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View article: Nanoscale Lattice Organization of Molecular Condensates Drives Compositional Degeneracy in Synaptic Plasticity
Nanoscale Lattice Organization of Molecular Condensates Drives Compositional Degeneracy in Synaptic Plasticity Open
Synaptic plasticity is essential for neuronal communication, involving coordinated structural, molecular and functional changes that are shaped by the nanoscale alterations of the active zone and postsynaptic density. Emerging evidence sug…
View article: Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM
Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM Open
View article: Author Correction: Nanoscale regulation of Ca2+ dependent phase transitions and real-time dynamics of SAP97/hDLG
Author Correction: Nanoscale regulation of Ca2+ dependent phase transitions and real-time dynamics of SAP97/hDLG Open
View article: Nanoscale regulation of Ca2+ dependent phase transitions and real-time dynamics of SAP97/hDLG
Nanoscale regulation of Ca2+ dependent phase transitions and real-time dynamics of SAP97/hDLG Open
Synapse associated protein-97/Human Disk Large (SAP97/hDLG) is a conserved, alternatively spliced, modular, scaffolding protein critical in regulating the molecular organization of cell-cell junctions in vertebrates. We confirm that the mo…
View article: Membrane Cholesterol Is a Critical Determinant for Hippocampal Neuronal Polarity
Membrane Cholesterol Is a Critical Determinant for Hippocampal Neuronal Polarity Open
Maintaining a normal cholesterol balance is crucial for the functioning of a healthy brain. Dysregulation in cholesterol metabolism and homeostasis in the brain have been correlated to various neurological disorders. The majority of previo…
View article: Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains
Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains Open
Alterations in the canonical processing of Amyloid Precursor Protein generate proteoforms that contribute to the onset of Alzheimer’s Disease. Modified composition of γ-secretase or mutations in its subunits has been directly linked to alt…
View article: Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases
Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases Open
Modulation of real-time reversible nanoscale distribution of HCN2 channels using optogenetic activation of cAMP in live cells.
View article: Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease
Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease Open
View article: Differential Scaling of Synaptic Molecules within Functional Zones of an Excitatory Synapse during Homeostatic Plasticity
Differential Scaling of Synaptic Molecules within Functional Zones of an Excitatory Synapse during Homeostatic Plasticity Open
Homeostatic scaling is a form of synaptic plasticity where individual synapses scale their strengths to compensate for global suppression or elevation of neuronal activity. This process can be studied by measuring miniature EPSP (mEPSP) am…
View article: Characterization of Nanoscale Organization of F-Actin in Morphologically Distinct Dendritic Spines<i>In Vitro</i>Using Supervised Learning
Characterization of Nanoscale Organization of F-Actin in Morphologically Distinct Dendritic Spines<i>In Vitro</i>Using Supervised Learning Open
The cytoarchitecture of a neuron is very important in defining morphology and ultrastructure. Although there is a wealth of information on the molecular components that make and regulate these ultrastructures, there is a dearth of understa…
View article: Phosphatidylserine and GTPase activation control Cdc42 nanoclustering to counter dissipative diffusion
Phosphatidylserine and GTPase activation control Cdc42 nanoclustering to counter dissipative diffusion Open
The anisotropic organization of plasma membrane constituents is indicative of mechanisms that drive the membrane away from equilibrium. However, defining these mechanisms is challenging due to the short spatiotemporal scales at which diffu…
View article: A quantitative imaging-based screen reveals the exocyst as a network hub connecting endocytosis and exocytosis
A quantitative imaging-based screen reveals the exocyst as a network hub connecting endocytosis and exocytosis Open
The coupling of endocytosis and exocytosis underlies fundamental biological processes ranging from fertilization to neuronal activity and cellular polarity. However, the mechanisms governing the spatial organization of endocytosis and exoc…