Explanipedia

Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis Open

Minjun Wang, Fei Chen, Junling Gao, Qinggui Liu, Zhi‐Xuan Li , et al. · 2025

Pericentral senescent hepatocytes secrete CLU to induce the proliferation and migration of mesothelial cells to endocytose fibers by its receptor LRP2, thus reducing liver fibrosis. The engineered CLUtide mimicking CLU may be promising for…

Molecular mechanisms and genetic features of cholangiocarcinoma: implications for targeted therapeutic strategies Open

Xiao Lu, Shoujia Xu, Zhe Deng, Minjun Wang, Fei Chen · 2025

Cholangiocarcinoma (CCA) is a biologically diverse and highly aggressive cancer that arises from the biliary epithelium. It is typically divided into intrahepatic, perihilar, and distal types, each with distinct clinical behavior, genetic …

MASH-Induced Splenic TRNP1+CD8+ T Cells Exacerbate Liver Fibrosis Open

Liyuan Zhang, Yahui Wang, Kai Wei, Wen Nie, Yayuan Feng , et al. · 2025

VEGF‐FGF Signaling Activates Quiescent CD63+ Liver Stem Cells to Proliferate and Differentiate (Adv. Sci. 33/2024) Open

Fei Chen, Kunshan Zhang, Minjun Wang, Zhiying He, Bing Yu , et al. · 2024

Activation of Quiescent Liver Stem Cells Quiescent liver stem cells are activated under certain circumstance to proliferate and differentiate. This process was similar to that flower buds break into bloom. The illustration shows a tree in …

The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases Open

Min-Jun Wang, Hailing Zhang, Fei Chen, Xiaojing Guo, Qinggui Liu , et al. · 2024

VEGF‐FGF Signaling Activates Quiescent CD63+ Liver Stem Cells to Proliferate and Differentiate Open

Fei Chen, Kunshan Zhang, Min-Jun Wang, Zhiying He, Bing Yu , et al. · 2024

Understanding the liver stem cells (LSCs) holds great promise for new insights into liver diseases and liver regeneration. However, the heterogenicity and plasticity of liver cells have made it controversial. Here, by employing single‐cell…

Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis Open

Kaiwei Jia, Ren-qi Yao, Yiwen Fan, Dingji Zhang, Ye Zhou , et al. · 2024

Background Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role in liver I/R injur…

Origin of the 6/5/6/5 Tetracyclic Cyclopiazonic Acids Open

Wenyuan Zhang, Xue-Jian Jiang, Min-Jun Wang, Zhizhen Zhang, Nan Wang · 2024

The natural product α-cyclopiazonic acid (α-CPA) is a very potent Ca2+-ATPase inhibitor. The CPA family of compounds comprise over 80 chemical entities with at least five distinct skeletons. While α-CPA features a canonical 6/5/6/5/5 skele…

Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study Open

Lei Yu, Junjun An, Qingchun Ren, Minjun Wang, Mingzhu Gao · 2023

Cholesteatoma is a noncancerous cystic lesion caused by an abnormal growth of keratinizing squamous epithelium which is invasive and capable of destroying structures. A prospective study on the expression of membrane type1-matrix metallopr…

Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis Open

Liyuan Zhang, Yue Dong, Luxin Zhang, Minjun Wang, Ye Zhou , et al. · 2023

Mitochondrial IRG1 traps Mcl-1 to induce hepatocyte apoptosis and promote carcinogenesis Open

Liyuan Zhang, Yue Dong, Luxin Zhang, Minjun Wang, Ye Zhou , et al. · 2023

Background Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, and the underlying mechanisms mediating cell death and the subsequent carcinogenesis remain to be fully investigated. Immunoresponsive gene 1 (IRG1…

Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells Open

Minjun Wang, Jiajia Chen, Shaohua Song, Jing Su, Linghao Zhao , et al. · 2021

Taken together, these findings pointed that induction of senescence in liver CSCs is an effective tumor suppression method for HCC, and SIRT1 may be served as a promising target for HCC treatment.

Apoptotic Extracellular Vesicles (ApoEVs) Safeguard Liver Homeostasis and RegenerationviaAssembling an ApoEV-Golgi Organelle Open

Bingdong Sui, Runci Wang, Chider Chen, Xiaoxing Kou, Di Wu , et al. · 2021

Summary Apoptosis is an integral physiological cell death process that occurs frequently and generates a huge number of apoptotic extracellular vesicles (apoEVs). However, whether apoEVs are necessary for maintaining organ homeostasis rema…

Aged-related Function Disorder of Liver is Reversed after Exposing to Young Milieu via Conversion of Hepatocyte Ploidy Open

Qinggui Liu, Fei Chen, Tao Yang, Jing Su, Shaohua Song , et al. · 2021

Previous study showed that senescent hepatocytes from aged liver could be rejuvenated after repopulated in the young recipient liver. The proliferative capacity of hepatocytes was restored with the senescence reversal. However, it is unkno…

Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine�A, a multi‑target anti‑Alzheimer's molecule Open

Xiaofeng Jin, Minjun Wang, Jieyi Shentu, Chunhui Huang, Yujing Bai , et al. · 2019

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by learning and memory impairments. Recent studies have suggested that AD can be induced by multiple factors, such as cholinergic system dysfunction and β-amyloid (Aβ) …

Generation of insulin-secreting cells from mouse gallbladder stem cells by small molecules in vitro Open

Fei Chen, Tuo Li, Yu Sun, Qinggui Liu, Tao Yang , et al. · 2019

Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging Open

Minjun Wang, Jiajia Chen, Fei Chen, Qinggui Liu, Yu Sun , et al. · 2018

Although aging is a physiological process, it has raised interest in the science of aging and rejuvenation because of the increasing burden on the rapidly aging global population. With advanced age, there is a decline in homeostatic mainte…

SPINK1 , PRSS1 , CTRC , and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis Open

Wen‐Bin Zou, Xin‐Ying Tang, Daizhan Zhou, Yang‐Yang Qian, Liang‐Hao Hu , et al. · 2018

We provide evidence that rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes significantly influence the age of onset and clinical outcomes of CP. Extensive gene-environment interactions were also identified.

The extent of liver injury determines hepatocyte fate toward senescence or cancer Open

Chao Wang, Wenjian Chen, Yingfu Wu, Pu You, Shangyong Zheng , et al. · 2018

Liver-enriched activator protein 1 as an isoform of CCAAT/enhancer-binding protein beta suppresses stem cell features of hepatocellular carcinoma Open

Lihua Yang, Ye Wang, Qiao Shi, Minjun Wang, Fei Chen , et al. · 2018

LAP1 suppressed the stem cell features of HCC, indicating that it possessed an antitumor effect in liver cancer, both in vitro and in vivo; therefore, LAP1 may prove to be a potential target in liver CSC-targeted therapy.

Insulin-like growth factor 2 is a key mitogen driving liver repopulation in mice Open

Minjun Wang, Fei Chen, Qinggui Liu, Changcheng Liu, Hao Yao , et al. · 2018

Trypsin-Dependent Pathway Gene Variants and Chronic Pancreatitis: A Large Chinese Cohort Study Open

Wen‐Bin Zou, Xin‐Ying Tang, Daizhan Zhou, Yang‐Yang Qian, Liang‐Hao Hu , et al. · 2018

Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice Open

Liping Chen, Chunhui Huang, Jieyi Shentu, Min-Jun Wang, Sicheng Yan , et al. · 2017

Indirubins are natural occurring alkaloids extracted from indigo dye-containing plants. Indirubins could inhibit various kinases, and might be used to treat chronic myelocytic leukemia, cancer and neurodegenerative disorders. 7-bromoindiru…

5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro Open

Jiaying Zhao, Fufeng Liu, Chunhui Huang, Jieyi Shentu, Min-Jun Wang , et al. · 2017

The oligomer of β-amyloid (Aβ) is considered the main neurotoxin in Alzheimer’s disease (AD). Therefore, the inhibition of the formation of Aβ oligomer could be a target for AD therapy. In this study, with the help of the dot blotting assa…

Hepatocyte polyploidization and its association with pathophysiological processes Open

Minjun Wang, Fei Chen, Joseph T.Y. Lau, Yiping Hu · 2017

A characteristic cellular feature of the mammalian liver is the progressive polyploidization of the hepatocytes, where individual cells acquire more than two sets of chromosomes. Polyploidization results from cytokinesis failure that takes…

Establishment of a novel human lymphoblastic cell strain with the long arm of chromosome 11 aberration without MLL rearrangement Open

Qian Wang, Lin Zhuang, Pei Li, Qiang Niu, Ping Zhu , et al. · 2017

Expression of estrogen receptors and androgen receptor and their clinical significance in gastric cancer Open

Wenbo Tang, Rujiao Liu, Yan Yan, Xiaoli Pan, Minjun Wang , et al. · 2017

The present study showed that positive ERα was associated with poor prognosis of Chinese GC patients. ERα might modulate the proliferation, migration and invasion via regulating the expression of p53, p21, p27, cyclin D1 and E-cadherin. ER…

Chest CT findings in systemic lupus erythematosus and its correlation with serum markers Open

Ping Li, Shenghong Li, Lan Li, Minjun Wang · 2016

The aim of this study was to assess the CT findings of chest lesions in patients with systemic lupus erythematosus (SLE), and to explore its correlation with the age and serum markers (anti-dsDNA antibodies, anti-Sm antibodies, CRP, ESR, C…

Altered Hepa1-6 cells by dimethyl sulfoxide (DMSO)-treatment induce anti-tumor immunity in vivo Open

Zhengyu Jiang, Hongxia Zhang, Ye Wang, Bin Yu, Chen Wang , et al. · 2016

Cancer immunotherapy is the use of the immune system to treat cancer. Our current research proposed an optional strategy of activating immune system involving in cancer immunotherapy. When being treated with 2% DMSO in culture medium, Hepa…

In vitro anti-proliferation assay in HCC cell lines. Open

Xin Hong, Ke Wang, Gang Hu, Xie Fubo, Kedong Ouyang , et al. · 2015

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