Minjun Ji
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View article: Study on BIM-based simulation of fire emergency evacuation in college library
Study on BIM-based simulation of fire emergency evacuation in college library Open
College libraries, as high-occupancy public spaces with complex layouts and atrium structures, face significant fire safety challenges, particularly regarding rapid smoke spread and safe evacuation. Existing studies often lack integrated s…
View article: A Mycobacterium tuberculosis multi-epitope DNA vaccine encoding adaptive immune antigens provokes IFNγ/Th1 immunity and confers potential protection
A Mycobacterium tuberculosis multi-epitope DNA vaccine encoding adaptive immune antigens provokes IFNγ/Th1 immunity and confers potential protection Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a significant global health threat. However, the licensed Bacille Calmette-Guérin- (BCG) vaccine provides only limited protection in adults, underscoring the urgent nee…
View article: Popular vegetarian diets in China: a sustainable dietary option for the globe?
Popular vegetarian diets in China: a sustainable dietary option for the globe? Open
Vegetarian practices have historically been ingrained in Chinese society. However, it is uncertain to what extent these practices correspond to the global concept of a sustainable diet. In this study, we aimed to identify popular vegetaria…
View article: Electroacupuncture alleviates the relapse of behaviors associated with pain sensory memory and pain-related aversive memory by activating MORs and inhibiting GABAergic neurons in the insular cortex
Electroacupuncture alleviates the relapse of behaviors associated with pain sensory memory and pain-related aversive memory by activating MORs and inhibiting GABAergic neurons in the insular cortex Open
Pain memory, which includes sensory and emotional memory, is one of the main causes of pain complications and prolongation. Recent research has identified the insular cortex (IC) as a critical brain region involved in the integration of in…
View article: <scp> <i>Akkermansia muciniphila</i> </scp> Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via <scp>PI3K</scp> /Akt Pathway
<span> <i>Akkermansia muciniphila</i> </span> Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via <span>PI3K</span> /Akt Pathway Open
Acetaminophen induced acute liver injury (ALI) has a high incidence and is a serious medical problem, but there is a lack of effective treatment. The enterohepatic axis is one of the targets of recent attention due to its important role in…
View article: Berberine ameliorates dextran sulfate sodium -induced colitis through tuft cells and bitter taste signalling
Berberine ameliorates dextran sulfate sodium -induced colitis through tuft cells and bitter taste signalling Open
Berberine ameliorates dextran sulfate sodium -induced colitis through tuft cells and bitter taste signalling. Our study reveals the unique pharmacological mechanisms of berberine in the context of colitis, laying the foundation for further…
View article: Impact of Douyin Beauty Brand Live Streaming on Consumers’ Purchase Intentions
Impact of Douyin Beauty Brand Live Streaming on Consumers’ Purchase Intentions Open
Nowadays, Douyin has become an important channel for promoting beauty brands, and how to enhance the influence of Douyin beauty live broadcast is still a topic that needs to be explored. In this context, this paper investigates what factor…
View article: The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring
The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring Open
Maternal immune activation (MIA) is critical for imparting neuropathology and altered behaviors in offspring; however, maternal-fetal immune cell populations have not been thoroughly investigated in MIA-induced autism spectrum disorders (A…
View article: Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury
Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury Open
Ischemia-reperfusion injury (IRI) remains an unavoidable challenge in liver surgery, with macrophages playing a critical role in its pathogenesis. However, the mechanisms by which macrophages regulate the pathogenesis of IRI are not well u…
View article: Computer-aided designing of a novel multi‑epitope DNA vaccine against severe fever with thrombocytopenia syndrome virus
Computer-aided designing of a novel multi‑epitope DNA vaccine against severe fever with thrombocytopenia syndrome virus Open
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease caused by the SFTS virus ( Dabie bandavirus ), which has become a substantial risk to public health. No specific treatment is available now, that ca…
View article: Helminth-derived molecules: Pathogenic and pharmacopeial roles
Helminth-derived molecules: Pathogenic and pharmacopeial roles Open
Parasitic helminths, taxonomically comprising trematodes, cestodes, and nematodes, are multicellular invertebrates widely disseminated in nature and have afflicted humans continuously for a long time. Helminths play potent roles in the hos…
View article: Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective
Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective Open
Neuropsychiatric disorders (NDDs) have been associated with maternal immune activation (MIA) in epidemiologic studies, such as prospective birth cohort studies. There is evidence linking maternal infectious pathogens and inflammation to a …
View article: Washed microbiota transplantation reduces glycemic variability in unstable diabetes
Washed microbiota transplantation reduces glycemic variability in unstable diabetes Open
Background Dysbiosis of gut microbiota is causally linked to impaired host glucose metabolism. We aimed to study effects of the new method of fecal microbiota transplantation, washed microbiota transplantation (WMT), on reducing glycemic v…
View article: Effects of virtual reality simulation on medical students’ learning and motivation in human parasitology instruction: a quasi-experimental study
Effects of virtual reality simulation on medical students’ learning and motivation in human parasitology instruction: a quasi-experimental study Open
Background Despite the proven effectiveness of simulation-based learning activities, its adoption in medical education remains limited, and the influence of simulation on student motivation, particularly subjective task values, is seldom e…
View article: Effects of virtual reality simulation on medical students’ learning and motivation in human parasitology instruction: A quasi-experimental study
Effects of virtual reality simulation on medical students’ learning and motivation in human parasitology instruction: A quasi-experimental study Open
Background Though research has suggested the effectiveness of simulation-based learning, the adoption of simulation in medical education is still limited, and its effects on motivation is rarely studied. The aim of this study was to invest…
View article: The impact of environmental and host factors on wolbachia density and efficacy as a biological tool
The impact of environmental and host factors on wolbachia density and efficacy as a biological tool Open
Wolbachia, a bacterium found naturally in some species of Aedes and Culex mosquitoes, has gained significant attention for it's potential in controlling mosquito-borne diseases and suppressing mosquito populations. However, Wolbachia-media…
View article: Identification and Characterization of Antigenic Properties of Schistosoma japonicum Heat Shock Protein 90α Derived Peptides
Identification and Characterization of Antigenic Properties of Schistosoma japonicum Heat Shock Protein 90α Derived Peptides Open
It is known that schistosome-derived antigens induce innate and adaptive immune responses that are essential for the formation of hepatic immunopathology. Here, we screened and synthesized four peptides derived from Schistosoma japonicum (…
View article: Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model
Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model Open
Background and Aims The heat shock protein (Hsp) 90α is induced by stress and regulates inflammation through multiple pathways. Elevated serum Hsp90α had been found in nonalcoholic steatohepatitis (NASH). Geranylgeranylacetone (GGA, also c…
View article: Up-regulation of MELK by E2F1 promotes the proliferation in cervical cancer cells
Up-regulation of MELK by E2F1 promotes the proliferation in cervical cancer cells Open
Cervical cancer is a common gynecologic cancer and a frequent cause of death. In this study, we investigated the role of MELK (maternal embryonic leucine zipper kinase) in cervical cancer. We found that HPV 18 E6/E7 promoted MELK expressio…
View article: Therapeutic inhibition of miR-802 protects against obesity through AMPK-mediated regulation of hepatic lipid metabolism
Therapeutic inhibition of miR-802 protects against obesity through AMPK-mediated regulation of hepatic lipid metabolism Open
Background: The host-parasite relationship is based on subtle interplay between parasite survival strategies and host defense mechanisms. It is well known that helminth infection, which afflicts more than one billion people globally, corre…
View article: P21 activated kinase‐1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection
P21 activated kinase‐1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection Open
CD4 + T cells differentiate into distinct functional effector and inhibitory subsets are facilitated by distinct cytokine cues present at the time of antigen recognition. Maintaining a balance between T helper 17 (Th17) and regulatory T (T…
View article: ASF1B promotes cervical cancer progression through stabilization of CDK9
ASF1B promotes cervical cancer progression through stabilization of CDK9 Open
Cervical cancer (CC) is one of the most deadly cancers in women, its current treatments still result in poor outcomes and developing the novel targets and therapeutic strategies are urgently needed. Recent studies have shown that anti-sile…
View article: A Biological and Immunological Characterization of Schistosoma Japonicum Heat Shock Proteins 40 and 90α
A Biological and Immunological Characterization of Schistosoma Japonicum Heat Shock Proteins 40 and 90α Open
We characterized Schistosoma japonicum HSP40 (Sjp40) and HSP90α (Sjp90α) in this study. Western blot analysis revealed both are present in soluble egg antigens and egg secretory proteins, implicating them in triggering the host immune resp…
View article: Wolbachia limits pathogen infections through induction of host innate immune responses
Wolbachia limits pathogen infections through induction of host innate immune responses Open
The presence of Wolbachia per se does not necessarily affect pathogen infections, suggesting that a competition for limited nutrients is not the main reason for Wolbachia-mediated pathogen suppression. Instead, host immune responses are re…
View article: Aberrant expression of long non-coding RNAs (lncRNAs) is involved in brain glioma development
Aberrant expression of long non-coding RNAs (lncRNAs) is involved in brain glioma development Open
Our data suggest that altered expression of lncRNAs may be a critical determinant of tumorigenesis in glioma patients.