Minjun An
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View article: The molecular mechanism of fluoride export by the eukaryotic fluoride channel FEX
The molecular mechanism of fluoride export by the eukaryotic fluoride channel FEX Open
Much of life on Earth, including plants, fungi, and bacteria, evolved to resist toxic environmental fluoride. In eukaryotes, the major resistance mechanism is fluoride export by membrane proteins known as FEX. Using electrophysiology and t…
View article: The molecular basis of sodium-dependent fluoride export by the eukaryotic fluoride channel FEX
The molecular basis of sodium-dependent fluoride export by the eukaryotic fluoride channel FEX Open
Much of life on Earth, including plants, fungi, and bacteria, evolved to resist toxic environmental fluoride. In eukaryotes, the major resistance mechanism is fluoride export by FEX proteins. Using electrophysiology and transport assays, w…
View article: Towards structural determination of fluoride export proteins
Towards structural determination of fluoride export proteins Open
Dental caries is often caused by Streptococci species, especially the cariogenic bacterium known as Streptococcus mutans (S. mutans). Fluoride (F-) is widely used to prevent tooth decay as an effective antimicrobial. CLCF proteins are know…
View article: Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer: a phase II trial of pembrolizumab
Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer: a phase II trial of pembrolizumab Open
This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.
View article: Fluoride export is required for the competitive fitness of pathogenic microorganisms in dental biofilm models
Fluoride export is required for the competitive fitness of pathogenic microorganisms in dental biofilm models Open
Microorganisms resist fluoride toxicity using fluoride export proteins from one of several different molecular families. Cariogenic species Streptococcus mutans and Candida albicans extrude intracellular fluoride using a CLC F F - /H + ant…
View article: Fluoride export is required for competitive fitness of pathogenic microorganisms in dental biofilm models
Fluoride export is required for competitive fitness of pathogenic microorganisms in dental biofilm models Open
Microorganisms resist fluoride toxicity using fluoride export proteins from one of several different molecular families. Cariogenic species Streptococcus mutans and Candida albicans extrude intracellular fluoride using a CLC F F − /H + ant…