Katherine Chung
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View article: Performance of GPT-4 on the American College of Radiology In-Service Examination
Performance of GPT-4 on the American College of Radiology In-Service Examination Open
Objectives No study has evaluated the ability of ChatGPT-4 to answer image-rich diagnostic radiology board exam questions or assessed for model drift in GPT-4’s image interpretation abilities. In our study we evaluate GPT-4’s performance o…
View article: Learning Topological Interactions for Multi-Class Medical Image Segmentation
Learning Topological Interactions for Multi-Class Medical Image Segmentation Open
Deep learning methods have achieved impressive performance for multi-class medical image segmentation. However, they are limited in their ability to encode topological interactions among different classes (e.g., containment and exclusion).…
View article: Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule
Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule Open
Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis acros…
View article: Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma
Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma Open
SUMMARY Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progression is not well understood. Leveraging an autochthonous mouse model, we demonstrate a causa…
View article: Unilateral Thalamic Venous Infarction in an Infant: A Rare Presentation of Bilateral Deep Cerebral Venous Thrombosis
Unilateral Thalamic Venous Infarction in an Infant: A Rare Presentation of Bilateral Deep Cerebral Venous Thrombosis Open
Cerebral venous thrombosis (CVT) may manifest as superficial cerebral venous thrombosis (SCVT) or deep cerebral venous thrombosis (DCVT). Of the two patterns, DCVT is less commonly observed, although it often results in greater morbidity a…
View article: HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells
HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells Open
Long-term persistent infection of HPV16 E6/E7 is frequently associated with lung cancers, especially in non-smokers and in Asians. However, molecular mechanisms of HPV16 E6/E7 induction of lung cancer are not fully understood. Using bi-dir…
View article: Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers Open
Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we leverage mosaic a…