Mei Yu
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View article: Fertility-sparing treatment for overweight patients with early-stage endometrial cancer or atypical endometrial hyperplasia under weight loss intervention
Fertility-sparing treatment for overweight patients with early-stage endometrial cancer or atypical endometrial hyperplasia under weight loss intervention Open
View article: Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling
Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling Open
SUMMARY The Calcitonin gene-related peptide (CGRP) receptor has gained attention in Alzheimer’s Disease (AD) research due to its involvement in regulating neuroinflammation. However, its role and mechanism in AD pathology remain unclear. H…
View article: A Novel GnRH Agonist-Based Regimen for Reducing Recurrence in Fertility-Preserved Atypical Polypoid Adenomyoma: A Retrospective Study
A Novel GnRH Agonist-Based Regimen for Reducing Recurrence in Fertility-Preserved Atypical Polypoid Adenomyoma: A Retrospective Study Open
Background Atypical polypoid adenomyoma (APA) is an uncommon uterine lesion characterized by a potential for recurrence and malignant transformation. Fertility-sparing treatment represents a critical option for patients who wish to preserv…
View article: Stage IA and IC Adult Granulosa Cell Tumors: Clinical Features, Long-Term Outcomes and Prognostic Factors in a 333-Patient Cohort Over Three Decades
Stage IA and IC Adult Granulosa Cell Tumors: Clinical Features, Long-Term Outcomes and Prognostic Factors in a 333-Patient Cohort Over Three Decades Open
Background Adult granulosa cell tumors (AGCTs) are rare low-grade malignant ovarian tumor, with 80–90% diagnosed at FIGO stage I. This study aimed to identify prognostic factors and refine management for stage I AGCT. Methods In this 30-ye…
View article: Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations
Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations Open
The predictive models enable clinicians to identify high-risk patients with coexisting mutations both preoperatively and postoperatively, supporting the development of individualized treatment strategies and potentially improving patient o…
View article: Circulating tumor DNA detection improves relapse prediction in epithelial ovarian cancer
Circulating tumor DNA detection improves relapse prediction in epithelial ovarian cancer Open
View article: Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice
Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice Open
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder with indistinct etiology and ill-defined pathophysiology. Intestinal inflammation involved in the pathogenesis of PD, but the underlying mechanism is not fully understood. …
View article: EP239/#122 The neoantigens landscape associated with histological subtypes in epithelial ovarian cancer
EP239/#122 The neoantigens landscape associated with histological subtypes in epithelial ovarian cancer Open
Introduction Neoantigens play a critical role in cancer immunotherapy. Epithelial ovarian cancer (EOC) is a strong heterogeneity tumor, often an immune desert, but immunotherapy is extremely important for intent to cure of cancer. We inves…
View article: Ultrasound and clinicopathological characteristics of papillary thyroid carcinoma predict the coexistence of TERT promoter and BRAFV600E mutations
Ultrasound and clinicopathological characteristics of papillary thyroid carcinoma predict the coexistence of TERT promoter and BRAFV600E mutations Open
Purpose: The coexistence of TERT promoter and BRAFV600E mutations is strongly associated with high aggressiveness and poor prognosis in papillary thyroid carcinoma. The aim of this study was to construct a preoperative and posto…
View article: Oncological and reproductive outcomes for gonadotropin-releasing hormone agonist combined with aromatase inhibitors or levonorgestrel-releasing intra-uterine system in women with endometrial cancer or atypical endometrial hyperplasia
Oncological and reproductive outcomes for gonadotropin-releasing hormone agonist combined with aromatase inhibitors or levonorgestrel-releasing intra-uterine system in women with endometrial cancer or atypical endometrial hyperplasia Open
GnRHa combined treatment provides favorable oncological and reproductive outcomes. Larger multi-institutional studies are required to confirm these preliminary findings.
View article: Neoantigens and the tumor microenvironment play important roles in the prognosis of high-grade serous ovarian cancer
Neoantigens and the tumor microenvironment play important roles in the prognosis of high-grade serous ovarian cancer Open
View article: Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study
Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study Open
Patients with high-grade EC exhibiting POLEmut have very good clinical outcomes, and should be identified urgently in daily work owing to their conflicting morphology. Our findings also provide guidance on subclassifying ECs with poor hist…
View article: Gonadotropin-Releasing Hormone Agonist Based Fertility-Sparing Treatment in Women with Endometrial Carcinoma or Atypical Endometrial Hyperplasia
Gonadotropin-Releasing Hormone Agonist Based Fertility-Sparing Treatment in Women with Endometrial Carcinoma or Atypical Endometrial Hyperplasia Open
Objectives：To evaluate the efficacy and safety of gonadotropin-releasing hormone agonist (GnRHa) combined with levonorgestrel-releasing intrauterine system (LNG-IUS) or aromatase inhibitor (AI) in women with endometrial carcinoma (EC) and …
View article: Lower growth arrest‐specific 5 level in endometrium is related to endometriosis via promoting cell proliferation and angiogenesis
Lower growth arrest‐specific 5 level in endometrium is related to endometriosis via promoting cell proliferation and angiogenesis Open
Long noncoding RNAs are a group of more than 200 nt, nonprotein coding RNAs, some of which are dysregulated in many pathophysiological processes including endometriosis. This study aims to clarify the roles of dysregulated growth arrest‐sp…
View article: Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance Open
Yolk sac tumors (YSTs) are a major histological subtype of malignant ovarian germ cell tumors with a relatively poor prognosis. The molecular basis of this disease has not been thoroughly characterized at the genomic level. Here we perform…
View article: Could Adjuvant Chemotherapy Improve Prognosis for Cervical Cancer Patients with Elevated Pretreatment Serum Squamous-Cell Carcinoma Antigen?
Could Adjuvant Chemotherapy Improve Prognosis for Cervical Cancer Patients with Elevated Pretreatment Serum Squamous-Cell Carcinoma Antigen? Open
For patients with elevated pretreatment SCC-Ag, adjuvant chemotherapy was not found to improve prognosis. Also, a considerable proportion of these patients had postoperative indications for adjuvant radiotherapy. For these cervical cancer …
View article: Identification of Somatic Mutations in Papanicolaou Smear DNA and Plasma Circulating Cell-Free DNA for Detection of Endometrial and Epithelial Ovarian Cancers: A Pilot Study
Identification of Somatic Mutations in Papanicolaou Smear DNA and Plasma Circulating Cell-Free DNA for Detection of Endometrial and Epithelial Ovarian Cancers: A Pilot Study Open
Objectives The aim of this study was to identify tumor-derived DNA from Papanicolaou (Pap) smear and plasma specimens collected from patients with endometrial cancer or atypical hyperplasia (EC/AH) or epithelial ovarian cancer (OC). Method…
View article: CYP27B1 Downregulation: A New Molecular Mechanism Regulating EZH2 in Ovarian Cancer Tumorigenicity
CYP27B1 Downregulation: A New Molecular Mechanism Regulating EZH2 in Ovarian Cancer Tumorigenicity Open
EZH2 plays an important role in promoting cell proliferation, migration, and invasion in ovarian cancer by regulating the core steroid biosynthesis gene via H3K27me3 methylation. Moreover, CYP27B1, the steroid biosynthesis hub gene,…
View article: 11-Methoxytabersonine Induces Necroptosis with Autophagy through AMPK/mTOR and JNK Pathways in Human Lung Cancer Cells
11-Methoxytabersonine Induces Necroptosis with Autophagy through AMPK/mTOR and JNK Pathways in Human Lung Cancer Cells Open
Aspidosperma alkaloids, a subclass of monoterpenoid indole alkaloids rich in the Apocynaceae plants, possess remarkable antitumor activities, but the underlying mechanisms have rarely been reported. In the current project, 11-methoxytabers…
View article: <p>Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction</p>
Importance of Standard Treatment in Prognosis of Patients with Ovarian Cancer and Associated Cerebral Infarction Open
Although the prognosis of patients with OC and associated CI was poor, those who underwent the standard treatment still benefited.
View article: Clinical and Expression Significance of AKT1 by Co-expression Network Analysis in Endometrial Cancer
Clinical and Expression Significance of AKT1 by Co-expression Network Analysis in Endometrial Cancer Open
Introduction: Endometrial cancer is one of the most common uterine cancers worldwide. AKT is reported to regulate progesterone receptor B dependent transcription and angiogenesis in endometrial cancer. However, the potential mechani…
View article: Laparoscopic vs. Open Abdominal Radical Hysterectomy for Cervical Cancer: A Single-Institution, Propensity Score Matching Study in China
Laparoscopic vs. Open Abdominal Radical Hysterectomy for Cervical Cancer: A Single-Institution, Propensity Score Matching Study in China Open
Study Objective: To compare the surgical and oncologic outcomes between open abdomen radical hysterectomy (ARH) and laparoscopic radical hysterectomy (LRH) for cervical cancer. Methods: Retrospective observational study with …
View article: Identification of a Prognostic Signature Associated With DNA Repair Genes in Ovarian Cancer
Identification of a Prognostic Signature Associated With DNA Repair Genes in Ovarian Cancer Open
Introduction: Ovarian cancer is a highly malignant cancer with a poor prognosis. At present, there is no accurate strategy for predicting the prognosis of ovarian cancer. A prognosis prediction signature associated with DNA repair g…
View article: Identification of prognosis markers for endometrial cancer by integrated analysis of DNA methylation and RNA-Seq data
Identification of prognosis markers for endometrial cancer by integrated analysis of DNA methylation and RNA-Seq data Open
View article: Uterine and Cervical Adenosarcoma: A Retrospective Study of Overall Oncologic Outcomes and Fertility Preservation in Early-Stage Disease
Uterine and Cervical Adenosarcoma: A Retrospective Study of Overall Oncologic Outcomes and Fertility Preservation in Early-Stage Disease Open
Background The management of adenosarcoma is based on the limited available data. This study aimed to explore the characteristics and oncologic outcomes of patients with uterine and cervical adenosarcoma. Materials and Methods A total of 2…
View article: Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation Sequencing
Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation Sequencing Open
Endometrial intraepithelial neoplasia (EIN), also known as endometrial atypical hyperplasia (EAH) is believed to be the precursor lesion of endometrioid endometrial carcinoma (EEC). Many genetic factors play important roles in the process …
View article: Defining Key Genes Regulating Morphogenesis of Apocrine Sweat Gland in Sheepskin
Defining Key Genes Regulating Morphogenesis of Apocrine Sweat Gland in Sheepskin Open
The apocrine sweat gland is a unique skin appendage in humans compared to mouse and chicken models. The absence of apocrine sweat glands in chicken and murine skin largely restrains further understanding of the complexity of human skin bio…
View article: Individualized treatment for a case of recurrent ovarian ependymoma
Individualized treatment for a case of recurrent ovarian ependymoma Open
Ovarian anaplastic ependymoma is a rare gynecologic malignancy. Owing to its rarity, treatment is challenging. Unilateral ovarian ependymoma was found during laparoscopy in a 19-year-old woman. After cytoreductive surgery, three cycles of …
View article: Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report
Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report Open
Malignant mixed ovarian germ cell tumors are very rare, accounting for ~5.3% of all malignant ovarian germ cell tumors (MOGCTs), with a very high degree of malignancy. The treatment of patients with persistent, refractory, or platinum-resi…
View article: Circular RNA profiling reveals circEXOC6B and circN4BP2L2 as novel prognostic biomarkers in epithelial ovarian cancer
Circular RNA profiling reveals circEXOC6B and circN4BP2L2 as novel prognostic biomarkers in epithelial ovarian cancer Open
Circular RNAs (circRNAs) are regarded as a novel class of widespread endogenous non-coding RNAs, which may play important roles in tumorigenesis by regulating gene expression. Nevertheless, the characterization of circRNAs in epithelial ov…