Remodeling of Cancer-Specific Metabolism under Hypoxia with Lactate Calcium Salt in Human Colorectal Cancer Cells
Remodeling of Cancer-Specific Metabolism under Hypoxia with Lactate Calcium Salt in Human Colorectal Cancer Cells Open
Hypoxic cancer cells meet their growing energy requirements by upregulating glycolysis, resulting in increased glucose consumption and lactate production. Herein, we used a unique approach to change in anaerobic glycolysis of cancer cells …
View article: Combination Antitumor Effect of Sorafenib via Calcium-Dependent Deactivation of Focal Adhesion Kinase Targeting Colorectal Cancer Cells
Combination Antitumor Effect of Sorafenib via Calcium-Dependent Deactivation of Focal Adhesion Kinase Targeting Colorectal Cancer Cells Open
Sorafenib has been recently used for the treatment of patients with advanced colorectal cancer (CRC) and is recognized for its therapeutic value. However, the continuous use of sorafenib may cause resistance in the treatment of cancer pati…
View article: Topiramate-related adverse events
Topiramate-related adverse events Open
Despite safety concerns associated with topiramate use, the pattern of adverse events and signal analysis of antiepileptic drugs remain elusive.We aimed to determine patient demographics and characteristics of reported AEs of topiramate an…
View article: Letter: An International Investigation Into the COVID-19 Pandemic and Workforce Depletion in Highly Specialized Neurointerventional Units – Insights From Stroke Thrombectomy and Aneurysm Registry and Endovascular Neurosurgery Research Group
Letter: An International Investigation Into the COVID-19 Pandemic and Workforce Depletion in Highly Specialized Neurointerventional Units – Insights From Stroke Thrombectomy and Aneurysm Registry and Endovascular Neurosurgery Research Group Open
To the Editor: The COVID-19 pandemic has imposed unprecedented challenges on health-care systems to protect providers while maintaining sufficient resources to handle emergent conditions. Endovascular thrombectomy for stroke is a time-sens…
View article: Rabies virus glycoprotein produced in Nicotiana benthamiana is an immunogenic antigen in mice
Rabies virus glycoprotein produced in Nicotiana benthamiana is an immunogenic antigen in mice Open
Rabies remains an infectious disease among humans and animals, and requires the development of an effective vaccine essential to prevent rabies. Advances in molecular biology and biotechnology have led to the development and improvement of…
View article: Potential Anticancer Effect of Calcium-mediated Src Degradation on Hormone-dependent Breast Cancer
Potential Anticancer Effect of Calcium-mediated Src Degradation on Hormone-dependent Breast Cancer Open
Sustained supply of calcium inhibited survival signaling via degradation of Src in hormone-dependent breast cancer cells.
View article: FlexPro MD®, a Combination of Krill Oil, Astaxanthin and Hyaluronic Acid, Reduces Pain Behavior and Inhibits Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats
FlexPro MD®, a Combination of Krill Oil, Astaxanthin and Hyaluronic Acid, Reduces Pain Behavior and Inhibits Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats Open
Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. Since there is no cure for OA and no effective treatment to slow its progression, current pharmacologic treatments, such as analgesics and non-ste…